{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T18:39:19Z","timestamp":1783708759007,"version":"3.55.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cranio-Maxillofacial Surgery"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.jcms.2016.08.001","type":"journal-article","created":{"date-parts":[[2016,8,9]],"date-time":"2016-08-09T16:58:31Z","timestamp":1470761911000},"page":"1694-1699","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"title":["Evaluation of surgical outcome and influencing risk factors in patients with medication-related osteonecrosis of the jaws"],"prefix":"10.1016","volume":"44","author":[{"given":"Christoph","family":"Klingelh\u00f6ffer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Zeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Meier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten Eugen","family":"Reichert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Ettl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.jcms.2016.08.001_bib1","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.jcms.2015.05.019","article-title":"Value of nonsurgical therapeutic management of stage I bisphosphonate-related osteonecrosis of the jaw","volume":"43","author":"Bodem","year":"2015","journal-title":"J\u00a0Craniomaxillofac Surg"},{"issue":"5 Suppl","key":"10.1016\/j.jcms.2016.08.001_bib2","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.joms.2009.01.006","article-title":"The role of surgical resection in the management of bisphosphonate-related osteonecrosis of the jaws","volume":"67","author":"Carlson","year":"2009","journal-title":"J\u00a0Oral Maxillofac Surg"},{"issue":"2","key":"10.1016\/j.jcms.2016.08.001_bib3","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s10549-011-1429-y","article-title":"Safety of zoledronic acid and incidence of osteonecrosis of the jaw (ONJ) during adjuvant therapy in a randomised phase III trial (AZURE: BIG 01-04) for women with stage II\/III breast cancer","volume":"127","author":"Coleman","year":"2011","journal-title":"Breast Cancer Res Treat"},{"issue":"5","key":"10.1016\/j.jcms.2016.08.001_bib4","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.bjoms.2011.08.004","article-title":"Treatment of bisphosphonate-related osteonecrosis of the jaws: presentation of a protocol and an observational longitudinal study of an Italian series of cases","volume":"50","author":"Ferlito","year":"2012","journal-title":"Br J Oral Maxillofac Surg"},{"issue":"9768","key":"10.1016\/j.jcms.2016.08.001_bib5","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S0140-6736(10)62344-6","article-title":"Denosumab versus zoledronic acid for treatment of bone metastases in men with castration-resistant prostate cancer: a randomised, double-blind study","volume":"377","author":"Fizazi","year":"2011","journal-title":"Lancet"},{"issue":"11","key":"10.1016\/j.jcms.2016.08.001_bib6","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1016\/j.joms.2012.05.019","article-title":"Resective surgical approach shows a high performance in the management of advanced cases of bisphosphonate-related osteonecrosis of the jaws: a retrospective survey of 347 cases","volume":"70","author":"Graziani","year":"2012","journal-title":"J\u00a0Oral Maxillofac Surg"},{"issue":"11","key":"10.1016\/j.jcms.2016.08.001_bib7","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.14219\/jada.archive.2010.0082","article-title":"The incidence of osteonecrosis of the jaw in patients receiving 5 milligrams of zoledronic acid: data from the health outcomes and reduced incidence with zoledronic acid once yearly clinical trials program","volume":"141","author":"Grbic","year":"2010","journal-title":"J\u00a0Am Dent Assoc"},{"issue":"2","key":"10.1016\/j.jcms.2016.08.001_bib8","doi-asserted-by":"crossref","first-page":"151","DOI":"10.4103\/0975-5950.127643","article-title":"Bisphosphonates related osteonecrosis of the jaw","volume":"4","author":"Gupta","year":"2013","journal-title":"Natl J Maxillofac Surg"},{"issue":"6","key":"10.1016\/j.jcms.2016.08.001_bib9","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1007\/s00428-007-0516-2","article-title":"Actinomycosis of the jaws\u2013histopathological study of 45 patients shows significant involvement in bisphosphonate-associated osteonecrosis and infected osteoradionecrosis","volume":"451","author":"Hansen","year":"2007","journal-title":"Virchows Arch"},{"issue":"3","key":"10.1016\/j.jcms.2016.08.001_bib10","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1600-0714.2006.00391.x","article-title":"Osteonecrosis of the jaws in patients treated with bisphosphonates \u2013 histomorphologic analysis in comparison with infected osteoradionecrosis","volume":"35","author":"Hansen","year":"2006","journal-title":"J\u00a0Oral Pathol