{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T07:38:23Z","timestamp":1778830703133,"version":"3.51.4"},"reference-count":30,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007446","name":"King Khalid University","doi-asserted-by":"publisher","award":["RGP1\/161\/46"],"award-info":[{"award-number":["RGP1\/161\/46"]}],"id":[{"id":"10.13039\/501100007446","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cranio-Maxillofacial Surgery"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.jcms.2026.104508","type":"journal-article","created":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T13:36:32Z","timestamp":1771940192000},"page":"104508","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical, technical, and economic outcomes of 3D-printed bone substitutes in maxillofacial reconstruction: a systematic review and meta-analysis"],"prefix":"10.1016","volume":"54","author":[{"given":"Abdulmajeed","family":"Okshah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravinder S.","family":"Saini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rayan Ibrahim H.","family":"Binduhayyim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3187-6761","authenticated-orcid":false,"given":"V.N.V.","family":"Madhav","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashish","family":"Kaushik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masroor Ahmed","family":"Kanji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waleed Ali F.","family":"Alshadidi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8329-3205","authenticated-orcid":false,"given":"Artak","family":"Heboyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1338-0551","authenticated-orcid":false,"given":"Javier","family":"Flores-Fraile","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario Alberto","family":"Alarc\u00f3n-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0335-4165","authenticated-orcid":false,"given":"Luca","family":"Fiorillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.jcms.2026.104508_bib34","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1016\/j.joms.2019.04.027","article-title":"Comprehensive Clinical Care Pathway for Microvascular Maxillofacial Reconstructive Surgery","volume":"77","author":"Abo Sharkh","year":"2019","journal-title":"J Oral Maxillofac Surg."},{"issue":"4","key":"10.1016\/j.jcms.2026.104508_bib1","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.joms.2019.11.013","article-title":"In-house surgeon-led virtual surgical planning for maxillofacial reconstruction","volume":"78","author":"Abo Sharkh","year":"2020","journal-title":"J. Oral Maxillofac. Surg."},{"issue":"6","key":"10.1016\/j.jcms.2026.104508_bib2","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1097\/SCS.0000000000008561","article-title":"Implementation of 3D printing and computer-aided design and manufacturing (CAD\/CAM) in craniofacial reconstruction","volume":"33","author":"Ahmed","year":"2022","journal-title":"J. Craniofac. Surg."},{"key":"10.1016\/j.jcms.2026.104508_bib3","doi-asserted-by":"crossref","DOI":"10.12659\/MSM.947152","article-title":"Current trends and innovations in oral and maxillofacial reconstruction","volume":"31","author":"Alfayez","year":"2025","journal-title":"Med. Sci. Monit."},{"issue":"10","key":"10.1016\/j.jcms.2026.104508_bib4","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/j.joms.2024.07.005","article-title":"Does a point-of-care 3-dimensional printer result in a decreased length of surgery for orbital fractures?","volume":"82","author":"Amin","year":"2024","journal-title":"J. Oral Maxillofac. Surg."},{"issue":"1","key":"10.1016\/j.jcms.2026.104508_bib5","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-70107-w","article-title":"Validation of a patient-specific system for mandible-first bimaxillary surgery: ramus and implant positioning precision assessment and guide design comparison","volume":"10","author":"Badiali","year":"2020","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/j.jcms.2026.104508_bib6","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.acra.2019.08.011","article-title":"Medical 3D printing cost-savings in orthopedic and maxillofacial surgery: cost analysis of operating room time saved with 3D printed anatomic models and surgical guides","volume":"27","author":"Ballard","year":"2020","journal-title":"Acad. Radiol."},{"issue":"7","key":"10.1016\/j.jcms.2026.104508_bib7","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.21037\/gs-21-264","article-title":"The accuracy of clinical 3D printing in reconstructive surgery: literature review and in vivo validation study","volume":"10","author":"Chae","year":"2021","journal-title":"Gland Surg."},{"issue":"1","key":"10.1016\/j.jcms.2026.104508_bib8","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1186\/s12903-020-01205-4","article-title":"Clinical and volumetric outcomes after vertical ridge augmentation using computer-aided-design\/computer-aided manufacturing (CAD\/CAM) customized titanium meshes: a pilot study","volume":"20","author":"Cucchi","year":"2020","journal-title":"BMC Oral Health"},{"issue":"Suppl. 1","key":"10.1016\/j.jcms.2026.104508_bib9","doi-asserted-by":"crossref","first-page":"S203","DOI":"10.4103\/njms.NJMS_65_20","article-title":"Three-dimensional printing in maxillofacial surgery: a quantum leap in future","volume":"13","author":"Dadhich","year":"2022","journal-title":"Natl. J. Maxillofac. Surg."},{"issue":"11","key":"10.1016\/j.jcms.2026.104508_bib10","doi-asserted-by":"crossref","first-page":"4117","DOI":"10.3390\/ma16114117","article-title":"Bone grafts in dental medicine: an overview of autografts, allografts and synthetic materials","volume":"16","author":"Ferraz","year":"2023","journal-title":"Materials (Basel)"},{"issue":"12","key":"10.1016\/j.jcms.2026.104508_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e32513","article-title":"Precise maxillofacial soft tissue reconstruction: a combination of cone beam computed tomography and 3dMD photogrammetry system","volume":"10","author":"Guo","year":"2024","journal-title":"Heliyon"},{"issue":"1","key":"10.1016\/j.jcms.2026.104508_bib12","doi-asserted-by":"crossref","first-page":"3397","DOI":"10.1038\/s41598-024-53686-w","article-title":"Customized three-dimensional printed ceramic bone grafts for osseous defects: a prospective randomized study","volume":"14","author":"Kim","year":"2024","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.jcms.2026.104508_bib13","doi-asserted-by":"crossref","first-page":"528","DOI":"10.3390\/mi13040528","article-title":"A review of 3D printed bone implants","volume":"13","author":"Li","year":"2022","journal-title":"Micromachines (Basel)"},{"issue":"5","key":"10.1016\/j.jcms.2026.104508_bib14","doi-asserted-by":"crossref","first-page":"427","DOI":"10.5301\/hipint.5000018","article-title":"Bone allograft in the U.K.: perceptions and realities","volume":"23","author":"Lomas","year":"2013","journal-title":"Hip Int."