{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T11:39:33Z","timestamp":1784201973406,"version":"3.55.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002714","name":"Albert-Ludwigs-Universit\u00e4t Freiburg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002714","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cranio-Maxillofacial Surgery"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.jcms.2020.02.006","type":"journal-article","created":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T09:31:08Z","timestamp":1582018268000},"page":"444-451","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Tooth extractions in patients under antiresorptive therapy for osteoporosis: Primary closure of the extraction socket with a mucoperiosteal flap versus application of platelet-rich fibrin for the prevention of antiresorptive agent-related osteonecrosis of the jaw"],"prefix":"10.1016","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1551-1797","authenticated-orcid":false,"given":"Philipp","family":"Poxleitner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Steybe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Kroneberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Andreas","family":"Ermer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcl Merve","family":"Yalcin-\u00dclker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Schmelzeisen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pit Jacob","family":"Voss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcms.2020.02.006_bib1","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1007\/s00784-016-2004-z","article-title":"Platelet-rich fibrin may reduce the risk of delayed recovery in tooth-extracted patients undergoing oral bisphosphonate therapy: a trial study","volume":"21","author":"Asaka","year":"2017","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.jcms.2020.02.006_bib2","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/jbmr.1494","article-title":"The effect of 3 versus 6 years of zoledronic acid treatment of osteoporosis: a randomized extension to the HORIZON-Pivotal Fracture Trial (PFT)","volume":"27","author":"Black","year":"2012","journal-title":"J\u00a0Bone Miner Res"},{"key":"10.1016\/j.jcms.2020.02.006_bib3","doi-asserted-by":"crossref","first-page":"e948","DOI":"10.4317\/medoral.17946","article-title":"Bone metabolism and clinical study of 44 patients with bisphosphonate-related osteonecrosis of the jaws","volume":"17","author":"Bocanegra-P\u00e9rez","year":"2012","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"10.1016\/j.jcms.2020.02.006_bib4","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.jcms.2015.02.018","article-title":"Incidence of bisphosphonate-related osteonecrosis of the jaw in high risk patients undergoing surgical tooth extraction","volume":"43","author":"Bodem","year":"2015","journal-title":"J\u00a0Cranio-Maxillofac Surg"},{"key":"10.1016\/j.jcms.2020.02.006_bib5","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/S2213-8587(17)30138-9","article-title":"10 years of denosumab treatment in postmenopausal women with osteoporosis: results from the phase 3 randomised FREEDOM trial and open-label extension","volume":"5","author":"Bone","year":"2017","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10.1016\/j.jcms.2020.02.006_bib6","first-page":"31","article-title":"Surgical protocol in patients at risk for bisphosphonate osteonecrosis of the jaws: clinical use of serum telopetide CTX in preventive monitoring of surgical risk","volume":"3","author":"Carini","year":"2012","journal-title":"Ann Stomatol"},{"key":"10.1016\/j.jcms.2020.02.006_bib7","first-page":"55","article-title":"An opportu-nity for implantology: PRF","author":"Choukroun","year":"2001","journal-title":"Implantodontie"},{"key":"10.1016\/j.jcms.2020.02.006_bib8","doi-asserted-by":"crossref","first-page":"e56","DOI":"10.1016\/j.tripleo.2005.07.011","article-title":"Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part IV: clinical effects on tissue healing","volume":"101","author":"Choukroun","year":"2006","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endodontology"},{"key":"10.1016\/j.jcms.2020.02.006_bib9","first-page":"646","article-title":"Diagnosis, prophylaxis, and treatment of osteoporosis","author":"Consensus Development Conference","year":"1993","journal-title":"Am J Med"},{"key":"10.1016\/j.jcms.2020.02.006_bib10","first-page":"33","article-title":"Bisphosphonate-related osteonecrosis of the jaws: a potential alternative to drug holidays","volume":"61","author":"Damm","year":"2013","journal-title":"Gen Dent"},{"key":"10.1016\/j.jcms.2020.02.006_bib11","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s10006-019-00769-y","article-title":"Usefulness of platelet-rich fibrin as a hemostatic agent after