{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T23:06:52Z","timestamp":1769555212717,"version":"3.49.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cranio-Maxillofacial Surgery"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.jcms.2017.05.033","type":"journal-article","created":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T09:30:17Z","timestamp":1498210217000},"page":"1948-1954","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Oral vitamin B1-substitution does not decrease genetically determined cleft rate in mice (A\/WySn)"],"prefix":"10.1016","volume":"45","author":[{"given":"Konstanze","family":"Scheller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Kalmring","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Scheller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Schubert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Bialek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcms.2017.05.033_bib1","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1597\/1545-1569_2001_038_0393_iiptpc_2.0.co_2","article-title":"Is it possible to prevent cleft palate by prenatal administration of folic acid? An experimental study","volume":"38","author":"Bienengr\u00e4ber","year":"2001","journal-title":"Cleft Palate Craniofac J"},{"key":"10.1016\/j.jcms.2017.05.033_bib2","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1097\/00001648-200207000-00019","article-title":"Maternal fever, multivitamin use, and selected birth defects: evidence of interaction?","volume":"13","author":"Botto","year":"2002","journal-title":"Epidemiology"},{"key":"10.1016\/j.jcms.2017.05.033_bib3","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1002\/bdra.20563","article-title":"Periconceptional folic acid and multivitamin supplementation for the prevention of neural tube defects and other congenital abnormalities","volume":"85","author":"Czeizel","year":"2009","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"10.1016\/j.jcms.2017.05.033_bib4","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1136\/bmj.306.6893.1645","article-title":"Prevention of congenital abnormalities by periconceptional multivitamin supplementation","volume":"306","author":"Czeizel","year":"1993","journal-title":"BMJ"},{"key":"10.1016\/j.jcms.2017.05.033_bib5","article-title":"Effects and safety of periconceptional oral folate supplementation for preventing birth defects","volume":"14","author":"De-Regil","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jcms.2017.05.033_bib6","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/nrg2933","article-title":"Cleft lip and palate: understanding genetic and environmental influences","volume":"12","author":"Dixon","year":"2011","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.jcms.2017.05.033_bib7","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1097\/00006534-200108000-00019","article-title":"An in\u00a0vitro mouse model of cleft palate: defining a critical intershelf distance necessary for palatal clefting","volume":"108","author":"Erfani","year":"2001","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.jcms.2017.05.033_bib8","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1017\/S0007114515003013","article-title":"Folic acid supplements and risk for oral clefts in the newborn: a population-based study","volume":"14","author":"Gildestad","year":"2015","journal-title":"Br J Nut"},{"key":"10.1016\/j.jcms.2017.05.033_bib9","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/1096-9926(200102)63:2<79::AID-TERA1013>3.0.CO;2-3","article-title":"Maternal multivitamin use and orofacial clefts in offspring","volume":"63","author":"Itikala","year":"2001","journal-title":"Teratology"},{"key":"10.1016\/j.jcms.2017.05.033_bib49","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1093\/ije\/dyn098","article-title":"Folate intake, markers of folate status and oral clefts: is the evidence converging?","volume":"37","author":"Johnson","year":"2008","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.jcms.2017.05.033_bib11","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1007\/s003350010284","article-title":"Unravelling the complex genetics of cleft lip in the mouse model","volume":"12","author":"Juriloff","year":"2001","journal-title":"Mamm Genome"},{"key":"10.1016\/j.jcms.2017.05.033_bib13","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/bdra.20430","article-title":"Mouse genetic models of cleft lip with or without cleft