{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T02:54:56Z","timestamp":1771988096074,"version":"3.50.1"},"reference-count":53,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cranio-Maxillofacial Surgery"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.jcms.2019.11.022","type":"journal-article","created":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T20:12:52Z","timestamp":1574971972000},"page":"49-55","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Facial cutaneous squamous cell carcinoma \u2014 microscopic safety margins and their impact on developing local recurrences"],"prefix":"10.1016","volume":"48","author":[{"given":"D.G.E.","family":"Thiem","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Scharr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.M.","family":"Pabst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Saka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.W.","family":"K\u00e4mmerer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcms.2019.11.022_bib2","volume":"vol. 53","author":"AJCC","year":"2018"},{"key":"10.1016\/j.jcms.2019.11.022_bib3","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1046\/j.1523-1747.2001.01224.x","article-title":"Melanocortin-1 receptor genotype is a risk factor for basal and squamous cell carcinoma","volume":"116","author":"Box","year":"2001","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jcms.2019.11.022_bib4","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S1470-2045(08)70178-5","article-title":"Analysis of risk factors determining prognosis of cutaneous squamous-cell carcinoma: a prospective study","volume":"9","author":"Brantsch","year":"2008","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.jcms.2019.11.022_bib5","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1002\/jso.23155","article-title":"The incidence of metastasis from cutaneous squamous cell carcinoma and the impact of its risk factors","volume":"106","author":"Brougham","year":"2012","journal-title":"J\u00a0Surg Oncol"},{"key":"10.1016\/j.jcms.2019.11.022_bib6","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1001\/jamadermatol.2015.4530","article-title":"Association between beta-genus human papillomavirus and cutaneous squamous cell carcinoma in immunocompetent individuals \u2014 a meta-analysis","volume":"152","author":"Chahoud","year":"2016","journal-title":"JAMA Dermatol"},{"key":"10.1016\/j.jcms.2019.11.022_bib7","first-page":"268","article-title":"Prognostic factors for metastasis in squamous cell carcinoma of the skin","volume":"28","author":"Cherpelis","year":"2002","journal-title":"Dermatol Surg"},{"key":"10.1016\/j.jcms.2019.11.022_bib8","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1038\/jid.2012.403","article-title":"Tumor recurrence 5 years after treatment of cutaneous basal cell carcinoma and squamous cell carcinoma","volume":"133","author":"Chren","year":"2013","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jcms.2019.11.022_bib9","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.12837.1","article-title":"Recent advances in field cancerization and management of multiple cutaneous squamous cell carcinomas","volume":"7","author":"Christensen","year":"2018","journal-title":"F1000Res"},{"key":"10.1016\/j.jcms.2019.11.022_bib1","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.jaad.2012.06.009","volume":"67","author":"Connolly","year":"2012","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.jcms.2019.11.022_bib10","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1111\/bjd.14352","article-title":"Survival with nonmelanoma skin cancer in Germany","volume":"174","author":"Eisemann","year":"2016","journal-title":"Brit J Dermatol"},{"key":"10.1016\/j.jcms.2019.11.022_bib11","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.jaad.2008.09.035","article-title":"Epidermolysis bullosa and the risk of life-threatening cancers: the National EB Registry experience, 1986\u20132006","volume":"60","author":"Fine","year":"2009","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.jcms.2019.11.022_bib12","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1002\/jso.24870","article-title":"Effective excision of cutaneous squamous cell carcinoma of the face using analysis of intra-operative frozen sections from the whole specimen","volume":"117","author":"Hutting","year":"2018","journal-title":"J\u00a0Surg Oncol"},{"key":"10.1016\/j.jcms.2019.11.022_bib13","first-page":"413","article-title":"Cancers\u00a0arising from burn scars: 62 