{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T07:08:07Z","timestamp":1765177687732,"version":"build-2065373602"},"reference-count":23,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cranio-Maxillofacial Surgery"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1016\/j.jcms.2015.02.005","type":"journal-article","created":{"date-parts":[[2015,2,17]],"date-time":"2015-02-17T19:49:40Z","timestamp":1424202580000},"page":"528-536","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"title":["Describing Crouzon and Pfeiffer syndrome based on principal component analysis"],"prefix":"10.1016","volume":"43","author":[{"given":"Femke C.R.","family":"Staal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allan J.T.","family":"Ponniah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Freida","family":"Angullia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clifford","family":"Ruff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maarten J.","family":"Koudstaal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Dunaway","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jcms.2015.02.005_bib1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1006\/cviu.1997.0607","article-title":"Shape and the information in medical images: a decade of the morphometric synthesis","volume":"66","author":"Bookstein","year":"1997","journal-title":"Computer Vis Image Underst"},{"issue":"3","key":"10.1016\/j.jcms.2015.02.005_bib2","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1097\/01.SCS.0000157078.53871.11","article-title":"Apert and Crouzon syndromes \u2013 clinical findings, genes and extracellular matrix","volume":"16","author":"Carinci","year":"2005","journal-title":"J\u00a0Craniofac Surg"},{"issue":"2","key":"10.1016\/j.jcms.2015.02.005_bib3","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1597\/1545-1569_1992_029_0129_cozmfs_2.3.co_2","article-title":"Cranio-orbito-zygomatic measurements from standard CT scans in unoperated Crouzon and Apert infants: comparison with normal controls","volume":"29","author":"Carr","year":"1992","journal-title":"Cleft Palate Craniofac J"},{"issue":"4","key":"10.1016\/j.jcms.2015.02.005_bib4","first-page":"545","article-title":"Dysostose cranio-faciale h\u00e9r\u00e9ditaire","volume":"33","author":"Crouzon","year":"1912","journal-title":"Bull Mem Soc Med Hop Paris"},{"key":"10.1016\/j.jcms.2015.02.005_bib5","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1601-6343.2007.00389.x","article-title":"Syndromic craniosynostosis: from history to hydrogen bonds","volume":"10","author":"Cunningham","year":"2007","journal-title":"Orthod Craniofac Res"},{"issue":"4","key":"10.1016\/j.jcms.2015.02.005_bib6","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1097\/01.scs.0000171847.58031.9e","article-title":"International anthropometric study of facial morphology in various ethnic groups\/races","volume":"16","author":"Farkas","year":"2005","journal-title":"J\u00a0Craniofac Surg"},{"issue":"4","key":"10.1016\/j.jcms.2015.02.005_bib7","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/ajmg.a.20665","article-title":"3D analysis of facial morphology","volume":"126A","author":"Hammond","year":"2004","journal-title":"Am J Med Genet A"},{"issue":"12","key":"10.1016\/j.jcms.2015.02.005_bib8","first-page":"2863","article-title":"Craniosynostosis","volume":"69","author":"Kabbani","year":"2004","journal-title":"Am Fam Physician"},{"key":"10.1016\/j.jcms.2015.02.005_bib9","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S1010-5182(05)80478-0","article-title":"Comparative three-dimensional analysis of CT-scans of the calvaria and cranial base in Apert and Crouzon syndromes","volume":"21","author":"Kreiborg","year":"1993","journal-title":"J\u00a0Craniomaxillofac Surg"},{"issue":"3","key":"10.1016\/j.jcms.2015.02.005_bib10","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/sj.ejhg.5201558","article-title":"Mutation screening in patients with syndromic craniosynostoses indicates that a limited number of recurrent FGFR2 mutations accounts for severe forms of Pfeiffer syndrome","volume":"14","author":"Lajeunie","year":"2006","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.jcms.2015.02.005_bib11","first-page":"491","article-title":"FGFR2 Exon Ilia and IlIc mutations in Crouzon, Jackson-Weiss, and Pfeiffer syndromes- evidence for missense changes, insertions, and a deletion due to alternative RNA splicing","volume":"58","author":"Meyers","year":"1996","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jcms.2015.02.005_bib12","first-page":"103","article-title":"The study of morphological variation in the hominid fossil record- biology, landmarks and geometry","volume":"197","author":"O'Higgins","year":"2000","journal-title":"J.