{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T08:38:31Z","timestamp":1790930311110,"version":"4.1.0"},"reference-count":67,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000738","name":"US Department of Veterans Affairs","doi-asserted-by":"publisher","award":["CDA IK2BX005875"],"award-info":[{"award-number":["CDA IK2BX005875"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007827","name":"American College of Gastroenterology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007827","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Institutes of Health National Cancer Institute","doi-asserted-by":"publisher","award":["5P30CA047904"],"award-info":[{"award-number":["5P30CA047904"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007408","name":"Medical Center, University of Pittsburgh","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007408","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007270","name":"University of Michigan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007270","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017065","name":"University of Michigan Medical Center Rogel Cancer Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","cmghjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/j.jcmgh.2026.101749","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:35:06Z","timestamp":1770078906000},"page":"101749","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Spatial Analysis of Intraductal Papillary Mucinous Neoplasms Defines a Paradoxical Keratin 17-Positive, Low-Grade Epithelial Population Harboring Malignant Features"],"prefix":"10.1016","volume":"20","author":[{"given":"Jay","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgina","family":"Branch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Macchia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed M.","family":"Elhossiny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nandini","family":"Arya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Padma","family":"Kadiyala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Peterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge D.","family":"Machicado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik-Jan","family":"Wamsteker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Schulman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Philips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacy","family":"Menees","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aatur D.","family":"Singhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaibhav","family":"Sahai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayun M.","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy L.","family":"Frankel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filip","family":"Bednar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Pasca di Magliano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6775-6943","authenticated-orcid":false,"given":"Eileen S.","family":"Carpenter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcmgh.2026.101749_bib1","first-page":"12","article-title":"Cancer statistics, 2024","volume":"74","author":"Siegel","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.jcmgh.2026.101749_bib2","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.4708","article-title":"Estimated projection of US cancer incidence and death to 2040","volume":"4","author":"Rahib","year":"2021","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.jcmgh.2026.101749_bib3","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nrgastro.2011.2","article-title":"Cystic precursors to invasive pancreatic cancer","volume":"8","author":"Matthaei","year":"2011","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2026.101749_bib4","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1016\/j.cgh.2024.02.018","article-title":"Global prevalence of pancreatic cystic lesions in the general population on magnetic resonance imaging: a systematic review and meta-analysis","volume":"22","author":"Vilela","year":"2024","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2026.101749_bib5","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.pan.2023.08.002","article-title":"Systematic review of challenging issues in pathology of intraductal papillary mucinous neoplasms","volume":"23","author":"Wood","year":"2023","journal-title":"Pancreatology"},{"key":"10.1016\/j.jcmgh.2026.101749_bib6","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1136\/gut.2010.210567","article-title":"Prognostic relevance of morphological types of intraductal papillary mucinous neoplasms of the pancreas","volume":"60","author":"Furukawa","year":"2011","journal-title":"Gut"},{"key":"10.1016\/j.jcmgh.2026.101749_bib7","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1097\/MPA.0000000000000253","article-title":"Molecular biomarkers for progression of intraductal papillary mucinous neoplasm of the