dental extractions in patients receiving anticoagulant therapy with factor Xa inhibitors: a case series","volume":"23","author":"de Almeida Barros Mour\u00e3o","year":"2019","journal-title":"Oral Maxillofac Surg"},{"key":"10.1016\/j.jcms.2020.02.006_bib12","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ejca.2014.10.015","article-title":"Autologous platelet concentrates for bisphosphonate-related osteonecrosis of the jaw treatment and prevention. A systematic review of the literature","volume":"51","author":"Del Fabbro","year":"2015","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.jcms.2020.02.006_bib13","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/01.sla.0000133083.54934.ae","article-title":"Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey","volume":"240","author":"Dindo","year":"2004","journal-title":"Ann Surg"},{"key":"10.1016\/j.jcms.2020.02.006_bib14","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1016\/j.tripleo.2005.07.009","article-title":"Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part II: platelet-related biologic features","volume":"101","author":"Dohan","year":"2006","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endodontol"},{"key":"10.1016\/j.jcms.2020.02.006_bib15","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1080\/08977190802636713","article-title":"Slow release of growth factors and thrombospondin-1 in Choukroun's platelet-rich fibrin (PRF): a gold standard to achieve for all surgical platelet concentrates technologies","volume":"27","author":"Ehrenfest","year":"2009","journal-title":"Growth Factors"},{"key":"10.1016\/j.jcms.2020.02.006_bib16","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.ygyno.2008.11.029","article-title":"Bisphosphonate-induced osteonecrosis of the jaw (ONJ): incidence and risk factors in patients with breast cancer and gynecological malignancies","volume":"112","author":"Fehm","year":"2009","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.jcms.2020.02.006_bib17","first-page":"593","article-title":"Dental extractions in patient treated with intravenous bisphosphonates and risk of osteonecrosis of jaws: presentation of a preventive protocol and case series","volume":"59","author":"Ferlito","year":"2010","journal-title":"Minerva Stomatol"},{"key":"10.1016\/j.jcms.2020.02.006_bib18","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.joms.2010.10.055","article-title":"Preventive protocol for tooth extractions in patients treated with zoledronate: a case series","volume":"69","author":"Ferlito","year":"2011","journal-title":"J\u00a0Oral Maxillofac Surg"},{"key":"10.1016\/j.jcms.2020.02.006_bib19","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.ijom.2015.01.026","article-title":"Treatment strategies and outcomes of bisphosphonate-related osteonecrosis of the jaw (BRONJ) with characterization of patients: a systematic review","volume":"44","author":"Fliefel","year":"2015","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.jcms.2020.02.006_bib20","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1007\/s00198-017-4063-7","article-title":"A\u00a0multicenter retrospective study of the risk factors associated with medication-related osteonecrosis of the jaw after tooth extraction in patients receiving oral bisphosphonate therapy: can primary wound closure and a drug holiday really prevent MRONJ?","volume":"28","author":"Hasegawa","year":"2017","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.jcms.2020.02.006_bib21","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.tripleo.2009.06.044","article-title":"A\u00a0comparative study of platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) on the effect of proliferation and differentiation of rat osteoblasts in\u00a0vitro","volume":"108","author":"He","year":"2009","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endodontol"},{"key":"10.1016\/j.jcms.2020.02.006_bib22","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.14219\/jada.archive.2011.0108","article-title":"Managing the care of patients receiving antiresorptive therapy for prevention and treatment of osteoporosis: executive summary of recommendations from the American Dental Association Council on Scientific Affairs","volume":"142","author":"Hellstein","year":"2011","journal-title":"J\u00a0Am Dent Assoc"},{"key":"10.1016\/j.jcms.2020.02.006_bib23","doi-asserted-by":"crossref","first-page":"e429","DOI":"10.1016\/j.oooo.2012.08.442","article-title":"Principles of oral surgery for prevention of bisphosphonate-related osteonecrosis of the jaw","volume":"117","author":"Heufelder","year":"2014","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"10.1016\/j.jcms.2020.02.006_bib24","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1007\/s00198-009-1024-9","article-title":"Oral bisphosphonate-related