{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T20:31:21Z","timestamp":1772569881901,"version":"3.50.1"},"reference-count":60,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cranio-Maxillofacial Surgery"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1016\/j.jcms.2011.10.024","type":"journal-article","created":{"date-parts":[[2011,11,15]],"date-time":"2011-11-15T23:51:04Z","timestamp":1321401064000},"page":"e229-e235","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":59,"title":["The cytotoxic effects of three different bisphosphonates in-vitro on human gingival fibroblasts, osteoblasts and osteogenic sarcoma cells"],"prefix":"10.1016","volume":"40","author":[{"given":"Y.","family":"A\u00e7il","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"M\u00f6ller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Niehoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Rachko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Gassling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Wiltfang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.J.K.","family":"Simon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcms.2011.10.024_bib1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jcms.2007.06.008","article-title":"\u201cBis-phossy jaws\u201d \u2013 high and low risk factors for bisphosphonate-induced osteonecrosis of the jaw","volume":"36","author":"Abu-Id","year":"2008","journal-title":"J\u00a0Craniomaxillofac Surg"},{"key":"10.1016\/j.jcms.2011.10.024_bib2","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0021-9673(94)87006-3","article-title":"A\u00a0rapid method for the isolation of the mature collagen cross-links, hydroxylysylpyridinoline (HP) and lysylpyridinoline (LP)","volume":"664","author":"A\u00e7il","year":"1994","journal-title":"J\u00a0Chromatogr A"},{"key":"10.1016\/j.jcms.2011.10.024_bib3","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1002\/1097-4636(20000915)51:4<703::AID-JBM19>3.0.CO;2-A","article-title":"Three-dimensional cultivation of human osteoblast-like cells on highly porous natural bone mineral","volume":"51","author":"Acil","year":"2000","journal-title":"J\u00a0Biomed Mater Res"},{"key":"10.1016\/j.jcms.2011.10.024_bib4","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1002\/jcb.10197","article-title":"Effects of bone morphogenetic protein-7 stimulation on osteoblasts cultured on different biomaterials","volume":"86","author":"Acil","year":"2002","journal-title":"J\u00a0Cell Biochem"},{"key":"10.1016\/j.jcms.2011.10.024_bib5","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s00223-004-0122-0","article-title":"Detection of mature collagen in human dental enamel","volume":"76","author":"Acil","year":"2005","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.jcms.2011.10.024_bib6","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1007\/s00066-007-1598-0","article-title":"Proof of direct radiogenic destruction of collagen in\u00a0vitro","volume":"183","author":"Acil","year":"2007","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.jcms.2011.10.024_bib7","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1177\/0022034509354298","article-title":"Is zoledronate toxic to human periodontal fibroblasts?","volume":"89","author":"Agis","year":"2010","journal-title":"J\u00a0Dent Res"},{"key":"10.1016\/j.jcms.2011.10.024_bib8","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.joms.2006.11.003","article-title":"American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaws","volume":"65","author":"American Association of Oral and Maxillofacial Surgeons","year":"2007","journal-title":"J\u00a0Oral Maxillofac Surg"},{"key":"10.1016\/j.jcms.2011.10.024_bib9","first-page":"275","article-title":"[Osteonecrosis of the jaw secondary to oral alendronate: report of three cases]","volume":"137","author":"Bocanegra-P\u00e9rez","year":"2009","journal-title":"Rev Med Chil"},{"issue":"Suppl.","key":"10.1016\/j.jcms.2011.10.024_bib10","first-page":"12","article-title":"Systemic conditions and treatments as risk for implant therapy","volume":"24","author":"Bornstein","year":"2009","journal-title":"Int J Oral Maxillofac Implants"},{"key":"10.1016\/j.jcms.2011.10.024_bib11","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1359\/jbmr.1998.13.11.1721","article-title":"Human