pancreas","volume":"44","author":"Kuboki","year":"2015","journal-title":"Pancreas"},{"key":"10.1016\/j.jcmgh.2026.101749_bib8","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1007\/s00595-019-01797-7","article-title":"Clinical assessment of the GNAS mutation status in patients with intraductal papillary mucinous neoplasm of the pancreas","volume":"49","author":"Ohtsuka","year":"2019","journal-title":"Surg Today"},{"key":"10.1016\/j.jcmgh.2026.101749_bib9","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1186\/s40064-016-2847-4","article-title":"KRAS, GNAS, and RNF43 mutations in intraductal papillary mucinous neoplasm of the pancreas: a meta-analysis","volume":"5","author":"Lee","year":"2016","journal-title":"Springerplus"},{"key":"10.1016\/j.jcmgh.2026.101749_bib10","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.humpath.2019.05.010","article-title":"Pancreatobiliary-type intraductal papillary mucinous neoplasm of the pancreas may have 2 subtypes with distinct clinicopathologic and genetic features","volume":"91","author":"Shimizu","year":"2019","journal-title":"Hum Pathol"},{"key":"10.1016\/j.jcmgh.2026.101749_bib11","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.37799","article-title":"Long-term outcomes and risk of pancreatic cancer in intraductal papillary mucinous neoplasms","volume":"6","author":"de la Fuente","year":"2023","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.jcmgh.2026.101749_bib12","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.pan.2017.07.007","article-title":"Revisions of international consensus Fukuoka guidelines for the management of IPMN of the pancreas","volume":"17","author":"Tanaka","year":"2017","journal-title":"Pancreatology"},{"key":"10.1016\/j.jcmgh.2026.101749_bib13","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1136\/gutjnl-2018-316027","article-title":"European evidence-based guidelines on pancreatic cystic neoplasms","volume":"67","year":"2018","journal-title":"Gut"},{"key":"10.1016\/j.jcmgh.2026.101749_bib14","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.pan.2023.01.011","article-title":"Diagnostic accuracy of the AGA, IAP, and European guidelines for detecting advanced neoplasia in intraductal papillary mucinous neoplasm\/neoplasia","volume":"23","author":"van Huijgevoort","year":"2023","journal-title":"Pancreatology"},{"key":"10.1016\/j.jcmgh.2026.101749_bib15","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.pan.2021.01.017","article-title":"Guidelines on management of pancreatic cysts detected in high-risk individuals: an evaluation of the 2017 Fukuoka guidelines and the 2020 International Cancer of the Pancreas Screening (CAPS) consortium statements","volume":"21","author":"Dbouk","year":"2021","journal-title":"Pancreatology"},{"key":"10.1016\/j.jcmgh.2026.101749_bib16","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1111\/hpb.12137","article-title":"Dysplasia at the surgical margin is associated with recurrence after resection of non-invasive intraductal papillary mucinous neoplasms","volume":"15","author":"Frankel","year":"2013","journal-title":"HPB (Oxford)"},{"key":"10.1016\/j.jcmgh.2026.101749_bib17","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1158\/1078-0432.CCR-18-1955","article-title":"Single-cell transcriptomics of pancreatic cancer precursors demonstrates epithelial and microenvironmental heterogeneity as an early event in neoplastic progression","volume":"25","author":"Bernard","year":"2019","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jcmgh.2026.101749_bib18","doi-asserted-by":"crossref","first-page":"4713","DOI":"10.1158\/1078-0432.CCR-12-0035","article-title":"miRNA biomarkers in cyst fluid augment the diagnosis and management of pancreatic cysts","volume":"18","author":"Matthaei","year":"2012","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jcmgh.2026.101749_bib19","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1158\/2159-8290.CD-22-1200","article-title":"Spatial transcriptomics of intraductal papillary mucinous neoplasms of the pancreas identifies NKX6-2 as a driver of gastric differentiation and indolent biological potential","volume":"13","author":"Sans","year":"2023","journal-title":"Cancer Discov"},{"key":"10.1016\/j.jcmgh.2026.101749_bib20","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.ade4582","article-title":"Digital spatial profiling of intraductal papillary mucinous neoplasms: Toward a molecular framework for risk stratification","volume":"9","author":"Iyer","year":"2023","journal-title":"Sci Adv"},{"key":"10.1016\/j.jcmgh.2026.101749_bib21","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20235871","article-title":"Different forms of TFF2, a lectin of the human gastric mucus barrier: in vitro binding studies","volume":"20","author":"Heuer","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jcmgh.2026.101749_bib22","doi-asserted-by":"crossref","first-page":"806","DOI":"10.3892\/ijo.2015.3090","article-title":"TFF2, a MUC6-binding lectin stabilizing the gastric mucus barrier and more (Review)","volume":"47","author":"Hoffmann","year":"2015","journal-title":"Int