{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T23:54:09Z","timestamp":1768434849221,"version":"3.49.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cranio-Maxillofacial Surgery"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1016\/j.jcms.2017.02.002","type":"journal-article","created":{"date-parts":[[2017,2,17]],"date-time":"2017-02-17T16:47:45Z","timestamp":1487350065000},"page":"781-787","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Aged rats under zoledronic acid therapy and oral surgery"],"prefix":"10.1016","volume":"45","author":[{"given":"Mariza Akemi","family":"Matsumoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa Mara","family":"de Abreu Furquim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ala\u00edde","family":"Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel Ferreira","family":"Santiago-J\u00fanior","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patr\u00edcia Pinto","family":"Saraiva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila Lopes","family":"Cardoso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo Salles","family":"Munerato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcms.2017.02.002_bib1","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/S0020-7519(03)00176-0","article-title":"The age-related resistance of rats to Plasmodium berghei infection is associated with differential cellular and humoral immune responses","volume":"33","author":"Adam","year":"2003","journal-title":"Int J Parasitol"},{"key":"10.1016\/j.jcms.2017.02.002_bib2","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s00198-007-0533-7","article-title":"Bisphosphonates alter trabecular bone collagen cross-linking and isomerization in beagle dog vertebra","volume":"19","author":"Allen","year":"2008","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.jcms.2017.02.002_bib3","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1097\/SCS.0000000000001313","article-title":"The impact of age upon healing: absolute quantification of osteogenic genes in calvarial critical-sized defects","volume":"27","author":"Alleyne","year":"2016","journal-title":"J\u00a0Craniofac Surg"},{"key":"10.1016\/j.jcms.2017.02.002_bib4","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1590\/S0102-67202012000100011","article-title":"Rat's age versus human's age: what is the relationship?","volume":"25","author":"Andreollo","year":"2012","journal-title":"Arq Bras Cir Dig"},{"key":"10.1016\/j.jcms.2017.02.002_bib5","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.jcms.2013.11.005","article-title":"Zoledronic acid-related osteonecrosis of the jaws. Experimental model with dental extractions in rats","volume":"42","author":"Barba-Recreo","year":"2014","journal-title":"J\u00a0Craniomaxillofac Surg"},{"key":"10.1016\/j.jcms.2017.02.002_bib6","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1093\/bmb\/ldw033","article-title":"Novel advances in the treatment of osteoporosis","volume":"119","author":"Chan","year":"2016","journal-title":"Br Med Bull"},{"key":"10.1016\/j.jcms.2017.02.002_bib7","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1590\/S0102-865020160050000003","article-title":"Medication-related osteonecrosis of the jaw. Introduction of a new modified experimental model","volume":"31","author":"Curra","year":"2016","journal-title":"Acta Cir Bras"},{"key":"10.1016\/j.jcms.2017.02.002_bib8","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1002\/jbmr.23","article-title":"Increased prevalence of bisphosphonate-related osteonecrosis of the jaw with vitamin D deficiency in rats","volume":"25","author":"Hokugo","year":"2010","journal-title":"J\u00a0Bone Miner Res"},{"issue":"6","key":"10.1016\/j.jcms.2017.02.002_bib9","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1097\/ID.0000000000000459","article-title":"Effect of UV photofunctionalization on osseointegration in aged rats","volume":"25","author":"Ishijima","year":"2016","journal-title":"Implant Dent."},{"key":"10.1016\/j.jcms.2017.02.002_bib10","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.bone.2009.12.016","article-title":"Osteocalcin immunolabeling during the alveolar healing process in ovariectomized rats treated with estrogen or raloxifene","volume":"46","author":"Luvizuto","year":"2010","journal-title":"Bone"},{"key":"10.1016\/j.jcms.2017.02.002_bib11","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.tem.2010.01.010","article-title":"What old means to bone","volume":"21","author":"Manolagas","year":"2010","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.jcms.2017.02.002_bib12","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1002\/jbmr.2190","article-title":"Bone cell senescence: mechanisms and perspectives","volume":"29","author":"Marie","year":"2014","journal-title":"J\u00a0Bone Miner