Med"},{"issue":"9","key":"10.1016\/j.jcms.2016.08.001_bib11","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1200\/JCO.2010.31.3304","article-title":"Randomized, double-blind study of denosumab versus zoledronic acid in the treatment of bone metastases in patients with advanced cancer (excluding breast and prostate cancer) or multiple myeloma","volume":"29","author":"Henry","year":"2011","journal-title":"J\u00a0Clin Oncol"},{"issue":"4","key":"10.1016\/j.jcms.2016.08.001_bib12","first-page":"151","article-title":"Medication related osteonecrosis of the jaw: 2015 position statement of the Korean society for bone and mineral research and the Korean Association of oral and maxillofacial surgeons","volume":"22","author":"Kim","year":"2015","journal-title":"J\u00a0Bone Metab"},{"issue":"2","key":"10.1016\/j.jcms.2016.08.001_bib13","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.joms.2009.03.050","article-title":"Predicting risk of osteonecrosis of the jaw with oral bisphosphonate exposure I: prevalence of osteonecrosis of the jaw in patients with oral bisphosphonate exposure","volume":"68","author":"Lo","year":"2010","journal-title":"J\u00a0Oral Maxillofac Surg"},{"issue":"9","key":"10.1016\/j.jcms.2016.08.001_bib14","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/S0278-2391(03)00720-1","article-title":"Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic","volume":"61","author":"Marx","year":"2003","journal-title":"J\u00a0Oral Maxillofac Surg"},{"issue":"3","key":"10.1016\/j.jcms.2016.08.001_bib15","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s10549-009-0432-z","article-title":"Osteonecrosis of the jaw and use of bisphosphonates in adjuvant breast cancer treatment: a meta-analysis","volume":"116","author":"Mauri","year":"2009","journal-title":"Breast Cancer Res Treat"},{"issue":"5","key":"10.1016\/j.jcms.2016.08.001_bib16","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.jcms.2008.12.004","article-title":"Bisphosphonate related osteonecrosis of the jaws treated by surgical resection and immediate osseous microvascular reconstruction","volume":"37","author":"Mucke","year":"2009","journal-title":"J\u00a0Craniomaxillofac Surg"},{"issue":"5","key":"10.1016\/j.jcms.2016.08.001_bib17","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1007\/s00432-010-0953-1","article-title":"Outcome of treatment and parameters influencing recurrence in patients with bisphosphonate-related osteonecrosis of the jaws","volume":"137","author":"Mucke","year":"2011","journal-title":"J\u00a0Cancer Res Clin Oncol"},{"issue":"4","key":"10.1016\/j.jcms.2016.08.001_bib18","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.jcms.2011.05.003","article-title":"Bisphosphonate-related osteonecrosis of the jaws \u2013 characteristics, risk factors, clinical features, localization and impact on oncological treatment","volume":"40","author":"Otto","year":"2012","journal-title":"J\u00a0Craniomaxillofac Surg"},{"issue":"3","key":"10.1016\/j.jcms.2016.08.001_bib19","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.joms.2008.09.037","article-title":"Fluorescence-guided bone resection in bisphosphonate-associated osteonecrosis of the jaws","volume":"67","author":"Pautke","year":"2009","journal-title":"J\u00a0Oral Maxillofac Surg"},{"issue":"2","key":"10.1016\/j.jcms.2016.08.001_bib20","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s10147-013-0561-6","article-title":"Risk of osteonecrosis of the jaw in cancer patients receiving denosumab: a meta-analysis of seven randomized controlled trials","volume":"19","author":"Qi","year":"2014","journal-title":"Int J Clin Oncol"},{"issue":"9","key":"10.1016\/j.jcms.2016.08.001_bib21","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1016\/j.jcms.2015.07.035","article-title":"Surgical treatment of bisphosphonate-associated osteonecrosis: prognostic score and long-term results","volume":"43","author":"Reich","year":"2015","journal-title":"J\u00a0Craniomaxillofac Surg"},{"issue":"2","key":"10.1016\/j.jcms.2016.08.001_bib22","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.jcms.2014.11.014","article-title":"Treatment perspectives for medication-related osteonecrosis of the jaw (MRONJ)","volume":"43","author":"Ristow","year":"2015","journal-title":"J\u00a0Craniomaxillofac Surg"},{"issue":"5 Suppl","key":"10.1016\/j.jcms.2016.08.001_bib23","first-page":"2","article-title":"American Association of oral and maxillofacial surgeons position paper on bisphosphonate-related osteonecrosis of the jaws\u20132009 update","volume":"67","author":"Ruggiero","year":"2009","journal-title":"J\u00a0Oral Maxillofac Surg"},{"issue":"10","key":"10.1016\/j.jcms.2016.08.001_bib24","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1016\/j.joms.2014.04.031","article-title":"American Association of oral and maxillofacial surgeons position paper on medication-related osteonecrosis of the jaw\u20132014 