{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T09:04:18Z","timestamp":1784106258114,"version":"3.55.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"vor","delay-in-days":96,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","cmghjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/j.jcmgh.2026.101786","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T20:36:20Z","timestamp":1776285380000},"page":"101786","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Maternal High-Fat Diet Worsens Necrotizing Enterocolitis via Effects on Mitochondrial Function in Newborn Mice"],"prefix":"10.1016","volume":"20","author":[{"given":"Koichi","family":"Tsuboi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee-Seong","family":"Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pranav","family":"Prakash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanxia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menghan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Thomas","family":"Prindle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William B.","family":"Fulton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chhinder P.","family":"Sodhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5195-8807","authenticated-orcid":false,"given":"David J.","family":"Hackam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcmgh.2026.101786_bib1","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1038\/s41575-022-00594-x","article-title":"Bench to bedside - new insights into the pathogenesis of necrotizing enterocolitis","volume":"19","author":"Hackam","year":"2022","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2026.101786_bib2","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/s00383-023-05619-3","article-title":"Necrotizing enterocolitis: current understanding of the prevention and management","volume":"40","author":"Hu","year":"2024","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.jcmgh.2026.101786_bib3","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jpeds.2019.11.011","article-title":"Contemporary outcomes for infants with necrotizing enterocolitis-a systematic review","volume":"220","author":"Jones","year":"2020","journal-title":"J Pediatr"},{"key":"10.1016\/j.jcmgh.2026.101786_bib4","doi-asserted-by":"crossref","first-page":"340","DOI":"10.3390\/nu13020340","article-title":"Optimizing nutritional strategies to prevent necrotizing enterocolitis and growth failure after bowel resection","volume":"13","author":"Moschino","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.jcmgh.2026.101786_bib5","doi-asserted-by":"crossref","first-page":"4660","DOI":"10.3390\/nu14214660","article-title":"Novel therapeutic approaches for mitigating complications in short bowel syndrome","volume":"14","author":"Bettag","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.jcmgh.2026.101786_bib6","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1007\/s00431-024-05569-5","article-title":"Neurodevelopmental outcomes of preterm with necrotizing enterocolitis: a systematic review and meta-analysis","volume":"183","author":"Wang","year":"2024","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.jcmgh.2026.101786_bib7","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2221470","article-title":"Necrotizing enterocolitis, gut microbes, and sepsis","volume":"15","author":"Duess","year":"2023","journal-title":"Gut Microbes"},{"key":"10.1016\/j.jcmgh.2026.101786_bib8","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/6978936","article-title":"The role of toll-like receptor 4 in infectious and noninfectious inflammation","volume":"2016","author":"Molteni","year":"2016","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.jcmgh.2026.101786_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113778","article-title":"Toll-like receptor 4 deficiency alleviates lipopolysaccharide-induced intestinal barrier dysfunction","volume":"155","author":"Zhan","year":"2022","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.jcmgh.2026.101786_bib10","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1007\/s00431-025-06146-0","article-title":"The predictive value of maternal and neonatal inflammatory biomarkers for necrotizing enterocolitis","volume":"184","author":"Matyas","year":"2025","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.jcmgh.2026.101786_bib11","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/s41372-025-02277-2","article-title":"The fifty billion dollar question: does formula cause necrotizing enterocolitis?","volume":"45","author":"Underwood","year":"2025","journal-title":"J Perinatol"},{"key":"10.1016\/j.jcmgh.2026.101786_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0296644","article-title":"Maternal body mass index and necrotizing enterocolitis: a case-control study","volume":"19","author":"Stumpf","year":"2024","journal-title":"PLoS One"},{"key":"10.1016\/j.jcmgh.2026.101786_bib13","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.040808","article-title":"Fetal exposure to maternal inflammation interrupts murine intestinal development and increases susceptibility to neonatal intestinal