Res"},{"key":"10.1016\/j.jcms.2017.02.002_bib13","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/S0278-2391(03)00720-1","article-title":"Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic","volume":"61","author":"Marx","year":"2003","journal-title":"J\u00a0Oral Maxillofac Surg"},{"key":"10.1016\/j.jcms.2017.02.002_bib14","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.archoralbio.2014.09.012","article-title":"Zoledronate inhibits receptor activator of nuclear factor kappa-B ligand-induced osteoclast differentiation via suppression of expression of nuclear factor of activated T-cell c1 and carbonic anhydrase 2","volume":"60","author":"Nakagawa","year":"2015","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.jcms.2017.02.002_bib15","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1007\/s00784-011-0614-z","article-title":"Bisphosphonates modulate the expression of OPG and M-CSF in hMSC-derived osteoblasts","volume":"16","author":"Ohe","year":"2012","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.jcms.2017.02.002_bib16","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1042\/CS20160004","article-title":"Gender, aging and longevity in humans: an update of an intriguing\/neglected scenario paving the way to a gender-specific medicine","volume":"130","author":"Ostan","year":"2016","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.jcms.2017.02.002_bib17","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1046\/j.1365-3083.2003.01262.x","article-title":"Age-related increase in resistance to acute Trypanosoma cruzi infection in rats is associated with an appropriate antibody response","volume":"58","author":"Pascutti","year":"2003","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.jcms.2017.02.002_bib18","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/nyas.13166","article-title":"Osteoporosis treatment: bisphosphonates reign to continue for a few more years, at least?","volume":"1376","author":"Pazianas","year":"2016","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.jcms.2017.02.002_bib19","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.otorri.2014.06.003","article-title":"Epidemiology, pharmacology and clinical characterization of bisphosphonate-related osteonecrosis of the jaw. A retrospective study of 70 cases","volume":"66","author":"Pelaz","year":"2015","journal-title":"Acta Otorrinolaringol Esp"},{"key":"10.1016\/j.jcms.2017.02.002_bib20","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.nut.2005.04.002","article-title":"Comparing rat's to human's age: how old is my rat in people years?","volume":"21","author":"Quinn","year":"2005","journal-title":"Nutrition"},{"key":"10.1016\/j.jcms.2017.02.002_bib21","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.bone.2010.11.008","article-title":"Biochemical and molecular mechanisms of action of bisphosphonates","volume":"49","author":"Rogers","year":"2011","journal-title":"Bone"},{"key":"10.1016\/j.jcms.2017.02.002_bib22","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1747-4477.2009.00213.x","article-title":"Task force on bisphosphonate-related osteonecrosis of the jaws, American Association of Oral and Maxillofacial Surgeons. American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaw \u2013 2009 update","volume":"35","author":"Ruggiero","year":"2009","journal-title":"Aust Endod J"},{"key":"10.1016\/j.jcms.2017.02.002_bib23","first-page":"624","article-title":"The laboratory rat: relating its age with humans","volume":"4","author":"Sengupta","year":"2013","journal-title":"Int J Prev Med"},{"key":"10.1016\/j.jcms.2017.02.002_bib24","doi-asserted-by":"crossref","first-page":"111","DOI":"10.7257\/1053-816X.2016.36.3.111","article-title":"Osteonecrosis of the jaw in patients receiving bone-targeted therapies: an overview-Part I","volume":"36","author":"Turner","year":"2016","journal-title":"Urol Nurs"}],"container-title":["Journal of Cranio-Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1010518217300549?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1010518217300549?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T14:36:16Z","timestamp":1760884576000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1010518217300549"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["S1010518217300549"],"URL":"https:\/\/doi.org\/10.1016\/j.jcms.2017.02.002","relation":{},"ISSN":["1010-5182"],"issn-type":[{"value":"1010-5182","type":"print"}],"subject":[],"published":{"date-parts":[[2017,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aged rats under zoledronic acid therapy and oral surgery","name":"articletitle","label":"Article Title"},{"value":"Journal of Cranio-Maxillofacial Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcms.2017.02.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}