{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T09:23:05Z","timestamp":1791969785163,"version":"4.3.4"},"reference-count":36,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370523"],"award-info":[{"award-number":["82370523"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012154","name":"Graduate Research and Innovation Projects of Jiangsu Province","doi-asserted-by":"publisher","award":["SJCX23_0674"],"award-info":[{"award-number":["SJCX23_0674"]}],"id":[{"id":"10.13039\/501100012154","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","cmghjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/j.jcmgh.2025.101640","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T08:03:45Z","timestamp":1758614625000},"page":"101640","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["EP300\/YAP1-SERPINE1 Signaling Regulates Ductular Reaction and Liver Fibrosis in Biliary Atresia"],"prefix":"10.1016","volume":"20","author":[{"given":"Zhongxian","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changgui","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufei","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruyi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zequan","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8499-9867","authenticated-orcid":false,"given":"Weibing","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcmgh.2025.101640_bib1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41572-024-00533-x","article-title":"Biliary atresia","volume":"10","author":"Tam","year":"2024","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.jcmgh.2025.101640_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2021.103689","article-title":"Biliary atresia - emerging diagnostic and therapy opportunities","volume":"74","author":"Lendahl","year":"2021","journal-title":"EBioMedicine"},{"key":"10.1016\/j.jcmgh.2025.101640_bib3","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1097\/PAS.0000000000000755","article-title":"Key histopathologic features of liver biopsies that distinguish biliary atresia from other causes of infantile cholestasis and their correlation with outcome: a multicenter study","volume":"40","author":"Russo","year":"2016","journal-title":"Am J Surg Pathol"},{"issue":"4 Suppl 2","key":"10.1016\/j.jcmgh.2025.101640_bib4","doi-asserted-by":"crossref","first-page":"S90","DOI":"10.1097\/01.mcg.0000155549.29643.ad","article-title":"Pathophysiology of cholangiopathies","volume":"39","author":"Strazzabosco","year":"2005","journal-title":"J Clin Gastroenterol"},{"key":"10.1016\/j.jcmgh.2025.101640_bib5","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.tibs.2020.08.008","article-title":"Hippo signaling in embryogenesis and development","volume":"46","author":"Wu","year":"2021","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.jcmgh.2025.101640_bib6","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.celrep.2014.06.017","article-title":"Yorkie promotes transcription by recruiting a histone methyltransferase complex","volume":"8","author":"Oh","year":"2014","journal-title":"Cell Rep"},{"key":"10.1016\/j.jcmgh.2025.101640_bib7","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s41232-022-00235-5","article-title":"Role of the Hippo pathway in liver regeneration and repair: recent advances","volume":"42","author":"Pibiri","year":"2022","journal-title":"Inflamm Regen"},{"key":"10.1016\/j.jcmgh.2025.101640_bib8","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1055\/s-0041-1742277","article-title":"Role of YAP1 signaling in biliary development, repair, and disease","volume":"42","author":"Molina","year":"2022","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.jcmgh.2025.101640_bib9","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/j.humpath.2014.01.002","article-title":"The use of Yes-associated protein expression in the diagnosis of persistent neonatal cholestatic liver disease","volume":"45","author":"Gurda","year":"2014","journal-title":"Hum Pathol"},{"key":"10.1016\/j.jcmgh.2025.101640_bib10","article-title":"YAP activation and implications in patients and a mouse model of biliary atresia","volume":"8","author":"Zheng","year":"2020","journal-title":"Front Pediatr"},{"key":"10.1016\/j.jcmgh.2025.101640_bib11","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.cgh.2011.01.003","article-title":"Design and validation of the biliary atresia research consortium histologic assessment system for cholestasis in infancy","volume":"9","author":"Russo","year":"2011","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2025.101640_bib12","article-title":"Dysregulated activation of Hippo-YAP1 signaling induces oxidative stress and aberrant development of intrahepatic biliary cells in biliary atresia","volume":"105","author":"Xie","year":"2024","journal-title":"Lab Invest"},{"key":"10.1016\/j.jcmgh.2025.101640_bib13","doi-asserted-by":"crossref","first-page":"4935","DOI":"10.7150\/thno.73223","article-title":"Histone acetyltransferases CBP\/p300 in tumorigenesis and CBP\/p300 inhibitors as promising novel anticancer agents","volume":"12","author":"Chen","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.jcmgh.2025.101640_bib14","doi-asserted-by":"crossref","first-page":"18698","DOI":"10.1074\/jbc.RA119.010176","article-title":"The transcription factor ETS1 promotes apoptosis resistance of senescent cholangiocytes by epigenetically up-regulating the apoptosis suppressor BCL2L1","volume":"294","author":"O\u2019Hara","year":"2019","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jcmgh.2025.101640_bib15","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.jhep.2021.12.014","article-title":"Long non-coding RNA ACTA2-AS1 promotes ductular reaction by interacting with the p300\/ELK1 complex","volume":"76","author":"Navarro-Corcuera","year":"2022","journal-title":"J Hepatol"},{"key":"10.1016\/j.jcmgh.2025.101640_bib16","doi-asserted-by":"crossref","first-page":"5057","DOI":"10.1021\/acs.jmedchem.7b00879","article-title":"Targeting transcriptional enhanced associate domains (TEADs)","volume":"61","author":"Gibault","year":"2018","journal-title":"J Med Chem"},{"key":"10.1016\/j.jcmgh.2025.101640_bib17","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.chembiol.2010.03.006","article-title":"Virtual ligand screening of the p300\/CBP histone acetyltransferase: identification of a selective small molecule inhibitor","volume":"17","author":"Bowers","year":"2010","journal-title":"Chem Biol"},{"key":"10.1016\/j.jcmgh.2025.101640_bib18","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.3390\/ijms20092180","article-title":"Intercellular communication between hepatic cells in liver