{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T07:33:00Z","timestamp":1786692780373,"version":"build-2736575974"},"reference-count":57,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"vor","delay-in-days":154,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","award":["2024ZD53160"],"award-info":[{"award-number":["2024ZD53160"]}],"id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","award":["2024ZD53164"],"award-info":[{"award-number":["2024ZD53164"]}],"id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019978","name":"Shanghai Pudong New Area Health Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019978","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270860"],"award-info":[{"award-number":["82270860"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011488","name":"Shanghai Pudong New Area Health Commission","doi-asserted-by":"publisher","award":["PW2025D-02"],"award-info":[{"award-number":["PW2025D-02"]}],"id":[{"id":"10.13039\/501100011488","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","cmghjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/j.jcmgh.2026.101828","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:18:46Z","timestamp":1781137126000},"page":"101828","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hepatic CREB Binding Protein\/E1A Binding Protein p300 Maintain Bile Acid Homeostasis Through Histone Acetylation-Mediated Kruppel-Like Transcription Factor 10\u2013Bile Salt Export Pump Axis"],"prefix":"10.1016","volume":"20","author":[{"given":"Mingzhu","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiru","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxiang","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruyuan","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0806-5381","authenticated-orcid":false,"given":"Li","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcmgh.2026.101828_bib1","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1007\/s00018-008-7568-6","article-title":"Bile acids: chemistry, pathochemistry, biology, pathobiology, and therapeutics","volume":"65","author":"Hofmann","year":"2008","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.jcmgh.2026.101828_bib2","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1146\/annurev.biochem.72.121801.161712","article-title":"The enzymes, regulation, and genetics of bile acid synthesis","volume":"72","author":"Russell","year":"2003","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.jcmgh.2026.101828_bib3","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1152\/physrev.00049.2019","article-title":"Molecular physiology of bile acid signaling in health, disease, and aging","volume":"101","author":"Perino","year":"2021","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jcmgh.2026.101828_bib4","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s13238-020-00804-9","article-title":"Targeting the alternative bile acid synthetic pathway for metabolic diseases","volume":"12","author":"Jia","year":"2021","journal-title":"Protein Cell"},{"key":"10.1016\/j.jcmgh.2026.101828_bib5","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.90780","article-title":"Bile acids initiate cholestatic liver injury by triggering a hepatocyte-specific inflammatory response","volume":"2","author":"Cai","year":"2017","journal-title":"JCI Insight"},{"key":"10.1016\/j.jcmgh.2026.101828_bib6","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.molmed.2021.12.006","article-title":"Crosstalk between bile acid-activated receptors and microbiome in entero-hepatic inflammation","volume":"28","author":"Thibaut","year":"2022","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.jcmgh.2026.101828_bib7","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/cld.861","article-title":"Bile acid biology, pathophysiology, and therapeutics","volume":"15","author":"Chiang","year":"2020","journal-title":"Clin Liver Dis (Hoboken)"},{"key":"10.1016\/j.jcmgh.2026.101828_bib8","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1080\/00498250802040584","article-title":"Bile acid transporters in health and disease","volume":"38","author":"Kosters","year":"2008","journal-title":"Xenobiotica"},{"key":"10.1016\/j.jcmgh.2026.101828_bib9","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jhep.2021.02.011","article-title":"Bile formation and secretion: an update","volume":"75","author":"Boyer","year":"2021","journal-title":"J Hepatol"},{"key":"10.1016\/j.jcmgh.2026.101828_bib10","doi-asserted-by":"crossref","first-page":"3497","DOI":"10.1002\/hep.32027","article-title":"On the mechanisms of biliary flux","volume":"74","author":"Vartak","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2026.101828_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.clinre.2021.101641","article-title":"Regulatory mechanisms of the bile salt export pump (BSEP\/ABCB11) and its role in related diseases","volume":"45","author":"Ren","year":"2021","journal-title":"Clin Res Hepatol