{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:16:27Z","timestamp":1792271787947,"version":"4.4.0"},"reference-count":74,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000646","name":"Japan Society for the Promotion of Science London","doi-asserted-by":"publisher","award":["19K08434"],"award-info":[{"award-number":["19K08434"]}],"id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000646","name":"Japan Society for the Promotion of Science London","doi-asserted-by":"publisher","award":["23K07368"],"award-info":[{"award-number":["23K07368"]}],"id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018501","name":"Cancer Research Institute, Kanazawa University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018501","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006004","name":"Tohoku University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006004","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","cmghjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/j.jcmgh.2025.101629","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T16:26:45Z","timestamp":1757521605000},"page":"101629","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Metabolic Syndrome Develops Cardia Cancer via Nuclear Factor-E2-related Factor 2-Programmed Death-Ligand 1 Signaling"],"prefix":"10.1016","volume":"20","author":[{"given":"Keisuke","family":"Kusano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaname","family":"Uno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Tamahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Asano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichiro","family":"Sudo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mizuki","family":"Tanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koya","family":"Ogasawara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Kanno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Koike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritsuko","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Masamune","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcmgh.2025.101629_bib1","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1007\/s00535-019-01577-7","article-title":"Time trends in the incidence of esophageal adenocarcinoma, gastric adenocarcinoma, and superficial esophagogastric junction adenocarcinoma","volume":"54","author":"Matsuno","year":"2019","journal-title":"J Gastroenterol"},{"key":"10.1016\/j.jcmgh.2025.101629_bib2","doi-asserted-by":"crossref","first-page":"198","DOI":"10.14309\/ajg.0000000000001001","article-title":"Risk factor profiles can distinguish esophageal adenocarcinoma from Barrett\u2019s esophagus","volume":"116","author":"Sawas","year":"2021","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jcmgh.2025.101629_bib3","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.3748\/wjg.v11.i18.2697","article-title":"Free radicals and antioxidant systems in reflux esophagitis and Barrett\u2019s esophagus","volume":"11","author":"Jim\u00e9nez","year":"2005","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jcmgh.2025.101629_bib4","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1038\/ajg.2014.351","article-title":"Risk factors for Barrett\u2019s esophagus compared between African Americans and non-Hispanic whites","volume":"109","author":"Nguyen","year":"2014","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jcmgh.2025.101629_bib5","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/1471-230X-9-56","article-title":"Visceral obesity and the risk of Barrett\u2019s esophagus in Japanese patients with non-alcoholic fatty liver disease","volume":"9","author":"Akiyama","year":"2009","journal-title":"BMC Gastroenterol"},{"key":"10.1016\/j.jcmgh.2025.101629_bib6","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1002\/cncr.30365","article-title":"Metabolic syndrome and risk of esophageal adenocarcinoma in elderly patients in the United States: an analysis of SEER-Medicare data","volume":"123","author":"Drahos","year":"2017","journal-title":"Cancer"},{"key":"10.1016\/j.jcmgh.2025.101629_bib7","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1136\/gutjnl-2020-321949","article-title":"Periodontal disease, tooth loss, and risk of oesophageal and gastric adenocarcinoma: a prospective study","volume":"70","author":"Lo","year":"2021","journal-title":"Gut"},{"key":"10.1016\/j.jcmgh.2025.101629_bib8","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1038\/s41591-019-0458-7","article-title":"Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer","volume":"25","author":"Yachida","year":"2019","journal-title":"Nat Med"},{"key":"10.1016\/j.jcmgh.2025.101629_bib9","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1053\/j.gastro.2022.03.054","article-title":"Metagenomic identification of microbial signatures predicting pancreatic cancer from a multinational study","volume":"163","author":"Nagata","year":"2022","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2025.101629_bib10","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1053\/j.gastro.2021.08.041","article-title":"High-fat