{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T03:37:26Z","timestamp":1792467446414,"version":"4.5.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1016\/j.jconrel.2011.01.026","type":"journal-article","created":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T04:14:54Z","timestamp":1296533694000},"page":"155-161","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"title":["Dectin-1 targeting delivery of TNF-\u03b1 antisense ODNs complexed with \u03b2-1,3-glucan protects mice from LPS-induced hepatitis"],"prefix":"10.1016","volume":"151","author":[{"given":"Shinichi","family":"Mochizuki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Sakurai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2011.01.026_bb0005","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1073\/pnas.75.1.280","article-title":"Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide","volume":"75","author":"Zamecnik","year":"1978","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.jconrel.2011.01.026_bb0010","doi-asserted-by":"crossref","first-page":"9087","DOI":"10.1038\/sj.onc.1207231","article-title":"Antisense oligonucleotide-based therapeutics for cancer","volume":"22","author":"Dean","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.jconrel.2011.01.026_bb0015","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/j.1440-1681.2006.04403.x","article-title":"Antisense oligonucleotides: from design to therapeutic application","volume":"33","author":"Chan","year":"2006","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.jconrel.2011.01.026_bb0020","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.2174\/1381612054546752","article-title":"Oligonucleotides as anticancer agents: from the benchside to the clinic and beyond","volume":"11","author":"Coppelli","year":"2005","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.jconrel.2011.01.026_bb0025","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/nrd2742","article-title":"Knocking down barriers: advances in siRNA delivery","volume":"8","author":"Whitehead","year":"2009","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jconrel.2011.01.026_bb0030","first-page":"17","article-title":"Clinical effect of sizofiran combined with irradiation in cervical cancer patients: a randomized controlled study. Cooperative Study Group on SPG for Gynecological Cancer","volume":"22","author":"Noda","year":"1992","journal-title":"Jpn J. Clin. Oncol."},{"key":"10.1016\/j.jconrel.2011.01.026_bb0035","doi-asserted-by":"crossref","first-page":"4520","DOI":"10.1021\/ja0000145","article-title":"Molecular recognition of adenine, cytosine, and uracil in a single-stranded RNA by a natural polysaccharide: schizophyllan","volume":"122","author":"Sakurai","year":"2000","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jconrel.2011.01.026_bb0040","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1002\/cbdv.200490073","article-title":"Proposal of a new hydrogen-bonding form to maintain curdlan triple helix","volume":"1","author":"Miyoshi","year":"2004","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.jconrel.2011.01.026_bb0045","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1021\/bm000121r","article-title":"Polysaccharide\u2013polynucleotide complexes. 2. Complementary polynucleotide mimic behavior of the natural polysaccharide schizophyllan in the macromolecular complex with single-stranded RNA and DNA","volume":"2","author":"Sakurai","year":"2001","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.jconrel.2011.01.026_bb0050","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1002\/pol.1980.180180314","article-title":"Triple helix of a schizophyllum commune polysaccharide in aqueous solution","volume":"18","author":"Norisuye","year":"1980","journal-title":"J. Polym. Sci., Polym. Phys. Ed."},{"key":"10.1016\/j.jconrel.2011.01.026_bb0055","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1021\/ma00236a006","article-title":"Triple helix of Schizophyllum commune polysaccharide in dilute solution. 5. Light scattering and refractometry in mixtures of water and dimethyl sulfoxide","volume":"16","author":"Sato","year":"1983","journal-title":"Macromolecules"},{"key":"10.1016\/j.jconrel.2011.01.026_bb0060","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/35092620","article-title":"Immune recognition. A new receptor for beta-glucans","volume":"413","author":"Brown","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.jconrel.2011.01.026_bb0065","doi-asserted-by":"crossref","first-page":"3876","DOI":"10.4049\/jimmunol.169.7.3876","article-title":"The beta-glucan receptor, dectin-1, is predominantly expressed on the surface of cells of the monocyte\/macrophage and neutrophil lineages","volume":"169","author":"Taylor","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.jconrel.2011.01.026_bb0070","doi-asserted-by":"crossref","first-page":"4569","DOI":"10.4049\/jimmunol.171.9.4569","article-title":"Dectin-1 expression and function are enhanced on alternatively activated and GM-CSF-treated macrophages and are negatively regulated by IL-10, dexamethasone, and lipopolysaccharide","volume":"171","author":"Willment","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.jconrel.2011.01.026_bb0075","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.bbagen.2003.10.019","article-title":"Chemically modified polysaccharide schizophyllan for antisense oligonucleotides delivery to enhance the cellular uptake efficiency","volume":"1670","author":"Matsumoto","year":"2004","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jconrel.2011.01.026_bb0080","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1084\/jem.121.1.153","article-title":"The differentiation of mononuclear phagocytes. Morphology, cytochemistry, and biochemistry","volume":"121","author":"Cohn","year":"1965","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jconrel.2011.01.026_bb0085","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1084\/jem.20030077","article-title":"Endothelial cells require STAT3 for protection against endotoxin-induced inflammation","volume":"198","author":"Kano","year":"2003","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jconrel.2011.01.026_bb0090","first-page":"469","article-title":"The effect of adherence on the in vitro induction of cytocidal activity by macrophages","volume":"61","author":"Friedman","year":"1987","journal-title":"Immunology"},{"key":"10.1016\/j.jconrel.2011.01.026_bb0095","doi-asserted-by":"crossref","first-page":"5691","DOI":"10.1093\/nar\/20.21.5691","article-title":"Intracellular availability of unmodified, phosphorothioated and liposomally encapsulated oligodeoxynucleotides for antisense activity","volume":"20","author":"Thierry","year":"1992","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jconrel.2011.01.026_bb0100","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1046\/j.1432-1033.2003.03555.x","article-title":"Antisense