Gastroenterol"},{"key":"10.1016\/j.jcmgh.2026.101828_bib12","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41576-018-0072-4","article-title":"The many lives of KATs - detectors, integrators and modulators of the cellular environment","volume":"20","author":"Sheikh","year":"2019","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.jcmgh.2026.101828_bib13","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/s41580-021-00441-y","article-title":"Modulation of cellular processes by histone and non-histone protein acetylation","volume":"23","author":"Shvedunova","year":"2022","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jcmgh.2026.101828_bib14","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.jhep.2021.12.019","article-title":"Histone acetylation of bile acid transporter genes plays a critical role in cirrhosis","volume":"76","author":"Garrido","year":"2022","journal-title":"J Hepatol"},{"key":"10.1016\/j.jcmgh.2026.101828_bib15","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/8168791","article-title":"p300\/CBP as a key nutritional sensor for hepatic energy homeostasis and liver fibrosis","volume":"2018","author":"Yao","year":"2018","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.jcmgh.2026.101828_bib16","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1002\/hep4.2043","article-title":"Inhibition of CBP\/beta-catenin signaling ameliorated fibrosis in cholestatic liver disease","volume":"6","author":"Kimura","year":"2022","journal-title":"Hepatol Commun"},{"key":"10.1016\/j.jcmgh.2026.101828_bib17","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1053\/gast.2001.24833","article-title":"Expression of sterol 12alpha-hydroxylase alters bile acid pool composition in primary rat hepatocytes and in vivo","volume":"120","author":"Pandak","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcmgh.2026.101828_bib18","doi-asserted-by":"crossref","first-page":"28857","DOI":"10.1074\/jbc.M011610200","article-title":"Human bile salt export pump promoter is transactivated by the farnesoid X receptor\/bile acid receptor","volume":"276","author":"Ananthanarayanan","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jcmgh.2026.101828_bib19","doi-asserted-by":"crossref","first-page":"39411","DOI":"10.1074\/jbc.M106340200","article-title":"Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450","volume":"276","author":"Schuetz","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jcmgh.2026.101828_bib20","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1042\/BST20210658","article-title":"Bile acid metabolism and FXR-mediated effects in human cholestatic liver disorders","volume":"50","author":"Molinaro","year":"2022","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.jcmgh.2026.101828_bib21","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s12929-018-0475-8","article-title":"Jaundice revisited: recent advances in the diagnosis and treatment of inherited cholestatic liver diseases","volume":"25","author":"Chen","year":"2018","journal-title":"J Biomed Sci"},{"key":"10.1016\/j.jcmgh.2026.101828_bib22","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1002\/hep.28991","article-title":"New therapeutic concepts in bile acid transport and signaling for management of cholestasis","volume":"65","author":"Trauner","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2026.101828_bib23","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1136\/gutjnl-2021-324305","article-title":"Novel therapeutic targets for cholestatic and fatty liver disease","volume":"71","author":"Trauner","year":"2022","journal-title":"Gut"},{"key":"10.1016\/j.jcmgh.2026.101828_bib24","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/ng829","article-title":"Increased insulin sensitivity despite lipodystrophy in Crebbp heterozygous mice","volume":"30","author":"Yamauchi","year":"2002","journal-title":"Nat Genet"},{"key":"10.1016\/j.jcmgh.2026.101828_bib25","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.cmet.2011.06.010","article-title":"Disrupting the CH1 domain structure in the acetyltransferases CBP and p300 results in lean mice with increased metabolic control","volume":"14","author":"Bedford","year":"2011","journal-title":"Cell Metab"},{"key":"10.1016\/j.jcmgh.2026.101828_bib26","doi-asserted-by":"crossref","first-page":"412","DOI":"10.2337\/db17-0237","article-title":"The p300 and CBP transcriptional coactivators are required for \u03b2-Cell and \u03b1-Cell proliferation","volume":"67","author":"Wong","year":"2018","journal-title":"Diabetes"},{"key":"10.1016\/j.jcmgh.2026.101828_bib27","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/s41419-020-02960-6","article-title":"Selective inhibition of CBP\/p300 HAT by A-485 results in suppression of lipogenesis and hepatic gluconeogenesis","volume":"11","author":"Zhou","year":"2020","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.jcmgh.2026.101828_bib28","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.molcel.2017.09.020","article-title":"mTORC1 phosphorylates acetyltransferase p300 to