J Oncol"},{"key":"10.1016\/j.jcmgh.2026.101749_bib23","first-page":"613","article-title":"An immunohistochemical study of primary signet-ring cell carcinoma of the stomach and colorectum: II. Expression of MUC1, MUC2, MUC5AC, and MUC6 in normal mucosa and in 42 cases","volume":"6","author":"Terada","year":"2013","journal-title":"Int J Clin Exp Pathol"},{"key":"10.1016\/j.jcmgh.2026.101749_bib24","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s12935-017-0426-6","article-title":"Pepsinogen C expression, regulation and its relationship with cancer","volume":"17","author":"Shen","year":"2017","journal-title":"Cancer Cell Int"},{"key":"10.1016\/j.jcmgh.2026.101749_bib25","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.2147\/CMAR.S243129","article-title":"KRT17 functions as a tumor promoter and regulates proliferation, migration and invasion in pancreatic cancer via mTOR\/S6k1 pathway","volume":"12","author":"Li","year":"2020","journal-title":"Cancer Manag Res"},{"key":"10.1016\/j.jcmgh.2026.101749_bib26","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-47519-4","article-title":"Keratin 17 identifies the most lethal molecular subtype of pancreatic cancer","volume":"9","author":"Roa-Pena","year":"2019","journal-title":"Sci Rep"},{"issue":"Suppl 3","key":"10.1016\/j.jcmgh.2026.101749_bib27","doi-asserted-by":"crossref","first-page":"S491","DOI":"10.1245\/s10434-011-1970-2","article-title":"Claudin-4 expression predicts survival in pancreatic ductal adenocarcinoma","volume":"19","author":"Tsutsumi","year":"2012","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.jcmgh.2026.101749_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0113023","article-title":"Carcinoembryonic antigen-related cell adhesion molecules (CEACAM) 1, 5 and 6 as biomarkers in pancreatic cancer","volume":"9","author":"Gebauer","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jcmgh.2026.101749_bib29","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/s41416-019-0483-9","article-title":"ZEB1 and IL-6\/11-STAT3 signalling cooperate to define invasive potential of pancreatic cancer cells via differential regulation of the expression of S100 proteins","volume":"121","author":"Al-Ismaeel","year":"2019","journal-title":"Br J Cancer"},{"key":"10.1016\/j.jcmgh.2026.101749_bib30","article-title":"S100 calcium-binding protein A6 promotes epithelial-mesenchymal transition through beta-catenin in pancreatic cancer cell line","volume":"10","author":"Chen","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jcmgh.2026.101749_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.114396","article-title":"S100A16 induces epithelial-mesenchymal transition in human PDAC cells and is a new therapeutic target for pancreatic cancer treatment that synergizes with gemcitabine","volume":"189","author":"Li","year":"2021","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.jcmgh.2026.101749_bib32","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1038\/ng.3398","article-title":"Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma","volume":"47","author":"Moffitt","year":"2015","journal-title":"Nat Genet"},{"key":"10.1016\/j.jcmgh.2026.101749_bib33","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1093\/ajcp\/aqae038","article-title":"Keratin 17 is a prognostic and predictive biomarker in pancreatic ductal adenocarcinoma","volume":"162","author":"Delgado-Coka","year":"2024","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.jcmgh.2026.101749_bib34","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.1038\/s41467-024-46994-2","article-title":"Identification of spatially-resolved markers of malignant transformation in Intraductal Papillary Mucinous Neoplasms","volume":"15","author":"Agostini","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.jcmgh.2026.101749_bib35","doi-asserted-by":"crossref","DOI":"10.1093\/database\/baz046","article-title":"PanglaoDB: a web server for exploration of mouse and human single-cell RNA sequencing data","volume":"2019","author":"Franzen","year":"2019","journal-title":"Database (Oxford)"},{"key":"10.1016\/j.jcmgh.2026.101749_bib36","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1158\/2159-8290.CD-23-0013","article-title":"Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions","volume":"13","author":"Carpenter","year":"2023","journal-title":"Cancer Discov"},{"key":"10.1016\/j.jcmgh.2026.101749_bib37","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.pan.2012.04.004","article-title":"International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas","volume":"12","author":"Tanaka","year":"2012","journal-title":"Pancreatology"},{"key":"10.1016\/j.jcmgh.2026.101749_bib38","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1038\/s43018-020-00121-4","article-title":"Multimodal mapping of the tumor and peripheral blood immune landscape in human pancreatic cancer","volume":"1","author":"Steele","year":"2020","journal-title":"Nat