{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:43:48Z","timestamp":1790228628211,"version":"4.1.0"},"reference-count":53,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2007,7]]},"DOI":"10.1016\/j.jconrel.2007.04.002","type":"journal-article","created":{"date-parts":[[2007,4,17]],"date-time":"2007-04-17T11:23:32Z","timestamp":1176809012000},"page":"70-78","source":"Crossref","is-referenced-by-count":139,"title":["Biodegradable elastomeric scaffolds with basic fibroblast growth factor release"],"prefix":"10.1016","volume":"120","author":[{"given":"Jianjun","family":"Guan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Stankus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R.","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2007.04.002_bib1","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1126\/science.284.5413.489","article-title":"Functional arteries grown in vitro","volume":"284","author":"Niklason","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.jconrel.2007.04.002_bib2","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/S1010-7940(01)00706-0","article-title":"Tissue engineering of small caliber vascular grafts","volume":"20","author":"Hoerstrup","year":"2001","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"10.1016\/j.jconrel.2007.04.002_bib3","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1096\/fj.01-0826com","article-title":"Development of a hybrid cardiovascular graft using a tissue engineering approach","volume":"16","author":"Tiwari","year":"2002","journal-title":"FASEB J."},{"key":"10.1016\/j.jconrel.2007.04.002_bib4","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1023\/B:ABME.0000012741.85600.f1","article-title":"Tissue engineering of ovine aortic blood vessel substitutes using applied shear stress and enzymatically derived vascular smooth muscle cells","volume":"32","author":"Opitz","year":"2004","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.jconrel.2007.04.002_bib5","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.1021\/bm0503322","article-title":"Synthesis, characterization and cytocompatibility of polyurethaneurea elastomers with designed elastase sensitivity","volume":"6","author":"Guan","year":"2005","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.jconrel.2007.04.002_bib6","doi-asserted-by":"crossref","first-page":"3961","DOI":"10.1016\/j.biomaterials.2004.10.018","article-title":"Preparation and characterization of highly porous, biodegradable polyurethane scaffolds for soft tissue applications","volume":"26","author":"Guan","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2007.04.002_bib7","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1038\/nbt0602-602","article-title":"A tough biodegradable elastomer","volume":"20","author":"Wang","year":"2002","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jconrel.2007.04.002_bib8","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1002\/adma.200306264","article-title":"Novel citric acid-based biodegradable elastomers for tissue engineering","volume":"16","author":"Yang","year":"2004","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2007.04.002_bib9","series-title":"An Introduction to Tissue\u2013Biomaterial Interactions","first-page":"127","author":"Dee","year":"2002"},{"key":"10.1016\/j.jconrel.2007.04.002_bib10","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1002\/jbm.a.10542","article-title":"Enhancing the vascularization of three-dimensional porous alginate scaffolds by incorporating controlled release basic fibroblast growth factor microspheres","volume":"65A","author":"Perets","year":"2003","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.jconrel.2007.04.002_bib11","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/bit.10594","article-title":"High-density seeding of myocyte cells for cardiac tissue engineering","volume":"82","author":"Radisic","year":"2003","journal-title":"Biotech. Bioeng."},{"key":"10.1016\/j.jconrel.2007.04.002_bib12","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1002\/bit.260420606","article-title":"Prevascularization of porous biodegradable polymers","volume":"42","author":"Mikos","year":"1993","journal-title":"Biotech. Bioeng."},{"key":"10.1016\/j.jconrel.2007.04.002_bib13","first-page":"3425","article-title":"Transplantation of hepatocytes using porous, biodegradable sponges","volume":"26","author":"Mooney","year":"1994","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.jconrel.2007.04.002_bib14","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1002\/jbm.1258","article-title":"Adsorption and release properties of growth factors from biodegradable implants","volume":"59","author":"Ziegler","year":"2002","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.jconrel.2007.04.002_bib15","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jconrel.2006.01.011","article-title":"Nano-fibrous scaffold for controlled delivery of recombinant human PDGF-BB","volume":"112","author":"Wei","year":"2006","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2007.04.002_bib16","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1016\/S0142-9612(00)00120-4","article-title":"Sustained release of vascular endothelial growth factor from mineralized poly(lactide-co-glycolide) scaffolds for tissue engineering","volume":"21","author":"Murphy","year":"2000","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2007.04.002_bib17","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1080\/10717540490493961","article-title":"Solvent-free protein encapsulation within biodegradable polymer foams","volume":"11","author":"Hile","year":"2004","journal-title":"Drug Deliv."