{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T19:13:10Z","timestamp":1790968390238,"version":"4.1.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2007,3]]},"DOI":"10.1016\/j.jconrel.2006.11.016","type":"journal-article","created":{"date-parts":[[2006,11,30]],"date-time":"2006-11-30T14:34:49Z","timestamp":1164897289000},"page":"65-77","source":"Crossref","is-referenced-by-count":108,"title":["Novel glycidyl methacrylated dextran (Dex-GMA)\/gelatin hydrogel scaffolds containing microspheres loaded with bone morphogenetic proteins: Formulation and characteristics"],"prefix":"10.1016","volume":"118","author":[{"given":"Fa-Ming","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Min","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Hua","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin-Tao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Fen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2006.11.016_bib1","doi-asserted-by":"crossref","first-page":"681","DOI":"10.3349\/ymj.2000.41.6.681","article-title":"Tissue restoration, tissue engineering and regenerative medicine","volume":"41","author":"Suh","year":"2000","journal-title":"Yonsei Med. J."},{"key":"10.1016\/j.jconrel.2006.11.016_bib2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1586\/17434440.3.1.29","article-title":"Growth factor-delivery systems for tissue engineering: a materials perspective","volume":"3","author":"Vasita","year":"2006","journal-title":"Expert Rev. Med. Devices"},{"key":"10.1016\/j.jconrel.2006.11.016_bib3","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0169-409X(01)00203-4","article-title":"Environment-sensitive hydrogels for drug delivery","volume":"53","author":"Qiu","year":"2001","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2006.11.016_bib4","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0939-6411(00)00090-4","article-title":"Hydrogels in pharmaceutical formulations","volume":"50","author":"Peppas","year":"2000","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.jconrel.2006.11.016_bib5","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1021\/cr000108x","article-title":"Hydrogels for tissue engineering","volume":"101","author":"Lee","year":"2001","journal-title":"Chem. Rev."},{"key":"10.1016\/j.jconrel.2006.11.016_bib6","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0169-409X(01)00239-3","article-title":"Hydrogels for biomedical applications","volume":"54","author":"Hoffman","year":"2002","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2006.11.016_bib7","doi-asserted-by":"crossref","first-page":"4307","DOI":"10.1016\/S0142-9612(02)00175-8","article-title":"Photopolymerizable hydrogels for tissue engineering applications","volume":"23","author":"Nguyen","year":"2002","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2006.11.016_bib8","doi-asserted-by":"crossref","first-page":"4337","DOI":"10.1016\/S0142-9612(03)00340-5","article-title":"Hydrogels for tissue engineering: scaffold design variables and applications","volume":"24","author":"Drury","year":"2003","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2006.11.016_bib9","doi-asserted-by":"crossref","first-page":"5413","DOI":"10.1073\/pnas.0737381100","article-title":"Engineering cell-invasion characteristics","volume":"100","author":"Lutolf","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jconrel.2006.11.016_bib10","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.biomaterials.2004.02.018","article-title":"Characterization of protein release from photocrosslinkable hyaluronic acid\u2013polyethylene glycol hydrogel tissue engineering scaffolds","volume":"26","author":"Leach","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2006.11.016_bib11","doi-asserted-by":"crossref","first-page":"322","DOI":"10.3171\/spi.2004.1.3.0322","article-title":"Mechanically engineered hydrogel scaffolds for axonal growth and angiogenesis after transplantation in spinal cord injury","volume":"1","author":"Bakshi","year":"2004","journal-title":"J. Neurosurg. Spine"},{"key":"10.1016\/j.jconrel.2006.11.016_bib12","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1007\/s11095-005-4589-9","article-title":"Insulin-like growth factor I-releasing alginate\u2013tricalciumphosphate composites for bone regeneration","volume":"22","author":"Luginbuehl","year":"2005","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2006.11.016_bib13","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1016\/j.biomaterials.2005.08.013","article-title":"Controlled release of bioactive TGF-beta 1 from microspheres embedded within biodegradable hydrogels","volume":"27","author":"DeFail","year":"2006","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2006.11.016_bib14","doi-asserted-by":"crossref","first-page":"2468","DOI":"10.1016\/j.biomaterials.2005.11.019","article-title":"Delivery of basic fibroblast growth factor (bFGF) from photoresponsive hydrogel scaffolds","volume":"27","author":"Andreopoulos","year":"2006","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2006.11.016_bib15","doi-asserted-by":"crossref","first-page":"5085","DOI":"10.1016\/j.biomaterials.2005.01.020","article-title":"Bovine BMP osteoinductive potential enhanced by functionalized dextran-derived hydrogels","volume":"26","author":"Maire","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2006.11.016_bib16","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1002\/(SICI)1097-4636(2000)53:3<258::AID-JBM11>3.0.CO;2-O","article-title":"Pore structure analysis of swollen dextran methacrylate hydrogels by SEM and mercury intrusion porosimetry","volume":"53","author":"Kim","year":"2000","journal-title":"J. Biomed. Mater. Res., B Appl. Biomater."