{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:22:32Z","timestamp":1789705352318,"version":"4.0.1"},"reference-count":28,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2004,8,1]],"date-time":"2004-08-01T00:00:00Z","timestamp":1091318400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2004,8]]},"DOI":"10.1016\/j.jconrel.2004.05.002","type":"journal-article","created":{"date-parts":[[2004,7,7]],"date-time":"2004-07-07T21:23:59Z","timestamp":1089235439000},"page":"269-279","source":"Crossref","is-referenced-by-count":143,"title":["Chitosan delivery systems for the treatment of oral mucositis: in vitro and in vivo studies"],"prefix":"10.1016","volume":"98","author":[{"given":"Pelin","family":"Aksungur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arzu","family":"Sungur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serhat","family":"\u00dcnal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alper B","family":"\u0130skit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher A","family":"Squier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sevda","family":"\u015eenel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.jconrel.2004.05.002_BIB1","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/S0030-6665(20)30744-1","article-title":"Fungal infections of the oral cavity","volume":"26","author":"Zegarelli","year":"1993","journal-title":"Otolaryngol. Clin. North Am."},{"issue":"2","key":"10.1016\/j.jconrel.2004.05.002_BIB2","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1177\/10454411940050020101","article-title":"Candida and oral candidosis: a review","volume":"5","author":"Scully","year":"1994","journal-title":"Crit. Rev. Oral Biol. Med."},{"key":"10.1016\/j.jconrel.2004.05.002_BIB3","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/S0140-6736(96)02308-2","article-title":"HIV-related oral disease","volume":"348","author":"Greenspan","year":"1996","journal-title":"Lancet"},{"issue":"12","key":"10.1016\/j.jconrel.2004.05.002_BIB4","doi-asserted-by":"crossref","first-page":"2630","DOI":"10.1200\/JCO.1994.12.12.2630","article-title":"Randomized trial of a chlorhexidine mouthwash for alleviation of radiation-induced mucositis","volume":"12","author":"Foote","year":"1994","journal-title":"J. Clin. Oncol."},{"issue":"3","key":"10.1016\/j.jconrel.2004.05.002_BIB5","first-page":"203","article-title":"Effectiveness of a topical antifungal regimen for the treatment of oral candidiasis in older, chronically ill, institutionalized, adults","volume":"61","author":"Banting","year":"1995","journal-title":"J. Can. Dent. Assoc."},{"issue":"3","key":"10.1016\/j.jconrel.2004.05.002_BIB6","doi-asserted-by":"crossref","first-page":"4561","DOI":"10.1248\/cpb.30.980","article-title":"Mucosal dosage form of lidocaine for toothache using hydroxypropyl cellulose and carbopol","volume":"30","author":"Ishida","year":"1982","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.jconrel.2004.05.002_BIB7","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0378-5173(87)90098-6","article-title":"Bioadhesive analysis of controlled release systems: III. Bioadhesive and release behavior of metronidazole-containing poly(acrylic acid)-hydroxypropyl methylcellulose systems","volume":"38","author":"Ponchel","year":"1987","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2004.05.002_BIB8","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0168-3659(87)90070-8","article-title":"Preliminary studies of oral mucosal delivery of peptide drugs","volume":"6","author":"Veillard","year":"1987","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2004.05.002_BIB9","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1002\/jbm.820221106","article-title":"Hydrogels for buccal drug delivery: properties relevant for mucoadhesion","volume":"22","author":"DeVries","year":"1988","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.jconrel.2004.05.002_BIB10","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0169-409X(94)90026-4","article-title":"Oral cavity as a site for bioadhesive drug delivery","volume":"13","author":"Gandhi","year":"1994","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2004.05.002_BIB11","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0378-5173(99)00334-8","article-title":"Chitosan films and hydrogels of chlorhexidine gluconate for oral mucosal delivery","volume":"193","author":"\u015eenel","year":"2000","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2004.05.002_BIB12","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/j.1600-051X.1997.tb00203.x","article-title":"An investigation of bioadhesion for periodontal and mucosal drug delivery","volume":"24","author":"Needleman","year":"1997","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.jconrel.2004.05.002_BIB13","series-title":"Chitosan Per Os: From Dietary Supplement to Drug