osteonecrosis of the jaw: the first report in Asia","volume":"21","author":"Hong","year":"2010","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.jcms.2020.02.006_bib25","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1359\/jbmr.1997.12.10.1700","article-title":"Elimination and biochemical responses to intravenous alendronate in postmenopausal osteoporosis","volume":"12","author":"Khan","year":"1997","journal-title":"J\u00a0Bone Miner Res"},{"key":"10.1016\/j.jcms.2020.02.006_bib26","doi-asserted-by":"crossref","first-page":"193","DOI":"10.5125\/jkaoms.2016.42.4.193","article-title":"Evaluation of the predisposing factors and involved outcome of surgical treatment in bisphosphonate-related osteonecrosis of the jaw cases including bone biopsies","volume":"42","author":"Kim","year":"2016","journal-title":"J\u00a0Korean Assoc Oral Maxillofac Surg"},{"key":"10.1016\/j.jcms.2020.02.006_bib27","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.joms.2009.03.050","article-title":"Prevalence of osteonecrosis of the jaw in patients with oral bisphosphonate exposure","volume":"68","author":"Lo","year":"2010","journal-title":"J\u00a0Oral Maxillofac Surg"},{"key":"10.1016\/j.jcms.2020.02.006_bib28","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.joms.2009.07.068","article-title":"Tooth extraction in patients taking intravenous bisphosphonates: a preventive protocol and case series","volume":"68","author":"Lodi","year":"2010","journal-title":"J\u00a0Oral Maxillofac Surg"},{"key":"10.1016\/j.jcms.2020.02.006_bib29","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.jcms.2016.05.004","article-title":"Medication-related osteonecrosis of the jaw: is autologous platelet concentrate application effective for prevention and treatment? A systematic review","volume":"44","author":"Lopez-Jornet","year":"2016","journal-title":"J\u00a0Cranio-Maxillofac Surg"},{"key":"10.1016\/j.jcms.2020.02.006_bib30","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/sj.bdj.2009.5","article-title":"Dental extractions and bisphosphonates: the assessment, consent and management, a proposed algorithm","volume":"206","author":"Malden","year":"2009","journal-title":"Br Dent J"},{"key":"10.1016\/j.jcms.2020.02.006_bib31","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.ijom.2010.11.002","article-title":"Bisphosphonate-related osteonecrosis of the jaws: a case series of 25 patients affected by osteoporosis","volume":"40","author":"Manfredi","year":"2011","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.jcms.2020.02.006_bib32","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/S1079-2104(98)90029-4","article-title":"Platelet-rich plasma: growth factor enhancement for bone grafts","volume":"85","author":"Marx","year":"1998","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endodontology"},{"key":"10.1016\/j.jcms.2020.02.006_bib33","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s00784-016-1762-y","article-title":"Primary wound closure after tooth extraction for prevention of medication-related osteonecrosis of the jaw in patients under denosumab","volume":"21","author":"Matsumoto","year":"2017","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.jcms.2020.02.006_bib34","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1007\/s00198-016-3553-3","article-title":"Cancel the denosumab holiday","volume":"27","author":"McClung","year":"2016","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.jcms.2020.02.006_bib35","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/cncr.21130","article-title":"Bisphosphonate-associated osteonecrosis of mandibular and maxillary bone","volume":"104","author":"Migliorati","year":"2005","journal-title":"Cancer"},{"key":"10.1016\/j.jcms.2020.02.006_bib36","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1080\/10428190802483778","article-title":"Antibiotic prophylaxis before dental procedures may reduce the incidence of osteonecrosis of the jaw in patients with multiple myeloma treated with bisphosphonates","volume":"49","author":"Montefusco","year":"2008","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.jcms.2020.02.006_bib37","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1007\/s00198-012-2239-8","article-title":"Tooth extraction in osteoporotic patients taking oral bisphosphonates","volume":"24","author":"Mozzati","year":"2013","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.jcms.2020.02.006_bib38","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1016\/j.joms.2011.08.033","article-title":"Bisphosphonate-related osteonecrosis of the jaw in patients with oral bisphosphonate exposure: clinical course and outcomes","volume":"70","author":"O'Ryan","year":"2012","journal-title":"J\u00a0Oral Maxillofac