palate","volume":"82","author":"Juriloff","year":"2008","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"10.1016\/j.jcms.2017.05.033_bib15","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.placenta.2016.08.080","article-title":"Alcohol exposure impairs trophoblast survival and alters subtype-specific gene expression in\u00a0vitro","volume":"46","author":"Kalisch-Smith","year":"2016","journal-title":"Placenta"},{"key":"10.1016\/j.jcms.2017.05.033_bib17","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s00394-004-0433-y","article-title":"Maternal dietary B vitamin intake, other than folate, and the association with orofacial cleft in the offspring","volume":"43","author":"Krapels","year":"2004","journal-title":"Eur J Nutr"},{"key":"10.1016\/j.jcms.2017.05.033_bib20","series-title":"Labor und Diagnose: Indikation und Bewertung von Laborbefunden f\u00fcr die medizinische Diagnostik","first-page":"1359","article-title":"Immunoreactive score","author":"Lothar","year":"2005"},{"key":"10.1016\/j.jcms.2017.05.033_bib22","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0940-9602(03)80109-7","article-title":"Sex-related differences in procarbazine-induced cleft palate and microgenia and the anti-teratogenic effect of prenatal folic acid supplementation in rats","volume":"185","author":"Malek","year":"2003","journal-title":"Ann Anat"},{"key":"10.1016\/j.jcms.2017.05.033_bib50","doi-asserted-by":"crossref","first-page":"3378","DOI":"10.1128\/JVI.80.7.3378-3385.2006","article-title":"A putative thiamine transport protein is a receptor for feline leukemia virus subgroup A","volume":"80","author":"Mendoza","year":"2006","journal-title":"J Virol"},{"key":"10.1016\/j.jcms.2017.05.033_bib23","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/S0140-6736(09)60695-4","article-title":"Cleft lip and palate","volume":"374","author":"Mossey","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.jcms.2017.05.033_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000337464","article-title":"Epidemiology of oral clefts 2012: an international perspective","volume":"16","author":"Mossey","year":"2012","journal-title":"Front Oral Biol"},{"key":"10.1016\/j.jcms.2017.05.033_bib25","doi-asserted-by":"crossref","first-page":"2512","DOI":"10.1097\/00006534-199812000-00050","article-title":"Direct effect of vitamins at the time of palatal fusion","volume":"102","author":"Natsume","year":"1998","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.jcms.2017.05.033_bib27","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1002\/(SICI)1096-9926(199912)60:6<344::AID-TERA6>3.0.CO;2-M","article-title":"Folinic acid reduces cleft lip [CL(P)] in A\/WySn mice","volume":"60","author":"Paros","year":"1999","journal-title":"Teratology"},{"key":"10.1016\/j.jcms.2017.05.033_bib28","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1080\/14786440009463897","article-title":"On the criterion that a given system of deviations from the probable in the case of a correlated system of variables is such that it can be reasonably supposed to have arisen from random sampling","volume":"50","author":"Pearson","year":"1900","journal-title":"Phil Mag Ser"},{"key":"10.1016\/j.jcms.2017.05.033_bib29","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0925-4439(01)00073-4","article-title":"SLC19A3 encodes a second thiamine transporter THTR2","volume":"1537","author":"Rajgopal","year":"2001","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jcms.2017.05.033_bib30","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jcms.2015.10.025","article-title":"Sex distribution is a factor in teratogenically induced clefts and in the anti-teratogenic effect of thiamine in mice, but not in genetically determined cleft appearance","volume":"44","author":"Scheller","year":"2016","journal-title":"J\u00a0Craniomaxillofac Surg"},{"key":"10.1016\/j.jcms.2017.05.033_bib31","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.joms.2012.04.002","article-title":"Vitamin B-complex application promotes secondary palate development in a palate organ model of the A\/WySnJ mouse","volume":"71","author":"Scheller","year":"2013","journal-title":"J\u00a0Oral Maxillofac Surg"},{"key":"10.1016\/j.jcms.2017.05.033_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.joms.2013.02.020","article-title":"Lower concentrations of B-vitamin subgroups in the serum and amniotic fluid correlate to CL\/P-appearance in the offspring of A\/WySn-mice","volume":"71","author":"Scheller","year":"2013","journal-title":"J\u00a0Oral Maxillofac