{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T12:40:20Z","timestamp":1790944820288,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2006,9]]},"DOI":"10.1016\/j.jconrel.2006.06.007","type":"journal-article","created":{"date-parts":[[2006,6,15]],"date-time":"2006-06-15T09:22:19Z","timestamp":1150363339000},"page":"334-342","source":"Crossref","is-referenced-by-count":75,"title":["Improved intestinal delivery of salmon calcitonin by Lys18-amine specific PEGylation: Stability, permeability, pharmacokinetic behavior and in vivo hypocalcemic efficacy"],"prefix":"10.1016","volume":"114","author":[{"given":"Yu Seok","family":"Youn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju Young","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Hyun","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun Dong","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang Choon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2006.06.007_bib1","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0168-3659(01)00454-0","article-title":"Absorption of water-soluble compounds with different molecular weights and [Asu1.7]-eel calcitonin from various mucosal administration sites","volume":"76","author":"Yamamoto","year":"2001","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2006.06.007_bib2","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0378-5173(02)00631-2","article-title":"In vitro evaluation of polymeric excipients protecting calcitonin against degradation by intestinal serine proteases","volume":"252","author":"Guggi","year":"2003","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2006.06.007_bib3","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0168-3659(03)00299-2","article-title":"Systemic peptide delivery via the stomach: in vivo evaluation of an oral dosage from for salmon calcitonin","volume":"92","author":"Guggi","year":"2003","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2006.06.007_bib4","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1023\/A:1018819012405","article-title":"Biopharmaceutical approaches for developing and assessing oral peptide delivery strategies and systems: in vitro permeability and in vivo oral absorption of salmon calcitonin (sCT)","volume":"16","author":"Sinko","year":"1999","journal-title":"Pham. Res."},{"key":"10.1016\/j.jconrel.2006.06.007_bib5","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0169-409X(89)90018-5","article-title":"Penetration and enzymatic barriers to peptide and protein absorption","volume":"4","author":"Lee","year":"1989","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2006.06.007_bib6","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0169-409X(00)00063-6","article-title":"Oral delivery of salmon calcitonin","volume":"42","author":"Lee","year":"2000","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2006.06.007_bib7","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/nrd1067","article-title":"Challenges for the oral delivery of macromolecules","volume":"2","author":"Goldverg","year":"2003","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jconrel.2006.06.007_bib8","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0168-3659(02)00238-9","article-title":"Preparation and evaluation of proliposomes containing salmon calcitonin","volume":"84","author":"Song","year":"2002","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2006.06.007_bib9","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.ejps.2005.02.008","article-title":"A comparative study of the potential of solid triglyceride nanostructures coated with chitosan or poly(ethylene glycol) as carriers for oral calcitonin delivery","volume":"25","author":"Garcia-Fuentes","year":"2005","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2006.06.007_bib10","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jconrel.2003.05.001","article-title":"Permeation enhancing polymer in oral delivery of hydrophilic macromolecules: thiomer\/GSH systems","volume":"93","author":"Bernkop-Schnurch","year":"2003","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2006.06.007_bib11","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1023\/A:1018968611962","article-title":"Effect of various protease inhibitors on the intestinal absorption and degradation of insulin in rats","volume":"11","author":"Yamamoto","year":"1994","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2006.06.007_bib12","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0378-5173(95)04395-0","article-title":"Improvement of intestinal absorption of human calcitonin by chemical modification with fatty acids: synergistic effects of acylation and absorption enhancers","volume":"134","author":"Fujita","year":"1996","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2006.06.007_bib13","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0168-3659(03)00008-7","article-title":"Reversible lipidization for the oral delivery of salmon calcitonin","volume":"88","author":"Wang","year":"2003","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2006.06.007_bib14","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0168-3659(01)00474-6","article-title":"Targeted PEG-based bioconjugates enhance the cellular uptake and transport of a HIV-1 TAT nonapeptide","volume":"77","author":"Ramanathan","year":"2001","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2006.06.007_bib15","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jconrel.2005.03.009","article-title":"Preparation and characterization of biodegradable nanoparticles entrapping immunodominant peptide conjugated with PEG for oral tolerance induction","volume":"105","author":"Lee","year":"2005","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2006.06.007_bib16","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1023\/A:1016089503186","article-title":"Enteral bioavailability of human granulocyte colony stimulating factor conjugated with poly(ethylene glycol)","volume":"13","author":"Jensen-Pippo","year":"2006","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2006.06.007_bib17","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.ejps.2004.03.015","article-title":"Development and in vivo evaluation of an oral insulin-PEG delivery system","volume":"22","author":"Caliceti","year":"2004","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2006.06.007_bib18","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ijpharm.2003.07.015","article-title":"Calcium phosphate-PEG-insulin-casein (CAPIC) particles as oral delivery systems for insulin","volume":"277","author":"Morcol","year":"2004","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2006.06.007_bib19","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jconrel.2005.11.005","article-title":"Influence of vitamin E TPGS poly(ethylene glycol) chain length on apical efflux transporters in Caco-2 cell monolayers","volume":"111","author":"Collnot","year":"2006","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2006.06.007_bib20","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s00223-002-1051-4","article-title":"Regulation of osteoclasts by calcitonin and amphiphilic calcitonin conjugates: role of cytosolic calcium","volume":"73","author":"Komarova","year":"2003","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.jconrel.2006.06.007_bib21","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1089\/152091502760306544","article-title":"Oral insulin product hexyl-insulin monoconjugate 2 (HIM2) in type 1 diabetes mellitus: The glucose stabilization effect of HIM2","volume":"4","author":"Clement","year":"2002","journal-title":"Diabetes Technol. Ther."