\u00a0Anat"},{"key":"10.1016\/j.jcms.2015.02.005_bib13","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/BF00447500","article-title":"Dominant erbliche akrocephalosyndaktylie","volume":"90","author":"Pfeiffer","year":"1964","journal-title":"Z Kinderheilk"},{"issue":"12","key":"10.1016\/j.jcms.2015.02.005_bib14","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1016\/j.bjps.2012.07.007","article-title":"Using principal component analysis to describe the Apert skull deformity and simulate its correction","volume":"65","author":"Pluijmers","year":"2012","journal-title":"J\u00a0Plast Reconstr Aesthet Surg"},{"issue":"6","key":"10.1016\/j.jcms.2015.02.005_bib15","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1097\/00006534-199311000-00005","article-title":"Crouzon syndrome quantitative assessment of presenting deformity and surgical results based on CT scans","volume":"92","author":"Posnick","year":"1993","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.jcms.2015.02.005_bib16","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1007\/s003810000320","article-title":"Management of craniosynostosis","volume":"16","author":"Renier","year":"2000","journal-title":"Childs Nerv Syst"},{"key":"10.1016\/j.jcms.2015.02.005_bib17","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1002\/ajpa.1330740407","article-title":"Comparative study of Normal, Crouzon, and Apert craniofacial morphology using finite element scaling analysis","volume":"74","author":"Richtsmeier","year":"1987","journal-title":"Am J Phys Anthropol"},{"issue":"2","key":"10.1016\/j.jcms.2015.02.005_bib18","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.pcl.2003.12.001","article-title":"Skull deformities","volume":"51","author":"Ridgway","year":"2004","journal-title":"Pediatr Clin North Am"},{"key":"10.1016\/j.jcms.2015.02.005_bib19","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/ng0295-173","article-title":"Identical mutations in the FGFR2 cause both Pfeiffer and Crouzon syndrome phenotypes","volume":"9","author":"Rutland","year":"1995","journal-title":"Nat Genet"},{"key":"10.1016\/j.jcms.2015.02.005_bib20","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1002\/(SICI)1096-8644(199707)103:3<415::AID-AJPA11>3.0.CO;2-3","article-title":"Brief communication: a sample of pediatric skulls available for study","volume":"103","author":"Shapiro","year":"1997","journal-title":"Am J Phys Anthropol"},{"key":"10.1016\/j.jcms.2015.02.005_bib21","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/(SICI)1096-8628(19961202)66:1<81::AID-AJMG19>3.0.CO;2-M","article-title":"FGFR2 mutation in clinically nonclassifiable autosomal dominant craniosynostosis with pronounced phenotypic variation","volume":"66","author":"Steinberger","year":"1996","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.jcms.2015.02.005_bib22","doi-asserted-by":"crossref","DOI":"10.1186\/1750-1172-1-19","article-title":"Pfeiffer syndrome","volume":"1","author":"Vogels","year":"2006","journal-title":"Orphanet J Rare Dis"},{"issue":"2","key":"10.1016\/j.jcms.2015.02.005_bib23","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1597\/1545-1569_1992_029_0118_csmboc_2.3.co_2","article-title":"Craniofacial skeletal measurements based on computed tomography: part II. Normal values and growth trends","volume":"29","author":"Waitzman","year":"1992","journal-title":"Cleft Palate Craniofac J"}],"container-title":["Journal of Cranio-Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S101051821500027X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S101051821500027X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T14:31:24Z","timestamp":1760884284000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S101051821500027X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["S101051821500027X"],"URL":"https:\/\/doi.org\/10.1016\/j.jcms.2015.02.005","relation":{},"ISSN":["1010-5182"],"issn-type":[{"type":"print","value":"1010-5182"}],"subject":[],"published":{"date-parts":[[2015,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Describing Crouzon and Pfeiffer syndrome based on principal component analysis","name":"articletitle","label":"Article Title"},{"value":"Journal of Cranio-Maxillofacial Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcms.2015.02.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}