{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:11:53Z","timestamp":1762866713327,"version":"build-2065373602"},"reference-count":29,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cranio-Maxillofacial Surgery"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.jcms.2015.08.032","type":"journal-article","created":{"date-parts":[[2015,9,11]],"date-time":"2015-09-11T15:38:41Z","timestamp":1441985921000},"page":"2000-2003","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effectiveness of intravenous haemocoagulase on haemorrhage control in bi-maxillary orthognathic surgery\u2014A prospective, randomised, controlled, double-blind study"],"prefix":"10.1016","volume":"43","author":[{"given":"Vikram","family":"Shetty","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ganapathy","family":"Sriram S.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"9\u201310","key":"10.1016\/j.jcms.2015.08.032_bib1","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S0300-9084(00)01178-0","article-title":"Snake venom proteins acting on hemostasis","volume":"82","author":"Braud","year":"2000","journal-title":"Biochimie"},{"issue":"5","key":"10.1016\/j.jcms.2015.08.032_bib2","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.ijom.2013.10.020","article-title":"Orthognathic surgery with or without induced hypotension","volume":"43","author":"Carlos","year":"2014","journal-title":"Int J Oral Maxillofac Surg"},{"issue":"1","key":"10.1016\/j.jcms.2015.08.032_bib3","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.joms.2008.08.015","article-title":"The effect of tranexamic acid on blood loss during orthognathic surgery: a randomized controlled trial","volume":"67","author":"Choi","year":"2009","journal-title":"J\u00a0Oral Maxillofac Surg"},{"issue":"7","key":"10.1016\/j.jcms.2015.08.032_bib4","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.jcms.2014.03.003","article-title":"Effectiveness of tranexamic acid on intraoperative blood loss in isolated Le Fort I osteotomies\u2014a prospective, triple blinded randomized clinical trial","volume":"42","author":"Christabel","year":"2014","journal-title":"J\u00a0Craniomaxillofac Surg"},{"issue":"3","key":"10.1016\/j.jcms.2015.08.032_bib5","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.bjoms.2003.11.001","article-title":"Blood transfusion requirements in bimaxillary osteotomies","volume":"42","author":"Dhariwal","year":"2004","journal-title":"Br J Oral Maxillofac Surg"},{"issue":"6","key":"10.1016\/j.jcms.2015.08.032_bib6","first-page":"737","article-title":"Effects of batroxobin on perioperative blood loss and coagulation in patients with low molecular weight heparin when undergoing the total hip replacement","volume":"35","author":"Ding","year":"2014","journal-title":"Zhonghua Liu Xing Bing Xue Za Zhi"},{"issue":"3","key":"10.1016\/j.jcms.2015.08.032_bib7","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s10006-013-0415-4","article-title":"Intraoperative blood loss and blood transfusion requirements in patients undergoing orthognathic surgery","volume":"18","author":"Faverani","year":"2014","journal-title":"Oral Maxillofac Surg"},{"issue":"4","key":"10.1016\/j.jcms.2015.08.032_bib8","first-page":"314","article-title":"Blood transfusions in bimaxillary orthognathic surgery: are they necessary?","volume":"17","author":"Gong","year":"2002","journal-title":"Int J Adult Orthodon Orthognath Surg"},{"issue":"5","key":"10.1016\/j.jcms.2015.08.032_bib9","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1097\/00000637-199611000-00010","article-title":"The role of DDAVP (desmopressin) in orthognathic surgery","volume":"37","author":"Guyuron","year":"1996","journal-title":"Ann Plast Surg"},{"issue":"4","key":"10.1016\/j.jcms.2015.08.032_bib10","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s00402-015-2183-0","article-title":"The beneficial effect of Batroxobin on blood loss reduction in spinal fusion surgery: a prospective, randomized, double-blind, placebo-controlled study","volume":"135","author":"Hu","year":"2015","journal-title":"Arch Orthop Trauma Surg"},{"issue":"7","key":"10.1016\/j.jcms.2015.08.032_bib11","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1007\/s12098-010-0326-4","article-title":"Role of hemocoagulase in pulmonary hemorrhage in preterm infants: a systematic review","volume":"78","author":"Lodha","year":"2011","journal-title":"Indian J Pediatr"},{"issue":"12","key":"10.1016\/j.jcms.2015.08.032_bib12","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1016\/S0041-0101(98)00126-3","article-title":"Snake venoms and the hemostatic system","volume":"36","author":"Markland","year":"1998","journal-title":"Toxicon"},{"issue":"8","key":"10.1016\/j.jcms.2015.08.032_bib13","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/0278-2391(95)90273-2","article-title":"Average blood loss and the risk of requiring perioperative blood transfusion in 506 orthognathic surgical procedures","volume":"53","author":"Moenning","year":"1995","journal-title":"J\u00a0Oral Maxillofac Surg"},{"issue":"3","key":"10.1016\/j.jcms.2015.08.032_bib14","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.joms.2010.07.019","article-title":"Blood loss in orthognathic surgery: a systematic review","volume":"69","author":"Pi\u00f1eiro-Aguilar","year":"2011","journal-title":"J\u00a0Oral Maxillofac Surg"},{"issue":"11","key":"10.1016\/j.jcms.2015.08.032_bib15","doi-asserted-by":"crossref","first-page":"e456","DOI":"10.1016\/j.joms.2011.02.085","article-title":"Factors that determine intraoperative blood loss in bimaxillary osteotomies and the need for