cases","volume":"130","author":"Jellouli-Elloumi","year":"2003","journal-title":"Ann Dermatol Venereol"},{"key":"10.1016\/j.jcms.2019.11.022_bib14","doi-asserted-by":"crossref","DOI":"10.5812\/ijcm.60846","article-title":"A\u00a0review of cutaneous squamous cell carcinoma epidemiology, diagnosis, and management","volume":"11","author":"Kabir","year":"2018","journal-title":"Int J Cancer Manage"},{"key":"10.1016\/j.jcms.2019.11.022_bib15","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1093\/aje\/153.6.559","article-title":"Skin cancer risk in relation to toenail arsenic concentrations in a US population-based case-control study","volume":"153","author":"Karagas","year":"2001","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.jcms.2019.11.022_bib16","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1001\/jamadermatol.2017.1680","article-title":"Clinical and incidental perineural invasion of cutaneous squamous cell carcinoma: a systematic review and pooled analysis of outcomes data","volume":"153","author":"Karia","year":"2017","journal-title":"JAMA Dermatol"},{"key":"10.1016\/j.jcms.2019.11.022_bib17","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1111\/bjd.13508","article-title":"Sentinel lymph node biopsy and risk factors for predicting metastasis in cutaneous squamous cell carcinoma","volume":"172","author":"Krediet","year":"2015","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jcms.2019.11.022_bib18","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1399-0004.1989.tb03365.x","article-title":"Albinism and skin cancer in Southern Africa","volume":"36","author":"Kromberg","year":"1989","journal-title":"Clin Genet"},{"key":"10.1016\/j.jcms.2019.11.022_bib19","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1016\/j.ejca.2010.02.046","article-title":"Cutaneous squamous cell carcinoma (SCC) of the head and neck: risk factors of overall and recurrence-free survival","volume":"46","author":"Kyrgidis","year":"2010","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.jcms.2019.11.022_bib20","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0196-0709(99)90026-1","article-title":"Mandibular invasion in carcinoma of the lower alveolus","volume":"20","author":"Lam","year":"1999","journal-title":"Am J Otolaryngol"},{"key":"10.1016\/j.jcms.2019.11.022_bib21","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0733-8635(18)30120-7","article-title":"Xeroderma pigmentosum","volume":"13","author":"Lambert","year":"1995","journal-title":"Dermatol Clin"},{"key":"10.1016\/j.jcms.2019.11.022_bib22","doi-asserted-by":"crossref","first-page":"f6153","DOI":"10.1136\/bmj.f6153","article-title":"Bath-Hextall F, Perkins W, Stanton W, Leonardi-Bee J: Interventions for non-metastatic squamous cell carcinoma of the skin: systematic review and pooled analysis of observational studies","volume":"347","author":"Lansbury","year":"2013","journal-title":"BMJ"},{"key":"10.1016\/j.jcms.2019.11.022_bib23","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.jaad.2005.02.059","article-title":"Cutaneous squamous cell carcinoma treated with Mohs micrographic surgery in Australia I. Experience over 10 years","volume":"53","author":"Leibovitch","year":"2005","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.jcms.2019.11.022_bib24","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1001\/archdermatol.2012.1374","article-title":"Bath-Hextall F: smoking and the risk of nonmelanoma skin cancer: systematic review and meta-analysis","volume":"148","author":"Leonardi-Bee","year":"2012","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jcms.2019.11.022_bib25","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1001\/jamadermatol.2015.1702","article-title":"Outcomes of patients with multiple cutaneous squamous cell carcinomas: a 10-year single-institution cohort study","volume":"151","author":"Levine","year":"2015","journal-title":"JAMA Dermatol"},{"key":"10.1016\/j.jcms.2019.11.022_bib26","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1001\/archderm.136.8.1007","article-title":"Therapeutic ionizing radiation and the incidence of basal cell carcinoma and squamous cell carcinoma. The New Hampshire Skin Cancer Study Group","volume":"136","author":"Lichter","year":"2000","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jcms.2019.11.022_bib27","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1111\/j.1365-2133.2012.10830.x","article-title":"A\u00a0systematic review of worldwide incidence of nonmelanoma skin