{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T13:23:52Z","timestamp":1777555432484,"version":"3.51.4"},"reference-count":25,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2006,1]]},"DOI":"10.1016\/j.jconrel.2005.09.047","type":"journal-article","created":{"date-parts":[[2005,11,8]],"date-time":"2005-11-08T12:12:12Z","timestamp":1131451932000},"page":"347-352","source":"Crossref","is-referenced-by-count":41,"title":["Enhancement of nasal absorption of large molecular weight compounds by combination of mucolytic agent and nonionic surfactant"],"prefix":"10.1016","volume":"110","author":[{"given":"Takahiro","family":"Matsuyama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Morita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Horikiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Yamahara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Yoshino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2005.09.047_bib1","doi-asserted-by":"crossref","first-page":"299","DOI":"10.2165\/00003088-198917050-00001","article-title":"Intranasal drug delivery: potential advantages and limitations from a clinical pharmacokinetic perspective","volume":"17","author":"Pontiroli","year":"1989","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.jconrel.2005.09.047_bib2","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0169-409X(97)00062-8","article-title":"Peptide hormones: review of current and emerging uses by nasal delivery","volume":"29","author":"Pontiroli","year":"1998","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2005.09.047_bib3","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3109\/10611869308996066","article-title":"Review: clinical opportunities provided by the nasal administration of peptides","volume":"1","author":"Harris","year":"1993","journal-title":"Drug Target"},{"key":"10.1016\/j.jconrel.2005.09.047_bib4","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0169-409X(97)00063-X","article-title":"Effects of physicochemical properties and other factors on systemic nasal drug delivery","volume":"29","author":"Behl","year":"1998","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2005.09.047_bib5","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1111\/j.1742-1241.1997.tb11466.x","article-title":"The nasal delivery of systemic drugs","volume":"51","author":"Jones","year":"1997","journal-title":"Int. J. Clin. Pract."},{"key":"10.1016\/j.jconrel.2005.09.047_bib6","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0378-5173(81)90010-7","article-title":"Mechanisms for the enhancement of the nasal absorption of insulin by surfactants","volume":"9","author":"Hirai","year":"1981","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2005.09.047_bib7","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1056\/NEJM198504253121702","article-title":"Intranasal aerosolized insulin: mixed-meal studies and long-term use in type I diabetes","volume":"312","author":"Salzman","year":"1985","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jconrel.2005.09.047_bib8","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1023\/A:1013330815253","article-title":"Enhanced bioavailability of calcitonin formulated with alkylglycosides following nasal and ocular administration in rats","volume":"18","author":"Ahsan","year":"2001","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2005.09.047_bib9","doi-asserted-by":"crossref","first-page":"7419","DOI":"10.1073\/pnas.82.21.7419","article-title":"Nasal absorption of insulin: enhancement by hydrophobic bile salts","volume":"82","author":"Gordon","year":"1985","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jconrel.2005.09.047_bib10","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1023\/A:1015930821648","article-title":"Site dependence of absorption-promoting actions of laureth-9, Na salicylate, Na2EDTA, and aprotinin on rectal, nasal, and buccal insulin delivery","volume":"5","author":"Aungst","year":"1988","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2005.09.047_bib11","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1248\/bpb1978.10.624","article-title":"Studies on the promoting effects of medium chain fatty acid salts on the nasal absorption of insulin in rats","volume":"10","author":"Mishima","year":"1987","journal-title":"J. Pharmacobio-Dyn."},{"key":"10.1016\/j.jconrel.2005.09.047_bib12","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/jps.2600760502","article-title":"Effects of sodium taurodihydrofusidate on nasal absorption of insulin in sheep","volume":"76","author":"Longenecker","year":"1987","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2005.09.047_bib13","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1023\/A:1018992716621","article-title":"The bioavailability of intranasal salmon calcitonin in healthy volunteers with and without a permeation enhancer","volume":"11","author":"Lee","year":"1994","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2005.09.047_bib14","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0378-5173(89)90262-7","article-title":"Enhanced nasal absorption of insulin in rats using lysophosphatidylcholine","volume":"57","author":"Illum","year":"1989","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2005.09.047_bib15","first-page":"1","article-title":"Intranasal drug delivery systems; an overview","volume":"58","author":"Prasad","year":"1996","journal-title":"Indian J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2005.09.047_bib16","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0169-409X(97)00064-1","article-title":"Optimization of systemic nasal drug delivery with pharmaceutical excipients","volume":"29","author":"Behl","year":"1998","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2005.09.047_bib17","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1023\/A:1016207809199","article-title":"Effects of absorption enhancers on rat nasal epithelium in vivo: release of marker compounds in the nasal cavity","volume":"12","author":"Marttin","year":"1995","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2005.09.047_bib18","unstructured":"Package insert, Mucomyst\u00ae (acetylcysteine solution, USP), Apothecon, revised January 2001."},{"key":"10.1016\/j.jconrel.2005.09.047_bib19","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1023\/A:1015884026056","article-title":"Nasal absorption enhancers for biosynthetic human growth hormone in rats","volume":"7","author":"O'Hagan","year":"1990","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2005.09.047_bib20","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/0378-5173(81)90058-2","article-title":"Absorption of drugs from the nasal mucosa of rat","volume":"7","author":"Hirai","year":"1981","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2005.09.047_bib21","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1159\/000194301","article-title":"Tracheobronchial function in health and disease. Effect of mucolytic substances","volume":"40","author":"Melville","year":"1980","journal-title":"Respiration"},{"key":"10.1016\/j.jconrel.2005.09.047_bib22","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/jcp.20066","article-title":"N-acetylcysteine inhibits Na+ absorption across human nasal epithelial cells","volume":"201","author":"Rochat","year":"2004","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.jconrel.2005.09.047_bib23","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1038\/sj.gt.3301525","article-title":"Mucus altering agents as adjuncts for nonviral gene transfer to airway epithelium","volume":"8","author":"Ferrari","year":"2001","journal-title":"Gene Ther."},{"key":"10.1016\/j.jconrel.2005.09.047_bib24","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1136\/bmj.284.6312.303","article-title":"Insulin given intranasally induces hypoglycaemia in normal and diabetic subjects","volume":"284","author":"Pontiroli","year":"1982","journal-title":"Br. Med. J."},{"key":"10.1016\/j.jconrel.2005.09.047_bib25","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1136\/bmj.290.6479.1390","article-title":"Intranasal calcitonin and plasma calcium concentrations in normal subjects","volume":"290","author":"Pontiroli","year":"1985","journal-title":"Br. Med. J."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365905005250?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365905005250?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T09:30:28Z","timestamp":1683279028000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365905005250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["S0168365905005250"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2005.09.047","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2006,1]]}}}