{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T19:20:23Z","timestamp":1759778423950,"version":"3.38.0"},"reference-count":63,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.1016\/j.jconrel.2011.10.027","type":"journal-article","created":{"date-parts":[[2011,10,31]],"date-time":"2011-10-31T08:40:05Z","timestamp":1320050405000},"page":"215-223","source":"Crossref","is-referenced-by-count":12,"title":["Polypeptide conjugates of d-penicillamine and idarubicin for anticancer therapy"],"prefix":"10.1016","volume":"158","author":[{"given":"Saurabh","family":"Wadhwa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Russell J.","family":"Mumper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2011.10.027_bb0150","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1191\/0960327102ht213oa","article-title":"Reactive oxygen species as double-edged swords in cellular processes: low-dose cell signaling versus high-dose toxicity","volume":"21","author":"Martin","year":"2002","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.jconrel.2011.10.027_bb0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20081386","article-title":"How mitochondria produce reactive oxygen species","volume":"417","author":"Murphy","year":"2009","journal-title":"Biochem. J."},{"key":"10.1016\/j.jconrel.2011.10.027_bb0160","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1023\/B:CACO.0000036189.61607.52","article-title":"Implications of oxidative stress and cell membrane lipid peroxidation in human cancer","volume":"15","author":"Cejas","year":"2004","journal-title":"Cancer Causes Control"},{"key":"10.1016\/j.jconrel.2011.10.027_bb0165","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0891-5849(00)00302-6","article-title":"Triggering and modulation of apoptosis by oxidative stress","volume":"29","author":"Chandra","year":"2000","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jconrel.2011.10.027_bb0170","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.freeradbiomed.2007.07.003","article-title":"Copper chelation by d-penicillamine generates reactive oxygen species that are cytotoxic to human leukemia and breast cancer cells","volume":"43","author":"Gupte","year":"2007","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jconrel.2011.10.027_bb0175","first-page":"1443","article-title":"Transformed and tumor-derived human cells exhibit preferential sensitivity to the thiol antioxidants, N-acetyl cysteine and penicillamine","volume":"62","author":"Havre","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.jconrel.2011.10.027_bb0180","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1021\/bc800042s","article-title":"Enhanced intracellular delivery of the reactive oxygen species (ROS)-generating copper chelator d-penicillamine via a novel gelatin-d-penicillamine conjugate","volume":"19","author":"Gupte","year":"2008","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.jconrel.2011.10.027_bb0185","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S0090-9556(25)08745-8","article-title":"The pharmacokinetics of albumin conjugates of d-penicillamine in rats","volume":"17","author":"Joyce","year":"1989","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.jconrel.2011.10.027_bb0190","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0090-9556(25)07118-1","article-title":"The pharmacokinetics of albumin conjugates of d-penicillamine in humans","volume":"19","author":"Joyce","year":"1991","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.jconrel.2011.10.027_bb0195","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/S0006-291X(81)80199-4","article-title":"Transport of D- and l-penicillamine by mammalian cells","volume":"102","author":"Lodemann","year":"1981","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jconrel.2011.10.027_bb0200","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1021\/mp1000058","article-title":"Intracellular delivery of the reactive oxygen species generating agent d-penicillamine upon conjugation to poly-l-glutamic acid","volume":"7","author":"Wadhwa","year":"2010","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jconrel.2011.10.027_bb0205","first-page":"80","article-title":"Idarubicin: a brief overview on pharmacology and clinical use","volume":"35","author":"Borchmann","year":"1997","journal-title":"Int. J. Clin. Pharmacol. Ther."},{"key":"10.1016\/j.jconrel.2011.10.027_bb0210","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0006-2952(98)00307-4","article-title":"A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin","volume":"57","author":"Gewirtz","year":"1999","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jconrel.2011.10.027_bb0215","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1124\/pr.56.2.6","article-title":"Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity","volume":"56","author":"Minotti","year":"2004","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.jconrel.2011.10.027_bb0220","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/0014-5793(84)81130-8","article-title":"Hydroxyl radical production and DNA damage induced by anthracycline\u2013iron complex","volume":"172","author":"Muindi","year":"1984","journal-title":"FEBS Lett."