cancer","volume":"166","author":"Lomas","year":"2012","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jcms.2019.11.022_bib28","first-page":"4214","article-title":"Skin autografts in epidermodysplasia verruciformis: human papillomavirus-associated cutaneous changes need over 20 years for malignant conversion","volume":"57","author":"Majewski","year":"1997","journal-title":"Cancer Res"},{"key":"10.1016\/j.jcms.2019.11.022_bib29","first-page":"18","article-title":"Defining field cancerization of the skin using noninvasive optical coherence tomography imaging to detect and monitor actinic keratosis in ingenol mebutate 0.015%-treated patients","volume":"9","author":"Markowitz","year":"2016","journal-title":"J\u00a0Clin Aesthet Dermatol"},{"key":"10.1016\/j.jcms.2019.11.022_bib30","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/S0266-4356(03)00119-0","article-title":"Influence of condition of surgical margins on local recurrence and disease-specific survival in oral and oropharyngeal cancer","volume":"41","author":"McMahon","year":"2003","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1016\/j.jcms.2019.11.022_bib31","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1245\/ASO.2006.07.022","article-title":"Invasive squamous cell carcinoma of the skin: defining a high-risk group","volume":"13","author":"Mullen","year":"2006","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.jcms.2019.11.022_bib32","series-title":"National Comprehensive Cancer Network: Head and Neck Cancers (Version 3.2019)","year":"2019"},{"key":"10.1016\/j.jcms.2019.11.022_bib33","series-title":"National Comprehensive Cancer Network: Squamous Cell Skin Cancer (Version 1.2020)","year":"2019"},{"key":"10.1016\/j.jcms.2019.11.022_bib34","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.jaad.2018.03.024","article-title":"Risk of skin cancer in patients with HIV: a Danish nationwide cohort study","volume":"79","author":"Omland","year":"2018","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.jcms.2019.11.022_bib35","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/ajd.12282","article-title":"Incidence and prevalence of non-melanoma skin cancer in Australia: a systematic review","volume":"56","author":"Perera","year":"2015","journal-title":"Australas J Dermatol"},{"key":"10.1016\/j.jcms.2019.11.022_bib36","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jaad.2017.08.059","article-title":"Cutaneous squamous cell carcinoma: incidence, risk factors, diagnosis, and staging","volume":"78","author":"Que","year":"2018","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.jcms.2019.11.022_bib37","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/0190-9622(92)70144-5","article-title":"Prognostic factors for local recurrence, metastasis, and survival rates in squamous cell carcinoma of the skin, ear, and lip. Implications for treatment modality selection","volume":"26","author":"Rowe","year":"1992","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.jcms.2019.11.022_bib38","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.4103\/jpbs.JPBS_109_17","article-title":"Oral field cancerization and its clinical implications in the management in potentially malignant disorders","volume":"9","author":"Sathiasekar","year":"2017","journal-title":"J\u00a0Pharm Bioallied Sci"},{"key":"10.1016\/j.jcms.2019.11.022_bib39","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/bjd.15906","article-title":"Is ultraviolet exposure acquired at work the most important risk factor for cutaneous squamous cell carcinoma? Results of the population-based case-control study FB-181","volume":"178","author":"Schmitt","year":"2018","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jcms.2019.11.022_bib40","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1001\/jamadermatol.2013.2139","article-title":"Factors predictive of recurrence and death from cutaneous squamous cell carcinoma: a 10-year, single-institution cohort study","volume":"149","author":"Schmults","year":"2013","journal-title":"JAMA Dermatol"},{"key":"10.1016\/j.jcms.2019.11.022_bib41","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.jaad.2015.10.022","article-title":"Skin color parameters and Fitzpatrick phototypes in estimating the risk of skin cancer: a case-control study in the Polish population","volume":"74","author":"Sitek","year":"2016","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.jcms.2019.11.022_bib42","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1002\/hed.24580","article-title":"Review of high-risk features of cutaneous squamous