regulate autophagy and lipogenesis","volume":"68","author":"Wan","year":"2017","journal-title":"Mol Cell"},{"key":"10.1016\/j.jcmgh.2026.101828_bib29","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/s41575-021-00566-7","article-title":"Role of bile acids and their receptors in gastrointestinal and hepatic pathophysiology","volume":"19","author":"Fuchs","year":"2022","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jcmgh.2026.101828_bib30","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1194\/jlr.R054114","article-title":"Intestinal transport and metabolism of bile acids","volume":"56","author":"Dawson","year":"2015","journal-title":"J Lipid Res"},{"key":"10.1016\/j.jcmgh.2026.101828_bib31","doi-asserted-by":"crossref","first-page":"437","DOI":"10.3109\/03602530903492004","article-title":"Role of the bile salt export pump, BSEP, in acquired forms of cholestasis","volume":"42","author":"Stieger","year":"2010","journal-title":"Drug Metab Rev"},{"key":"10.1016\/j.jcmgh.2026.101828_bib32","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jhep.2012.08.002","article-title":"Bile acid transporters and regulatory nuclear receptors in the liver and beyond","volume":"58","author":"Halilbasic","year":"2013","journal-title":"J Hepatol"},{"key":"10.1016\/j.jcmgh.2026.101828_bib33","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s43066-025-00451-x","article-title":"The role of hepatobiliary transporters in bile acid homeostasis","volume":"15","author":"Mohammed","year":"2025","journal-title":"Egypt Liver J"},{"key":"10.1016\/j.jcmgh.2026.101828_bib34","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1002\/hep.31651","article-title":"Targeting the four pillars of enterohepatic bile salt cycling; lessons from genetics and pharmacology","volume":"73","author":"Kunst","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2026.101828_bib35","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1111\/apt.16118","article-title":"Review article: liver disease in adults with variants in the cholestasis-related genes ABCB11, ABCB4 and ATP8B1","volume":"52","author":"Nayagam","year":"2020","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.jcmgh.2026.101828_bib36","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/978-3-642-14541-4_5","article-title":"The role of the sodium-taurocholate cotransporting polypeptide (NTCP) and of the bile salt export pump (BSEP) in physiology and pathophysiol ogy of bile formation","author":"Stieger","year":"2011","journal-title":"Handb Exp Pharmacol"},{"key":"10.1016\/j.jcmgh.2026.101828_bib37","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1124\/dmd.107.014902","article-title":"Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines","volume":"35","author":"Hilgendorf","year":"2007","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.jcmgh.2026.101828_bib38","doi-asserted-by":"crossref","first-page":"7470","DOI":"10.3748\/wjg.v26.i47.7470","article-title":"Molecular overview of progressive familial intrahepatic cholestasis","volume":"26","author":"Amirneni","year":"2020","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jcmgh.2026.101828_bib39","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/j.jhep.2017.07.004","article-title":"Sequencing of FIC1, BSEP and MDR3 in a large cohort of patients with cholestasis revealed a high number of different genetic variants","volume":"67","author":"Dr\u00f6ge","year":"2017","journal-title":"J Hepatol"},{"key":"10.1016\/j.jcmgh.2026.101828_bib40","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1002\/hep.27171","article-title":"Transcriptional dynamics of bile salt export pump during pregnancy: mechanisms and implications in intrahepatic cholestasis of pregnancy","volume":"60","author":"Song","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2026.101828_bib41","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1053\/jhep.2002.31724","article-title":"Farnesoid X receptor and bile salts are involved in transcriptional regulation of the gene encoding the human bile salt export pump","volume":"35","author":"Plass","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2026.101828_bib42","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1194\/jlr.M700417-JLR200","article-title":"Liver receptor homolog 1 transcriptionally regulates human bile salt export pump expression","volume":"49","author":"Song","year":"2008","journal-title":"J Lipid Res"},{"key":"10.1016\/j.jcmgh.2026.101828_bib43","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1002\/hep.23151","article-title":"Nuclear factor erythroid 2-related factor 2 is a positive regulator of human bile salt export pump expression","volume":"50","author":"Weerachayaphorn","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.jcmgh.2026.101828_bib44","doi-asserted-by":"crossref","first-page":"35086","DOI":"10.1074\/jbc.M803531200","article-title":"The p300 acetylase is critical for ligand-activated farnesoid X receptor (FXR) induction of