{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T07:32:59Z","timestamp":1786692779260,"version":"build-2736575974"},"reference-count":50,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":77,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP21H03002"],"award-info":[{"award-number":["JP21H03002"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP22K16475"],"award-info":[{"award-number":["JP22K16475"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP25K12028"],"award-info":[{"award-number":["JP25K12028"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP20K17572"],"award-info":[{"award-number":["JP20K17572"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP18K08694"],"award-info":[{"award-number":["JP18K08694"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP23K21448"],"award-info":[{"award-number":["JP23K21448"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP25293284"],"award-info":[{"award-number":["JP25293284"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","cmghjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/j.jcmgh.2026.101773","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T01:16:31Z","timestamp":1774487791000},"page":"101773","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Colon-Restricted Phosphatase and Tensin Homolog Deleted From Chromosome 10 Haploinsufficiency Models Phosphoinositide 3-Kinase Pathway-Driven Invasion in Colorectal Cancer"],"prefix":"10.1016","volume":"20","author":[{"given":"Haruki","family":"Sada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Niitsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Urabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hikaru","family":"Nakahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Kochi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoya","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Sotomaru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotaka","family":"Tashiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiro","family":"Oka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Ohdan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric R.","family":"Fearon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0462-6177","authenticated-orcid":false,"given":"Takao","family":"Hinoi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcmgh.2026.101773_bib1","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/0092-8674(90)90186-I","article-title":"A genetic model for colorectal tumorigenesis","volume":"61","author":"Fearon","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.jcmgh.2026.101773_bib2","doi-asserted-by":"crossref","first-page":"4283","DOI":"10.1073\/pnas.0712345105","article-title":"Comparative lesion sequencing provides insights into tumor evolution","volume":"105","author":"Jones","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jcmgh.2026.101773_bib3","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1126\/science.1235122","article-title":"Cancer genome landscapes","volume":"339","author":"Vogelstein","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.jcmgh.2026.101773_bib4","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/ng.3214","article-title":"A Big Bang model of human colorectal tumor growth","volume":"47","author":"Sottoriva","year":"2015","journal-title":"Nat Genet"},{"key":"10.1016\/j.jcmgh.2026.101773_bib5","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1038\/s41559-018-0642-z","article-title":"The evolutionary landscape of colorectal tumorigenesis","volume":"2","author":"Cross","year":"2018","journal-title":"Nat Ecol Evol"},{"key":"10.1016\/j.jcmgh.2026.101773_bib6","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1186\/s13059-019-1782-4","article-title":"An enhanced genetic model of colorectal cancer progression history","volume":"20","author":"Yang","year":"2019","journal-title":"Genome Biol"},{"key":"10.1016\/j.jcmgh.2026.101773_bib7","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.8842","article-title":"A unified simulation model for understanding the diversity of cancer evolution","volume":"8","author":"Niida","year":"2020","journal-title":"PeerJ"},{"key":"10.1016\/j.jcmgh.2026.101773_bib8","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1038\/s41467-020-14908-7","article-title":"Minimal barriers to invasion during human colorectal tumor growth","volume":"11","author":"Ryser","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.jcmgh.2026.101773_bib9","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/s41586-022-05311-x","article-title":"Phenotypic plasticity and genetic control in colorectal cancer evolution","volume":"611","author":"Househam","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.jcmgh.2026.101773_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1005778","article-title":"Integrated multiregional analysis proposing a new model of colorectal cancer evolution","volume":"12","author":"Uchi","year":"2016","journal-title":"PLoS Genet"},{"key":"10.1016\/j.jcmgh.2026.101773_bib11","doi-asserted-by":"crossref","first-page":"2884","DOI":"10.1038\/s41467-018-05226-0","article-title":"A temporal shift of the evolutionary principle shaping intratumor heterogeneity in colorectal cancer","volume":"9","author":"Saito","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.jcmgh.2026.101773_bib12","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1053\/j.gastro.2008.12.049","article-title":"Mouse models of colon cancer","volume":"136","author":"Taketo","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2026.101773_bib13","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.3748\/wjg.v26.i13.1394","article-title":"Mouse models of colorectal cancer: past, present and future perspectives","volume":"26","author":"B\u00fcrtin","year":"2020","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jcmgh.2026.101773_bib14","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1126\/science.2296722","article-title":"A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse","volume":"247","author":"Moser","year":"1990","journal-title":"Science"},{"key":"10.1016\/j.jcmgh.2026.101773_bib15","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1126\/science.1350108","article-title":"Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene","volume":"256","author":"Su","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.jcmgh.2026.101773_bib16","doi-asserted-by":"crossref","first-page":"9721","DOI":"10.1158\/0008-5472.CAN-07-2735","article-title":"Mouse