},{"key":"10.1016\/j.jconrel.2011.10.027_bb0225","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1124\/mol.105.013383","article-title":"Molecular pharmacology of the interaction of anthracyclines with iron","volume":"68","author":"Xu","year":"2005","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.jconrel.2011.10.027_bb0230","doi-asserted-by":"crossref","first-page":"542","DOI":"10.2307\/3579272","article-title":"Role of Fenton chemistry in thiol-induced toxicity and apoptosis","volume":"145","author":"Held","year":"1996","journal-title":"Radiat. Res."},{"key":"10.1016\/j.jconrel.2011.10.027_bb0235","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1021\/bi00300a021","article-title":"Oxidative destruction of DNA by the adriamycin\u2013iron complex","volume":"23","author":"Eliot","year":"1984","journal-title":"Biochemistry"},{"key":"10.1016\/j.jconrel.2011.10.027_bb0240","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/nrd1088","article-title":"The dawning era of polymer therapeutics","volume":"2","author":"Duncan","year":"2003","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jconrel.2011.10.027_bb0245","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1016\/S0968-0896(99)00209-6","article-title":"Acid-sensitive polyethylene glycol conjugates of doxorubicin: preparation, in vitro efficacy and intracellular distribution","volume":"7","author":"Rodrigues","year":"1999","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.jconrel.2011.10.027_bb0250","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0168-3659(99)00141-8","article-title":"Polymeric drugs based on conjugates of synthetic and natural macromolecules. I. Synthesis and physico-chemical characterisation","volume":"64","author":"Ulbrich","year":"2000","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2011.10.027_bb0255","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0168-3659(02)00348-6","article-title":"HPMA copolymers with pH-controlled release of doxorubicin: in vitro cytotoxicity and in vivo antitumor activity","volume":"87","author":"Ulbrich","year":"2003","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2011.10.027_bb0260","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1021\/bc00017a001","article-title":"Conjugates of anticancer agents and polymers: advantages of macromolecular therapeutics in vivo","volume":"3","author":"Maeda","year":"1992","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.jconrel.2011.10.027_bb0265","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.ejpb.2008.11.010","article-title":"Polymeric drugs for efficient tumor-targeted drug delivery based on EPR-effect","volume":"71","author":"Maeda","year":"2009","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.jconrel.2011.10.027_bb0270","doi-asserted-by":"crossref","first-page":"E200","DOI":"10.1208\/aapsj0902022","article-title":"Polymer-drug conjugates as modulators of cellular apoptosis","volume":"9","author":"Vicent","year":"2007","journal-title":"AAPS J."},{"key":"10.1016\/j.jconrel.2011.10.027_bb0275","doi-asserted-by":"crossref","first-page":"458s-458s","DOI":"10.1200\/jco.2005.23.16_suppl.5012","article-title":"Phase II study of paclitaxel poliglumex (PPX)\/carboplatin (C) for 1st line induction and maintenance therapy of stage III\/IV ovarian or primary peritoneal carcinoma","volume":"23","author":"Herzog","year":"2005","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.jconrel.2011.10.027_bb0280","doi-asserted-by":"crossref","first-page":"4061","DOI":"10.1002\/anie.200462960","article-title":"Polymer therapeutics designed for a combination therapy of hormone-dependent cancer","volume":"44","author":"Vicent","year":"2005","journal-title":"Angew. Chem. Int. Ed Engl."},{"key":"10.1016\/j.jconrel.2011.10.027_bb0285","doi-asserted-by":"crossref","first-page":"12962","DOI":"10.1073\/pnas.0504274102","article-title":"Tumor-specific targeting of an anticancer drug delivery system by LHRH peptide","volume":"102","author":"Dharap","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jconrel.2011.10.027_bb0290","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/S0022-3565(25)22921-4","article-title":"Mechanism of protection afforded by polyaspartic acid against gentamicin-induced phospholipidosis. II. Comparative in vitro and in vivo studies with poly-L-aspartic, poly-l-glutamic and poly-d-glutamic acids","volume":"255","author":"Kishore","year":"1990","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.jconrel.2011.10.027_bb0295","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1021\/bc049910m","article-title":"Synthesis and characterization of poly(l-glutamic acid) gadolinium chelate: a new biodegradable MRI contrast agent","volume":"15","author":"Wen","year":"2004","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.jconrel.2011.10.027_bb0300","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/S0169-409X(02)00045-5","article-title":"Poly(l-glutamic acid) \u2014 anticancer drug conjugates","volume":"54","author":"Li","year":"2002","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2011.10.027_bb0305","doi-asserted-by":"crossref","first-page":"375","DOI":"10.2147\/nano.2006.1.4.375","article-title":"Biological and clinical characterization of paclitaxel poliglumex (PPX, CT-2103), a macromolecular polymer-drug