{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T02:21:30Z","timestamp":1793413290647,"version":"4.5.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"vor","delay-in-days":125,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170660"],"award-info":[{"award-number":["82170660"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82570767"],"award-info":[{"award-number":["82570767"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570582"],"award-info":[{"award-number":["81570582"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","cmghjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/j.jcmgh.2026.101810","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T13:08:22Z","timestamp":1778764102000},"page":"101810","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Kupffer Cell\u2013Derived Exosomal S100A8\/A9 Promotes Inflammasome\u2013Dependent Pyroptotic Lung Injury in Acute Pancreatitis"],"prefix":"10.1016","volume":"20","author":[{"given":"Wen-Qi","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Rui","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Ping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Qin","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Fei","family":"Sha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0553-3829","authenticated-orcid":false,"given":"Jian-Dong","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcmgh.2026.101810_bib1","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/S0140-6736(20)31310-6","article-title":"Acute pancreatitis","volume":"396","author":"Boxhoorn","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.jcmgh.2026.101810_bib2","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/(SICI)1096-9896(200002)190:2<117::AID-PATH494>3.0.CO;2-K","article-title":"Inflammatory mediators in acute pancreatitis","volume":"190","author":"Bhatia","year":"2000","journal-title":"J Pathol"},{"key":"10.1016\/j.jcmgh.2026.101810_bib3","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.pan.2011.12.012","article-title":"Lung injury in acute pancreatitis: mechanisms underlying augmented secondary injury","volume":"12","author":"Elder","year":"2012","journal-title":"Pancreatology"},{"key":"10.1016\/j.jcmgh.2026.101810_bib4","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.it.2017.08.002","article-title":"Exosomes, DAMPs and miRNA: features of stress physiology and immune homeostasis","volume":"38","author":"Fleshner","year":"2017","journal-title":"Trends Immunol"},{"key":"10.1016\/j.jcmgh.2026.101810_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.111301","article-title":"Inhibition of circulating exosomes release with GW4869 mitigates severe acute pancreatitis-stimulated intestinal barrier damage through suppressing NLRP3 inflammasome-mediated pyroptosis","volume":"126","author":"Shao","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.jcmgh.2026.101810_bib6","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/path.4771","article-title":"Involvement of exosomes in lung inflammation associated with experimental acute pancreatitis","volume":"240","author":"Bonjoch","year":"2016","journal-title":"J Pathol"},{"key":"10.1016\/j.jcmgh.2026.101810_bib7","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202300237R","article-title":"Circulating exosomal miR-155-5p contributes to severe acute pancreatitis-associated intestinal barrier injury by targeting SOCS1 to activate NLRP3 inflammasome-mediated pyroptosis","volume":"37","author":"Shao","year":"2023","journal-title":"FASEB J"},{"key":"10.1016\/j.jcmgh.2026.101810_bib8","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/path.5811","article-title":"Inflammatory capacity of exosomes released in the early stages of acute pancreatitis predicts the severity of the disease","volume":"256","author":"Carrascal","year":"2022","journal-title":"J Pathol"},{"key":"10.1016\/j.jcmgh.2026.101810_bib9","doi-asserted-by":"crossref","first-page":"3660","DOI":"10.1007\/s10620-023-08021-0","article-title":"Plasma exosomes aggravate acute pancreatitis by promoting M1 polarization of adipose tissue macrophages in obesity-related severe acute pancreatitis","volume":"68","author":"Han","year":"2023","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.jcmgh.2026.101810_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2020.165685","article-title":"Plasma-derived exosomes contribute to pancreatitis-associated lung injury by triggering NLRP3-dependent pyroptosis in alveolar macrophages","volume":"1866","author":"Wu","year":"2020","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"10.1016\/j.jcmgh.2026.101810_bib11","doi-asserted-by":"crossref","first-page":"4593","DOI":"10.1038\/ncomms5593","article-title":"Alarmin S100A8\/S100A9 as a biomarker for molecular imaging of local inflammatory activity","volume":"5","author":"Vogl","year":"2014","journal-title":"Nat Commun"},{"key":"10.1016\/j.jcmgh.2026.101810_bib12","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s12931-021-01641-y","article-title":"S100A9 blockade prevents lipopolysaccharide-induced lung injury via suppressing the NLRP3 pathway","volume":"22","author":"Zhao","year":"2021","journal-title":"Respir Res"},{"key":"10.1016\/j.jcmgh.2026.101810_bib13","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1007\/s10753-024-02161-9","article-title":"Critical role of S100A9 in sepsis-associated acute kidney injury: mechanistic insights through pyroptosis pathway modulation","volume":"48","author":"Zhang","year":"2025","journal-title":"Inflammation"},{"key":"10.1016\/j.jcmgh.2026.101810_bib14","doi-asserted-by":"crossref","first-page":"2960","DOI":"10.1182\/blood-2016-07-730556","article-title":"The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype","volume":"128","author":"Basiorka","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.jcmgh.2026.101810_bib15","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1161\/CIRCRESAHA.120.315865","article-title":"S100A9 