osteoclast formation and activity in\u00a0vitro: effects of alendronate","volume":"13","author":"Breuil","year":"1998","journal-title":"J\u00a0Bone Miner Res"},{"key":"10.1016\/j.jcms.2011.10.024_bib12","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3816\/CLM.2008.n.013","article-title":"Osteonecrosis of the jaw in patients with multiple myeloma treated with bisphosphonates: definition and management of the risk related to zoledronic acid","volume":"8","author":"Cafro","year":"2008","journal-title":"Clin Lymphoma Myeloma"},{"key":"10.1016\/j.jcms.2011.10.024_bib13","doi-asserted-by":"crossref","first-page":"2556","DOI":"10.2106\/JBJS.H.01774","article-title":"Bilateral low-energy simultaneous or sequential femoral fractures in patients on long-term alendronate therapy","volume":"91","author":"Capeci","year":"2009","journal-title":"J\u00a0Bone Joint Surg Am"},{"key":"10.1016\/j.jcms.2011.10.024_bib14","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1053\/ctrv.2000.0210","article-title":"Metastatic bone disease: clinical features, pathophysiology, and treatment strategies","volume":"27","author":"Coleman","year":"2001","journal-title":"Cancer Treat Rev"},{"key":"10.1016\/j.jcms.2011.10.024_bib15","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1708-8208.2003.tb00210.x","article-title":"Immediately loaded bar-connected implants with an anodized surface inserted in the anterior mandible in a patient treated with diphosphonates for osteoporosis: a case report with a 12-month follow-up","volume":"5","author":"Degidi","year":"2003","journal-title":"Clin Implant Dental Relat Res"},{"key":"10.1016\/j.jcms.2011.10.024_bib16","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.14219\/jada.archive.2008.0110","volume":"139","author":"Edwards","year":"2008","journal-title":"J\u00a0Am Dent Assoc"},{"key":"10.1016\/j.jcms.2011.10.024_bib17","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1111\/j.1600-051X.2005.00842.x","article-title":"Osteonecrosis of the jaws in periodontal patients with a history of bisphosphonates treatment","volume":"32","author":"Ficarra","year":"2005","journal-title":"J\u00a0Clin Periodontol"},{"key":"10.1016\/j.jcms.2011.10.024_bib18","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1210\/edrv.19.1.0325","article-title":"Bisphosphonates: mechanisms of action","volume":"19","author":"Fleisch","year":"1998","journal-title":"Endocr Rev"},{"key":"10.1016\/j.jcms.2011.10.024_bib19","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.joms.2009.09.037","article-title":"The nature and frequency of bisphosphonate-associated osteonecrosis of the jaws in dental implant patients: a South Australian case series","volume":"68","author":"Goss","year":"2010","journal-title":"J\u00a0Oral Maxillofac Surg"},{"key":"10.1016\/j.jcms.2011.10.024_bib20","doi-asserted-by":"crossref","first-page":"563","DOI":"10.3892\/ijo_00000705","article-title":"Development of novel ploy bisphosphonate conjugate for treat of skeletal metastasis and osteoporosis","volume":"37","author":"Holmberg","year":"2010","journal-title":"Int J Oncol"},{"key":"10.1016\/j.jcms.2011.10.024_bib21","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1007\/s00198-009-1024-9","article-title":"Oral bisphosphonate-related osteonecrosis of the jaw: the first report in Asia","volume":"21","author":"Hong","year":"2010","journal-title":"Osteoporos"},{"key":"10.1016\/j.jcms.2011.10.024_bib22","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1056\/NEJM199612123352401","article-title":"Efficacy of pamidronate in reducing skeletal complications in patients with breast cancer and lytic bone metastases","volume":"335","author":"Hortobagyi","year":"1996","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jcms.2011.10.024_bib23","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s00223-008-9104-y","article-title":"Aminobisphosphonates cause osteoblast apoptosis and inhibit bone nodule formation in\u00a0vitro","volume":"82","author":"Idris","year":"2008","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.jcms.2011.10.024_bib24","doi-asserted-by":"crossref","first-page":"4105","DOI":"10.1016\/j.biomaterials.2003.11.024","article-title":"Osteoblast