diseases","volume":"20","author":"Sato","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jcmgh.2025.101640_bib19","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1002\/hep.30706","article-title":"Proteasomal degradation of enhancer of zeste homologue 2 in cholangiocytes promotes biliary fibrosis","volume":"70","author":"Jalan-Sakrikar","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2025.101640_bib20","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.stem.2019.04.004","article-title":"Single-cell analysis of the liver epithelium reveals dynamic heterogeneity and an essential role for YAP in homeostasis and regeneration","volume":"25","author":"Pepe-Mooney","year":"2019","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jcmgh.2025.101640_bib21","article-title":"LATS-YAP\/TAZ controls lineage specification by regulating TGFbeta signaling and Hnf4alpha expression during liver development","volume":"7","author":"Lee","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.jcmgh.2025.101640_bib22","doi-asserted-by":"crossref","first-page":"5914","DOI":"10.1096\/fj.201801256RR","article-title":"TAZ stimulates liver regeneration through interleukin-6-induced hepatocyte proliferation and inhibition of cell death after liver injury","volume":"33","author":"Kim","year":"2019","journal-title":"FASEB J"},{"key":"10.1016\/j.jcmgh.2025.101640_bib23","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.jhep.2015.05.031","article-title":"Accumulation of duct cells with activated YAP parallels fibrosis progression in non-alcoholic fatty liver disease","volume":"63","author":"Machado","year":"2015","journal-title":"J Hepatol"},{"key":"10.1016\/j.jcmgh.2025.101640_bib24","doi-asserted-by":"crossref","first-page":"4962","DOI":"10.1038\/s41467-018-07338-z","article-title":"Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap","volume":"9","author":"Lee","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.jcmgh.2025.101640_bib25","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/s41580-021-00441-y","article-title":"Modulation of cellular processes by histone and non-histone protein acetylation","volume":"23","author":"Shvedunova","year":"2022","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jcmgh.2025.101640_bib26","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/jcb.26146","article-title":"Plasminogen activator inhibitor type-1 as a regulator of fibrosis","volume":"119","author":"Rabieian","year":"2018","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.jcmgh.2025.101640_bib27","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1055\/s-0036-1586228","article-title":"The role of plasminogen activator inhibitor type-1 in fibrosis","volume":"43","author":"Flevaris","year":"2017","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.jcmgh.2025.101640_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103038","article-title":"Endothelial H(2)S-AMPK dysfunction upregulates the angiocrine factor PAI-1 and contributes to lung fibrosis","volume":"70","author":"Chen","year":"2024","journal-title":"Redox Biol"},{"key":"10.1016\/j.jcmgh.2025.101640_bib29","doi-asserted-by":"crossref","first-page":"3098","DOI":"10.1016\/j.febslet.2007.05.049","article-title":"PAI-1 deficiency reduces liver fibrosis after bile duct ligation in mice through activation of tPA","volume":"581","author":"Wang","year":"2007","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jcmgh.2025.101640_bib30","doi-asserted-by":"crossref","DOI":"10.1172\/JCI178392","article-title":"The secreted micropeptide C4orf48 enhances renal fibrosis via an RNA-binding mechanism","volume":"134","author":"Yang","year":"2024","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jcmgh.2025.101640_bib31","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1161\/CIRCULATIONAHA.110.955245","article-title":"Genetic deficiency of plasminogen activator inhibitor-1 promotes cardiac fibrosis in aged mice: involvement of constitutive transforming growth factor-beta signaling and endothelial-to-mesenchymal transition","volume":"122","author":"Ghosh","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.jcmgh.2025.101640_bib32","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1002\/hep.30150","article-title":"Ductular reaction in liver diseases: pathological mechanisms and translational significances","volume":"69","author":"Sato","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2025.101640_bib33","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.tips.2024.01.010","article-title":"Histone lysine acetyltransferase inhibitors: an emerging class of drugs for cancer therapy","volume":"45","author":"White","year":"2024","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.jcmgh.2025.101640_bib34","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.cell.2018.04.033","article-title":"Time-resolved analysis reveals rapid dynamics and broad scope of the CBP\/p300 acetylome","volume":"174","author":"Weinert","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.jcmgh.2025.101640_bib35","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.3390\/cancers13112799","article-title":"Pharmacological inhibition of CBP\/p300 blocks estrogen receptor alpha (ERalpha) function through suppressing enhancer H3K27 acetylation in luminal breast cancer","volume":"13","author":"Waddell","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jcmgh.2025.101640_bib36","doi-asserted-by":"crossref","first-page":"6931","DOI":"10.3748\/wjg.v21.i22.6931","article-title":"Assessment of liver fibrosis by Fibroscan as compared to liver biopsy in biliary atresia","volume":"21","author":"Shen","year":"2015","journal-title":"World J Gastroenterol"}],"container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X2500181X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X2500181X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T08:19:42Z","timestamp":1765786782000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352345X2500181X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026]]}},"alternative-id":["S2352345X2500181X"],"URL":"https:\/\/doi.org\/10.1016\/j.jcmgh.2025.101640","relation":{},"ISSN":["2352-345X"],"issn-type":[{"value":"2352-345X","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"EP300\/YAP1-SERPINE1 Signaling Regulates Ductular Reaction and Liver Fibrosis in Biliary Atresia","name":"articletitle","label":"Article Title"},{"value":"Cellular and Molecular Gastroenterology and Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcmgh.2025.101640","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of the AGA Institute.","name":"copyright","label":"Copyright"}],"article-number":"101640"}}