{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:25:15Z","timestamp":1790821515246,"version":"4.1.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2006,5]]},"DOI":"10.1016\/j.jconrel.2006.01.003","type":"journal-article","created":{"date-parts":[[2006,2,22]],"date-time":"2006-02-22T07:28:35Z","timestamp":1140593315000},"page":"43-50","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Inhibition of gentamicin binding to rat renal brush-border membrane by megalin ligands and basic peptides"],"prefix":"10.1016","volume":"112","author":[{"given":"Junya","family":"Nagai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Adachi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoko","family":"Yumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikihisa","family":"Takano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2006.01.003_bib1","series-title":"Goodman and Gilman's The Pharmacological Basis of Therapeutics","first-page":"1219","article-title":"The aminoglycosides","author":"Chambers","year":"2001"},{"key":"10.1016\/j.jconrel.2006.01.003_bib2","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1128\/AAC.43.5.1003","article-title":"Aminoglycoside nephrotoxicity","volume":"43","author":"Mingeot-Leclercq","year":"1999","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jconrel.2006.01.003_bib3","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1097\/00041552-199707000-00013","article-title":"Cell biology of aminoglycoside nephrotoxicity: newer aspects","volume":"6","author":"Molitoris","year":"1997","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"10.1016\/j.jconrel.2006.01.003_bib4","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2133\/dmpk.19.159","article-title":"Targeted prevention of renal accumulation and toxicity of gentamicin by aminoglycoside binding receptor antagonists","volume":"19","author":"Nagai","year":"2004","journal-title":"Drug Metab. Pharmacokin."},{"key":"10.1016\/j.jconrel.2006.01.003_bib5","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0022-3565(25)31739-8","article-title":"Evidence for luminal uptake of gentamicin in the perfused rat kidney","volume":"210","author":"Collier","year":"1979","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.jconrel.2006.01.003_bib6","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/S0022-3565(25)38916-0","article-title":"In vivo uptake kinetics of aminoglycosides in the kidney cortex of rats","volume":"236","author":"Giuliano","year":"1986","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.jconrel.2006.01.003_bib7","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/S0022-2275(20)40692-3","article-title":"Purification of polyphosphoinositides by chromatography on immobilized neomycin","volume":"19","author":"Schacht","year":"1978","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.jconrel.2006.01.003_bib8","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/BF00455236","article-title":"Isolation of an aminoglycoside receptor from guinea pig inner ear tissues and kidney","volume":"224","author":"Schacht","year":"1979","journal-title":"Arch. Oto-Rhino-Laryngol."},{"key":"10.1016\/j.jconrel.2006.01.003_bib9","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/S0022-3565(25)33203-9","article-title":"Identification of the aminoglycoside binding site in rat renal brush border membranes","volume":"222","author":"Sastrasinh","year":"1982","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.jconrel.2006.01.003_bib10","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1172\/JCI118176","article-title":"Evidence that epithelial glycoprotein 330\/megalin mediates uptake of polybasic drugs","volume":"96","author":"Moestrup","year":"1995","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jconrel.2006.01.003_bib11","doi-asserted-by":"crossref","first-page":"F337","DOI":"10.1152\/ajprenal.2001.281.2.F337","article-title":"Role of megalin in renal handling of aminoglycosides","volume":"281","author":"Nagai","year":"2001","journal-title":"Am. J. Physiol., Renal Fluid Electrolyte Physiol."},{"key":"10.1016\/j.jconrel.2006.01.003_bib12","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1074\/jbc.M109959200","article-title":"Megalin deficiency offers protection from renal aminoglycoside accumulation","volume":"277","author":"Schmitz","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jconrel.2006.01.003_bib13","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.jconrel.2003.12.005","article-title":"Targeted prevention of renal accumulation and toxicity of gentamicin by aminoglycoside binding receptor antagonists","volume":"95","author":"Watanabe","year":"2004","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2006.01.003_bib14","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1126\/science.2255912","article-title":"gCap39, a calcium ion- and polyphosphoinositide-regulated actin capping protein","volume":"250","author":"Yu","year":"1990","journal-title":"Science"},{"key":"10.1016\/j.jconrel.2006.01.003_bib15","doi-asserted-by":"crossref","first-page":"11818","DOI":"10.1016\/S0021-9258(19)49772-X","article-title":"Phosphoinositide-binding peptides derived from the sequences of gelsolin and villin","volume":"267","author":"Janmey","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jconrel.2006.01.003_bib16","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1126\/science.290.5492.801","article-title":"Integration of multiple signals through cooperative regulation of the N-WASP-Arp2\/3 complex","volume":"290","author":"Prehoda","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.jconrel.2006.01.003_bib17","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/0005-2736(94)90118-X","article-title":"Differential sensitivity of organic anion transporters in rat renal brush-border membrane to diethyl pyrocarbonate","volume":"1192","author":"Takano","year":"1994","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jconrel.2006.01.003_bib18","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/S0024-3205(00)00704-9","article-title":"Effect of cisplatin on H+ transport by H+-ATPase and Na+\/H+ exchanger in rat renal brush-border membrane","volume":"67","author":"Shiraishi","year":"2000","journal-title":"Life Sci."},{"key":"10.1016\/j.jconrel.2006.01.003_bib19","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1046\/j.1523-1755.2002.00623.x","article-title":"Cisplatin-induced inhibition of receptor-mediated endocytosis of protein in the kidney","volume":"62","author":"Takano","year":"2002","journal-title":"Kidney Int."},{"key":"10.1016\/j.jconrel.2006.01.003_bib20","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein\u2013dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.jconrel.2006.01.003_bib21","doi-asserted-by":"crossref","first-page":"C1308","DOI":"10.1152\/ajpcell.1997.272.4.C1309","article-title":"Cellular mechanism of aminoglycoside tolerance in long-term gentamicin treatment","volume":"272","author":"Sundin","year":"1997","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.jconrel.2006.01.003_bib22","doi-asserted-by":"crossref","first-page":"9725","DOI":"10.1073\/pnas.91.21.9725","article-title":"Complete cloning and sequencing of rat gp330\/\u201cmegalin,\u201d a distinctive member of the low density lipoprotein receptor gene family","volume":"91","author":"Saito","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jconrel.2006.01.003_bib23","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/nrm778","article-title":"Megalin and cubilin: multifunctional endocytic receptors","volume":"3","author":"Christensen","year":"2002","journal-title":"Nat. Rev., Mol. Cell Biol."},{"key":"10.1016\/j.jconrel.2006.01.003_bib24","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1126\/science.3283935","article-title":"Apolipoprotein E: cholesterol transport protein with expanding role in cell biology","volume":"240","author":"Mahley","year":"1988","journal-title":"Science"}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365906000332?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365906000332?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T15:20:11Z","timestamp":1759159211000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365906000332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["S0168365906000332"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2006.01.003","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2006,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of gentamicin binding to rat renal brush-border membrane by megalin ligands and basic peptides","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2006.01.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}