proliferation and maturation by bisphosphonates","volume":"25","author":"Im","year":"2004","journal-title":"Biomaterials"},{"key":"10.1016\/j.jcms.2011.10.024_bib25","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s002239900505","article-title":"Comparison of cytotoxic effects of bisphosphonates in\u00a0vitro and in\u00a0vivo","volume":"63","author":"Ito","year":"1998","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.jcms.2011.10.024_bib26","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-2697(81)90261-X","article-title":"A\u00a0simple method to determine nanogram levels of 4-hydroxyproline in biological tissues","volume":"112","author":"Jamall","year":"1981","journal-title":"Anal Biochem"},{"key":"10.1016\/j.jcms.2011.10.024_bib27","doi-asserted-by":"crossref","first-page":"R4","DOI":"10.1186\/bcr1845","article-title":"Extracellular calcium increases bisphosphonate-induced growth inhibition of breast cancer cells","volume":"10","author":"Journ\u00e9","year":"2008","journal-title":"Breast Cancer Res"},{"key":"10.1016\/j.jcms.2011.10.024_bib28","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.amjoto.2008.07.014","article-title":"Clinical experiences with bisphosphonate-associated osteonecrosis of the jaws: analysis of 21 cases","volume":"30","author":"Junquera","year":"2009","journal-title":"Am J Otolaryngol"},{"key":"10.1016\/j.jcms.2011.10.024_bib29","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00774-009-0128-9","article-title":"Zoledronic acid delays wound healing of the tooth extraction socket, inhibits oral epithelial cell migration, and promotes proliferation and adhesion to hydroxyapatite of oral bacteria, without causing osteonecrosis of the jaw, in mice","volume":"28","author":"Kobayashi","year":"2010","journal-title":"J\u00a0Bone Miner Metab"},{"key":"10.1016\/j.jcms.2011.10.024_bib30","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1746-160X-6-12","article-title":"The impact of bisphosphonates on the osteoblast proliferation and collagen gene expression in\u00a0vitro","volume":"6","author":"Koch","year":"2010","journal-title":"Head Face Med"},{"key":"10.1016\/j.jcms.2011.10.024_bib31","doi-asserted-by":"crossref","first-page":"63","DOI":"10.5005\/jcdp-9-1-63","article-title":"Osteonecrosis of the jaws secondary to bisphosphonate therapy: a case serious","volume":"9","author":"Kumar","year":"2008","journal-title":"J\u00a0Contemp Dent Pract"},{"key":"10.1016\/j.jcms.2011.10.024_bib32","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.bone.2009.07.011","article-title":"Bisphosphonate-associated osteonecrosis of the jaw: a key role of inflammation?","volume":"45","author":"Lesclous","year":"2009","journal-title":"Bone"},{"key":"10.1016\/j.jcms.2011.10.024_bib33","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.joms.2009.03.050","article-title":"Predicting risk of osteonecrosis of the jaws with oral bisphosphonate exposure (PROBE) investigators. Prevalence of osteonecrosis of the jaw in patients with oral bisphosphonate exposure","volume":"68","author":"Lo","year":"2010","journal-title":"J\u00a0Oral Maxillofac Surg"},{"key":"10.1016\/j.jcms.2011.10.024_bib34","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1359\/jbmr.1998.13.4.581","article-title":"Nitrogen-containing bisphosphonates inhibit the mevalonate path-way and prevent post-translational prenylation of GTP-binding pro-teins, including Ras","volume":"13","author":"Luckman","year":"1998","journal-title":"J\u00a0Bone Miner Res"},{"key":"10.1016\/j.jcms.2011.10.024_bib35","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/S0278-2391(03)00720-1","article-title":"Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic","volume":"61","author":"Marx","year":"2003","journal-title":"J\u00a0Oral Maxillofac Surg"},{"key":"10.1016\/j.jcms.2011.10.024_bib36","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1016\/j.joms.2005.07.010","article-title":"Bisphosphonate-induced exposed bone (osteonecrosis\/osteopetrosis) of the jaws: risk factors, recognition, prevention, and treatment","volume":"63","author":"Marx","year":"2005","journal-title":"J\u00a0Oral Maxillofac Surg"},{"key":"10.1016\/j.jcms.2011.10.024_bib37","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1007\/s00198-008-0816-7","article-title":"Effect