{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T21:44:42Z","timestamp":1780091082985,"version":"3.54.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81302350"],"award-info":[{"award-number":["81302350"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570957"],"award-info":[{"award-number":["81570957"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Beijing Science and Technology Committee","award":["Z161100000516201"],"award-info":[{"award-number":["Z161100000516201"]}]},{"DOI":"10.13039\/501100005090","name":"Beijing Nova Programme","doi-asserted-by":"crossref","award":["Z151100000315045"],"award-info":[{"award-number":["Z151100000315045"]}],"id":[{"id":"10.13039\/501100005090","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Discipline Construction Fund of Beijing Stomatological Hospital","award":["15-09-12"],"award-info":[{"award-number":["15-09-12"]}]},{"name":"Capital medical university","award":["XSKY2017180"],"award-info":[{"award-number":["XSKY2017180"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cranio-Maxillofacial Surgery"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.jcms.2017.06.013","type":"journal-article","created":{"date-parts":[[2017,7,4]],"date-time":"2017-07-04T15:30:58Z","timestamp":1499182258000},"page":"1478-1485","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Clinicopathological features, management and outcome of patients with poorly-differentiated oral and oropharyngeal squamous cell carcinoma"],"prefix":"10.1016","volume":"45","author":[{"given":"Zhien","family":"Feng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao Shi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Zhong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming Hui","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li Zheng","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengxue","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcms.2017.06.013_bib1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1097\/01.pas.0000149687.90710.21","article-title":"Oral squamous cell carcinoma: histologic risk assessment, but not margin status, is strongly predictive of local disease-free and overall survival","volume":"29","author":"Brandwein-Gensler","year":"2005","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.jcms.2017.06.013_bib2","first-page":"401","article-title":"Oral cavity and oropharyngeal squamous cell carcinoma \u2014 an update","volume":"65","author":"Chi","year":"2015","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.jcms.2017.06.013_bib3","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s00428-016-2015-9","article-title":"A\u00a0critical evaluation of lymph node ratio in head and neck cancer","volume":"469","author":"de Ridder","year":"2016","journal-title":"Virchows Arch"},{"key":"10.1016\/j.jcms.2017.06.013_bib4","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1002\/hed.21600","article-title":"Lymph node ratio as an independent prognostic factor in oral squamous cell carcinoma","volume":"33","author":"Ebrahimi","year":"2011","journal-title":"Head Neck"},{"key":"10.1016\/j.jcms.2017.06.013_bib5","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1016\/j.joms.2007.12.025","article-title":"Oral squamous cell carcinoma: a clinicopathologic review of 233 cases in Lagos, Nigeria","volume":"66","author":"Effiom","year":"2008","journal-title":"J\u00a0Oral Maxillofac Surg"},{"key":"10.1016\/j.jcms.2017.06.013_bib6","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1016\/j.ijom.2014.05.018","article-title":"Selective versus comprehensive neck dissection in the treatment of patients with a pathologically node-positive neck with or without microscopic extracapsular spread in oral squamous cell carcinoma","volume":"43","author":"Feng","year":"2014","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.jcms.2017.06.013_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0026399","article-title":"CCND1 as a predictive biomarker of neoadjuvant chemotherapy in patients with locally advanced head and neck squamous cell carcinoma","volume":"6","author":"Feng","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jcms.2017.06.013_bib8","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.oraloncology.2014.08.003","article-title":"Risk factors and treatment of contralateral neck recurrence for unilateral oral squamous cell carcinoma: a retrospective study of 1482 cases","volume":"50","author":"Feng","year":"2014","journal-title":"Oral Oncol"},{"key":"10.1016\/j.jcms.2017.06.013_bib9","doi-asserted-by":"crossref","first-page":"E680","DOI":"10.1002\/hed.24070","article-title":"Neck recurrence of oral squamous cell carcinoma in unusual sites: retrospective study of 1658 cases","volume":"38","author":"Feng","year":"2016","journal-title":"Head Neck"},{"key":"10.1016\/j.jcms.2017.06.013_bib10","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1016\/j.joms.2015.03.027","article-title":"Nodal yield: is it a prognostic factor for head and neck squamous cell carcinoma?","volume":"73","author":"Feng","year":"2015","journal-title":"J\u00a0Oral Maxillofac Surg"},{"key":"10.1016\/j.jcms.2017.06.013_bib11","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.oooo.2015.10.031","article-title":"Risk factors for patients with multiple synchronous primary cancers involving oral and oropharyngeal subsites","volume":"121","author":"Feng","year":"2016","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"10.1016\/j.jcms.2017.06.013_bib12","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.oooo.2016.08.013","article-title":"Second primary cancer after index head and neck squamous cell carcinoma