{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:41:56Z","timestamp":1791294116879,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"crossref","award":["018 716"],"award-info":[{"award-number":["018 716"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Association Fran\u00e7aise contre les Myopathies"},{"name":"Vaincre La Mucoviscidose"},{"DOI":"10.13039\/501100004431","name":"Fondation de France","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004431","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.1016\/j.jconrel.2011.12.019","type":"journal-article","created":{"date-parts":[[2011,12,29]],"date-time":"2011-12-29T18:05:33Z","timestamp":1325181933000},"page":"461-469","source":"Crossref","is-referenced-by-count":38,"title":["Paromomycin and neomycin B derived cationic lipids: Synthesis and transfection studies"],"prefix":"10.1016","volume":"158","author":[{"given":"Mathieu","family":"M\u00e9vel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Sainlos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beno\u00eet","family":"Chatin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noufissa","family":"Oudrhiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mich\u00e8le","family":"Hauchecorne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Lambert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Vigneron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Lehn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Pitard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marie","family":"Lehn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.jconrel.2011.12.019_bb0005","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1021\/bc025557d","article-title":"Effects of structure of polyamidoamine dendrimer on gene transfer efficiency of the dendrimer conjugate with alpha-cyclodextrin","volume":"13","author":"Kihara","year":"2002","journal-title":"Bioconjug. Chem."},{"issue":"11","key":"10.1016\/j.jconrel.2011.12.019_bb0010","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1089\/hum.2005.16.1318","article-title":"Amphiphilic block copolymers promote gene delivery in vivo to pathological skeletal muscles","volume":"16","author":"Richard","year":"2005","journal-title":"Hum. Gene Ther."},{"issue":"6","key":"10.1016\/j.jconrel.2011.12.019_bb0015","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1021\/mp900096u","article-title":"Synergistic effect of low cytotoxic linear polyethylenimine and multiarm polyethylene glycol: study of physicochemical properties and in vitro gene transfection","volume":"6","author":"Namgung","year":"2009","journal-title":"Mol. Pharm."},{"issue":"6","key":"10.1016\/j.jconrel.2011.12.019_bb0020","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1021\/bm800132n","article-title":"Further investigation of lipid-substituted poly(l-Lysine) polymers for transfection of human skin fibroblasts","volume":"9","author":"Abbasi","year":"2008","journal-title":"Biomacromolecules"},{"issue":"3","key":"10.1016\/j.jconrel.2011.12.019_bb0025","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1021\/bc9801070","article-title":"Efficient gene transfer by histidylated polylysine\/pDNA complexes","volume":"10","author":"Midoux","year":"1999","journal-title":"Bioconjug. Chem."},{"issue":"2","key":"10.1016\/j.jconrel.2011.12.019_bb0030","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.jconrel.2009.12.001","article-title":"DODAG; a versatile new cationic lipid that mediates efficient delivery of pDNA and siRNA","volume":"143","author":"Mevel","year":"2010","journal-title":"J. Control. Release"},{"issue":"2","key":"10.1016\/j.jconrel.2011.12.019_bb0035","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s10709-009-9405-8","article-title":"Nature as a source of inspiration for cationic lipid synthesis","volume":"138","author":"Labas","year":"2009","journal-title":"Genetica"},{"issue":"5","key":"10.1016\/j.jconrel.2011.12.019_bb0040","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1021\/ar9703241","article-title":"Chemical approaches to triggerable lipid vesicles for drug and gene delivery","volume":"36","author":"Guo","year":"2003","journal-title":"Acc. Chem. Res."