{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:46:29Z","timestamp":1760921189721,"version":"build-2065373602"},"reference-count":40,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T00:00:00Z","timestamp":1701216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010571","name":"BMBF Berlin","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010571","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["03VP07631"],"award-info":[{"award-number":["03VP07631"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cranio-Maxillofacial Surgery"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.jcms.2023.11.007","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T23:01:21Z","timestamp":1701212481000},"page":"127-135","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Bone regeneration in critical-size defects of the mandible using biomechanically adapted CAD\/CAM hybrid scaffolds: An in vivo study in miniature pigs"],"prefix":"10.1016","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4737-5953","authenticated-orcid":false,"given":"Juliane","family":"Wagner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sascha","family":"Luck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaas","family":"Loger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yahya","family":"A\u00e7il","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes H.","family":"Spille","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sascha","family":"Kurz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8067-1116","authenticated-orcid":false,"given":"Matthias","family":"Ahlhelm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Schwarzer-Fischer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lena-Christin","family":"Ingwersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anika","family":"Jonitz-Heincke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sam","family":"Sedaghat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg","family":"Wiltfang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5650-246X","authenticated-orcid":false,"given":"Hendrik","family":"Naujokat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.jcms.2023.11.007_bib1","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1002\/1097-4636(20000915)51:4<703::AID-JBM19>3.0.CO;2-A","article-title":"Three-dimensional cultivation of human osteoblast-like cells on highly porous natural bone mineral","volume":"51","author":"A\u00e7il","year":"2000","journal-title":"J. Biomed. Mater. Res."},{"issue":"12","key":"10.1016\/j.jcms.2023.11.007_bib2","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1016\/j.jeurceramsoc.2015.12.020","article-title":"Innovative and novel manufacturing methods of ceramics and metal-ceramic composites for biomedical applications","volume":"36","author":"Ahlhelm","year":"2016","journal-title":"J. Eur. Ceram. Soc."},{"key":"10.1016\/j.jcms.2023.11.007_bib3","first-page":"91","article-title":"Novel ceramic composites for personalized 3D structures","volume":"8","author":"Ahlhelm","year":"2017","journal-title":"J. Ceram. Sci. Technol."},{"issue":"10","key":"10.1016\/j.jcms.2023.11.007_bib4","doi-asserted-by":"crossref","first-page":"281","DOI":"10.3390\/jcs5100281","article-title":"Mechanically stable \u03b2-TCP structural hybrid scaffolds for potential bone replacement","volume":"5","author":"Ahlhelm","year":"2021","journal-title":"Journal of Composites Science"},{"issue":"11","key":"10.1016\/j.jcms.2023.11.007_bib5","doi-asserted-by":"crossref","first-page":"e181","DOI":"10.1016\/j.oraloncology.2009.07.004","article-title":"Endocultivation: 3D printed customized porous scaffolds for heterotopic bone induction","volume":"45","author":"Becker","year":"2009","journal-title":"Oral Oncol."},{"issue":"1","key":"10.1016\/j.jcms.2023.11.007_bib6","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1177\/0194599812458879","article-title":"Leg compartment syndrome after fibula free flap","volume":"148","author":"Berzofsky","year":"2013","journal-title":"Otolaryngol. Head Neck Surg."},{"issue":"6","key":"10.1016\/j.jcms.2023.11.007_bib7","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1002\/jor.1100180613","article-title":"Osteoprogenitor cells within skeletal muscle","volume":"18","author":"Bosch","year":"2000","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.jcms.2023.11.007_bib8","doi-asserted-by":"crossref","DOI":"10.1177\/2041731418776819","article-title":"Bone substitutes: a review of their characteristics, clinical use, and perspectives for large bone defects management","volume":"9","author":"Fernandez de Grado","year":"2018","journal-title":"J. Tissue Eng."},{"issue":"2","key":"10.1016\/j.jcms.2023.11.007_bib9","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.bjps.2015.10.007","article-title":"Long-term donor-site morbidity after vascularized free fibula flap harvesting: clinical and gait analysis","volume":"69","author":"Feuvrier","year":"2016","journal-title":"J. Plast. Reconstr. Aesthetic Surg."},{"issue":"8","key":"10.1016\/j.jcms.2023.11.007_bib10","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.ijom.2017.02.1276","article-title":"Three-dimensional surgical modelling with an open-source software protocol: study of precision and reproducibility in mandibular reconstruction with the fibula free flap","volume":"46","author":"Ganry","year":"2017","journal-title":"Int. J. Oral Maxillofac. Surg."