of daily oral minodronate on vertebral fractures in Japanese postmenopausal women with established osteoporosis: a randomized placebo-controlled double-blind study","volume":"20","author":"Matsumoto","year":"2009","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.jcms.2011.10.024_bib38","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.joms.2006.10.061","article-title":"Nature and frequency of bisphosphonate-associated osteonecrosis of the jaws in Australia","volume":"65","author":"Mayrokokki","year":"2007","journal-title":"J\u00a0Oral Maxillofac Surg"},{"key":"10.1016\/j.jcms.2011.10.024_bib39","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.mvr.2009.07.004","article-title":"Metronomic administration of ibandronate and ist anti-angiogenic effects in\u00a0vitro","volume":"78","author":"Morgan","year":"2009","journal-title":"Microvasc Res"},{"key":"10.1016\/j.jcms.2011.10.024_bib40","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.bone.2005.05.003","article-title":"Novel insights into actions of bisphosphonates on bone: differences in interactions with hydroxyapatite","volume":"38","author":"Nancollas","year":"2006","journal-title":"Bone"},{"key":"10.1016\/j.jcms.2011.10.024_bib41","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1080\/09553000600840948","article-title":"Increased excretion of collagen crosslinks in irradiated patients indicates destruction of collagen","volume":"82","author":"Niehoff","year":"2006","journal-title":"Int J Radiat Biol"},{"key":"10.1016\/j.jcms.2011.10.024_bib42","article-title":"The influence of bisphosphonates on viability, migration, and apoptosis of human oral keratinocytes \u2013 in\u00a0vitro study","author":"Pabst","year":"2011","journal-title":"Clin Oral Invest"},{"key":"10.1016\/j.jcms.2011.10.024_bib43","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.colsurfb.2008.02.002","article-title":"In\u00a0vitro response of hFOB cells to pamidronate modified sodium silicate coated cellulose scaffolds","volume":"64","author":"Ponader","year":"2008","journal-title":"Colloids Surf B Biointerfaces"},{"key":"10.1016\/j.jcms.2011.10.024_bib44","doi-asserted-by":"crossref","first-page":"417","DOI":"10.5694\/j.1326-5377.2005.tb06762.x","article-title":"Bisphosphonates and osteonecrosis of the jaw","volume":"182","author":"Purcell","year":"2005","journal-title":"Med J Aust"},{"key":"10.1016\/j.jcms.2011.10.024_bib45","first-page":"1261","article-title":"Bisphosphonates in the prevention and treatment of bone metastasis","volume":"17","author":"Ramaswamy","year":"2003","journal-title":"Oncology"},{"key":"10.1016\/j.jcms.2011.10.024_bib46","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.archoralbio.2010.11.003","article-title":"Bisphosphonate effects on the behaviour of oral epithelial cells and oral fibroblasts","volume":"56","author":"Ravosa","year":"2011","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.jcms.2011.10.024_bib47","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.bone.2008.09.012","article-title":"Osteonecrosis of the jaw \u2013 who gets it, and why?","volume":"44","author":"Reid","year":"2009","journal-title":"Bone"},{"key":"10.1016\/j.jcms.2011.10.024_bib48","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.1002\/1097-0142(20000615)88:12+<2961::AID-CNCR12>3.0.CO;2-L","article-title":"Cellular and molecular mechanisms of action of bisphosphonates","volume":"88","author":"Rogers","year":"2000","journal-title":"Cancer"},{"key":"10.1016\/j.jcms.2011.10.024_bib49","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.joms.2004.02.004","article-title":"Osteonecrosis of the jaws associated with the use of bisphosphonates: a review of 63 cases","volume":"62","author":"Ruggiero","year":"2004","journal-title":"J\u00a0Oral Maxillofac Surg"},{"key":"10.1016\/j.jcms.2011.10.024_bib50","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1196\/annals.1346.041","article-title":"Bisphosphonates: from bench to bedside","volume":"1068","author":"Russell","year":"2006","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.jcms.2011.10.024_bib51","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1093\/jnci\/94.19.1458","article-title":"Zoledronic