model of colonic adenoma-carcinoma progression based on somatic Apc inactivation","volume":"67","author":"Hinoi","year":"2007","journal-title":"Cancer Res"},{"key":"10.1016\/j.jcmgh.2026.101773_bib17","doi-asserted-by":"crossref","first-page":"3489","DOI":"10.1182\/blood-2009-11-251728","article-title":"The Apc(min) mouse has altered hematopoietic stem cell function and provides a model for MPD\/MDS","volume":"115","author":"Lane","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.jcmgh.2026.101773_bib18","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/path.4312","article-title":"PTEN loss and KRAS activation leads to the formation of serrated adenomas and metastatic carcinoma in the mouse intestine","volume":"233","author":"Davies","year":"2014","journal-title":"J Pathol"},{"key":"10.1016\/j.jcmgh.2026.101773_bib19","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1101\/gad.293449.116","article-title":"Oncogenic Kras drives invasion and maintains metastases in colorectal cancer","volume":"31","author":"Boutin","year":"2017","journal-title":"Genes Dev"},{"key":"10.1016\/j.jcmgh.2026.101773_bib20","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1158\/0008-5472.CAN-17-3303","article-title":"Combined mutation of Apc, Kras, and Tgfbr2 effectively drives metastasis of intestinal cancer","volume":"78","author":"Sakai","year":"2018","journal-title":"Cancer Res"},{"key":"10.1016\/j.jcmgh.2026.101773_bib21","doi-asserted-by":"crossref","first-page":"4179","DOI":"10.1158\/0008-5472.CAN-22-1369","article-title":"The cAMP\/PKA\/CREB and TGF\u03b2\/SMAD4 pathways regulate stemness and metastatic potential in colorectal cancer cells","volume":"82","author":"Fujishita","year":"2022","journal-title":"Cancer Res"},{"key":"10.1016\/j.jcmgh.2026.101773_bib22","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1158\/1940-6207.CAPR-15-0003","article-title":"Colon tumors with the simultaneous induction of driver mutations in APC, KRAS, and PIK3CA still progress through the adenoma-to-carcinoma sequence","volume":"8","author":"Hadac","year":"2015","journal-title":"Cancer Prev Res (Phila)"},{"key":"10.1016\/j.jcmgh.2026.101773_bib23","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ccr.2012.11.014","article-title":"Loss of p53 in enterocytes generates an inflammatory microenvironment enabling invasion and lymph node metastasis of carcinogen-induced colorectal tumors","volume":"23","author":"Schwitalla","year":"2013","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jcmgh.2026.101773_bib24","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20191515","article-title":"AKT-dependent NOTCH3 activation drives tumor progression in a model of mesenchymal colorectal cancer","volume":"217","author":"Varga","year":"2020","journal-title":"J Exp Med"},{"key":"10.1016\/j.jcmgh.2026.101773_bib25","doi-asserted-by":"crossref","first-page":"11859","DOI":"10.1073\/pnas.1614057113","article-title":"Generation of an inducible colon-specific Cre enzyme mouse line for colon cancer research","volume":"113","author":"Tetteh","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jcmgh.2026.101773_bib26","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/nature07602","article-title":"Crypt stem cells as the cells-of-origin of intestinal cancer","volume":"457","author":"Barker","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.jcmgh.2026.101773_bib27","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.cell.2012.02.042","article-title":"The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor","volume":"149","author":"Powell","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.jcmgh.2026.101773_bib28","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nmeth.1182","article-title":"Generating somatic mosaicism with a Cre recombinase-microsatellite sequence transgene","volume":"5","author":"Akyol","year":"2008","journal-title":"Nat Methods"},{"key":"10.1016\/j.jcmgh.2026.101773_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0132435","article-title":"Chlorinated water modulates the development of colorectal tumors with chromosomal instability and gut microbiota in Apc-deficient mice","volume":"10","author":"Sasada","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jcmgh.2026.101773_bib30","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s00535-015-1121-9","article-title":"Mouse model of proximal colon-specific tumorigenesis driven by microsatellite instability-induced Cre-mediated inactivation of Apc and activation of Kras","volume":"51","author":"Kawaguchi","year":"2016","journal-title":"J Gastroenterol"},{"key":"10.1016\/j.jcmgh.2026.101773_bib31","doi-asserted-by":"crossref","DOI":"10.1038\/oncsis.2016.47","article-title":"KRAS mutation leads to decreased expression of regulator of calcineurin 2, resulting in tumor proliferation in colorectal cancer","volume":"5","author":"Niitsu","year":"2016","journal-title":"Oncogenesis"},{"key":"10.1016\/j.jcmgh.2026.101773_bib32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0166422","article-title":"Gasdermin C is upregulated by inactivation of transforming growth factor beta receptor type II in the presence of mutated Apc, promoting colorectal cancer proliferation","volume":"11","author":"Miguchi","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jcmgh.2026.101773_bib33","doi-asserted-by":"crossref","first-page":"3540","DOI":"10.1111\/cas.14558","article-title":"Oncogenic mutation in RAS-RAF axis leads to increased expression of GREB1, resulting in tumor proliferation in colorectal cancer","volume":"111","author":"Kochi","year":"2020","journal-title":"Cancer Sci"},{"key":"10.1016\/j.jcmgh.2026.101773_bib34","doi-asserted-by":"crossref","first-page":"10887","DOI":"10.1073\/pnas.93.20.10887","article-title":"Ligand-activated site-specific recombination in