{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T14:20:37Z","timestamp":1781360437382,"version":"3.54.1"},"reference-count":29,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cranio-Maxillofacial Surgery"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.jcms.2015.05.019","type":"journal-article","created":{"date-parts":[[2015,6,6]],"date-time":"2015-06-06T10:54:18Z","timestamp":1433588058000},"page":"1139-1143","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Value of nonsurgical therapeutic management of stage I bisphosphonate-related osteonecrosis of the jaw"],"prefix":"10.1016","volume":"43","author":[{"given":"Jens Philipp","family":"Bodem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Kargus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Engel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Freudlsperger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcms.2015.05.019_bib1","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.1053\/j.seminoncol.2007.10.002","article-title":"Management of bisphosphonate treatment in clinical practice","volume":"34","author":"Aapro","year":"2007","journal-title":"Semin Oncol"},{"key":"10.1016\/j.jcms.2015.05.019_bib2","doi-asserted-by":"crossref","first-page":"e157","DOI":"10.1016\/j.jcms.2013.07.014","article-title":"Intraoperative efficiency of fluorescence imaging by Visually Enhanced Lesion Scope (VELscope) in patients with bisphosphonate related osteonecrosis of the jaw (BRONJ)","volume":"42","author":"Assaf","year":"2014","journal-title":"J\u00a0Craniomaxillofac Surg"},{"key":"10.1016\/j.jcms.2015.05.019_bib3","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1002\/(SICI)1097-0142(19971015)80:8+<1661::AID-CNCR16>3.0.CO;2-Y","article-title":"Bisphosphonates in multiple myeloma","volume":"80","author":"Berenson","year":"1997","journal-title":"Cancer"},{"key":"10.1016\/j.jcms.2015.05.019_bib4","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.jcms.2015.02.018","article-title":"Incidence of bisphosphonate-related osteonecrosis of the jawin high-risk patients undergoing surgical tooth extraction","volume":"43","author":"Bodem","year":"2015","journal-title":"J Cranio-Maxillo-Facial Surg"},{"key":"10.1016\/j.jcms.2015.05.019_bib5","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.bone.2011.07.020","article-title":"Bone-bound bisphosphonate inhibits growth of adjacent non-bone cells","volume":"49","author":"Cornish","year":"2011","journal-title":"Bone"},{"key":"10.1016\/j.jcms.2015.05.019_bib6","first-page":"462","article-title":"The use of bisphosphonates in the treatment of osteoporosis","volume":"17","author":"Delmas","year":"2005","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.jcms.2015.05.019_bib7","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1056\/NEJM200507073530120","article-title":"Osteonecrosis of the jaw and bisphosphonates","volume":"353","author":"Durie","year":"2005","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jcms.2015.05.019_bib8","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1111\/j.1600-051X.2005.00842.x","article-title":"Osteonecrosis of the jaws in periodontal patients with a history of bisphosphonates treatment","volume":"32","author":"Ficarra","year":"2005","journal-title":"J\u00a0Clin Periodontol"},{"key":"10.1016\/j.jcms.2015.05.019_bib9","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1359\/jbmr.0707onj","article-title":"Bisphosphonate-associated osteonecrosis of the jaw: report of a task force of the American Society for Bone and Mineral Research","volume":"22","author":"Khosla","year":"2007","journal-title":"J\u00a0Bone Miner Res"},{"key":"10.1016\/j.jcms.2015.05.019_bib10","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1002\/(SICI)1097-0142(19971015)80:8+<1668::AID-CNCR17>3.0.CO;2-Y","article-title":"Bisphosphonates and breast carcinoma","volume":"80","author":"Lipton","year":"1997","journal-title":"Cancer"},{"key":"10.1016\/j.jcms.2015.05.019_bib11","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/S0278-2391(03)00720-1","article-title":"Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic","volume":"61","author":"Marx","year":"2003","journal-title":"J\u00a0Oral Maxillofac Surg"},{"key":"10.1016\/j.jcms.2015.05.019_bib12","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1016\/j.joms.2005.07.010","article-title":"Bisphosphonate-induced exposed bone (osteonecrosis\/osteopetrosis) of the jaws: risk factors, recognition, prevention, and treatment","volume":"63","author":"Marx","year":"2005","journal-title":"J\u00a0Oral Maxillofac Surg"},{"key":"10.1016\/j.jcms.2015.05.019_bib13","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0889-8529(02)00079-8","article-title":"Bisphosphonates","volume":"32","author":"McClung","year":"2003","journal-title":"Endocrinol Metab Clin North Am"},{"key":"10.1016\/j.jcms.2015.05.019_bib14","doi-asserted-by":"crossref","first-page":"251","DOI":"10.2165\/00019053-200826030-00007","article-title":"Zoledronic acid: a pharmacoeconomic review of its use in the management of bone metastases","volume":"26","author":"McKeage","year":"2008","journal-title":"Pharmacoeconomics"},{"key":"10.1016\/j.jcms.2015.05.019_bib15","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/nrendo.2010.195","article-title":"Osteonecrosis of the jaw and bisphosphonates in cancer: a narrative