injury","volume":"12","author":"Elgin","year":"2019","journal-title":"Dis Model Mech"},{"key":"10.1016\/j.jcmgh.2026.101786_bib14","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-54098-x","article-title":"Obesity during pregnancy results in maternal intestinal inflammation, placental hypoxia, and alters fetal glucose metabolism at mid-gestation","volume":"9","author":"Wallace","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.jcmgh.2026.101786_bib15","doi-asserted-by":"crossref","first-page":"3090","DOI":"10.3390\/ijms20123090","article-title":"Diabetic pregnancy and maternal high-fat diet impair mitochondrial dynamism in the developing fetal rat heart by sex-specific mechanisms","volume":"20","author":"Larsen","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jcmgh.2026.101786_bib16","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.jnutbio.2011.12.008","article-title":"Maternal high-fat intake during pregnancy programs metabolic-syndrome-related phenotypes through liver mitochondrial DNA copy number and transcriptional activity of liver PPARGC1A","volume":"24","author":"Burgueno","year":"2013","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jcmgh.2026.101786_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2022.101546","article-title":"Mitochondrial function in intestinal epithelium homeostasis and modulation in diet-induced obesity","volume":"63","author":"Guerbette","year":"2022","journal-title":"Mol Metab"},{"key":"10.1016\/j.jcmgh.2026.101786_bib18","article-title":"Mitochondrial metabolism in the intestinal stem cell niche-sensing and signaling in health and disease","volume":"8","author":"Urbauer","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.jcmgh.2026.101786_bib19","doi-asserted-by":"crossref","first-page":"H1202","DOI":"10.1152\/ajpheart.00013.2019","article-title":"A maternal high-fat, high-sucrose diet induces transgenerational cardiac mitochondrial dysfunction independently of maternal mitochondrial inheritance","volume":"316","author":"Ferey","year":"2019","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jcmgh.2026.101786_bib20","doi-asserted-by":"crossref","first-page":"856","DOI":"10.3390\/antiox12040856","article-title":"The 4-hydroxynonenal-protein adducts and their biological relevance: are some proteins preferred targets?","volume":"12","author":"Milkovic","year":"2023","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.jcmgh.2026.101786_bib21","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.redox.2014.09.006","article-title":"Proteomic analysis of 4-hydroxynonenal (4-HNE) modified proteins in liver mitochondria from chronic ethanol-fed rats","volume":"2","author":"Andringa","year":"2014","journal-title":"Redox Biol"},{"key":"10.1016\/j.jcmgh.2026.101786_bib22","doi-asserted-by":"crossref","first-page":"9335","DOI":"10.1074\/jbc.M608589200","article-title":"Membrane-mediated amyloidogenesis and the promotion of oxidative lipid damage by amyloid beta proteins","volume":"282","author":"Murray","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jcmgh.2026.101786_bib23","article-title":"Energy metabolism in intestinal epithelial cells during maturation along the crypt-villus axis","volume":"6","author":"Yang","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.jcmgh.2026.101786_bib24","article-title":"Mitochondrial dynamics, mitophagy, and mitochondria-endoplasmic reticulum contact sites crosstalk under hypoxia","volume":"10","author":"Wang","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.jcmgh.2026.101786_bib25","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/s41419-021-03945-9","article-title":"Endoplasmic reticulum-mitochondria coupling increases during doxycycline-induced mitochondrial stress in HeLa cells","volume":"12","author":"Lopez-Crisosto","year":"2021","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.jcmgh.2026.101786_bib26","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.3390\/biom13081198","article-title":"Role of mitochondria-ER contact sites in mitophagy","volume":"13","author":"Ruhmkorf","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.jcmgh.2026.101786_bib27","article-title":"Risk factors for necrotizing enterocolitis in neonates: a meta-analysis","volume":"10","author":"Su","year":"2022","journal-title":"Front Pediatr"},{"key":"10.1016\/j.jcmgh.2026.101786_bib28","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.pathophys.2013.11.007","article-title":"Toll-like receptor regulation of intestinal development and inflammation in the pathogenesis of necrotizing enterocolitis","volume":"21","author":"Lu","year":"2014","journal-title":"Pathophysiology"},{"key":"10.1016\/j.jcmgh.2026.101786_bib29","doi-asserted-by":"crossref","first-page":"203","DOI":"10.3390\/nu10020203","article-title":"Toll-like receptors: regulators of the immune response in the human gut","volume":"10","author":"Hug","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.jcmgh.2026.101786_bib30","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/s41586-025-09190-w","article-title":"Kupffer cell programming by maternal obesity triggers fatty liver