conjugate","volume":"1","author":"Chipman","year":"2006","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.jconrel.2011.10.027_bb0310","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1097\/JTO.0b013e3181753b4b","article-title":"Phase III trial comparing paclitaxel poliglumex (CT-2103, PPX) in combination with carboplatin versus standard paclitaxel and carboplatin in the treatment of PS 2 patients with chemotherapy-naive advanced non-small cell lung cancer","volume":"3","author":"Langer","year":"2008","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.jconrel.2011.10.027_bb0315","doi-asserted-by":"crossref","first-page":"4523","DOI":"10.1200\/JCO.2004.12.043","article-title":"Phase II study of CT-2103 in patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal carcinoma","volume":"22","author":"Sabbatini","year":"2004","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.jconrel.2011.10.027_bb0320","doi-asserted-by":"crossref","first-page":"8063","DOI":"10.1021\/ja061036f","article-title":"Site-specific cleavage of RNA by a metal-free artificial nuclease attached to antisense oligonucleotides","volume":"128","author":"Gnaccarini","year":"2006","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jconrel.2011.10.027_bb0010","doi-asserted-by":"crossref","first-page":"825","DOI":"10.2147\/IJN.S13482","article-title":"Synthesis, characterization, and biological evaluation of poly(l-gamma-glutamyl-glutamine)-paclitaxel nanoconjugate","volume":"5","author":"Van","year":"2010","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.jconrel.2011.10.027_bb0015","first-page":"319","article-title":"Body condition scoring: a rapid and accurate method for assessing health status in mice","volume":"49","author":"Ullman-Cullere","year":"1999","journal-title":"Lab. Anim. Sci."},{"key":"10.1016\/j.jconrel.2011.10.027_bb0020","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.addr.2003.10.040","article-title":"Polymeric anticancer drugs with pH-controlled activation","volume":"56","author":"Ulbrich","year":"2004","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2011.10.027_bb0025","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1073\/pnas.97.2.745","article-title":"Enzymatic reduction of disulfide bonds in lysosomes: characterization of a gamma-interferon-inducible lysosomal thiol reductase (GILT)","volume":"97","author":"Arunachalam","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jconrel.2011.10.027_bb0030","doi-asserted-by":"crossref","first-page":"6567","DOI":"10.1002\/anie.201001868","article-title":"Poly(ethylene glycol) with observable shedding","volume":"49","author":"Gao","year":"2010","journal-title":"Angew. Chem. Int. Ed Engl."},{"key":"10.1016\/j.jconrel.2011.10.027_bb0035","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/BF01025358","article-title":"Cross-linking of protein by omega-maleimido alkanoyl N-hydroxysuccinimido esters","volume":"2","author":"Partis","year":"1983","journal-title":"J. Protein Chem."},{"key":"10.1016\/j.jconrel.2011.10.027_bb0040","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S0960-894X(97)00069-3","article-title":"Synthesis of new maleimide derivatives of daunorubicin and biological activity of acid labile transferrin conjugates","volume":"7","author":"Kratz","year":"1997","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.jconrel.2011.10.027_bb0045","doi-asserted-by":"crossref","first-page":"5523","DOI":"10.1021\/jm020276c","article-title":"Probing the cysteine-34 position of endogenous serum albumin with thiol-binding doxorubicin derivatives. Improved efficacy of an acid-sensitive doxorubicin derivative with specific albumin-binding properties compared to that of the parent compound","volume":"45","author":"Kratz","year":"2002","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jconrel.2011.10.027_bb0050","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0168-3659(03)00216-5","article-title":"Evaluation of an elastin-like polypeptide-doxorubicin conjugate for cancer therapy","volume":"91","author":"Dreher","year":"2003","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2011.10.027_bb0055","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1038\/nmat2569","article-title":"Self-assembling chimeric polypeptide\u2013doxorubicin conjugate nanoparticles that abolish tumours after a single injection","volume":"8","author":"MacKay","year":"2009","journal-title":"Nat. Mater."},{"key":"10.1016\/j.jconrel.2011.10.027_bb0060","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s00249-011-0673-8","article-title":"Stability and folding dynamics of polyglutamic acid","volume":"40","author":"Krejtschi","year":"2011","journal-title":"Eur. Biophys. J."},{"key":"10.1016\/j.jconrel.2011.10.027_bb0065","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1002\/bip.1964.360020507","article-title":"The dynamics of the helix-coil transition in poly-\u03b1, l-glutamic acid","volume":"2","author":"Lumry","year":"1964","journal-title":"Biopolymers"},{"key":"10.1016\/j.jconrel.2011.10.027_bb0070","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/1616-5195(20020101)2:1<43::AID-MABI43>3.0.CO;2-8","article-title":"Synthesis of HPMA copolymers containing doxorubicin bound via a hydrazone linkage. Effect of spacer on drug release and in vitro cytotoxicity","volume":"2","author":"Etrych","year":"2002","journal-title":"Macromol. Biosci."