technologies. Improvement through novel chemical modifications","volume":"270","author":"Kurreck","year":"2003","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.jconrel.2011.01.026_bb0105","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1126\/science.3754653","article-title":"Control of cachectin (tumor necrosis factor) synthesis: mechanisms of endotoxin resistance","volume":"232","author":"Beutler","year":"1986","journal-title":"Science"},{"key":"10.1016\/j.jconrel.2011.01.026_bb0110","doi-asserted-by":"crossref","first-page":"5231","DOI":"10.1158\/1078-0432.CCR-06-0608","article-title":"Preclinical characterization of AEG35156\/GEM 640, a second-generation antisense oligonucleotide targeting X-linked inhibitor of apoptosis","volume":"12","author":"LaCasse","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.jconrel.2011.01.026_bb0115","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1084\/jem.20021890","article-title":"Dectin-1 mediates the biological effects of beta-glucans","volume":"197","author":"Brown","year":"2003","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jconrel.2011.01.026_bb0120","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1084\/jem.165.3.657","article-title":"Lethal toxicity of lipopolysaccharide and tumor necrosis factor in normal and d-galactosamine-treated mice","volume":"165","author":"Lehmann","year":"1987","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jconrel.2011.01.026_bb0125","doi-asserted-by":"crossref","first-page":"3352","DOI":"10.3748\/wjg.v12.i21.3352","article-title":"Adiponectin deficiency exacerbates lipopolysaccharide\/d-galactosamine-induced liver injury in mice","volume":"12","author":"Matsumoto","year":"2006","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.jconrel.2011.01.026_bb0130","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1034\/j.1600-0528.2002.017408.x","article-title":"Local control of the immune response in the liver","volume":"174","author":"Knolle","year":"2000","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.jconrel.2011.01.026_bb0135","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1038\/82161","article-title":"Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance","volume":"6","author":"Limmer","year":"2000","journal-title":"Nat. Med."},{"key":"10.1016\/j.jconrel.2011.01.026_bb0140","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1002\/hep.510280620","article-title":"Interleukin-10 expression and function in experimental murine liver inflammation and fibrosis","volume":"28","author":"Thompson","year":"1998","journal-title":"Hepatology"},{"key":"10.1016\/j.jconrel.2011.01.026_bb0145","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/78475","article-title":"Reduction of liver Fas expression by an antisense oligonucleotide protects mice from fulminant hepatitis","volume":"18","author":"Zhang","year":"2000","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jconrel.2011.01.026_bb0150","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/jgm.1293","article-title":"Reduction of liver tumor necrosis factor-alpha expression by targeting delivery of antisense oligonucleotides into Kupffer cells protects rats from fulminant hepatitis","volume":"11","author":"Dong","year":"2009","journal-title":"J. Gene Med."},{"key":"10.1016\/j.jconrel.2011.01.026_bb0155","first-page":"6387","article-title":"A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs","volume":"46","author":"Matsumura","year":"1986","journal-title":"Cancer Res."},{"key":"10.1016\/j.jconrel.2011.01.026_bb0160","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0065-2571(00)00013-3","article-title":"The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting","volume":"41","author":"Maeda","year":"2001","journal-title":"Adv. Enzyme Regul."},{"key":"10.1016\/j.jconrel.2011.01.026_bb0165","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/nrc903","article-title":"Ligand-targeted therapeutics in anticancer therapy","volume":"2","author":"Allen","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jconrel.2011.01.026_bb0170","doi-asserted-by":"crossref","first-page":"5971","DOI":"10.1016\/S0021-9258(19)70726-1","article-title":"Low temperature selectively inhibits fusion between pinocytic vesicles and lysosomes during heterophagy of 125I-asialofetuin by the perfused rat liver","volume":"255","author":"Dunn","year":"1980","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jconrel.2011.01.026_bb0175","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1182\/blood-2005-03-1239","article-title":"Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production","volume":"106","author":"Underhill","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.jconrel.2011.01.026_bb0180","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1021\/bc1001196","article-title":"Enhanced cytokine secretion from primary macrophages due to dectin-1 mediated uptake of CpG DNA\/\u03b2-1,3-glucan complex","volume":"22","author":"Minari","year":"2011","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.jconrel.2011.01.026_bb0185","doi-asserted-by":"crossref","first-page":"7297","DOI":"10.1073\/pnas.92.16.7297","article-title":"A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine","volume":"92","author":"Boussif","year":"1995","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.jconrel.2011.01.026_bb0190","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S1089-3261(02)00018-1","article-title":"Pathogenesis of autoimmune hepatitis","volume":"6","author":"Vergani","year":"2002","journal-title":"Clin. Liver Dis."},{"key":"10.1016\/j.jconrel.2011.01.026_bb0195","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1084\/jem.173.4.1021","article-title":"Detection of interleukin 8 and tumor necrosis factor in normal humans after intravenous endotoxin: the effect of antiinflammatory agents","volume":"173","author":"Martich","year":"1991","journal-title":"J. Exp. Med."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365911000320?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365911000320?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T15:24:53Z","timestamp":1759159493000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365911000320"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["S0168365911000320"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2011.01.026","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2011,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dectin-1 targeting delivery of TNF-\u03b1 antisense ODNs complexed with \u03b2-1,3-glucan protects mice from LPS-induced hepatitis","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2011.01.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}