links inflammation and repair in myocardial infarction","volume":"127","author":"Marinkovic","year":"2020","journal-title":"Circ Res"},{"key":"10.1016\/j.jcmgh.2026.101810_bib16","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1097\/00000658-199902000-00011","article-title":"Activation of alveolar macrophages in lung injury associated with experimental acute pancreatitis is mediated by the liver","volume":"229","author":"Closa","year":"1999","journal-title":"Ann Surg"},{"key":"10.1016\/j.jcmgh.2026.101810_bib17","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/path.2123","article-title":"Importance of the liver in systemic complications associated with acute pancreatitis: the role of Kupffer cells","volume":"211","author":"Folch-Puy","year":"2007","journal-title":"J Pathol"},{"key":"10.1016\/j.jcmgh.2026.101810_bib18","doi-asserted-by":"crossref","first-page":"403","DOI":"10.3748\/wjg.v12.i3.403","article-title":"Role of Kupffer cells in acute hemorrhagic necrotizing pancreatitis-associated lung injury of rats","volume":"12","author":"Liu","year":"2006","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jcmgh.2026.101810_bib19","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/S1091-255X(98)80033-4","article-title":"Hepatic Kupffer cell blockade reduces mortality of acute hemorrhagic pancreatitis in mice","volume":"2","author":"Gloor","year":"1998","journal-title":"J Gastrointest Surg"},{"key":"10.1016\/j.jcmgh.2026.101810_bib20","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1097\/00006676-200011000-00013","article-title":"Kupffer cell blockade reduces hepatic and systemic cytokine levels and lung injury in hemorrhagic pancreatitis in rats","volume":"21","author":"Gloor","year":"2000","journal-title":"Pancreas"},{"key":"10.1016\/j.jcmgh.2026.101810_bib21","doi-asserted-by":"crossref","first-page":"3579","DOI":"10.3390\/cells11223579","article-title":"S100A8-mediated NLRP3 inflammasome-dependent pyroptosis in macrophages facilitates liver fibrosis progression","volume":"11","author":"Liu","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.jcmgh.2026.101810_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0072138","article-title":"S100A8 and S100A9 induce cytokine expression and regulate the NLRP3 inflammasome via ROS-dependent activation of NF-kappaB(1.)","volume":"8","author":"Simard","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jcmgh.2026.101810_bib23","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/nature08710","article-title":"Hsp70 stabilizes lysosomes and reverts Niemann-Pick disease-associated lysosomal pathology","volume":"463","author":"Kirkegaard","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.jcmgh.2026.101810_bib24","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.4161\/cc.9.12.12052","article-title":"Connecting Hsp70, sphingolipid metabolism and lysosomal stability","volume":"9","author":"Petersen","year":"2010","journal-title":"Cell Cycle"},{"key":"10.1016\/j.jcmgh.2026.101810_bib25","doi-asserted-by":"crossref","first-page":"27432","DOI":"10.1074\/jbc.M114.560334","article-title":"Heat shock protein 70.1 (Hsp70.1) affects neuronal cell fate by regulating lysosomal acid sphingomyelinase","volume":"289","author":"Zhu","year":"2014","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jcmgh.2026.101810_bib26","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/s41419-019-1491-7","article-title":"HSP70 is a negative regulator of NLRP3 inflammasome activation","volume":"10","author":"Martine","year":"2019","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.jcmgh.2026.101810_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154358","article-title":"Cathepsin B\/HSP70 complex induced by Ilexsaponin I suppresses NLRP3 inflammasome activation in myocardial ischemia\/reperfusion injury","volume":"105","author":"Wu","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jcmgh.2026.101810_bib28","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s00134-003-2001-y","article-title":"Inhibition of inflammatory responses by ambroxol, a mucolytic agent, in a murine model of acute lung injury induced by lipopolysaccharide","volume":"30","author":"Su","year":"2004","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.jcmgh.2026.101810_bib29","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.jhep.2007.04.019","article-title":"Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis","volume":"47","author":"Rivera","year":"2007","journal-title":"J Hepatol"}],"container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X26000883?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X26000883?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T07:15:23Z","timestamp":1786691723000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352345X26000883"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":29,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026]]}},"alternative-id":["S2352345X26000883"],"URL":"https:\/\/doi.org\/10.1016\/j.jcmgh.2026.101810","relation":{},"ISSN":["2352-345X"],"issn-type":[{"value":"2352-345X","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Kupffer Cell\u2013Derived Exosomal S100A8\/A9 Promotes Inflammasome\u2013Dependent Pyroptotic Lung Injury in Acute Pancreatitis","name":"articletitle","label":"Article Title"},{"value":"Cellular and Molecular Gastroenterology and Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcmgh.2026.101810","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of American Gastroenterological Association Institute.","name":"copyright","label":"Copyright"}],"article-number":"101810"}}