},{"issue":"12","key":"10.1016\/j.jcms.2023.11.007_bib11","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.addr.2012.06.008","article-title":"Demineralized bone matrix in bone repair: history and use","volume":"64","author":"Gruskin","year":"2012","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"Suppl. 2","key":"10.1016\/j.jcms.2023.11.007_bib12","article-title":"Bioresorbability, porosity and mechanical strength of bone substitutes: what is optimal for bone regeneration?","volume":"42","author":"Hannink","year":"2011","journal-title":"Injury"},{"issue":"2","key":"10.1016\/j.jcms.2023.11.007_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10020513","article-title":"Single application of low-dose, hydroxyapatite-bound BMP-2 or GDF-5 induces long-term bone formation and biomechanical stabilization of a bone defect in a senile sheep lumbar osteopenia model","volume":"10","author":"Hasenbein","year":"2022","journal-title":"Biomedicines"},{"issue":"1","key":"10.1016\/j.jcms.2023.11.007_bib14","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ijom.2006.07.011","article-title":"rh-BMP2-induced ectopic bone for grafting critical size defects: a preliminary histological evaluation in rat calvariae","volume":"36","author":"Inoda","year":"2007","journal-title":"Int. J. Oral Maxillofac. Surg."},{"issue":"2","key":"10.1016\/j.jcms.2023.11.007_bib15","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1097\/SCS.0000000000004119","article-title":"Mandibular reconstruction using a customized three-dimensional titanium implant applied on the lingual surface of the mandible","volume":"29","author":"Jo","year":"2018","journal-title":"J. Craniofac. Surg."},{"issue":"6 Pt 1","key":"10.1016\/j.jcms.2023.11.007_bib16","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1083\/jcb.127.6.1755","article-title":"Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage","volume":"127","author":"Katagiri","year":"1994","journal-title":"J. Cell Biol."},{"issue":"2","key":"10.1016\/j.jcms.2023.11.007_bib17","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1006\/excr.1996.3432","article-title":"Bone morphogenetic protein-2 inhibits terminal differentiation of myogenic cells by suppressing the transcriptional activity of MyoD and myogenin","volume":"230","author":"Katagiri","year":"1997","journal-title":"Exp. Cell Res."},{"issue":"3","key":"10.1016\/j.jcms.2023.11.007_bib18","doi-asserted-by":"crossref","first-page":"128","DOI":"10.5125\/jkaoms.2018.44.3.128","article-title":"Maxillofacial reconstruction with Medpor porous polyethylene implant: a case series study","volume":"44","author":"Khorasani","year":"2018","journal-title":"J Korean Assoc Oral Maxillofac Surg"},{"issue":"1","key":"10.1016\/j.jcms.2023.11.007_bib19","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0169-409X(00)00078-8","article-title":"Potential applications and delivery strategies for bone morphogenetic proteins","volume":"43","author":"Kirker-Head","year":"2000","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"4","key":"10.1016\/j.jcms.2023.11.007_bib20","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S8756-3282(01)00585-3","article-title":"Osteoprogenitor cells of mature human skeletal muscle tissue: an in vitro study","volume":"29","author":"Levy","year":"2001","journal-title":"Bone"},{"issue":"8","key":"10.1016\/j.jcms.2023.11.007_bib21","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1177\/0022034511435260","article-title":"Osteoinduction: a review of old concepts with new standards","volume":"91","author":"Miron","year":"2012","journal-title":"J. Dent. Res."},{"issue":"6","key":"10.1016\/j.jcms.2023.11.007_bib22","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1046\/j.1440-1622.2001.02128.x","article-title":"Synthetic bone graft substitutes","volume":"71","author":"Moore","year":"2001","journal-title":"ANZ J. Surg."},{"issue":"11","key":"10.1016\/j.jcms.2023.11.007_bib23","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1016\/j.ijom.2018.05.006","article-title":"Man as a living bioreactor: long-term histological aspects of a mandibular replacement engineered in the patient's own body","volume":"47","author":"Naujokat","year":"2018","journal-title":"Int. J. Oral Maxillofac. Surg."},{"issue":"5","key":"10.1016\/j.jcms.2023.11.007_bib24","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1055\/s-0036-1586497","article-title":"Solid implants in facial plastic surgery: potential complications and how to prevent them","volume":"32","author":"Patel","year":"2016","journal-title":"Facial Plast. Surg."},{"key":"10.1016\/j.jcms.2023.11.007_bib25","first-page":"44","article-title":"Three-dimensional planning and computer-assisted surgery in craniofacial reconstruction","volume":"46","author":"Rana","year":"2017","journal-title":"Int. J. Oral Maxillofac. Surg."},{"issue":"8","key":"10.1016\/j.jcms.2023.11.007_bib26","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1016\/j.jcms.2017.04.003","article-title":"Increasing the accuracy of mandibular reconstruction with free fibula flaps using functionalized selective laser-melted patient-specific implants: a retrospective multicenter analysis","volume":"45","author":"Rana","year":"2017","journal-title":"J. Cranio-Maxillo-Fac. Surg."},{"issue":"4","key":"10.1016\/j.jcms.2023.11.007_bib27","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1055\/s-0036-1597823","article-title":"Functional outcome of CAD\/CAM-assisted versus conventional microvascular, fibular free flap reconstruction of the mandible: a retrospective study of 30 cases","volume":"33","author":"Ritschl","year":"2017","journal-title":"J. Reconstr. Microsurg."