},{"issue":"18","key":"10.1016\/j.jconrel.2011.12.019_bb0045","doi-asserted-by":"crossref","first-page":"9682","DOI":"10.1073\/pnas.93.18.9682","article-title":"Guanidinium-cholesterol cationic lipids: efficient vectors for the transfection of eukaryotic cells","volume":"93","author":"Vigneron","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.jconrel.2011.12.019_bb0050","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1021\/cr800409e","article-title":"Nonviral vectors for gene delivery","volume":"109","author":"Mintzer","year":"2009","journal-title":"Chem. Rev."},{"key":"10.1016\/j.jconrel.2011.12.019_bb0225","doi-asserted-by":"crossref","unstructured":"X. Guo, L. Huang, Recent advances in non viral vectors for gene delivery. Acc Chem Res (in press) (doi:10.1021\/ar200151m).","DOI":"10.1021\/ar200151m"},{"issue":"3","key":"10.1016\/j.jconrel.2011.12.019_bb0060","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.ymthe.2004.12.006","article-title":"Formation and intracellular trafficking of lipoplexes and polyplexes","volume":"11","author":"Elouahabi","year":"2005","journal-title":"Mol. Ther."},{"issue":"2","key":"10.1016\/j.jconrel.2011.12.019_bb0065","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/S0006-3495(96)79309-8","article-title":"The role of helper lipids in cationic liposome-mediated gene transfer","volume":"71","author":"Hui","year":"1996","journal-title":"Biophys. J."},{"issue":"5","key":"10.1016\/j.jconrel.2011.12.019_bb0070","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1016\/S0006-3495(97)78282-1","article-title":"Structural and fusogenic properties of cationic liposomes in the presence of plasmid DNA","volume":"73","author":"Mok","year":"1997","journal-title":"Biophys. J."},{"issue":"2","key":"10.1016\/j.jconrel.2011.12.019_bb0075","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1039\/B514532E","article-title":"A dialkynoyl analogue of DOPE improves gene transfer of lower-charged, cationic lipoplexes","volume":"4","author":"Fletcher","year":"2006","journal-title":"Org. Biomol. Chem."},{"issue":"13","key":"10.1016\/j.jconrel.2011.12.019_bb0230","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1039\/b716247b","article-title":"A new helper phospholipid for gene delivery","author":"Prata","year":"2008","journal-title":"Chem. Commun."},{"issue":"2","key":"10.1016\/j.jconrel.2011.12.019_bb0085","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/j.1476-5381.2009.00288.x","article-title":"Chemical vectors for gene delivery: a current review on polymers, peptides and lipids containing histidine or imidazole as nucleic acids carriers","volume":"157","author":"Midoux","year":"2009","journal-title":"Br. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.jconrel.2011.12.019_bb0235","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1002\/(SICI)1521-3773(20000204)39:3<629::AID-ANIE629>3.0.CO;2-K","article-title":"Cationic phosphonolipids containing quaternary phosphonium and arsonium groups for DNA transfection with good efficiency and low cellular toxicity**","volume":"39","author":"Guenin","year":"2000","journal-title":"Angew. Chem. Int. Ed Engl."},{"issue":"15","key":"10.1016\/j.jconrel.2011.12.019_bb0095","doi-asserted-by":"crossref","first-page":"3744","DOI":"10.1021\/jm0499763","article-title":"Pyridinium cationic lipids in gene delivery: a structure\u2013activity correlation study","volume":"47","author":"Ilies","year":"2004","journal-title":"J. Med. Chem."},{"issue":"9","key":"10.1016\/j.jconrel.2011.12.019_bb0100","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1021\/bc900163s","article-title":"Anionic nucleotide\u2013lipids for in vitro DNA transfection","volume":"20","author":"Khiati","year":"2009","journal-title":"Bioconjug. Chem."