preoperative blood preparation","volume":"69","author":"Rummasak","year":"2011","journal-title":"J\u00a0Oral Maxillofac Surg"},{"issue":"1","key":"10.1016\/j.jcms.2015.08.032_bib16","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0278-2391(96)90295-5","article-title":"Blood loss and transfusion requirements in orthognatic surgery","volume":"54","author":"Samman","year":"1996","journal-title":"J\u00a0Oral Maxillofac Surg"},{"issue":"6","key":"10.1016\/j.jcms.2015.08.032_bib17","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.ijom.2012.01.008","article-title":"Evaluation of the efficacy of tranexamic acid on blood loss in orthognathic surgery. A prospective, randomized clinical study","volume":"41","author":"Sankar","year":"2012","journal-title":"Int J Oral Maxillofac Surg"},{"issue":"2","key":"10.1016\/j.jcms.2015.08.032_bib18","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1159\/000085826","article-title":"New treatment of neonatal pulmonary hemorrhage with hemocoagulase in addition to mechanical ventilation","volume":"88","author":"Shi","year":"2005","journal-title":"Biol Neonate"},{"issue":"3","key":"10.1016\/j.jcms.2015.08.032_bib19","first-page":"199","article-title":"Effect of hemocoagulase for\u00a0prevention of pulmonary hemorrhage in critical newborns on mechanical ventilation: a randomized controlled trial","volume":"45","author":"Shi","year":"2008","journal-title":"Indian Pediatr"},{"issue":"5","key":"10.1016\/j.jcms.2015.08.032_bib20","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1054\/bjom.2001.0664","article-title":"Aprotinin reduces blood loss and the need for transfusion in orthognathic surgery","volume":"39","author":"Stewart","year":"2001","journal-title":"Br J Oral Maxillofac Surg"},{"issue":"4","key":"10.1016\/j.jcms.2015.08.032_bib21","first-page":"402","article-title":"Percutaneous injection of hemostatic agents for active liver hemorrhage","volume":"9","author":"Tang","year":"2010","journal-title":"Hepatobiliary Pancreat Dis Int"},{"issue":"2","key":"10.1016\/j.jcms.2015.08.032_bib22","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1080\/17843286.1977.11717851","article-title":"Double-blind trials with ethamsylate, batroxobin or tranexamic acid on blood loss after adenotonsillectomy","volume":"32","author":"Verstraete","year":"1977","journal-title":"Acta Clin Belg"},{"issue":"1","key":"10.1016\/j.jcms.2015.08.032_bib23","first-page":"50","article-title":"Hypofibrinogenemia caused by long-term administration of hemocoagulase: three cases report and literature review","volume":"35","author":"Wang","year":"2014","journal-title":"Zhonghua Xue Ye Xue Za Zhi"},{"issue":"1","key":"10.1016\/j.jcms.2015.08.032_bib24","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00402-011-1390-6","article-title":"Which is more effective in adolescent idiopathic scoliosis surgery: batroxobin, tranexamic acid or a combination?","volume":"132","author":"Xu","year":"2012","journal-title":"Arch Orthop Trauma Surg"},{"issue":"3","key":"10.1016\/j.jcms.2015.08.032_bib25","first-page":"4727","article-title":"Serious anaphylactic shock induced by hemocoagulase agkistrodon during anesthesia in a 5-year-old child","volume":"8","author":"Xu","year":"2015","journal-title":"Int J Clin Exp Med"},{"issue":"3","key":"10.1016\/j.jcms.2015.08.032_bib26","first-page":"307","article-title":"Intra-operative blood loss and operating time in orthognathic surgery using induced hypotensive general anaesthesia: prospective study","volume":"6","author":"Yu","year":"2000","journal-title":"Hong Kong Med J"},{"issue":"6","key":"10.1016\/j.jcms.2015.08.032_bib27","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.joms.2004.02.001","article-title":"Evaluation of hemorrhage depressors on blood loss during orthognathic surgery: a retrospective study","volume":"62","author":"Zellin","year":"2004","journal-title":"J\u00a0Oral Maxillofac Surg"},{"issue":"4","key":"10.1016\/j.jcms.2015.08.032_bib28","first-page":"353","article-title":"Impact of hemocoagulase on coagulatory function and deep venous thrombosis after abdominal surgery","volume":"15","author":"Zeng","year":"2012","journal-title":"Zhonghua Wei Chang Wai Ke Za Zhi"},{"issue":"2","key":"10.1016\/j.jcms.2015.08.032_bib29","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1097\/MBC.0b013e3283254532","article-title":"Are batroxobin agents effective for perioperative hemorrhage in thoracic surgery? A systematic review of randomized controlled trials","volume":"20","author":"Zeng","year":"2009","journal-title":"Blood Coagul Fibrinolysis"}],"container-title":["Journal of Cranio-Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1010518215003108?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1010518215003108?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T14:31:00Z","timestamp":1760884260000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1010518215003108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":29,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["S1010518215003108"],"URL":"https:\/\/doi.org\/10.1016\/j.jcms.2015.08.032","relation":{},"ISSN":["1010-5182"],"issn-type":[{"type":"print","value":"1010-5182"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effectiveness of intravenous haemocoagulase on haemorrhage control in bi-maxillary orthognathic surgery\u2014A prospective, randomised, controlled, double-blind study","name":"articletitle","label":"Article Title"},{"value":"Journal of Cranio-Maxillofacial Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcms.2015.08.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}