},{"issue":"7","key":"10.1016\/j.jcms.2023.11.007_bib28","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s10856-023-06734-2","article-title":"BMP-2 (and partially GDF-5) coating significantly accelerates and augments bone formation close to hydroxyapatite\/tricalcium-phosphate\/brushite implant cylinders for tibial bone defects in senile, osteopenic sheep","volume":"34","author":"Sachse","year":"2023","journal-title":"J. Mater. Sci. Mater. Med."},{"issue":"3","key":"10.1016\/j.jcms.2023.11.007_bib29","doi-asserted-by":"crossref","DOI":"10.1097\/PRS.0b013e31829ad0d9","article-title":"Alloplastic mandibular reconstruction: a systematic review and meta-analysis of the current century case series","volume":"132","author":"Sadr-Eshkevari","year":"2013","journal-title":"Plast. Reconstr. Surg."},{"issue":"28","key":"10.1016\/j.jcms.2023.11.007_bib30","doi-asserted-by":"crossref","first-page":"20352","DOI":"10.1016\/S0021-9258(19)88709-4","article-title":"Recombinant human osteogenic protein-1 (hOP-1) induces new bone formation in vivo with a specific activity comparable with natural bovine osteogenic protein and stimulates osteoblast proliferation and differentiation in vitro","volume":"267","author":"Sampath","year":"1992","journal-title":"J. Biol. Chem."},{"issue":"24","key":"10.1016\/j.jcms.2023.11.007_bib31","doi-asserted-by":"crossref","first-page":"9484","DOI":"10.1073\/pnas.85.24.9484","article-title":"Purification and characterization of other distinct bone-inducing factors","volume":"85","author":"Wang","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.jcms.2023.11.007_bib32","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1097\/MOO.0b013e328344a569","article-title":"Modern concepts in mandibular reconstruction in oral and oropharyngeal cancer","volume":"19","author":"Wang","year":"2011","journal-title":"Curr. Opin. Otolaryngol. Head Neck Surg."},{"issue":"9436","key":"10.1016\/j.jcms.2023.11.007_bib33","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/S0140-6736(04)16935-3","article-title":"Growth and transplantation of a custom vascularised bone graft in a man","volume":"364","author":"Warnke","year":"2004","journal-title":"Lancet"},{"issue":"8","key":"10.1016\/j.jcms.2023.11.007_bib34","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1089\/ten.tec.2015.0501","article-title":"Man as a living bioreactor: prefabrication of a custom vascularized bone graft in the gastrocolic omentum","volume":"22","author":"Wiltfang","year":"2016","journal-title":"Tissue Eng. C Methods"},{"issue":"4885","key":"10.1016\/j.jcms.2023.11.007_bib35","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1126\/science.3201241","article-title":"Novel regulators of bone formation: molecular clones and activities","volume":"242","author":"Wozney","year":"1988","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.jcms.2023.11.007_bib36","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.jpor.2017.08.010","article-title":"Current bone substitutes for implant dentistry","volume":"62","author":"Yamada","year":"2018","journal-title":"J Prosthodont Res"},{"issue":"2","key":"10.1016\/j.jcms.2023.11.007_bib37","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1006\/bbrc.1996.0411","article-title":"Effects of BMP-2, BMP-4, and BMP-6 on osteoblastic differentiation of bone marrow-derived stromal cell lines, ST2 and MC3T3-G2\/PA6","volume":"220","author":"Yamaguchi","year":"1996","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"6","key":"10.1016\/j.jcms.2023.11.007_bib38","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S8756-3282(96)00259-1","article-title":"Bone morphogenetic protein receptors","volume":"19","author":"Yamashita","year":"1996","journal-title":"Bone"},{"issue":"2","key":"10.1016\/j.jcms.2023.11.007_bib39","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S1010-5182(98)80050-4","article-title":"Osteoinduction capability of recombinant human bone morphogenetic protein-2 in intramuscular and subcutaneous sites: an experimental study","volume":"26","author":"Yoshida","year":"1998","journal-title":"J. Cranio-Maxillo-Fac. Surg."},{"issue":"4","key":"10.1016\/j.jcms.2023.11.007_bib40","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1007\/s00784-001-0140-5","article-title":"Donor site morbidity after microvascular fibula transfer","volume":"5","author":"Zimmermann","year":"2001","journal-title":"Clin. Oral Invest."}],"container-title":["Journal of Cranio-Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1010518223002366?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1010518223002366?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T14:47:15Z","timestamp":1760885235000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1010518223002366"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["S1010518223002366"],"URL":"https:\/\/doi.org\/10.1016\/j.jcms.2023.11.007","relation":{},"ISSN":["1010-5182"],"issn-type":[{"type":"print","value":"1010-5182"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bone regeneration in critical-size defects of the mandible using biomechanically adapted CAD\/CAM hybrid scaffolds: An in vivo study in miniature pigs","name":"articletitle","label":"Article Title"},{"value":"Journal of Cranio-Maxillofacial Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcms.2023.11.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Ltd on behalf of European Association for Cranio-Maxillo-Facial Surgery.","name":"copyright","label":"Copyright"}]}}