},{"issue":"26","key":"10.1016\/j.jconrel.2011.12.019_bb0105","doi-asserted-by":"crossref","first-page":"14412","DOI":"10.1073\/pnas.94.26.14412","article-title":"Virus-sized self-assembling lamellar complexes between plasmid DNA and cationic micelles promote gene transfer","volume":"94","author":"Pitard","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"19","key":"10.1016\/j.jconrel.2011.12.019_bb0110","doi-asserted-by":"crossref","first-page":"3792","DOI":"10.1093\/nar\/27.19.3792","article-title":"Plasmid DNA size does not affect the physicochemical properties of lipoplexes but modulates gene transfer efficiency","volume":"27","author":"Kreiss","year":"1999","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.jconrel.2011.12.019_bb0115","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/(SICI)1521-2254(200001\/02)2:1<32::AID-JGM78>3.0.CO;2-U","article-title":"Formulations which increase the size of lipoplexes prevent serum-associated inhibition of transfection","volume":"2","author":"Turek","year":"2000","journal-title":"J. Gene Med."},{"issue":"5","key":"10.1016\/j.jconrel.2011.12.019_bb0120","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1002\/jgm.297","article-title":"Aminoglycoside-derived cationic lipids as efficient vectors for gene transfection in vitro and in vivo","volume":"4","author":"Belmont","year":"2002","journal-title":"J. Gene Med."},{"key":"10.1016\/j.jconrel.2011.12.019_bb0240","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.1002\/ejoc.200300164","article-title":"Aminoglycoside-derived cationic lipids for gene transfection: synthesis of kanamycin A derivatives","volume":"15","author":"Sainlos","year":"2003","journal-title":"Eur. J. Org. Chem."},{"issue":"6","key":"10.1016\/j.jconrel.2011.12.019_bb0130","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1002\/cbic.200400344","article-title":"Kanamycin A-derived cationic lipids as vectors for gene transfection","volume":"6","author":"Sainlos","year":"2005","journal-title":"Chembiochem"},{"issue":"23","key":"10.1016\/j.jconrel.2011.12.019_bb0135","doi-asserted-by":"crossref","first-page":"5385","DOI":"10.1021\/ja003052x","article-title":"Aminoglycoside-nucleic acid interactions: remarkable stabilization of DNA and RNA triple helices by neomycin","volume":"123","author":"Arya","year":"2001","journal-title":"J. Am. Chem. Soc."},{"issue":"39","key":"10.1016\/j.jconrel.2011.12.019_bb0140","doi-asserted-by":"crossref","first-page":"12306","DOI":"10.1021\/ja049437n","article-title":"Chemoenzymatic synthesis and high-throughput screening of an aminoglycoside-polyamine library: identification of high-affinity displacers and DNA-binding ligands","volume":"126","author":"Rege","year":"2004","journal-title":"J. Am. Chem. Soc."},{"issue":"6","key":"10.1016\/j.jconrel.2011.12.019_bb0145","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1021\/ci050082g","article-title":"Investigation of DNA-binding properties of an aminoglycoside-polyamine library using quantitative structure\u2013activity relationship (QSAR) models","volume":"45","author":"Rege","year":"2005","journal-title":"J. Chem. Inf. Model."},{"issue":"9","key":"10.1016\/j.jconrel.2011.12.019_bb0245","doi-asserted-by":"crossref","first-page":"3626","DOI":"10.1021\/jm1000437","article-title":"Antibacterial activities of aminoglycoside antibiotics-derived cationic amphiphiles. Polyol-modified neomycin B-, kanamycin A-, amikacin-, and neamine-based amphiphiles with potent broad spectrum antibacterial activity","volume":"53","author":"Bera","year":"2010","journal-title":"J. Med. Chem."},{"issue":"40","key":"10.1016\/j.jconrel.2011.12.019_bb0155","doi-asserted-by":"crossref","first-page":"11223","DOI":"10.1021\/bi701071h","article-title":"An aminoglycoside microarray platform for directly monitoring and studying antibiotic resistance","volume":"46","author":"Disney","year":"2007","journal-title":"Biochemistry"},{"issue":"16","key":"10.1016\/j.jconrel.2011.12.019_bb0160","doi-asserted-by":"crossref","first-page":"3641","DOI":"10.1021\/ja964290o","article-title":"Direct observation of aminoglycoside\u2013RNA interactions by surface plasmon resonance","volume":"119","author":"Hendrix","year":"1997","journal-title":"J. Am. Chem. Soc."