},{"issue":"1","key":"10.1016\/j.jcms.2026.104508_bib15","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/jrsm.1411","article-title":"Risk-of-bias VISualization (robvis): an R package and shiny web app for visualizing risk-of-bias assessments","volume":"12","author":"McGuinness","year":"2021","journal-title":"Res. Synth. Methods"},{"issue":"18","key":"10.1016\/j.jcms.2026.104508_bib16","doi-asserted-by":"crossref","first-page":"3822","DOI":"10.3390\/polym15183822","article-title":"Synthetic calcium-phosphate materials for bone grafting","volume":"15","author":"Mishchenko","year":"2023","journal-title":"Polymers (Basel)"},{"key":"10.1016\/j.jcms.2026.104508_bib17","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"issue":"3","key":"10.1016\/j.jcms.2026.104508_bib18","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1055\/s-0039-1693020","article-title":"Bone grafts, bone substitutes, and orthobiologics: applications in plastic surgery","volume":"33","author":"Raghuram","year":"2019","journal-title":"Semin. Plast. Surg."},{"key":"10.1016\/j.jcms.2026.104508_bib19","doi-asserted-by":"crossref","first-page":"e356","DOI":"10.1016\/j.wneu.2020.12.138","article-title":"3D-printer-assisted patient-specific polymethyl methacrylate cranioplasty: a case series of 16 consecutive patients","volume":"148","author":"Sch\u00f6n","year":"2021","journal-title":"World Neurosurg."},{"issue":"1","key":"10.1016\/j.jcms.2026.104508_bib20","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1177\/00220345241285566","article-title":"Comparison of implant precision with robots, navigation, or static guides","volume":"104","author":"Shi","year":"2025","journal-title":"J. Dent. Res."},{"issue":"5","key":"10.1016\/j.jcms.2026.104508_bib21","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.3390\/jcm9051579","article-title":"Three-dimensional analysis of isolated orbital floor fractures pre- and post-reconstruction with standard titanium meshes and \u201chybrid\u201d patient-specific implants","volume":"9","author":"Sigron","year":"2020","journal-title":"J. Clin. Med."},{"issue":"12","key":"10.1016\/j.jcms.2026.104508_bib22","doi-asserted-by":"crossref","first-page":"6586","DOI":"10.1021\/acsbiomaterials.3c01171","article-title":"3D printing applications for craniomaxillofacial reconstruction: a sweeping review","volume":"9","author":"Slavin","year":"2023","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"9","key":"10.1016\/j.jcms.2026.104508_bib23","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1111\/ans.14353","article-title":"Maxillofacial reconstruction using in-house virtual surgical planning","volume":"88","author":"Smithers","year":"2018","journal-title":"ANZ J. Surg."},{"key":"10.1016\/j.jcms.2026.104508_bib25","article-title":"ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions","volume":"355","author":"Sterne","year":"2016","journal-title":"BMJ"},{"key":"10.1016\/j.jcms.2026.104508_bib27","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.oraloncology.2018.01.005","article-title":"Three-dimensional printing of patient-specific surgical plates in head and neck reconstruction: a prospective pilot study","volume":"78","author":"Yang","year":"2018","journal-title":"Oral Oncol."},{"issue":"1","key":"10.1016\/j.jcms.2026.104508_bib28","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1245\/s10434-020-08732-y","article-title":"Three-dimensionally printed patient-specific surgical plates increase accuracy of oncologic head and neck reconstruction versus conventional surgical plates: a comparative study","volume":"28","author":"Yang","year":"2021","journal-title":"Ann. Surg Oncol."},{"issue":"6","key":"10.1016\/j.jcms.2026.104508_bib29","doi-asserted-by":"crossref","DOI":"10.1002\/hsr2.2205","article-title":"Sculpting the future: a narrative review of 3D printing in plastic surgery and prosthetic devices","volume":"7","author":"Zahid","year":"2024","journal-title":"Health Sci. Rep."},{"issue":"10","key":"10.1016\/j.jcms.2026.104508_bib30","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.3390\/molecules26103007","article-title":"Bone grafts and substitutes in dentistry: a review of current trends and developments","volume":"26","author":"Zhao","year":"2021","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.jcms.2026.104508_bib31","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12967-018-1759-1","article-title":"An innovative total temporomandibular joint prosthesis with customized design and 3D printing additive fabrication: a prospective clinical study","volume":"17","author":"Zheng","year":"2019","journal-title":"J. Transl. Med."}],"container-title":["Journal of Cranio-Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S101051822600065X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S101051822600065X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T07:05:33Z","timestamp":1778137533000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S101051822600065X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S101051822600065X"],"URL":"https:\/\/doi.org\/10.1016\/j.jcms.2026.104508","relation":{},"ISSN":["1010-5182"],"issn-type":[{"value":"1010-5182","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical, technical, and economic outcomes of 3D-printed bone substitutes in maxillofacial reconstruction: a systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Journal of Cranio-Maxillofacial Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcms.2026.104508","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd on behalf of European Association for Cranio-Maxillo-Facial Surgery.","name":"copyright","label":"Copyright"}],"article-number":"104508"}}