},{"key":"10.1016\/j.jconrel.2006.11.016_bib17","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1021\/bm005574a","article-title":"Pore sizes in hydrated dextran microspheres","volume":"1","author":"Stenekes","year":"2000","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.jconrel.2006.11.016_bib18","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1023\/B:JMSM.0000036274.83104.fe","article-title":"Synthesis and characterization of partially biodegradable and thermosensitive hydrogel","volume":"15","author":"Zhang","year":"2004","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"10.1016\/j.jconrel.2006.11.016_bib19","doi-asserted-by":"crossref","first-page":"4719","DOI":"10.1016\/j.biomaterials.2003.11.040","article-title":"Synthesis and characterization of partially biodegradable, temperature and pH sensitive Dex-MA\/PNIPAAm hydrogels","volume":"25","author":"Zhang","year":"2004","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2006.11.016_bib20","doi-asserted-by":"crossref","first-page":"7436","DOI":"10.1016\/j.biomaterials.2005.05.054","article-title":"Macroporous interconnected dextran scaffolds of controlled porosity for tissue-engineering applications","volume":"26","author":"Levesque","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2006.11.016_bib21","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/jbm.b.30394","article-title":"Structural analysis of dextran-based hydrogels obtained chemoenzymatically","volume":"77","author":"Ferreira","year":"2006","journal-title":"J. Biomed. Mater. Res., B Appl. Biomater."},{"key":"10.1016\/j.jconrel.2006.11.016_bib22","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1002\/jbm.a.30647","article-title":"Porous gelatin\u2013chondroitin\u2013hyaluronate tri-copolymer scaffold containing microspheres loaded with TGF-beta1 induces differentiation of mesenchymal stem cells in vivo for enhancing cartilage repair","volume":"77","author":"Fan","year":"2006","journal-title":"J. Biomed. Mater. Res., A"},{"key":"10.1016\/j.jconrel.2006.11.016_bib23","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0168-3659(03)00258-X","article-title":"In vitro release of transforming growth factor-beta 1 from gelatin microparticles encapsulated in biodegradable, injectable oligo(poly(ethylene glycol) fumarate) hydrogels","volume":"91","author":"Holland","year":"2003","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2006.11.016_bib24","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jconrel.2004.07.004","article-title":"Dual growth factor delivery from degradable oligo(poly(ethylene glycol) fumarate) hydrogel scaffolds for cartilage tissue engineering","volume":"101","author":"Holland","year":"2005","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2006.11.016_bib25","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.bone.2004.02.027","article-title":"Dual growth factor delivery and controlled scaffold degradation enhance in vivo bone formation by transplanted bone marrow stromal cells","volume":"35","author":"Simmons","year":"2004","journal-title":"Bone"},{"key":"10.1016\/j.jconrel.2006.11.016_bib26","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1016\/S0142-9612(00)00057-0","article-title":"Preparation of interpenetrating networks of gelatin and dextran as degradable biomaterials","volume":"21","author":"Kosmala","year":"2000","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2006.11.016_bib27","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0969-806X(98)00324-7","article-title":"Thermally controlled protein release from gelatin\u2013dextran hydrogels","volume":"55","author":"Aso","year":"1999","journal-title":"Radiat. Phys. Chem."},{"key":"10.1016\/j.jconrel.2006.11.016_bib28","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.jconrel.2005.09.023","article-title":"Gelatin as a delivery vehicle for the controlled release of bioactive molecules","volume":"109","author":"Young","year":"2005","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2006.11.016_bib29","doi-asserted-by":"crossref","first-page":"4375","DOI":"10.1016\/S0142-9612(03)00337-5","article-title":"Controlled release by biodegradable hydrogels enhances the ectopic bone formation of bone morphogenetic protein","volume":"24","author":"Yamamoto","year":"2003","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2006.11.016_bib30","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jconrel.2006.03.011","article-title":"Aminated gelatin microspheres as a nasal delivery system for peptide drugs: evaluation of in vitro release and in vivo insulin absorption in rats","volume":"113","author":"Wang","year":"2006","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2006.11.016_bib31","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0168-3659(97)00257-5","article-title":"Controlled delivery of antibacterial proteins from biodegradable matrices","volume":"53","author":"Kuijpers","year":"1998","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2006.11.016_bib32","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ijpharm.2005.09.024","article-title":"Release of bioactive BMP from dextran-derived microspheres: A novel delivery concept","volume":"307","author":"Chen","year":"2006","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2006.11.016_bib33","doi-asserted-by":"crossref","first-page":"3411","DOI":"10.1021\/ma961764v","article-title":"Reaction