},{"key":"10.1016\/j.jconrel.2011.10.027_bb0075","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1002\/jps.20096","article-title":"Release from polymeric prodrugs: linkages and their degradation","volume":"93","author":"D'Souza","year":"2004","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2011.10.027_bb0080","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1021\/bc0255900","article-title":"Tat-conjugated synthetic macromolecules facilitate cytoplasmic drug delivery to human ovarian carcinoma cells","volume":"14","author":"Nori","year":"2003","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.jconrel.2011.10.027_bb0085","doi-asserted-by":"crossref","first-page":"690","DOI":"10.2165\/00003495-199142040-00010","article-title":"Idarubicin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in the chemotherapy of cancer","volume":"42","author":"Hollingshead","year":"1991","journal-title":"Drugs"},{"key":"10.1016\/j.jconrel.2011.10.027_bb0090","first-page":"6600","article-title":"Evaluation in vitro of adriamycin immunoconjugates synthesized using an acid-sensitive hydrazone linker","volume":"50","author":"Greenfield","year":"1990","journal-title":"Cancer Res."},{"key":"10.1016\/j.jconrel.2011.10.027_bb0095","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0168-3659(98)00186-2","article-title":"Chronic exposure to HPMA copolymer-bound adriamycin does not induce multidrug resistance in a human ovarian carcinoma cell line","volume":"59","author":"Minko","year":"1999","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2011.10.027_bb0100","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1021\/jm020022r","article-title":"Synthesis and in vivo antitumor activity of poly(l-glutamic acid) conjugates of 20S-camptothecin","volume":"46","author":"Bhatt","year":"2003","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jconrel.2011.10.027_bb0105","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jconrel.2005.03.007","article-title":"Substantial increases in idarubicin plasma concentration by liposome encapsulation mediates improved antitumor activity","volume":"105","author":"Dos Santos","year":"2005","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2011.10.027_bb0110","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1002\/jps.10129","article-title":"Pharmacokinetics and tissue distribution of idarubicin-loaded solid lipid nanoparticles after duodenal administration to rats","volume":"91","author":"Zara","year":"2002","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2011.10.027_bb0115","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s00280-006-0296-4","article-title":"In vitro and in vivo metabolism of paclitaxel poliglumex: identification of metabolites and active proteases","volume":"59","author":"Shaffer","year":"2007","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.jconrel.2011.10.027_bb0120","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0140-6736(92)93274-Q","article-title":"Idarubicin cardiotoxicity in acute myeloid leukaemia","volume":"340","author":"Chan-Lam","year":"1992","journal-title":"Lancet"},{"key":"10.1016\/j.jconrel.2011.10.027_bb0125","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1097\/00001813-199908000-00007","article-title":"Comparative cardiotoxicity of idarubicin and doxorubicin using the isolated perfused rat heart model","volume":"10","author":"Platel","year":"1999","journal-title":"Anticancer Drugs"},{"key":"10.1016\/j.jconrel.2011.10.027_bb0130","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1128\/IAI.01176-07","article-title":"In vivo fate and distribution of poly-gamma-d-glutamic acid, the capsular antigen from Bacillus anthracis","volume":"76","author":"Sutherland","year":"2008","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jconrel.2011.10.027_bb0135","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1166\/jbn.2009.1021","article-title":"Development of idarubicin and doxorubicin solid lipid nanoparticles to overcome Pgp-mediated multiple drug resistance in leukemia","volume":"5","author":"Ma","year":"2009","journal-title":"J. Biomed. Nanotechnol."},{"key":"10.1016\/j.jconrel.2011.10.027_bb0140","first-page":"6691","article-title":"Interstitial hypertension in superficial metastatic melanomas in humans","volume":"51","author":"Boucher","year":"1991","journal-title":"Cancer Res."},{"key":"10.1016\/j.jconrel.2011.10.027_bb0145","first-page":"3039","article-title":"Transport of molecules in the tumor interstitium: a review","volume":"47","author":"Jain","year":"1987","journal-title":"Cancer Res."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365911009990?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365911009990?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T13:33:48Z","timestamp":1741872828000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365911009990"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3]]},"references-count":63,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["S0168365911009990"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2011.10.027","relation":{},"ISSN":["0168-3659"],"issn-type":[{"type":"print","value":"0168-3659"}],"subject":[],"published":{"date-parts":[[2012,3]]}}}