Surg"},{"key":"10.1016\/j.jcms.2017.05.033_bib33","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.ijom.2011.02.020","article-title":"In\u00a0vitro investigation of the secondary palate development in two strains of mice","volume":"40","author":"Scheller","year":"2011","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.jcms.2017.05.033_bib34","first-page":"206","article-title":"A\u00a0modified mating regimen for the laboratory mouse","volume":"27","author":"Schmidt","year":"1980","journal-title":"Z\u00a0Versuchstierkd"},{"key":"10.1016\/j.jcms.2017.05.033_bib36","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S1010-5182(05)80053-8","article-title":"New findings explaining the mode of action in prevention of facial clefting and first clinical experience","volume":"18","author":"Schubert","year":"1990","journal-title":"J\u00a0Craniomaxillofac Surg"},{"key":"10.1016\/j.jcms.2017.05.033_bib37","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1054\/ijom.2001.0212","article-title":"B\u00a0group vitamins and cleft lip and cleft palate","volume":"31","author":"Schubert","year":"2002","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.jcms.2017.05.033_bib38","first-page":"83","article-title":"Prevention of experimentally induced cleft palate in mice","volume":"19","author":"Schubert","year":"1982","journal-title":"Cleft Palate J"},{"key":"10.1016\/j.jcms.2017.05.033_bib39","first-page":"945","article-title":"Standardized nomenclature for inbred strains of mice: eighth listing","volume":"45","author":"Staats","year":"1985","journal-title":"Cancer Res"},{"key":"10.1016\/j.jcms.2017.05.033_bib40","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.jcms.2003.09.003","article-title":"The time of palatal fusion in mice: a factor of strain susceptibility to teratogens","volume":"32","author":"Syska","year":"2004","journal-title":"J\u00a0Craniomaxillofac Surg"},{"key":"10.1016\/j.jcms.2017.05.033_bib41","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1002\/(SICI)1096-8628(19980113)75:2<126::AID-AJMG2>3.0.CO;2-R","article-title":"Classification and birth prevalence of orofacial clefts","volume":"75","author":"Tolarov\u00e1","year":"1998","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.jcms.2017.05.033_bib42","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/tera.1420510205","article-title":"Reduced recurrence of orofacial clefts after periconceptional supplementation with high-dose folic acid and multivitamins","volume":"51","author":"Tolarov\u00e1","year":"1995","journal-title":"Teratology"},{"key":"10.1016\/j.jcms.2017.05.033_bib43","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.ypmed.2004.02.036","article-title":"Periconceptional folate intake by supplement and food reduces the risk of nonsyndromic cleft lip with or without cleft palate","volume":"39","author":"van Rooij","year":"2004","journal-title":"Prev Med"},{"key":"10.1016\/j.jcms.2017.05.033_bib47","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1136\/bmj.39079.618287.0B","article-title":"Folic acid supplements and risk of facial clefts: national population based case\u2013control study","volume":"334","author":"Wilcox","year":"2007","journal-title":"Br Med J"},{"key":"10.1016\/j.jcms.2017.05.033_bib48","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1002\/bdra.23514","article-title":"Folic acid fortification and prevalences of neural tube defects, orofacial clefts, and gastroschisis in California, 1989 to 2010","volume":"106","author":"Yang","year":"2016","journal-title":"Birth Defects Res A Clin Mol Teratol"}],"container-title":["Journal of Cranio-Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1010518217301993?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1010518217301993?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T14:36:56Z","timestamp":1760884616000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1010518217301993"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":38,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["S1010518217301993"],"URL":"https:\/\/doi.org\/10.1016\/j.jcms.2017.05.033","relation":{},"ISSN":["1010-5182"],"issn-type":[{"value":"1010-5182","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oral vitamin B1-substitution does not decrease genetically determined cleft rate in mice (A\/WySn)","name":"articletitle","label":"Article Title"},{"value":"Journal of Cranio-Maxillofacial Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcms.2017.05.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}