mice","volume":"93","author":"Feil","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jcmgh.2026.101773_bib35","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1006\/bbrc.1997.7124","article-title":"Regulation of Cre recombinase activity by mutated estrogen receptor ligand-binding domains","volume":"237","author":"Feil","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jcmgh.2026.101773_bib36","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1093\/carcin\/bgm186","article-title":"Heterozygous disruption of the PTEN promotes intestinal neoplasia in APCmin\/+ mouse: roles of osteopontin","volume":"28","author":"Shao","year":"2007","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.jcmgh.2026.101773_bib37","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.3390\/cancers17142346","article-title":"PTEN inactivation in mouse colonic epithelial cells curtails DSS-induced colitis and accelerates recovery","volume":"17","author":"Kotelevets","year":"2025","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jcmgh.2026.101773_bib38","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1093\/carcin\/bgr011","article-title":"LOH and copy neutral LOH (cnLOH) act as alternative mechanism in sporadic colorectal cancers with chromosomal and microsatellite instability","volume":"32","author":"Melcher","year":"2011","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.jcmgh.2026.101773_bib39","doi-asserted-by":"crossref","first-page":"13544","DOI":"10.1073\/pnas.0800041105","article-title":"Inhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in ApcDelta716 mice","volume":"105","author":"Fujishita","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jcmgh.2026.101773_bib40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0096023","article-title":"Rapamycin inhibition of polyposis and progression to dysplasia in a mouse model","volume":"9","author":"Hardiman","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jcmgh.2026.101773_bib41","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/nature13896","article-title":"mTORC1-mediated translational elongation limits intestinal tumour initiation and growth","volume":"517","author":"Faller","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.jcmgh.2026.101773_bib42","doi-asserted-by":"crossref","DOI":"10.1172\/JCI186035","article-title":"LIN28B-mediated PI3K\/AKT pathway activation promotes metastasis in colorectal cancer models","volume":"135","author":"Shin","year":"2025","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jcmgh.2026.101773_bib43","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/nrm3330","article-title":"The functions and regulation of the PTEN tumour suppressor","volume":"13","author":"Song","year":"2012","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jcmgh.2026.101773_bib44","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1038\/s41467-022-29366-6","article-title":"Single-cell and spatial analysis reveal interaction of FAP(+) fibroblasts and SPP1(+) macrophages in colorectal cancer","volume":"13","author":"Qi","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.jcmgh.2026.101773_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111929","article-title":"Spatial and single-cell transcriptomics decipher the cellular environment containing HLA-G+ cancer cells and SPP1+ macrophages in colorectal cancer","volume":"42","author":"Ozato","year":"2023","journal-title":"Cell Rep"},{"key":"10.1016\/j.jcmgh.2026.101773_bib46","doi-asserted-by":"crossref","first-page":"3913","DOI":"10.1158\/1078-0432.CCR-10-2900","article-title":"Pathogenesis and consequences of uniparental disomy in cancer","volume":"17","author":"Makishima","year":"2011","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jcmgh.2026.101773_bib47","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1182\/blood-2009-10-201848","article-title":"Copy neutral loss of heterozygosity: a novel chromosomal lesion in myeloid malignancies","volume":"115","author":"O'Keefe","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.jcmgh.2026.101773_bib48","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1136\/gutjnl-2019-319438","article-title":"Genomic and transcriptomic profiling of carcinogenesis in patients with familial adenomatous polyposis","volume":"69","author":"Li","year":"2020","journal-title":"Gut"},{"key":"10.1016\/j.jcmgh.2026.101773_bib49","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1111\/den.12644","article-title":"Narrow-band imaging (NBI) magnifying endoscopic classification of colorectal tumors proposed by the Japan NBI Expert Team","volume":"28","author":"Sano","year":"2016","journal-title":"Dig Endosc"},{"key":"10.1016\/j.jcmgh.2026.101773_bib50","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1053\/gast.2002.36598","article-title":"CDX2 regulates liver intestine-cadherin expression in normal and malignant colon epithelium and intestinal metaplasia","volume":"123","author":"Hinoi","year":"2002","journal-title":"Gastroenterology"}],"container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X26000512?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X26000512?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T07:15:48Z","timestamp":1786691748000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352345X26000512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":50,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026]]}},"alternative-id":["S2352345X26000512"],"URL":"https:\/\/doi.org\/10.1016\/j.jcmgh.2026.101773","relation":{},"ISSN":["2352-345X"],"issn-type":[{"value":"2352-345X","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Colon-Restricted Phosphatase and Tensin Homolog Deleted From Chromosome 10 Haploinsufficiency Models Phosphoinositide 3-Kinase Pathway-Driven Invasion in Colorectal Cancer","name":"articletitle","label":"Article Title"},{"value":"Cellular and Molecular Gastroenterology and Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcmgh.2026.101773","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of American Gastroenterological Association Institute.","name":"copyright","label":"Copyright"}],"article-number":"101773"}}