},{"key":"10.1016\/j.jconrel.2007.04.002_bib18","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/1097-4636(20000905)51:3<383::AID-JBM12>3.0.CO;2-D","article-title":"Development and in vitro characterization of vascular endothelial growth factor (VEGF)-loaded poly(dl-lactic-co-glycolic acid)\/poly(ethylene glycol) microspheres using a solid encapsulation\/single emulsion\/solvent extraction technique","volume":"51","author":"King","year":"2000","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.jconrel.2007.04.002_bib19","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/jcp.1041280317","article-title":"Heparin protects basic and acidic FGF from inactivation","volume":"128","author":"Gospodarowicz","year":"1986","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.jconrel.2007.04.002_bib20","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1210\/edrv-8-2-95","article-title":"Structural characterization and biological function of fibroblast growth factor","volume":"8","author":"Gospodarowicz","year":"1987","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.jconrel.2007.04.002_bib21","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.jconrel.2005.03.023","article-title":"Control of basic fibroblast growth factor release from fibrin gel with heparin and concentrations of fibrinogen and thrombin","volume":"105","author":"Jeon","year":"2005","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2007.04.002_bib22","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1002\/jbm.10204","article-title":"Synthesis, characterization and cytocompatibility of elastomeric, biodegradable poly(ester-urethane)ureas based on poly(caprolactone) and putrescine","volume":"61","author":"Guan","year":"2002","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.jconrel.2007.04.002_bib23","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/1097-4636(200108)56:2<216::AID-JBM1086>3.0.CO;2-N","article-title":"Sustained release of basic fibroblast growth factor and angiogenesis in a novel covalently crosslinked gel of heparin and alginate","volume":"56","author":"Tanihara","year":"2001","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.jconrel.2007.04.002_bib24","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1042\/bj3260661","article-title":"Heparin inhibits the binding of basic fibroblast growth factor to cultured human aortic smooth-muscle cells","volume":"326","author":"Bono","year":"1997","journal-title":"Biochem. J."},{"key":"10.1016\/j.jconrel.2007.04.002_bib25","first-page":"185","article-title":"Isolation of vascular smooth muscle cells from a single murine aorta","volume":"23","author":"Ray","year":"2002","journal-title":"Methods Cell Sci."},{"key":"10.1016\/j.jconrel.2007.04.002_bib26","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1002\/(SICI)1097-4636(19990315)44:4<446::AID-JBM11>3.0.CO;2-F","article-title":"Poly(\u03b1-hydroxyl acids)\/hydroxyapatite porous composites for bone-tissue engineering, I. Preparation and morphology","volume":"44","author":"Zhang","year":"1999","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.jconrel.2007.04.002_bib27","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/(SICI)1097-4636(199704)35:1<107::AID-JBM11>3.0.CO;2-G","article-title":"Effect of polymer foam morphology and density on kinetics of in vitro controlled release of isoniazid from compressed foam matrices","volume":"35","author":"Hsu","year":"1997","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.jconrel.2007.04.002_bib28","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1021\/bp0100878","article-title":"Effects of filtration seeding on cell density, spatial distribution, and proliferation in nonwoven fibrous matrices","volume":"17","author":"Li","year":"2001","journal-title":"Biotechnol. Prog."},{"key":"10.1016\/j.jconrel.2007.04.002_bib29","doi-asserted-by":"crossref","first-page":"723","DOI":"10.3727\/000000001783986198","article-title":"The efficacy of prevascularization by basic FGF for hepatocyte transplantation using polymer devices in rats","volume":"10","author":"Ogawa","year":"2001","journal-title":"Cell Transplant."},{"key":"10.1016\/j.jconrel.2007.04.002_bib30","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1067\/mtc.2002.121293","article-title":"Prevascularization with gelatin microspheres containing basic fibroblast growth factor enhances the benefits of cardiomyocyte transplantation","volume":"124","author":"Sakakibara","year":"2001","journal-title":"J. Thorac Cardiovasc. Surg."},{"key":"10.1016\/j.jconrel.2007.04.002_bib31","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S0142-9612(99)00207-0","article-title":"Accelerated tissue regeneration through incorporation of basic fibroblast growth factor-impregnated gelatin microspheres into artificial dermis","volume":"21","author":"Kawai","year":"2000","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2007.04.002_bib32","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.jconrel.2005.09.023","article-title":"Gelatin as a delivery vehicle for the controlled release of bioactive molecules","volume":"109","author":"Young","year":"2005","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2007.04.002_bib33","doi-asserted-by":"crossref","first-page":"3761","DOI":"10.1016\/j.biomaterials.2003.10.026","article-title":"Denatured collagen as support for a FGF-2 delivery system: physicochemical characterizations and in vitro release kinetics and bioactivity","volume":"25","author":"Cote","year":"2004","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2007.04.002_bib34","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/0142-9612(94)90164-3","article-title":"Heparin\u2013fibroblast growth factor\u2013fibrin complex: in vitro and in vivo applications to collagen-based materials","volume":"15","author":"DeBlois","year":"1994","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2007.04.002_bib35","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/1097-4636(200108)56:2<216::AID-JBM1086>3.0.CO;2-N","article-title":"Sustained release of basic fibroblast growth factor and angiogenesis in a novel covalently crosslinked gel of heparin and alginate","volume":"56","author":"Tanihara","year":"2001","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.jconrel.2007.04.002_bib36","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/0142-9612(91)90107-L","article-title":"Controlled