diet promotes colorectal tumorigenesis through modulating gut microbiota and metabolites","volume":"162","author":"Yang","year":"2022","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2025.101629_bib11","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1053\/j.gastro.2019.04.013","article-title":"High-fat diet accelerates carcinogenesis in a mouse model of Barrett\u2019s esophagus via Interleukin 8 and alterations to the gut microbiome","volume":"157","author":"M\u00fcnch","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2025.101629_bib12","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1038\/s41416-022-01974-5","article-title":"A blood-based circulating microbial metagenomic panel for early diagnosis and prognosis of oesophageal adenocarcinoma","volume":"127","author":"Zaidi","year":"2022","journal-title":"Br J Cancer"},{"key":"10.1016\/j.jcmgh.2025.101629_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241411790","article-title":"Significance of lipopolysaccharides in gastric cancer and their potential as a biomarker for nivolumab sensitivity","volume":"24","author":"Nakazawa","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jcmgh.2025.101629_bib14","doi-asserted-by":"crossref","first-page":"5538","DOI":"10.4049\/jimmunol.169.10.5538","article-title":"Expression of programmed death 1 ligands by murine T cells and APC","volume":"169","author":"Yamazaki","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.jcmgh.2025.101629_bib15","doi-asserted-by":"crossref","first-page":"2706","DOI":"10.1002\/eji.200324228","article-title":"Regulation of PD-1, PD-L1, and PD-L2 expression during normal and autoimmune responses","volume":"33","author":"Liang","year":"2003","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jcmgh.2025.101629_bib16","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1084\/jem.192.7.1027","article-title":"Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation","volume":"192","author":"Freeman","year":"2000","journal-title":"J Exp Med"},{"key":"10.1016\/j.jcmgh.2025.101629_bib17","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/nm730","article-title":"Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion","volume":"8","author":"Dong","year":"2002","journal-title":"Nat Med"},{"key":"10.1016\/j.jcmgh.2025.101629_bib18","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1053\/j.gastro.2006.07.014","article-title":"Carcinogenesis in mouse stomach by simultaneous activation of the Wnt signaling and prostaglandin E2 pathway","volume":"131","author":"Oshima","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2025.101629_bib19","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1111\/j.1349-7006.2009.01430.x","article-title":"CD44+ slow-cycling tumor cell expansion is triggered by cooperative actions of Wnt and prostaglandin E2 in gastric tumorigenesis","volume":"101","author":"Ishimoto","year":"2010","journal-title":"Cancer Sci"},{"key":"10.1016\/j.jcmgh.2025.101629_bib20","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.aninu.2021.06.009","article-title":"Dietary ferulic acid and vanillic acid on inflammation, gut barrier function and growth performance in lipopolysaccharide-challenged piglets","volume":"8","author":"Hu","year":"2022","journal-title":"Anim Nutr"},{"key":"10.1016\/j.jcmgh.2025.101629_bib21","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1002\/ijc.30219","article-title":"Dysregulated hepatic bile acids collaboratively promote liver carcinogenesis","volume":"139","author":"Xie","year":"2016","journal-title":"Int J Cancer"},{"key":"10.1016\/j.jcmgh.2025.101629_bib22","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1093\/jnci\/88.21.1586","article-title":"Epithelial cell hyperproliferation induced in the exocrine pancreas of mice by a western-style diet","volume":"88","author":"Xue","year":"1996","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.jcmgh.2025.101629_bib23","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jbiotec.2024.04.005","article-title":"Caproicibacter sp. BJN0012, a potential new species isolated from cellar mud for caproic acid production from glucose","volume":"388","author":"Dai","year":"2024","journal-title":"J Biotechnol"},{"key":"10.1016\/j.jcmgh.2025.101629_bib24","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1017\/S0007114508888733","article-title":"Physiological concentrations of short-chain fatty acids immediately suppress colonic epithelial permeability","volume":"100","author":"Suzuki","year":"2008","journal-title":"Br J Nutr"},{"key":"10.1016\/j.jcmgh.2025.101629_bib25","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.chom.2015.03.005","article-title":"Crosstalk between microbiota-derived short-chain fatty acids and intestinal epithelial HIF augments tissue barrier function","volume":"17","author":"Kelly","year":"2015","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jcmgh.2025.101629_bib26","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1093\/advances\/nmx009","article-title":"Butyrate: a double-edged sword for health?","volume":"9","author":"Liu","year":"2018","journal-title":"Adv