},{"issue":"4","key":"10.1016\/j.jconrel.2011.12.019_bb0165","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1021\/cr0681546","article-title":"Targeting RNA with small molecules","volume":"108","author":"Thomas","year":"2008","journal-title":"Chem. Rev."},{"issue":"7","key":"10.1016\/j.jconrel.2011.12.019_bb0170","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1021\/jm981108g","article-title":"Docking of cationic antibiotics to negatively charged pockets in RNA folds","volume":"42","author":"Hermann","year":"1999","journal-title":"J. Med. Chem."},{"issue":"2","key":"10.1016\/j.jconrel.2011.12.019_bb0250","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1002\/cbic.200500354","article-title":"Aminoglycoside-quinacridine conjugates: towards recognition of the P6.1 element of telomerase RNA","volume":"7","author":"Kaiser","year":"2006","journal-title":"Chembiochem"},{"issue":"5","key":"10.1016\/j.jconrel.2011.12.019_bb0180","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1021\/ja993387i","article-title":"Neomycin-acridine conjugate: a potent inhibitor of Rev-RRE binding","volume":"122","author":"Kirk","year":"2000","journal-title":"J. Am. Chem. Soc."},{"issue":"4","key":"10.1016\/j.jconrel.2011.12.019_bb0185","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.bmc.2004.11.028","article-title":"Ngamma-aryl glutamine analogues as probes of the ASCT2 neutral amino acid transporter binding site","volume":"13","author":"Esslinger","year":"2005","journal-title":"Bioorg. Med. Chem."},{"issue":"2","key":"10.1016\/j.jconrel.2011.12.019_bb0190","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1006\/bbrc.2001.4401","article-title":"Efficient gene transfection by bisguanylated diacetylene lipid formulations","volume":"281","author":"Patel","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"5","key":"10.1016\/j.jconrel.2011.12.019_bb0195","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1002\/jgm.211","article-title":"Sterically stabilized BGTC-based lipoplexes: structural features and gene transfection into the mouse airways in vivo","volume":"3","author":"Pitard","year":"2001","journal-title":"J. Gene Med."},{"issue":"8\u20139","key":"10.1016\/j.jconrel.2011.12.019_bb0200","first-page":"591","article-title":"Synthesis and structure activity relationships of new guanidino derivatives of aminoglycoside antibiotics","volume":"9","author":"Streicher","year":"1983","journal-title":"Drug Exp. Clin. Res"},{"issue":"3","key":"10.1016\/j.jconrel.2011.12.019_bb0205","doi-asserted-by":"crossref","first-page":"276","DOI":"10.7164\/antibiotics.53.276","article-title":"DNase I induced DNA degradation is inhibited by neomycin","volume":"53","author":"Woegerbauer","year":"2000","journal-title":"J. Antibiot. (Tokyo)"},{"issue":"4","key":"10.1016\/j.jconrel.2011.12.019_bb0255","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1021\/bc900393r","article-title":"Transfection efficiency of cationic lipids with different hydrophobic domains in gene delivery","volume":"21","author":"Zhi","year":"2010","journal-title":"Bioconjug. Chem."},{"issue":"5","key":"10.1016\/j.jconrel.2011.12.019_bb0215","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1021\/bc070089z","article-title":"Dicationic lipophosphoramidates as DNA carriers","volume":"18","author":"Mevel","year":"2007","journal-title":"Bioconjug. Chem."},{"issue":"42","key":"10.1016\/j.jconrel.2011.12.019_bb0220","doi-asserted-by":"crossref","first-page":"16534","DOI":"10.1073\/pnas.0707431104","article-title":"Self-assembled lamellar complexes of siRNA with lipidic aminoglycoside derivatives promote efficient siRNA delivery and interference","volume":"104","author":"Desigaux","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016836591101145X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016836591101145X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T01:39:55Z","timestamp":1588815595000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016836591101145X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["S016836591101145X"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2011.12.019","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2012,3]]}}}