update","volume":"72","author":"Ruggiero","year":"2014","journal-title":"J\u00a0Oral Maxillofac Surg"},{"issue":"5","key":"10.1016\/j.jcms.2016.08.001_bib25","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.joms.2004.02.004","article-title":"Osteonecrosis of the jaws associated with the use of bisphosphonates: a review of 63 cases","volume":"62","author":"Ruggiero","year":"2004","journal-title":"J\u00a0Oral Maxillofac Surg"},{"issue":"6","key":"10.1016\/j.jcms.2016.08.001_bib26","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/s00198-007-0540-8","article-title":"Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy","volume":"19","author":"Russell","year":"2008","journal-title":"Osteoporos Int"},{"issue":"2","key":"10.1016\/j.jcms.2016.08.001_bib27","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/lary.20076","article-title":"Bisphosphonate-related osteonecrosis of the jaw and its associated risk factors: a Belgian case series","volume":"119","author":"Saussez","year":"2009","journal-title":"Laryngoscope"},{"issue":"12","key":"10.1016\/j.jcms.2016.08.001_bib28","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1097\/JTO.0b013e31826aec2b","article-title":"Overall survival improvement in patients with lung cancer and bone metastases treated with denosumab versus zoledronic acid: subgroup analysis from a randomized phase 3 study","volume":"7","author":"Scagliotti","year":"2012","journal-title":"J\u00a0Thorac Oncol"},{"issue":"5","key":"10.1016\/j.jcms.2016.08.001_bib29","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.joms.2008.12.057","article-title":"Outcome of surgical management of bisphosphonate-related osteonecrosis of the jaws: review of 33 surgical cases","volume":"67","author":"Stanton","year":"2009","journal-title":"J\u00a0Oral Maxillofac Surg"},{"issue":"4","key":"10.1016\/j.jcms.2016.08.001_bib30","first-page":"449","article-title":"Osteotomy and primary wound closure in bisphosphonate-associated osteonecrosis of the jaw: a prospective clinical study with 12 months follow-up","volume":"18","author":"Stockmann","year":"2010","journal-title":"Support Care Cancer"},{"issue":"35","key":"10.1016\/j.jcms.2016.08.001_bib31","doi-asserted-by":"crossref","first-page":"5132","DOI":"10.1200\/JCO.2010.29.7101","article-title":"Denosumab compared with zoledronic acid for the treatment of bone metastases in patients with advanced breast cancer: a randomized, double-blind study","volume":"28","author":"Stopeck","year":"2010","journal-title":"J\u00a0Clin Oncol"},{"issue":"32","key":"10.1016\/j.jcms.2016.08.001_bib32","doi-asserted-by":"crossref","first-page":"5356","DOI":"10.1200\/JCO.2009.21.9584","article-title":"Longitudinal cohort study of risk factors in cancer patients of bisphosphonate-related osteonecrosis of the jaw","volume":"27","author":"Vahtsevanos","year":"2009","journal-title":"J\u00a0Clin Oncol"},{"issue":"2","key":"10.1016\/j.jcms.2016.08.001_bib33","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1093\/annonc\/mdn630","article-title":"Initial experience with conservative treatment in cancer patients with osteonecrosis of the jaw (ONJ) and predictors of outcome","volume":"20","author":"Van den Wyngaert","year":"2009","journal-title":"Ann Oncol"},{"key":"10.1016\/j.jcms.2016.08.001_bib34","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1746-160X-6-11","article-title":"Prevalence of bisphosphonate associated osteonecrosis of the jaws in multiple myeloma patients","volume":"6","author":"Walter","year":"2010","journal-title":"Head Face Med"},{"issue":"5","key":"10.1016\/j.jcms.2016.08.001_bib35","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.eururo.2008.06.070","article-title":"Prevalence and risk factors of bisphosphonate-associated osteonecrosis of the jaw in prostate cancer patients with advanced disease treated with zoledronate","volume":"54","author":"Walter","year":"2008","journal-title":"Eur Urol"}],"container-title":["Journal of Cranio-Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1010518216301639?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1010518216301639?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T14:35:15Z","timestamp":1760884515000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1010518216301639"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":35,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["S1010518216301639"],"URL":"https:\/\/doi.org\/10.1016\/j.jcms.2016.08.001","relation":{},"ISSN":["1010-5182"],"issn-type":[{"value":"1010-5182","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of surgical outcome and influencing risk factors in patients with medication-related osteonecrosis of the jaws","name":"articletitle","label":"Article Title"},{"value":"Journal of Cranio-Maxillofacial Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcms.2016.08.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}