Nutr"},{"key":"10.1016\/j.jcmgh.2025.101629_bib27","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1365-2036.2007.03562.x","article-title":"The role of butyrate on colonic function","volume":"27","author":"Hamer","year":"2008","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.jcmgh.2025.101629_bib28","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s11739-023-03374-w","article-title":"Gut microbiota, intestinal permeability, and systemic inflammation: a narrative review","volume":"19","author":"Di Vincenzo","year":"2024","journal-title":"Intern Emerg Med"},{"key":"10.1016\/j.jcmgh.2025.101629_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2024.1380713","article-title":"Intestinal barrier permeability: the influence of gut microbiota, nutrition, and exercise","volume":"15","author":"Dmytriv","year":"2024","journal-title":"Front Physiol"},{"key":"10.1016\/j.jcmgh.2025.101629_bib30","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.3390\/nu15132992","article-title":"NAD+ precursors and intestinal inflammation: therapeutic insights involving gut microbiota","volume":"15","author":"Ni\u00f1o-Narvi\u00f3n","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.jcmgh.2025.101629_bib31","first-page":"328","article-title":"Polyamines in gut epithelial renewal and barrier function","volume":"35","author":"Rao","year":"2020","journal-title":"Physiology (Bethesda)"},{"key":"10.1016\/j.jcmgh.2025.101629_bib32","first-page":"389","article-title":"Fasting gastric fluid and fecal polyamine concentrations in premature infants","volume":"24","author":"Forget","year":"1997","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.jcmgh.2025.101629_bib33","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nri.2017.7","article-title":"Dysbiosis and the immune system","volume":"17","author":"Levy","year":"2017","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jcmgh.2025.101629_bib34","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1038\/s41586-024-07754-w","article-title":"Gut microbiota carcinogen metabolism causes distal tissue tumours","volume":"632","author":"Roje","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.jcmgh.2025.101629_bib35","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/s41392-023-01693-0","article-title":"Intratumoural microbiota: a new frontier in cancer development and therapy","volume":"9","author":"Cao","year":"2024","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.jcmgh.2025.101629_bib36","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.3390\/antiox11061212","article-title":"Dietary polyphenol, gut microbiota, and health benefits","volume":"11","author":"Wang","year":"2022","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.jcmgh.2025.101629_bib37","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3390\/compounds3010005","article-title":"Polyphenols in health and disease: gut microbiota, bioaccessibility, and bioavailability","volume":"3","author":"Bi\u00e9","year":"2023","journal-title":"Compounds"},{"key":"10.1016\/j.jcmgh.2025.101629_bib38","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s12929-018-0483-8","article-title":"Microbiota dysbiosis and barrier dysfunction in inflammatory bowel disease and colorectal cancers: exploring a common ground hypothesis","volume":"25","author":"Yu","year":"2018","journal-title":"J Biomed Sci"},{"key":"10.1016\/j.jcmgh.2025.101629_bib39","doi-asserted-by":"crossref","first-page":"4200","DOI":"10.1038\/s41388-022-02395-7","article-title":"Parvimonas micra promotes colorectal tumorigenesis and is associated with prognosis of colorectal cancer patients","volume":"41","author":"Zhao","year":"2022","journal-title":"Oncogene"},{"key":"10.1016\/j.jcmgh.2025.101629_bib40","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1136\/gutjnl-2024-333020","article-title":"Fasting-mimicking diet-enriched Bifidobacterium pseudolongum suppresses colorectal cancer by inducing memory CD8+ T cells","volume":"74","author":"Nan","year":"2025","journal-title":"Gut"},{"key":"10.1016\/j.jcmgh.2025.101629_bib41","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1016\/j.cgh.2023.03.012","article-title":"Antibiotic exposure is associated with a risk of esophageal adenocarcinoma","volume":"21","author":"Thanawala","year":"2023","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2025.101629_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2172-8-1","article-title":"Transcriptional profiling of the LPS induced NF-kappa B response in macrophages","volume":"8","author":"Sharif","year":"2007","journal-title":"BMC Immunol"},{"key":"10.1016\/j.jcmgh.2025.101629_bib43","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1038\/s41388-019-1078-x","article-title":"The reciprocal interaction between tumor cells and activated fibroblasts mediated by TNF-\u03b1\/IL-33\/ST2L signaling promotes gastric cancer metastasis","volume":"39","author":"Zhou","year":"2020","journal-title":"Oncogene"},{"key":"10.1016\/j.jcmgh.2025.101629_bib44","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s40425-019-0530-3","article-title":"Increased