and modulated release of basic fibroblast growth factor","volume":"12","author":"Edelman","year":"1991","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2007.04.002_bib37","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/S0142-9612(00)00357-4","article-title":"Poly(d,l-lactide) foams modified by poly(ethylene oxide)-block-poly(d,l-lactide) copolymers and a-FGF: in vitro and in vivo evaluation for spinal cord regeneration","volume":"22","author":"Maquet","year":"2001","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2007.04.002_bib38","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1002\/jbm.a.30343","article-title":"Combined chondrocyte-copolymer implantation with slow release of basic fibroblast growth factor for tissue engineering an auricular cartilage construct","volume":"74","author":"Isogai","year":"2005","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.jconrel.2007.04.002_bib39","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1080\/10717540490493961","article-title":"Solvent-free protein encapsulation within biodegradable polymer foams","volume":"11","author":"Hile","year":"2004","journal-title":"Drug Deliv."},{"key":"10.1016\/j.jconrel.2007.04.002_bib40","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0168-3659(99)00268-0","article-title":"Active growth factor delivery from poly(d,l-lactide-co-glycolide) foams prepared in supercritical CO2","volume":"66","author":"Hile","year":"2000","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2007.04.002_bib41","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1016\/j.biomaterials.2005.11.041","article-title":"Sustained delivery of growth factors from methylidene malonate 2.1.2-based polymers","volume":"27","author":"Desire","year":"2006","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2007.04.002_bib42","series-title":"7th World Biomaterials Congress","first-page":"710","article-title":"Pore size controls angiogenesis in subcutaneously implanted porous matrices","author":"Marshall","year":"2004"},{"key":"10.1016\/j.jconrel.2007.04.002_bib43","first-page":"142","volume":"vol. 2","author":"Valenta","year":"1993"},{"key":"10.1016\/j.jconrel.2007.04.002_bib44","series-title":"Strength of Biological Materials","first-page":"115","author":"Evans","year":"1980"},{"key":"10.1016\/j.jconrel.2007.04.002_bib45","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1089\/ten.2005.11.1122","article-title":"Mechanical properties and remodeling of hybrid cardiac constructs made from heart cells, fibrin, and biodegradable, elastomeric knitted fabric","volume":"11","author":"Boublik","year":"2005","journal-title":"Tissue Eng."},{"key":"10.1016\/j.jconrel.2007.04.002_bib46","doi-asserted-by":"crossref","first-page":"3828","DOI":"10.1523\/JNEUROSCI.12-10-03828.1992","article-title":"A time course for the focal elevation of synthesis of basic fibroblast growth factor and one of its high-affinity receptors (flg) following a localized cortical brain injury","volume":"12","author":"Logan","year":"1992","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jconrel.2007.04.002_bib47","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1067\/mva.2000.106420","article-title":"Mitogenicity and release of vascular endothelial growth factor with and without heparin from fibrin glue","volume":"31","author":"Shireman","year":"2000","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.jconrel.2007.04.002_bib48","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1093\/oxfordjournals.bmb.a072333","article-title":"Fibroblast growth factors","volume":"45","author":"Baird","year":"1989","journal-title":"Br. Med. Bull."},{"key":"10.1016\/j.jconrel.2007.04.002_bib49","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1146\/annurev.bi.58.070189.003043","article-title":"The heparin-binding (fibroblast) growth factor family of proteins","volume":"58","author":"Burgess","year":"1989","journal-title":"Ann. Rev. Biochem."},{"key":"10.1016\/j.jconrel.2007.04.002_bib50","doi-asserted-by":"crossref","DOI":"10.1161\/01.ATV.0000090140.20291.CE","article-title":"Ethanol inhibits fibroblast growth factor-induced proliferation of aortic smooth muscle cells","volume":"23","author":"Ghiselli","year":"2003","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.jconrel.2007.04.002_bib51","doi-asserted-by":"crossref","first-page":"10999","DOI":"10.1021\/bi00202a020","article-title":"Diminished heparin-binding of a basic fibroblast growth-factor mutant is associated with reduced receptor-binding, mitogenesis, plasminogen-activator induction, and in-vitro angiogenesis","volume":"33","author":"Li","year":"1994","journal-title":"Biochemistry"},{"key":"10.1016\/j.jconrel.2007.04.002_bib52","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1126\/science.271.5252.1116","article-title":"Heparin structure and interactions with basic fibroblast growth factor","volume":"271","author":"Faham","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.jconrel.2007.04.002_bib53","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1042\/bj3260661","article-title":"Heparin inhibits the binding of basic fibroblast growth factor to cultured juman aortic smooth-muscle cells","volume":"326","author":"Bono","year":"1997","journal-title":"Biochem. J."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365907001770?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365907001770?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,27]],"date-time":"2019-04-27T06:37:54Z","timestamp":1556347074000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365907001770"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7]]},"references-count":53,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2007,7]]}},"alternative-id":["S0168365907001770"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2007.04.002","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2007,7]]}}}