Carrier","first-page":"241","article-title":"Application of chitosan in dental drug delivery and therapy","author":"\u015eenel","year":"2000"},{"key":"10.1016\/j.jconrel.2004.05.002_BIB14","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1248\/bpb.17.745","article-title":"Chitosan and sodium alginate based bioadhesive tablets for intraoral delivery","volume":"17","author":"Miyazaki","year":"1994","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.jconrel.2004.05.002_BIB15","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0378-5173(92)90259-5","article-title":"Simple tests demonstrating the antimycotic effect of chitosan","volume":"80","author":"Knapczyk","year":"1992","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2004.05.002_BIB16","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1016\/S0142-9612(00)00134-4","article-title":"Enhancing effect of chitosan on peptide drug delivery across buccal mucosa","volume":"21","author":"\u015eenel","year":"2000","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2004.05.002_BIB17","author":"\u015eenel","year":"2002"},{"issue":"4","key":"10.1016\/j.jconrel.2004.05.002_BIB18","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/0030-4220(90)90376-4","article-title":"An animal model for mucositis induced by cancer chemotherapy","volume":"69","author":"Sonis","year":"1990","journal-title":"Oral Surg. Oral Med. Oral Pathol."},{"issue":"4","key":"10.1016\/j.jconrel.2004.05.002_BIB19","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S1368-8375(00)00012-9","article-title":"Defining mechanisms of action of interleukin-11 on the progression of radiation-induced oral mucositis in hamsters","volume":"36","author":"Sonis","year":"2000","journal-title":"Oral Oncol."},{"key":"10.1016\/j.jconrel.2004.05.002_BIB20","author":"Aksungur","year":"2001"},{"key":"10.1016\/j.jconrel.2004.05.002_BIB21","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0378-5173(01)00974-7","article-title":"Effect of chitosan on a periodontal pathogen, Porphyromonas gingivalis","volume":"235","author":"\u0130kinci","year":"2002","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2004.05.002_BIB22","doi-asserted-by":"crossref","first-page":"3637","DOI":"10.1016\/S0142-9612(02)00096-0","article-title":"Molecular weight and degree of deacetylation effects on lipase-loaded chitosan bead characteristics","volume":"23","author":"Alsarra Ibrahim","year":"2002","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2004.05.002_BIB23","doi-asserted-by":"crossref","first-page":"779","DOI":"10.3109\/03639049809082726","article-title":"Different molecular weight chitosan microspheres: influence on drug loading and drug release","volume":"24","author":"Genta","year":"1998","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.jconrel.2004.05.002_BIB24","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0168-3659(93)90080-O","article-title":"Controlled release of indomethacin by chitosan\u2013polelectrolyte complex: optimization and in vivo\/in vitro evaluation","volume":"25","author":"Shiraishi","year":"1993","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2004.05.002_BIB25","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0168-3659(00)00208-X","article-title":"pH-sensitive freeze-dried chitosan\u2013polyvinil pyrrolidone hydrogels as controlled release systems for antibiotic delivery","volume":"68","author":"Risbud","year":"2000","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2004.05.002_BIB26","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.3109\/03639048909062758","article-title":"Preparation and evaluation of drug-containing chitosan beads","volume":"15","author":"Bodmeier","year":"1989","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.jconrel.2004.05.002_BIB27","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0378-5173(00)00403-8","article-title":"A novel approach to prepare tripolyphosphate\/chitosan complex beads for controlled release drug delivery","volume":"201","author":"Shu","year":"2000","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2004.05.002_BIB28","series-title":"Oral Mucosal Delivery","first-page":"157","article-title":"The flow of saliva and its influence on the movement, deposition and removal of drugs administered to the oral cavity","author":"Weatherell","year":"1996"}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365904002330?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365904002330?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T02:16:40Z","timestamp":1624501000000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365904002330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,8]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,8]]}},"alternative-id":["S0168365904002330"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2004.05.002","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2004,8]]}}}