intratumoral mast cells foster immune suppression and gastric cancer progression through TNF-\u03b1-PD-L1 pathway","volume":"7","author":"Lv","year":"2019","journal-title":"J Immunother Cancer"},{"key":"10.1016\/j.jcmgh.2025.101629_bib45","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.584626","article-title":"Regulation of PD-L1 expression by NF-kB in cancer","volume":"11","author":"Antonangeli","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.jcmgh.2025.101629_bib46","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1056\/NEJM199802123380706","article-title":"Chemokines--chemotactic cytokines that mediate inflammation","volume":"338","author":"Luster","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jcmgh.2025.101629_bib47","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.ebiom.2019.08.067","article-title":"Role of CXCR3 signaling in response to anti-PD-1 therapy","volume":"48","author":"Han","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.jcmgh.2025.101629_bib48","article-title":"The role of CXCR3 and its ligands in cancer","volume":"12","author":"Wang","year":"2022","journal-title":"Front Oncol"},{"key":"10.1016\/j.jcmgh.2025.101629_bib49","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1038\/s41419-021-04293-4","article-title":"Gut-derived lipopolysaccharide remodels tumoral microenvironment and synergizes with PD-L1 checkpoint blockade via TLR4\/MyD88\/AKT\/NF-kB pathway in pancreatic cancer","volume":"12","author":"Yin","year":"2021","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.jcmgh.2025.101629_bib50","doi-asserted-by":"crossref","first-page":"9997","DOI":"10.1002\/jcb.27329","article-title":"LPS promotes the expression of PD-L1 in gastric cancer cells through NF-kB activation","volume":"119","author":"Li","year":"2018","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.jcmgh.2025.101629_bib51","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1042\/BST20150014","article-title":"Dissecting molecular cross-talk between Nrf2 and NF-kB response pathways","volume":"43","author":"Wardyn","year":"2015","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.jcmgh.2025.101629_bib52","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1184079","article-title":"Nrf2 signaling pathway: current status and potential therapeutic targetable role in human cancers","volume":"13","author":"Lin","year":"2023","journal-title":"Front Oncol"},{"key":"10.1016\/j.jcmgh.2025.101629_bib53","article-title":"Tumor-immune microenvironment and NRF2 associate with clinical efficacy of PD-1 blockade combined with chemotherapy in lung squamous cell carcinoma","volume":"4","author":"Duan","year":"2023","journal-title":"Cell Rep Med"},{"key":"10.1016\/j.jcmgh.2025.101629_bib54","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.2337\/db06-1491","article-title":"Metabolic endotoxemia initiates obesity and insulin resistance","volume":"56","author":"Cani","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.jcmgh.2025.101629_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcmgh.2025.101505","article-title":"Loss of FXR or bile acid-dependent inhibition accelerate carcinogenesis of gastroesophageal adenocarcinoma","volume":"19","author":"Baumeister","year":"2025","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2025.101629_bib56","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.cmet.2012.05.012","article-title":"Hyperresponsivity to low-dose endotoxin during progression to nonalcoholic steatohepatitis is regulated by leptin-mediated signaling","volume":"16","author":"Imajo","year":"2012","journal-title":"Cell Metab"},{"key":"10.1016\/j.jcmgh.2025.101629_bib57","article-title":"Injections of lipopolysaccharide into mice to mimic entrance of microbial-derived products after intestinal barrier breach","volume":"135","author":"Raduolovic","year":"2018","journal-title":"J Vis Exp"},{"key":"10.1016\/j.jcmgh.2025.101629_bib58","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1902\/jop.2008.070575","article-title":"P. gingivalis and E. coli lipopolysaccharides exhibit different systemic but similar local induction of inflammatory markers","volume":"79","author":"Liu","year":"2008","journal-title":"J Periodontol"},{"key":"10.1016\/j.jcmgh.2025.101629_bib59","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.2337\/dc10-2197","article-title":"Bacterial endotoxin activity in human serum is associated with dyslipidemia, insulin resistance, obesity, and chronic inflammation","volume":"34","author":"Lassenius","year":"2011","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jcmgh.2025.101629_bib60","doi-asserted-by":"crossref","first-page":"7003","DOI":"10.1073\/pnas.1220180110","article-title":"Intestinal alkaline phosphatase prevents metabolic syndrome in mice","volume":"110","author":"Kaliannan","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jcmgh.2025.101629_bib61","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.3389\/fimmu.2019.01404","article-title":"Dietary toll-like receptor stimulants promote hepatic inflammation and impair reverse cholesterol transport in