acid prostate cancer study group. A randomized, placebo controlled trial of zoledronic acid in patients with hormone-refractory metastatic prostate carcinoma","volume":"94","author":"Saad","year":"2002","journal-title":"J\u00a0Natl Cancer Inst"},{"key":"10.1016\/j.jcms.2011.10.024_bib52","first-page":"1351","article-title":"Changes in bone resorption and vascular endothelial growth factor after a single zoledronic acid infusion in cancer patients with bone metastases from solid tumours","volume":"15","author":"Santini","year":"2006","journal-title":"Oncol Rep"},{"key":"10.1016\/j.jcms.2011.10.024_bib53","doi-asserted-by":"crossref","first-page":"413","DOI":"10.3109\/17453670903139914","article-title":"Incidence of stress fractures of the femoral shaft in women treated with bisphosphonate","volume":"80","author":"Schilcher","year":"2009","journal-title":"Acta Orthop"},{"key":"10.1016\/j.jcms.2011.10.024_bib54","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.joms.2007.11.035","article-title":"Identification of microbial biofilms in osteonecrosis of the jaws secondary to bisphosphonate therapy","volume":"66","author":"Sedghizadeh","year":"2008","journal-title":"J\u00a0Oral Maxillofac Surg"},{"key":"10.1016\/j.jcms.2011.10.024_bib55","doi-asserted-by":"crossref","first-page":"61","DOI":"10.14219\/jada.archive.2009.0019","article-title":"Oral bisphosphonate use and the prevalence of osteonecrosis of the jaw: an institutional inquiry","volume":"140","author":"Sedghizadeh","year":"2009","journal-title":"J\u00a0Am Dent Assoc"},{"key":"10.1016\/j.jcms.2011.10.024_bib56","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s00784-009-0312-2","article-title":"Expression profile and synthesis of different collagen types I, II, III, and V of human gingival fibroblasts, osteoblasts, and SaOS-2 cells after bisphosphonate treatment","volume":"14","author":"Simon","year":"2010","journal-title":"Clin Oral Invest"},{"key":"10.1016\/j.jcms.2011.10.024_bib57","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1007\/s00776-007-1180-8","article-title":"Effect of etidronate on COX-2 expression and PGE2 production in macrophage-like RAW 264.7 cells stimulated by titanium particles","volume":"12","author":"Suzuki","year":"2007","journal-title":"J\u00a0Orthop Sci"},{"key":"10.1016\/j.jcms.2011.10.024_bib58","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s00784-009-0266-4","article-title":"Influence of bisphosphonates on endothelial cells, fibroblasts, and osteogenic cells","volume":"14","author":"Walter","year":"2010","journal-title":"Clin Oral Invest"},{"key":"10.1016\/j.jcms.2011.10.024_bib59","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1124\/jpet.102.035295","article-title":"Novel antiangiogenic effects of the bisphosphonate compound zoledronic acid","volume":"302","author":"Wood","year":"2002","journal-title":"J\u00a0Pharmacol Exp Ther"},{"key":"10.1016\/j.jcms.2011.10.024_bib60","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s12018-009-9055-5","article-title":"Oral bisphosphonate-related osteonecrosis of the jaw: incidence, clinical features, prevention, and treatment recommendations","volume":"8","author":"Yarom","year":"2010","journal-title":"Clinic Rev Bone Miner Metab"}],"container-title":["Journal of Cranio-Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1010518211002393?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1010518211002393?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T14:26:49Z","timestamp":1760884009000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1010518211002393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":60,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["S1010518211002393"],"URL":"https:\/\/doi.org\/10.1016\/j.jcms.2011.10.024","relation":{},"ISSN":["1010-5182"],"issn-type":[{"value":"1010-5182","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The cytotoxic effects of three different bisphosphonates in-vitro on human gingival fibroblasts, osteoblasts and osteogenic sarcoma cells","name":"articletitle","label":"Article Title"},{"value":"Journal of Cranio-Maxillofacial Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcms.2011.10.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}