},{"key":"10.1016\/j.jconrel.2006.06.007_bib22","doi-asserted-by":"crossref","first-page":"421","DOI":"10.2337\/diacare.26.2.421","article-title":"Control of postprandial plasma glucose by an oral insulin product (HIM2) in patients with type 2 diabetes","volume":"26","author":"Kipnes","year":"2003","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jconrel.2006.06.007_bib23","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1021\/bc049735+","article-title":"Synthesis, characterization, and pharmacokinetic studies of PEGylated glucagon-like peptide-1","volume":"16","author":"Lee","year":"2005","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.jconrel.2006.06.007_bib24","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1023\/A:1023402123119","article-title":"N-terminal site-specific mono-PEGylation of epidermal growth factor","volume":"20","author":"Lee","year":"2003","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2006.06.007_bib25","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1023\/A:1018861616465","article-title":"Isolation, characterization, and stability of positional isomers of mono-PEGylated salmon calcitonins","volume":"16","author":"Lee","year":"1999","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2006.06.007_bib26","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1081\/PDT-100101361","article-title":"Preparation and characterization of polyethylene glycol modified salmon calcitonins","volume":"4","author":"Lee","year":"1999","journal-title":"Pharm. Dev. Technol."},{"key":"10.1016\/j.jconrel.2006.06.007_bib27","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1081\/PDT-65686","article-title":"Oral delivery of mono-PEGylated sCT (Lys18) in rats: regional difference in stability and hypocalcemic effect","volume":"10","author":"Mansoor","year":"2005","journal-title":"Pharm. Dev. Technol."},{"key":"10.1016\/j.jconrel.2006.06.007_bib28","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s00223-002-0034-9","article-title":"Intranasal delivery of PEGylated salmon calcitonins: hypocalcemic effects in rats","volume":"73","author":"Lee","year":"2003","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.jconrel.2006.06.007_bib29","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1248\/cpb.48.1921","article-title":"Pharmacokinetic disposition of polyethylene glycol-modified salmon calcitonin","volume":"48","author":"Yoo","year":"2000","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.jconrel.2006.06.007_bib30","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1002\/jps.10537","article-title":"Stability of PEGylated salmon calcitonin in nasal mucosa","volume":"93","author":"Na","year":"2004","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2006.06.007_bib31","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.chroma.2004.10.062","article-title":"Chromatographic separation and mass spectrometric identification of positional isomers of polyethylene glycol-modified growth hormone-releasing factor (1\u201329)","volume":"1061","author":"Youn","year":"2004","journal-title":"J. Chromatogr., A"},{"key":"10.1016\/j.jconrel.2006.06.007_bib32","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0378-4347(00)00599-5","article-title":"Identification of the modifying sites of mono-PEGylated salmon calcitonins by capillary electrophoresis and MALDI-TOF mass spectrometry","volume":"754","author":"Na","year":"2001","journal-title":"J. Chromatogr., B"},{"key":"10.1016\/j.jconrel.2006.06.007_bib33","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0304-4165(01)00125-8","article-title":"Discovery of a non-peptide small molecule that selectively mimics the biological actions of calcitonin","volume":"1526","author":"Katayama","year":"2001","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jconrel.2006.06.007_bib34","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.regpep.2005.01.010","article-title":"Dose-linear pharmacokinetics, tissue distribution, and excretion of a recombinant fusion protein 125I-GST-TatdMt possessing potent anti-obesity activity","volume":"129","author":"Shin","year":"2005","journal-title":"Regul. Pept."},{"key":"10.1016\/j.jconrel.2006.06.007_bib35","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1016\/j.biocel.2005.01.014","article-title":"Carbohydrate-specifically polyethylene glycol-modified ricin A-chain with improved therapeutic potential","volume":"37","author":"Youn","year":"2005","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.jconrel.2006.06.007_bib36","first-page":"165","article-title":"Effect of surfactants to nasal absorption of insulin in rats","volume":"9","author":"Hirai","year":"1994","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2006.06.007_bib37","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0167-0115(98)00155-4","article-title":"Biological activity of GLP-1-analogues with N-terminal modifications","volume":"79","author":"Siegel","year":"1999","journal-title":"Regul. Pept."},{"issue":"S1","key":"10.1016\/j.jconrel.2006.06.007_bib38","first-page":"T2162","article-title":"Pulmonary delivery of Lys18-mono-PEGylated salmon calcitonin","volume":"6","author":"Youn","year":"2004","journal-title":"AAPS J."},{"key":"10.1016\/j.jconrel.2006.06.007_bib39","series-title":"The Calcitonins: Physiology and Pharmacology","author":"Azria","year":"1989"}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016836590600280X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016836590600280X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T13:22:03Z","timestamp":1547558523000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016836590600280X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["S016836590600280X"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2006.06.007","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2006,9]]}}}