SHP","volume":"283","author":"Fang","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jcmgh.2026.101828_bib45","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3390\/cancers10060161","article-title":"KLF10 as a tumor suppressor gene and its TGF-beta signaling","volume":"10","author":"Memon","year":"2018","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jcmgh.2026.101828_bib46","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.3390\/ijms25021276","article-title":"New insights into the role of KLF10 in tissue fibrosis","volume":"25","author":"Yaseen","year":"2024","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jcmgh.2026.101828_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2024.155909","article-title":"Kr\u00fcppel-like factor 10 protects against metabolic dysfunction-associated steatohepatitis by regulating HNF4\u03b1-mediated metabolic pathways","volume":"155","author":"Pan","year":"2024","journal-title":"Metabolism"},{"key":"10.1016\/j.jcmgh.2026.101828_bib48","article-title":"KLF10 integrates circadian timing and sugar signaling to coordinate hepatic metabolism","volume":"10","author":"Anthony","year":"2021","journal-title":"Elife"},{"key":"10.1016\/j.jcmgh.2026.101828_bib49","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1007\/s00125-017-4412-2","article-title":"KLF10 transcription factor regulates hepatic glucose metabolism in mice","volume":"60","author":"Yang","year":"2017","journal-title":"Diabetologia"},{"key":"10.1016\/j.jcmgh.2026.101828_bib50","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202154229","article-title":"KLF10 promotes nonalcoholic steatohepatitis progression through transcriptional activation of zDHHC7","volume":"23","author":"Yang","year":"2022","journal-title":"EMBO Rep"},{"key":"10.1016\/j.jcmgh.2026.101828_bib51","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.gendis.2022.06.005","article-title":"Kruppel-like factor 10 (KLF10) as a critical signaling mediator: versatile functions in physiological and pathophysiological processes","volume":"10","author":"Luo","year":"2023","journal-title":"Genes Dis"},{"key":"10.1016\/j.jcmgh.2026.101828_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2024.155916","article-title":"Hepatic Klf10-Fh1 axis promotes exercise-mediated amelioration of NASH in mice","volume":"155","author":"Luo","year":"2024","journal-title":"Metabolism"},{"key":"10.1016\/j.jcmgh.2026.101828_bib53","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/s10020-023-00751-1","article-title":"Loss of Kruppel-like factor-10 facilitates the development of chemical-induced liver cancer in mice","volume":"29","author":"Yoo","year":"2023","journal-title":"Mol Med"},{"key":"10.1016\/j.jcmgh.2026.101828_bib54","doi-asserted-by":"crossref","DOI":"10.1111\/apha.13394","article-title":"Novel role of Tieg1 in muscle metabolism and mitochondrial oxidative capacities","volume":"228","author":"Kammoun","year":"2020","journal-title":"Acta Physiol (Oxf)"},{"key":"10.1016\/j.jcmgh.2026.101828_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109310","article-title":"Compensatory hepatic adaptation accompanies permanent absence of intrahepatic biliary network due to YAP1 loss in liver progenitors","volume":"36","author":"Molina","year":"2021","journal-title":"Cell Rep"},{"key":"10.1016\/j.jcmgh.2026.101828_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2020.100086","article-title":"Protocol for primary mouse hepatocyte isolation","volume":"1","author":"Charni-Natan","year":"2020","journal-title":"STAR Protoc"},{"key":"10.1016\/j.jcmgh.2026.101828_bib57","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1038\/s41467-019-09982-5","article-title":"CUT&Tag for efficient epigenomic profiling of small samples and single cells","volume":"10","author":"Kaya-Okur","year":"2019","journal-title":"Nat Commun"}],"container-title":["Cellular and Molecular Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X26001062?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352345X26001062?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T07:16:09Z","timestamp":1786691769000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352345X26001062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":57,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026]]}},"alternative-id":["S2352345X26001062"],"URL":"https:\/\/doi.org\/10.1016\/j.jcmgh.2026.101828","relation":{},"ISSN":["2352-345X"],"issn-type":[{"value":"2352-345X","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hepatic CREB Binding Protein\/E1A Binding Protein p300 Maintain Bile Acid Homeostasis Through Histone Acetylation-Mediated Kruppel-Like Transcription Factor 10\u2013Bile Salt Export Pump Axis","name":"articletitle","label":"Article Title"},{"value":"Cellular and Molecular Gastroenterology and Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcmgh.2026.101828","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of American Gastroenterological Association Institute.","name":"copyright","label":"Copyright"}],"article-number":"101828"}}