{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T18:17:12Z","timestamp":1763662632474},"reference-count":26,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2007,7]]},"DOI":"10.1016\/j.jconrel.2007.04.006","type":"journal-article","created":{"date-parts":[[2007,4,19]],"date-time":"2007-04-19T11:28:22Z","timestamp":1176982102000},"page":"88-94","source":"Crossref","is-referenced-by-count":18,"title":["Influence of fillers in powder formulations containing N-acetyl-l-cysteine on nasal peptide absorption"],"prefix":"10.1016","volume":"120","author":[{"given":"Takahiro","family":"Matsuyama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Morita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Horikiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Yamahara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Yoshino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2007.04.006_bib1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0169-409X(97)00060-4","article-title":"Intranasal drug delivery","volume":"29","author":"Husaain","year":"1998","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2007.04.006_bib2","doi-asserted-by":"crossref","first-page":"299","DOI":"10.2165\/00003088-198917050-00001","article-title":"Intranasal drug delivery: potential advantages and limitations from a clinical pharmacokinetic perspective","volume":"17","author":"Pontiroli","year":"1989","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.jconrel.2007.04.006_bib3","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0169-409X(97)00062-8","article-title":"Peptide hormones: review of current and emerging uses by nasal delivery","volume":"29","author":"Pontiroli","year":"1998","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2007.04.006_bib4","doi-asserted-by":"crossref","first-page":"7419","DOI":"10.1073\/pnas.82.21.7419","article-title":"Nasal absorption of insulin: enhancement by hydrophobic bile salts","volume":"82","author":"Gordon","year":"1985","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jconrel.2007.04.006_bib5","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/jps.2600760502","article-title":"Effects of sodium taurodihydrofusidate on nasal absorption of insulin in sheep","volume":"76","author":"Longenecker","year":"1987","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2007.04.006_bib6","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1023\/A:1018992716621","article-title":"The bioavailability of intranasal salmon calcitonin in healthy volunteers with and without a permeation enhancer","volume":"11","author":"Lee","year":"1994","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2007.04.006_bib7","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1248\/bpb1978.10.624","article-title":"Studies on the promoting effects of medium chain fatty acid salts on the nasal absorption of insulin in rats","volume":"10","author":"Mishima","year":"1987","journal-title":"J. Pharmacobio-dyn."},{"key":"10.1016\/j.jconrel.2007.04.006_bib8","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0378-5173(81)90010-7","article-title":"Mechanisms for the enhancement of the nasal absorption of insulin by surfactants","volume":"9","author":"Hirai","year":"1981","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2007.04.006_bib9","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1056\/NEJM198504253121702","article-title":"Intranasal aerosolized insulin: mixed-meal studies and long-term use in type I diabetes","volume":"312","author":"Salzman","year":"1985","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jconrel.2007.04.006_bib10","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1023\/A:1013330815253","article-title":"Enhanced bioavailability of calcitonin formulated with alkylglycosides following nasal and ocular administration in rats","volume":"18","author":"Ahsan","year":"2001","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2007.04.006_bib11","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1023\/A:1018999414088","article-title":"Nasal insulin delivery with dimethyl-beta-cyclodextrin as an absorption enhancer in rabbits: powder more effective than liquid formulations","volume":"10","author":"Schipper","year":"1993","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2007.04.006_bib12","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1007\/BF00318047","article-title":"Methylated beta-cyclodextrins are able to improve the nasal absorption of salmon calcitonin","volume":"56","author":"Schipper","year":"1995","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.jconrel.2007.04.006_bib13","series-title":"Drug Permeation Enhancement, Theory and Application","first-page":"345","article-title":"Toxicological evaluation of intranasal peptide and protein drugs","author":"Dorado","year":"1994"},{"key":"10.1016\/j.jconrel.2007.04.006_bib14","first-page":"91","article-title":"Mucosal penetration enhancers for facilitation of peptide and protein drug absorption","volume":"8","author":"Lee","year":"1991","journal-title":"Crit. Rev. Ther. Drug Carr. Syst."},{"key":"10.1016\/j.jconrel.2007.04.006_bib15","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.jconrel.2005.09.047","article-title":"Enhancement of nasal absorption of large molecular weight compounds by combination of mucolytic agent and nonionic surfactant","volume":"110","author":"Matsuyama","year":"2006","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2007.04.006_bib16","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jconrel.2006.08.004","article-title":"Improved nasal absorption of salmon calcitonin by powder formulation with N-acetyl-l-cysteine as a mucolytic agent","volume":"115","author":"Matsuyama","year":"2006","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2007.04.006_bib17","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1023\/A:1019881706159","article-title":"Insoluble powder formulation as an effective nasal drug delivery system","volume":"19","author":"Ishikawa","year":"2002","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2007.04.006_bib18","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0378-5173(81)90010-7","article-title":"Mechanisms for the enhancement of the nasal absorption of insulin by surfactants","volume":"9","author":"Hirai","year":"1981","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2007.04.006_bib19","series-title":"The 16th Symposium on Particulate Preparations and Designs","first-page":"163","article-title":"Stabilization of production for drug product containing herbal medicine by agitating granulation","author":"Takeda","year":"1999"},{"key":"10.1016\/j.jconrel.2007.04.006_bib20","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0378-5173(01)00736-0","article-title":"Improved nasal bioavailability of elcatonin by insoluble powder formulation","volume":"224","author":"Ishikawa","year":"2001","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2007.04.006_bib21","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0168-3659(02)00034-2","article-title":"Mucoadhesive beclomethasone microspheres for powder inhalation: their pharmacokinetics and pharmacodynamics evaluation","volume":"80","author":"Sakagami","year":"2002","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2007.04.006_bib22","first-page":"191","article-title":"Nasal drug delivery: trends and perspectives","volume":"vol. 10","author":"Merkus","year":"1994"},{"key":"10.1016\/j.jconrel.2007.04.006_bib23","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1159\/000194301","article-title":"Tracheobronchial function in health and disease. Effect of mucolytic substances","volume":"40","author":"Melville","year":"1980","journal-title":"Respiration"},{"key":"10.1016\/j.jconrel.2007.04.006_bib24","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1023\/A:1014849630520","article-title":"Impact of regional intestinal pH modulation on absorption of peptide drugs: oral absorption studies of salmon calcitonin in beagle dogs","volume":"16","author":"Lee","year":"1999","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2007.04.006_bib25","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1056\/NEJM198504253121702","article-title":"Intranasal aerosolized insulin: mixed-meal studies and long-term use in type I diabetes","volume":"312","author":"Salzman","year":"1985","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jconrel.2007.04.006_bib26","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/jps.2600760502","article-title":"Effects of sodium taurodihydrofusidate on nasal absorption of insulin in sheep","volume":"76","author":"Longenecker","year":"1987","journal-title":"J. Pharm. Sci."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365907001812?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365907001812?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,27]],"date-time":"2019-04-27T11:37:55Z","timestamp":1556365075000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365907001812"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7]]},"references-count":26,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2007,7]]}},"alternative-id":["S0168365907001812"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2007.04.006","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2007,7]]}}}