Cancer"},{"key":"10.1016\/j.jcmgh.2026.101749_bib39","doi-asserted-by":"crossref","first-page":"7781","DOI":"10.1245\/s10434-022-12157-0","article-title":"Multidimensional immunophenotyping of intraductal papillary mucinous neoplasms reveals novel T cell and macrophage signature","volume":"29","author":"Eckhoff","year":"2022","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.jcmgh.2026.101749_bib40","doi-asserted-by":"crossref","first-page":"4303","DOI":"10.1158\/1078-0432.CCR-12-1075","article-title":"Genome-wide somatic copy number alterations in low-grade PanINs and IPMNs from individuals with a family history of pancreatic cancer","volume":"18","author":"Hong","year":"2012","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jcmgh.2026.101749_bib41","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1136\/gutjnl-2020-321217","article-title":"Multiregion whole-exome sequencing of intraductal papillary mucinous neoplasms reveals frequent somatic KLF4 mutations predominantly in low-grade regions","volume":"70","author":"Fujikura","year":"2021","journal-title":"Gut"},{"key":"10.1016\/j.jcmgh.2026.101749_bib42","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1158\/2767-9764.CRC-22-0419","article-title":"Integrated molecular characterization of intraductal papillary mucinous neoplasms: an NCI cancer moonshot precancer atlas pilot project","volume":"3","author":"Semaan","year":"2023","journal-title":"Cancer Res Commun"},{"key":"10.1016\/j.jcmgh.2026.101749_bib43","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/his.13975","article-title":"The 2019 WHO classification of tumours of the digestive system","volume":"76","author":"Nagtegaal","year":"2020","journal-title":"Histopathology"},{"key":"10.1016\/j.jcmgh.2026.101749_bib44","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.stem.2023.07.002","article-title":"Tff2 defines transit-amplifying pancreatic acinar progenitors that lack regenerative potential and are protective against Kras-driven carcinogenesis","volume":"30","author":"Jiang","year":"2023","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jcmgh.2026.101749_bib45","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1158\/1078-0432.CCR-23-1421","article-title":"KRT17High\/CXCL8+ tumor cells display both classical and basal features and regulate myeloid infiltration in the pancreatic cancer microenvironment","volume":"30","author":"Carpenter","year":"2024","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jcmgh.2026.101749_bib46","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1053\/j.gastro.2018.10.029","article-title":"Pathways of progression from intraductal papillary mucinous neoplasm to pancreatic ductal adenocarcinoma based on molecular features","volume":"156","author":"Omori","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2026.101749_bib47","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1053\/j.gastro.2019.08.032","article-title":"Long-term risk of malignancy in branch-duct intraductal papillary mucinous neoplasms","volume":"158","author":"Oyama","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2026.101749_bib48","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1097\/SLA.0000000000006535","article-title":"Unraveling the long-term natural history of branch duct intraductal papillary mucinous neoplasm: beyond 10 years","volume":"281","author":"Assawasirisin","year":"2025","journal-title":"Ann Surg"},{"key":"10.1016\/j.jcmgh.2026.101749_bib49","first-page":"473","article-title":"[Effects of progesterone therapy in a case of probable epileptic-endocrinal syndrome]","volume":"48","author":"Carollo","year":"1972","journal-title":"Boll Soc Ital Biol Sper"},{"key":"10.1016\/j.jcmgh.2026.101749_bib50","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.gie.2020.12.054","article-title":"High performance in risk stratification of intraductal papillary mucinous neoplasms by confocal laser endomicroscopy image analysis with convolutional neural networks (with video)","volume":"94","author":"Machicado","year":"2021","journal-title":"Gastrointest Endosc"},{"key":"10.1016\/j.jcmgh.2026.101749_bib51","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.vgie.2019.04.020","article-title":"EUS-guided through-the-needle biopsy for pancreatic cystic lesions","volume":"4","author":"Samarasena","year":"2019","journal-title":"VideoGIE"},{"key":"10.1016\/j.jcmgh.2026.101749_bib52","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1080\/17474124.2021.2007765","article-title":"Experience of the moray micro forceps biopsy for pancreatic cystic lesions: lessons and insights from the MAUDE database","volume":"15","author":"Londono Castillo","year":"2021","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2026.101749_bib53","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1053\/j.gastro.2022.09.028","article-title":"Prospective, multi-institutional, real-time next-generation sequencing of pancreatic cyst fluid reveals diverse genomic alterations that improve the clinical management of pancreatic