in northern China","volume":"123","author":"Feng","year":"2017","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"10.1016\/j.jcms.2017.06.013_bib13","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.bjoms.2015.09.024","article-title":"Risk factors for relapse of middle-stage squamous cell carcinoma of the submandibular region and floor of mouth: the importance of en bloc resection","volume":"54","author":"Feng","year":"2016","journal-title":"Br J Oral Maxillofac Surg"},{"issue":"7","key":"10.1016\/j.jcms.2017.06.013_bib14","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1097\/PAS.0b013e318253a2d1","article-title":"Validation of methods for oropharyngeal cancer HPV status determination in US cooperative group trials","volume":"36","author":"Jordan","year":"2012","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.jcms.2017.06.013_bib15","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.oraloncology.2011.07.018","article-title":"Outcome analysis of patients with well-differentiated oral cavity squamous cell carcinoma","volume":"47","author":"Kang","year":"2011","journal-title":"Oral Oncol"},{"key":"10.1016\/j.jcms.2017.06.013_bib16","doi-asserted-by":"crossref","first-page":"e223","DOI":"10.1016\/j.ijrobp.2011.03.060","article-title":"The number of pathologically positive lymph nodes and pathological tumor depth predicts prognosis in patients with poorly differentiated squamous cell carcinoma of the oral cavity","volume":"81","author":"Kang","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.jcms.2017.06.013_bib17","doi-asserted-by":"crossref","first-page":"105","DOI":"10.5230\/jgc.2016.16.2.105","article-title":"The influence of metastatic lymph node ratio on the treatment outcomes in the adjuvant chemoradiotherapy in stomach tumors (ARTIST) trial: a phase III trial","volume":"16","author":"Kim","year":"2016","journal-title":"J\u00a0Gastric Cancer"},{"key":"10.1016\/j.jcms.2017.06.013_bib18","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1245\/s10434-007-9761-5","article-title":"Analysis of risk factors of predictive local tumor control in oral cavity cancer","volume":"15","author":"Liao","year":"2008","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.jcms.2017.06.013_bib19","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.oraloncology.2011.10.017","article-title":"Neck dissection field and lymph node density predict prognosis in patients with oral cavity cancer and pathological node metastases treated with adjuvant therapy","volume":"48","author":"Liao","year":"2012","journal-title":"Oral Oncol"},{"key":"10.1016\/j.jcms.2017.06.013_bib20","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1002\/cncr.22959","article-title":"Analysis of risk factors for distant metastases in squamous cell carcinoma of the oral cavity","volume":"110","author":"Liao","year":"2007","journal-title":"Cancer"},{"key":"10.1016\/j.jcms.2017.06.013_bib21","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1016\/j.joms.2014.05.021","article-title":"Prognostic factors of squamous cell carcinoma of the buccal mucosa: a retrospective study of 168 cases in north China","volume":"72","author":"Niu","year":"2014","journal-title":"J\u00a0Oral Maxillofac Surg"},{"key":"10.1016\/j.jcms.2017.06.013_bib22","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1038\/bjc.2013.570","article-title":"International Consortium for Outcome Research (ICOR) in head and neck cancer: lymph node density in oral cavity cancer: results of the International Consortium for Outcome Research","volume":"109","author":"Patel","year":"2013","journal-title":"Br J Cancer"},{"key":"10.1016\/j.jcms.2017.06.013_bib23","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1002\/hed.23662","article-title":"Lymph node ratio influence on risk of head and neck cancer locoregional recurrence after initial surgical resection: implications for adjuvant therapy","volume":"37","author":"Prabhu","year":"2015","journal-title":"Head Neck"},{"key":"10.1016\/j.jcms.2017.06.013_bib24","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1002\/cncr.29242","article-title":"The role of postoperative chemoradiation for oropharynx carcinoma: a critical appraisal of the published literature and National Comprehensive Cancer Network guidelines","volume":"121","author":"Sinha","year":"2015","journal-title":"Cancer"},{"key":"10.1016\/j.jcms.2017.06.013_bib25","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.tranon.2016.10.005","article-title":"Prognostic value of tumor-infiltrating lymphocytes for patients with head and neck squamous cell carcinoma","volume":"10","author":"Xu","year":"2017","journal-title":"Transl Oncol"}],"container-title":["Journal of Cranio-Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1010518217302135?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1010518217302135?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T14:36:54Z","timestamp":1760884614000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1010518217302135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":25,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["S1010518217302135"],"URL":"https:\/\/doi.org\/10.1016\/j.jcms.2017.06.013","relation":{},"ISSN":["1010-5182"],"issn-type":[{"value":"1010-5182","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinicopathological features, management and outcome of patients with poorly-differentiated oral and oropharyngeal squamous cell carcinoma","name":"articletitle","label":"Article Title"},{"value":"Journal of Cranio-Maxillofacial Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcms.2017.06.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}