cell carcinoma and discrepancies between the American joint committee on cancer and NCCN clinical practice guidelines in oncology","volume":"39","author":"Skulsky","year":"2017","journal-title":"Head Neck"},{"key":"10.1016\/j.jcms.2019.11.022_bib43","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1002\/1097-0142(195309)6:5<963::AID-CNCR2820060515>3.0.CO;2-Q","article-title":"Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric origin","volume":"6","author":"Slaughter","year":"1953","journal-title":"Cancer"},{"key":"10.1016\/j.jcms.2019.11.022_bib44","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1016\/j.ejca.2015.06.110","article-title":"Diagnosis and treatment of invasive squamous cell carcinoma of the skin: European consensus-based interdisciplinary guideline","volume":"51","author":"Stratigos","year":"2015","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.jcms.2019.11.022_bib45","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1111\/bjd.16713","article-title":"Photosensitizing antihypertensive drug use and risk of cutaneous squamous cell carcinoma","volume":"179","author":"Su","year":"2018","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jcms.2019.11.022_bib46","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1001\/jamadermatol.2015.4994","article-title":"Risk factors for cutaneous squamous cell carcinoma recurrence, metastasis, and disease-specific death: a systematic review and meta-analysis","volume":"152","author":"Thompson","year":"2016","journal-title":"JAMA Dermatol"},{"key":"10.1016\/j.jcms.2019.11.022_bib47","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/ajmg.c.30037","article-title":"The genetics of skin cancer","volume":"131C","author":"Tsai","year":"2004","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"10.1016\/j.jcms.2019.11.022_bib48","article-title":"Clinical characteristics of non-melanoma skin cancers recurring within 5 years after Mohs micrographic surgery: single institution retrospective chart review","volume":"5","author":"Vajdi","year":"2017","journal-title":"J\u00a0Clin Investig Dermatol"},{"key":"10.1016\/j.jcms.2019.11.022_bib49","first-page":"249","article-title":"Oral field cancerization: carcinogen-induced independent events or micrometastatic deposits?","volume":"9","author":"van Oijen","year":"2000","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.jcms.2019.11.022_bib50","doi-asserted-by":"crossref","first-page":"e5909","DOI":"10.1136\/bmj.e5909","article-title":"Indoor tanning and non-melanoma skin cancer: systematic review and meta-analysis","volume":"345","author":"Wehner","year":"2012","journal-title":"BMJ"},{"key":"10.1016\/j.jcms.2019.11.022_bib51","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.ejso.2014.07.039","article-title":"Prediction score for lymph node metastasis from cutaneous squamous cell carcinoma of the external ear","volume":"41","author":"Wermker","year":"2015","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.jcms.2019.11.022_bib52","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.jaad.2017.10.007","article-title":"Guidelines of care for the management of cutaneous squamous cell carcinoma","volume":"78","author":"Work","year":"2018","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.jcms.2019.11.022_bib53","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1001\/jamadermatol.2014.762","article-title":"Incidence of nonmelanoma skin cancer in relation to ambient UV radiation in white populations, 1978\u20132012: empirical relationships","volume":"150","author":"Xiang","year":"2014","journal-title":"JAMA Dermatol"}],"container-title":["Journal of Cranio-Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1010518219311254?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1010518219311254?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T14:42:20Z","timestamp":1760884940000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1010518219311254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["S1010518219311254"],"URL":"https:\/\/doi.org\/10.1016\/j.jcms.2019.11.022","relation":{},"ISSN":["1010-5182"],"issn-type":[{"value":"1010-5182","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Facial cutaneous squamous cell carcinoma \u2014 microscopic safety margins and their impact on developing local recurrences","name":"articletitle","label":"Article Title"},{"value":"Journal of Cranio-Maxillofacial Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcms.2019.11.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}