cysts","volume":"164","author":"Paniccia","year":"2023","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2026.101749_bib54","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1053\/j.gastro.2019.06.001","article-title":"Intraductal papillary mucinous neoplasms arise from multiple independent clones, each with distinct mutations","volume":"157","author":"Fischer","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2026.101749_bib55","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1136\/gutjnl-2024-332412","article-title":"Metabolic reprogramming by mutant GNAS creates an actionable dependency in intraductal papillary mucinous neoplasms of the pancreas","volume":"74","author":"Makino","year":"2024","journal-title":"Gut"},{"key":"10.1016\/j.jcmgh.2026.101749_bib56","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1053\/j.gastro.2016.07.045","article-title":"Loss of trefoil factor 2 from pancreatic duct glands promotes formation of intraductal papillary mucinous neoplasms in mice","volume":"151","author":"Yamaguchi","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2026.101749_bib57","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1053\/j.gastro.2020.11.046","article-title":"Extracellular vesicle analysis allows for identification of invasive IPMN","volume":"160","author":"Yang","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2026.101749_bib58","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12092383","article-title":"Marker identification of the grade of dysplasia of intraductal papillary mucinous neoplasm in pancreatic cyst fluid by quantitative proteomic profiling","volume":"12","author":"Do","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jcmgh.2026.101749_bib59","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1136\/gutjnl-2016-313586","article-title":"Preoperative next-generation sequencing of pancreatic cyst fluid is highly accurate in cyst classification and detection of advanced neoplasia","volume":"67","author":"Singhi","year":"2018","journal-title":"Gut"},{"key":"10.1016\/j.jcmgh.2026.101749_bib60","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.jamcollsurg.2017.07.521","article-title":"Prostaglandin E(2): a pancreatic fluid biomarker of intraductal papillary mucinous neoplasm dysplasia","volume":"225","author":"Yip-Schneider","year":"2017","journal-title":"J Am Coll Surg"},{"key":"10.1016\/j.jcmgh.2026.101749_bib61","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jcmgh.2026.101749_bib62","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","article-title":"The Molecular Signatures Database (MSigDB) hallmark gene set collection","volume":"1","author":"Liberzon","year":"2015","journal-title":"Cell Syst"},{"key":"10.1016\/j.jcmgh.2026.101749_bib63","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2105-14-7","article-title":"GSVA: gene set variation analysis for microarray and RNA-seq data","volume":"14","author":"Hanzelmann","year":"2013","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.jcmgh.2026.101749_bib64","doi-asserted-by":"crossref","DOI":"10.1093\/gigascience\/giaa151","article-title":"SoupX removes ambient RNA contamination from droplet-based single-cell RNA sequencing data","volume":"9","author":"Young","year":"2020","journal-title":"Gigascience"},{"key":"10.1016\/j.jcmgh.2026.101749_bib65","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.jcmgh.2026.101749_bib66","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1038\/nmeth.4463","article-title":"SCENIC: single-cell regulatory network inference and clustering","volume":"14","author":"Aibar","year":"2017","journal-title":"Nat Methods"},{"key":"10.1016\/j.jcmgh.2026.101749_bib67","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/s41587-021-00830-w","article-title":"Robust decomposition of cell type mixtures in spatial transcriptomics","volume":"40","author":"Cable","year":"2022","journal-title":"Nat Biotechnol"}],"container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X26000275?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X26000275?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T08:12:36Z","timestamp":1778832756000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352345X26000275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":67,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026]]}},"alternative-id":["S2352345X26000275"],"URL":"https:\/\/doi.org\/10.1016\/j.jcmgh.2026.101749","relation":{},"ISSN":["2352-345X"],"issn-type":[{"value":"2352-345X","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Spatial Analysis of Intraductal Papillary Mucinous Neoplasms Defines a Paradoxical Keratin 17-Positive, Low-Grade Epithelial Population Harboring Malignant Features","name":"articletitle","label":"Article Title"},{"value":"Cellular and Molecular Gastroenterology and Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcmgh.2026.101749","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc. on behalf of the American Gastroenterological Association Institute.","name":"copyright","label":"Copyright"}],"article-number":"101749"}}