disease","volume":"644","author":"Huang","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.jcmgh.2026.101786_bib31","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1016\/j.cell.2018.08.063","article-title":"Spatial reconstruction of single enterocytes uncovers broad zonation along the intestinal villus axis","volume":"175","author":"Moor","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.jcmgh.2026.101786_bib32","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1096\/fj.201601002","article-title":"Cell proliferation within small intestinal crypts is the principal driving force for cell migration on villi","volume":"31","author":"Parker","year":"2017","journal-title":"FASEB J"},{"key":"10.1016\/j.jcmgh.2026.101786_bib33","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1093\/nutrit\/nux053","article-title":"Developmental origins of health and disease: current knowledge and potential mechanisms","volume":"75","author":"Hoffman","year":"2017","journal-title":"Nutr Rev"},{"key":"10.1016\/j.jcmgh.2026.101786_bib34","doi-asserted-by":"crossref","first-page":"755","DOI":"10.3389\/fphys.2018.00755","article-title":"ER-mitochondria microdomains in cardiac ischemia-reperfusion injury: a fresh perspective","volume":"9","author":"Zhou","year":"2018","journal-title":"Front Physiol"},{"key":"10.1016\/j.jcmgh.2026.101786_bib35","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1038\/s41418-020-00705-8","article-title":"ER-mitochondria contact sites in neurodegeneration: genetic screening approaches to investigate novel disease mechanisms","volume":"28","author":"Wilson","year":"2021","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.jcmgh.2026.101786_bib36","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.3390\/cells9122552","article-title":"Amyloid beta-peptide increases mitochondria-endoplasmic reticulum contact altering mitochondrial function and autophagosome formation in Alzheimer's disease-related models","volume":"9","author":"Leal","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.jcmgh.2026.101786_bib37","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1007\/s00018-024-05286-0","article-title":"Redox regulation of UPR signalling and mitochondrial ER contact sites","volume":"81","author":"Casas-Martinez","year":"2024","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.jcmgh.2026.101786_bib38","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.920228","article-title":"The potential of small molecules to modulate the mitochondria-endoplasmic reticulum interplay in Alzheimer's disease","volume":"10","author":"Dentoni","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.jcmgh.2026.101786_bib39","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1021\/acs.jmedchem.4c01368","article-title":"Modulation of mitochondria-endoplasmic reticulum contacts (MERCs) by small molecules as a new strategy for restoring lipid metabolism in an amyotrophic lateral sclerosis model","volume":"68","author":"Etxebeste-Mitxeltorena","year":"2025","journal-title":"J Med Chem"},{"key":"10.1016\/j.jcmgh.2026.101786_bib40","doi-asserted-by":"crossref","first-page":"439","DOI":"10.2147\/DMSO.S234665","article-title":"Guidelines and considerations for metabolic tolerance tests in mice","volume":"13","author":"Benede-Ubieto","year":"2020","journal-title":"Diabetes Metab Syndr Obes"},{"key":"10.1016\/j.jcmgh.2026.101786_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.acthis.2020.151646","article-title":"Mitochondria: A worthwhile object for ultrastructural qualitative characterization and quantification of cells at physiological and pathophysiological states using conventional transmission electron microscopy","volume":"122","author":"Duranova","year":"2020","journal-title":"Acta Histochem"},{"key":"10.1016\/j.jcmgh.2026.101786_bib42","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.3390\/cells10092177","article-title":"A universal approach to analyzing transmission electron microscopy with ImageJ","volume":"10","author":"Lam","year":"2021","journal-title":"Cells"}],"container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X26000640?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X26000640?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T08:14:04Z","timestamp":1784103244000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352345X26000640"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":42,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026]]}},"alternative-id":["S2352345X26000640"],"URL":"https:\/\/doi.org\/10.1016\/j.jcmgh.2026.101786","relation":{},"ISSN":["2352-345X"],"issn-type":[{"value":"2352-345X","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Maternal High-Fat Diet Worsens Necrotizing Enterocolitis via Effects on Mitochondrial Function in Newborn Mice","name":"articletitle","label":"Article Title"},{"value":"Cellular and Molecular Gastroenterology and Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcmgh.2026.101786","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of American Gastroenterological Association Institute.","name":"copyright","label":"Copyright"}],"article-number":"101786"}}