of dextran with glycidyl methacrylate: an unexpected transesterification","volume":"30","author":"van Dijk-Wolthuis","year":"1997","journal-title":"Macromolecules"},{"key":"10.1016\/j.jconrel.2006.11.016_bib34","doi-asserted-by":"crossref","first-page":"6235","DOI":"10.1016\/S0032-3861(97)00189-4","article-title":"A new class of polymerizable dextrans with hydrolyzable groups: hydroxyethyl methacrylated dextran with and without oligolactate spacer","volume":"38","author":"van Dijk-Wolthuis","year":"1997","journal-title":"Polymer"},{"key":"10.1016\/j.jconrel.2006.11.016_bib35","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.jconrel.2006.05.014","article-title":"Enhancement of periodontal tissue regeneration by locally controlled delivery of insulin-like growth factor-I from dextran-co-gelatin microspheres","volume":"114","author":"Chen","year":"2006","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2006.11.016_bib36","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1073\/pnas.7.4.115","article-title":"Note on a method of determining the distribution of pore sizes in a porous material","volume":"7","author":"Washburn","year":"1921","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jconrel.2006.11.016_bib37","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1163\/156856298X00091","article-title":"Heterogeneous PHPMA hydrogels for tissue repair and axonal regeneration in the injured spinal cord","volume":"9","author":"Woerly","year":"1998","journal-title":"J. Biomater. Sci., Polym. Ed."},{"key":"10.1016\/j.jconrel.2006.11.016_bib38","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0142-9612(02)00009-1","article-title":"Assessment of the cytotoxicity of photocrosslinked dextran and hyaluronan-based hydrogels to vascular smooth muscle cells","volume":"23","author":"Trudel","year":"2002","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2006.11.016_bib39","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1002\/jbm.a.30122","article-title":"Fabrication of biodegradable elastomeric scaffolds with sub-micron morphologies","volume":"70","author":"Stankus","year":"2004","journal-title":"J. Biomed. Mater. Res., A"},{"key":"10.1016\/j.jconrel.2006.11.016_bib40","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1002\/(SICI)1097-4636(199811)42:2<312::AID-JBM17>3.0.CO;2-K","article-title":"In vitro and in vivo degradation of poly(propylene fumarate-co-ethylene glycol) hydrogels","volume":"42","author":"Suggs","year":"1998","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.jconrel.2006.11.016_bib41","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0927-7765(99)00086-7","article-title":"Effect of polysaccharide structure on protein adsorption","volume":"17","author":"McArthur","year":"2000","journal-title":"Colloids Surf., B"},{"key":"10.1016\/j.jconrel.2006.11.016_bib42","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1002\/1097-4636(20010905)56:3<390::AID-JBM1108>3.0.CO;2-L","article-title":"Immobilized RGD peptides on surfaces-grafted dextran promote biospecific cell attachment","volume":"56","author":"Massia","year":"2001","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.jconrel.2006.11.016_bib43","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0168-3659(98)00193-X","article-title":"Controlled release of a model protein from enzymatically degrading dextran microspheres","volume":"59","author":"Franssen","year":"1999","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2006.11.016_bib44","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s11095-005-8417-z","article-title":"Thermoresponsive gelatin\/monomethoxy poly(ethylene glycol)\u2013poly(d,l-lactide) hydrogels: formulation, characterization, and antibacterial drug delivery","volume":"23","author":"Yang","year":"2006","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2006.11.016_bib45","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0168-3659(97)00247-2","article-title":"Dual-stimuli-responsive drug release from interpenetrating polymer network-structured hydrogels of gelatin and dextran","volume":"54","author":"Kurisawa","year":"1998","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2006.11.016_bib46","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1159\/000088212","article-title":"Preparation and biological characteristics of recombinant human bone morphogenetic protein-2-loaded dextran-co-gelatin hydrogel microspheres, in vitro and in vivo studies","volume":"75","author":"Chen","year":"2005","journal-title":"Pharmacology"},{"key":"10.1016\/j.jconrel.2006.11.016_bib47","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1111\/j.1745-7254.2005.00180.x","article-title":"Preparation of recombinant human bone morphogenetic protein-2 loaded dextran-based microspheres and their characteristics","volume":"26","author":"Chen","year":"2005","journal-title":"Acta Pharmacol. Sin."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365906006766?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365906006766?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,11]],"date-time":"2019-01-11T06:59:09Z","timestamp":1547189949000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365906006766"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,3]]}},"alternative-id":["S0168365906006766"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2006.11.016","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2007,3]]}}}