mice via macrophage-dependent interleukin-1 production","volume":"10","author":"Faraj","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.jcmgh.2025.101629_bib62","doi-asserted-by":"crossref","first-page":"H72","DOI":"10.1111\/j.1750-3841.2010.02018.x","article-title":"Accumulation of stimulants of Toll-like receptor (TLR)-2 and TLR4 in meat products stored at 5 \u00b0C","volume":"76","author":"Erridge","year":"2011","journal-title":"J Food Sci"},{"key":"10.1016\/j.jcmgh.2025.101629_bib63","doi-asserted-by":"crossref","first-page":"967","DOI":"10.3748\/wjg.v29.i6.967","article-title":"Periodontal treatment and microbiome-targeted therapy in management of periodontitis-related nonalcoholic fatty liver disease with oral and gut dysbiosis","volume":"29","author":"Kuraji","year":"2023","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jcmgh.2025.101629_bib64","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1006\/bbrc.1997.6943","article-title":"An Nrf2\/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements","volume":"236","author":"Itoh","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jcmgh.2025.101629_bib65","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1038\/aps.2017.185","article-title":"Artemisinin analogue SM934 ameliorates DSS-induced mouse ulcerative colitis via suppressing neutrophils and macrophages","volume":"39","author":"Yan","year":"2018","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.jcmgh.2025.101629_bib66","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.biopha.2018.09.067","article-title":"PMA treated THP-1-derived-IL-6 promotes EMT of SW48 through STAT3\/ERK-dependent activation of Wnt\/b-catenin signaling pathway","volume":"108","author":"Gao","year":"2018","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.jcmgh.2025.101629_bib67","doi-asserted-by":"crossref","first-page":"632","DOI":"10.3892\/ijmm.2014.1807","article-title":"b-catenin regulates NF-kB activity and inflammatory cytokine expression in bronchial epithelial cells treated with lipopolysaccharide","volume":"34","author":"Jang","year":"2014","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.jcmgh.2025.101629_bib68","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/s41419-020-2264-z","article-title":"The concentration of tumor necrosis factor-a determines its protective or damaging effect on liver injury by regulating Yap activity","volume":"11","author":"Zhao","year":"2020","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.jcmgh.2025.101629_bib69","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.ebiom.2018.12.047","article-title":"TNF-\u03b1 is a potential therapeutic target to overcome sorafenib resistance in hepatocellular carcinoma","volume":"40","author":"Tan","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.jcmgh.2025.101629_bib70","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1161\/circ.106.25.3143","volume":"106","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.jcmgh.2025.101629_bib71","doi-asserted-by":"crossref","first-page":"629","DOI":"10.5551\/jat.7922","article-title":"The concept of metabolic syndrome: contribution of visceral fat accumulation and its molecular mechanism","volume":"18","author":"Matsuzawa","year":"2011","journal-title":"J Atheroscler Thromb"},{"key":"10.1016\/j.jcmgh.2025.101629_bib72","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1161\/CIRCULATIONAHA.105.169404","article-title":"Diagnosis and management of the metabolic syndrome: an American Heart Association\/National Heart, Lung, and Blood Institute Scientific Statement","volume":"112","author":"Grundy","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.jcmgh.2025.101629_bib73","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"10.1016\/j.jcmgh.2025.101629_bib74","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0131607","article-title":"Inter-individual differences in the oral bacteriome are greater than intra-day fluctuations in individuals","volume":"10","author":"Sato","year":"2015","journal-title":"PLoS One"}],"container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X25001705?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X25001705?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T17:48:16Z","timestamp":1766166496000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352345X25001705"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":74,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026]]}},"alternative-id":["S2352345X25001705"],"URL":"https:\/\/doi.org\/10.1016\/j.jcmgh.2025.101629","relation":{},"ISSN":["2352-345X"],"issn-type":[{"value":"2352-345X","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metabolic Syndrome Develops Cardia Cancer via Nuclear Factor-E2-related Factor 2-Programmed Death-Ligand 1 Signaling","name":"articletitle","label":"Article Title"},{"value":"Cellular and Molecular Gastroenterology and Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcmgh.2025.101629","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of the AGA Institute.","name":"copyright","label":"Copyright"}],"article-number":"101629"}}