Surg"},{"key":"10.1016\/j.jcms.2020.02.006_bib39","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1056\/NEJMc062792","article-title":"Prolonged bisphosphonate release after treatment in children","volume":"356","author":"Papapoulos","year":"2007","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jcms.2020.02.006_bib40","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.jcms.2014.11.014","article-title":"Treatment perspectives for medication-related osteonecrosis of the jaw (MRONJ)","volume":"43","author":"Ristow","year":"2015","journal-title":"J\u00a0Cranio-Maxillofac Surg"},{"key":"10.1016\/j.jcms.2020.02.006_bib41","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1016\/j.joms.2014.04.031","article-title":"American Association of Oral and Maxillofacial Surgeons position paper on medication-related osteonecrosis of the jaw\u20142014 update","volume":"72","author":"Ruggiero","year":"2014","journal-title":"J\u00a0Oral Maxillofac Surg"},{"key":"10.1016\/j.jcms.2020.02.006_bib42","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1563\/1548-1336(2007)33[116:IOAOIM]2.0.CO;2","article-title":"Inhibition of alveolar osteitis in mandibular tooth extraction sites using platelet-rich plasma","volume":"33","author":"Rutkowski","year":"2007","journal-title":"J\u00a0Oral Implantol"},{"key":"10.1016\/j.jcms.2020.02.006_bib43","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.joms.2009.10.026","article-title":"Occurrence of bisphosphonate-related osteonecrosis of the jaw after surgical tooth extraction","volume":"68","author":"Saia","year":"2010","journal-title":"J\u00a0Oral Maxillofac Surg"},{"key":"10.1016\/j.jcms.2020.02.006_bib44","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1563\/AAID-JOI-D-11-00001","article-title":"Prevention of hemorrhagic complications after dental extractions into open heart surgery patients under anticoagulant therapy: the use of leukocyte- and platelet-rich fibrin","volume":"37","author":"Sammartino","year":"2011","journal-title":"J\u00a0Oral Implantol"},{"key":"10.1016\/j.jcms.2020.02.006_bib45","series-title":"S3-Leitlinie antiresorptiva-assoziierte Kiefernekrosen (AR-ONJ)","author":"Schiegnitz","year":"2018"},{"key":"10.1016\/j.jcms.2020.02.006_bib47","first-page":"220","article-title":"Primary wound closure and perioperative antibiotic therapy for prevention of bisphosphonate-related osteonecrosis of the jaw after tooth extraction","volume":"51","author":"Spanou","year":"2020","journal-title":"Quintessence Int"},{"key":"10.1016\/j.jcms.2020.02.006_bib48","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1080\/09537104.2017.1336212","article-title":"Production of platelet-rich plasma gel from elderly patients under antithrombotic drugs: perspectives in chronic wounds care","volume":"29","author":"Velier","year":"2018","journal-title":"Platelets"},{"key":"10.1016\/j.jcms.2020.02.006_bib49","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s10266-018-0362-5","article-title":"Osteonecrosis of the jaw in patients transitioning from bisphosphonates to denosumab treatment for osteoporosis","volume":"106","author":"Voss","year":"2018","journal-title":"Odontology"},{"key":"10.1016\/j.jcms.2020.02.006_bib50","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1746-160X-6-11","article-title":"Prevalence of bisphosphonate associated osteonecrosis of the jaws in multiple myeloma patients","volume":"6","author":"Walter","year":"2010","journal-title":"Head Face Med"},{"key":"10.1016\/j.jcms.2020.02.006_bib51","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/j.jdent.2014.05.001","article-title":"The national-scale cohort study on bisphosphonate-related osteonecrosis of the jaw in Taiwan","volume":"42","author":"Yuh","year":"2014","journal-title":"J\u00a0Dent"}],"container-title":["Journal of Cranio-Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1010518220300445?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1010518220300445?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T14:43:03Z","timestamp":1760884983000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1010518220300445"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":50,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["S1010518220300445"],"URL":"https:\/\/doi.org\/10.1016\/j.jcms.2020.02.006","relation":{},"ISSN":["1010-5182"],"issn-type":[{"value":"1010-5182","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tooth extractions in patients under antiresorptive therapy for osteoporosis: Primary closure of the extraction socket with a mucoperiosteal flap versus application of platelet-rich fibrin for the prevention of antiresorptive agent-related osteonecrosis of the jaw","name":"articletitle","label":"Article Title"},{"value":"Journal of Cranio-Maxillofacial Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcms.2020.02.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}