review","volume":"7","author":"Migliorati","year":"2011","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.jcms.2015.05.019_bib16","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/S1470-2045(06)70726-4","article-title":"Bisphosphonate-associated osteonecrosis: a long-term complication of bisphosphonate treatment","volume":"7","author":"Migliorati","year":"2006","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.jcms.2015.05.019_bib17","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.tripleo.2007.01.008","article-title":"Biphosphonate-associated osteonecrosis can be controlled by nonsurgical management","volume":"104","author":"Montebugnoli","year":"2007","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.jcms.2015.05.019_bib18","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.tripleo.2011.02.037","article-title":"Osteonecrosis of the jaw in oncology patients treated with bisphosphonates: prospective experience of a dental oncology referral center","volume":"112","author":"Nicolatou-Galitis","year":"2011","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.jcms.2015.05.019_bib19","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.jcms.2014.11.014","article-title":"Treatment perspectives for medication-related osteonecrosis of the jaw (MRONJ)","volume":"43","author":"Ristow","year":"2015","journal-title":"J\u00a0Craniomaxillofac Surg"},{"key":"10.1016\/j.jcms.2015.05.019_bib20","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1002\/(SICI)1097-0142(19971015)80:8+<1652::AID-CNCR15>3.0.CO;2-Z","article-title":"Overview of bisphosphonates","volume":"80","author":"Rogers","year":"1997","journal-title":"Cancer"},{"key":"10.1016\/j.jcms.2015.05.019_bib21","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1747-4477.2009.00213.x","article-title":"American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaw \u2013 2009 update","volume":"35","author":"Ruggiero","year":"2009","journal-title":"Aust Endod J"},{"key":"10.1016\/j.jcms.2015.05.019_bib22","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1016\/j.joms.2014.04.031","article-title":"American Association of Oral and Maxillofacial Surgeons position paper on medication-related osteonecrosis of the jaw\u20132014 update","volume":"72","author":"Ruggiero","year":"2014","journal-title":"J\u00a0Oral Maxillofac Surg"},{"key":"10.1016\/j.jcms.2015.05.019_bib23","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1200\/jop.2006.2.1.7","article-title":"Practical guidelines for the prevention, diagnosis, and treatment of osteonecrosis of the jaw in patients with cancer","volume":"2","author":"Ruggiero","year":"2006","journal-title":"J\u00a0Oncol Pract"},{"key":"10.1016\/j.jcms.2015.05.019_bib24","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.joms.2004.02.004","article-title":"Osteonecrosis of the jaws associated with the use of bisphosphonates: a review of 63 cases","volume":"62","author":"Ruggiero","year":"2004","journal-title":"J\u00a0Oral Maxillofac Surg"},{"key":"10.1016\/j.jcms.2015.05.019_bib25","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1196\/annals.1402.089","article-title":"Bisphosphonates: an update on mechanisms of action and how these relate to clinical efficacy","volume":"1117","author":"Russell","year":"2007","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.jcms.2015.05.019_bib26","doi-asserted-by":"crossref","first-page":"380","DOI":"10.5489\/cuaj.10167","article-title":"Guidelines for the management of castrate-resistant prostate cancer","volume":"4","author":"Saad","year":"2010","journal-title":"Can Urol Assoc J"},{"key":"10.1016\/j.jcms.2015.05.019_bib27","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1053\/j.seminoncol.2007.10.006","article-title":"Clinical benefits and considerations of bisphosphonate treatment in metastatic bone disease","volume":"34","author":"Saad","year":"2007","journal-title":"Semin Oncol"},{"key":"10.1016\/j.jcms.2015.05.019_bib28","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1093\/annonc\/mdg401","article-title":"The antineoplastic role of bisphosphonates: from basic research to clinical evidence","volume":"14","author":"Santini","year":"2003","journal-title":"Ann Oncol"},{"key":"10.1016\/j.jcms.2015.05.019_bib29","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1093\/annonc\/mdn630","article-title":"Initial experience with conservative treatment in cancer patients with osteonecrosis of the jaw (ONJ) and predictors of outcome","volume":"20","author":"Van den Wyngaert","year":"2009","journal-title":"Ann Oncol"}],"container-title":["Journal of Cranio-Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1010518215001626?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1010518215001626?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T14:33:57Z","timestamp":1760884437000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1010518215001626"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":29,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["S1010518215001626"],"URL":"https:\/\/doi.org\/10.1016\/j.jcms.2015.05.019","relation":{},"ISSN":["1010-5182"],"issn-type":[{"value":"1010-5182","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Value of nonsurgical therapeutic management of stage I bisphosphonate-related osteonecrosis of the jaw","name":"articletitle","label":"Article Title"},{"value":"Journal of Cranio-Maxillofacial Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcms.2015.05.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}