{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T20:15:49Z","timestamp":1791144949688,"version":"4.1.0"},"reference-count":99,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001427","name":"All India Council for Technical Education","doi-asserted-by":"crossref","award":["1-51\/RIFD\/EF(13)\/2011\u20132012"],"award-info":[{"award-number":["1-51\/RIFD\/EF(13)\/2011\u20132012"]}],"id":[{"id":"10.13039\/501100001427","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1016\/j.jconrel.2012.11.005","type":"journal-article","created":{"date-parts":[[2012,11,13]],"date-time":"2012-11-13T21:03:00Z","timestamp":1352840580000},"page":"129-138","source":"Crossref","is-referenced-by-count":217,"title":["Polymeric hydrogels for oral insulin delivery"],"prefix":"10.1016","volume":"165","author":[{"given":"Kiran","family":"Chaturvedi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuntal","family":"Ganguly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mallikarjuna N.","family":"Nadagouda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tejraj M.","family":"Aminabhavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2012.11.005_bb0005","first-page":"251","article-title":"The internal secretion of the pancreas","volume":"7","author":"Banting","year":"1922","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0010","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.pbiomolbio.2005.05.012","article-title":"Molecular variants and derivatives of insulin for improved glycemic control in diabetes","volume":"91","author":"Bhatnagar","year":"2006","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0015","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1517\/17425247.5.4.403","article-title":"Developments in polymeric devices for oral insulin delivery","volume":"5","author":"Ramesh Babu","year":"2008","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0020","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1007\/s11095-005-6137-z","article-title":"Regional dependent role of the mucous\/glycocalyx layers in insulin permeation across rat small intestinal membrane","volume":"22","author":"Aoki","year":"2005","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0025","first-page":"76","article-title":"Current status of the oral delivery of insulin","volume":"25","author":"Agarwal","year":"2001","journal-title":"Pharm. Technol."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0030","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1080\/02652040110081406","article-title":"The effect of oral absorption enhancers on the in vivo performance of insulin-loaded poly(ethylcyanoacrylate) nanospheres in diabetic rats","volume":"19","author":"Radwant","year":"2002","journal-title":"J. Microencapsul."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0035","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1002\/jps.2600840604","article-title":"Absorption characteristics of chemically modified-insulin derivatives with various fatty acids in the small and large intestine","volume":"84","author":"Asada","year":"1995","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0040","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1023\/A:1007696723125","article-title":"Design and in vivo evaluation of an oral delivery system for insulin","volume":"17","author":"Marschutz","year":"2000","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0045","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1023\/A:1016009313548","article-title":"Enteral absorption of insulin in rats from mucoadhesive chitosan-coated liposomes","volume":"13","author":"Takeuchi","year":"1996","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0050","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jconrel.2004.07.030","article-title":"Transmucosal macromolecular drug delivery","volume":"101","author":"Prego","year":"2005","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2012.11.005_bb0055","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0168-3659(02)00019-6","article-title":"Elucidation of the mechanism of incorporation of insulin in controlled release systems based on complexation polymers","volume":"81","author":"Morishita","year":"2002","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2012.11.005_bb0060","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.jconrel.2004.03.008","article-title":"Mucosal insulin delivery systems based on complexation polymer hydrogels: effect of particle size on insulin enteral absorption","volume":"97","author":"Morishita","year":"2004","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2012.11.005_bb0065","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.ejpb.2004.02.008","article-title":"Investigation of the cytotoxicity and insulin transport of acrylic-based copolymer protein delivery systems in contact with Caco-2 cultures","volume":"57","author":"Foss","year":"2004","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0070","doi-asserted-by":"crossref","first-page":"3384","DOI":"10.1016\/j.biomaterials.2010.01.042","article-title":"Enteric-coated capsules filled with freeze-dried chitosan\/poly(g-glutamic acid) nanoparticles for oral insulin delivery","volume":"31","author":"Sonaje","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2012.11.005_bb0075","doi-asserted-by":"crossref","first-page":"3275","DOI":"10.1021\/cr000700m","article-title":"Peroral Route: An Opportunity for Protein and Peptide Drug Delivery","volume":"101","author":"Sood","year":"2001","journal-title":"Chem. Rev."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0080","doi-asserted-by":"crossref","first-page":"3695","DOI":"10.1002\/adfm.201001014","article-title":"Self-assembled pH-sensitive nanoparticles: a platform for oral delivery of protein drugs","volume":"20","author":"Sonaje","year":"2010","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0085","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1016\/j.biomaterials.2008.12.066","article-title":"In vivo evaluation of safety and efficacy of self-assembled nanoparticles for oral insulin delivery","volume":"30","author":"Sonaje","year":"2009","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2012.11.005_bb0090","doi-asserted-by":"crossref","first-page":"9826","DOI":"10.1016\/j.biomaterials.2011.08.087","article-title":"A review of the prospects for polymeric nanoparticle platforms in oral insulin delivery","volume":"32","author":"Chen","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2012.11.005_bb0095","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/j.progpolymsci.2012.04.004","article-title":"Strategies for effective oral insulin delivery with modified chitosan nanoparticles: a review","volume":"37","author":"Mukhopadhyay","year":"2012","journal-title":"Prog. Polym. Sci."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0100","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1023\/A:1015893832222","article-title":"Degradation of Insulin by trypsin and \u03b1-chymotrypsin","volume":"8","author":"Schilling","year":"1991","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0105","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0301-4622(91)85011-E","article-title":"The self-association of zinc-free human insulin and insulin analogue B13-glutamine","volume":"39","author":"Hansen","year":"1991","journal-title":"Biophys. Chem."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0110","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1023\/A:1015888529728","article-title":"Dissociation of insulin oligomers by bile salt micelles and its effect on \u03b1-chymotrypsin-mediated proteolytic degradation","volume":"9","author":"Li","year":"1992","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0115","doi-asserted-by":"crossref","first-page":"7788","DOI":"10.1073\/pnas.79.24.7788","article-title":"Receptor-mediated endocytosis of insulin: role of microvilli, coated pits, and coated vesicles","volume":"79","author":"Fan","year":"1982","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0120","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1002\/(SICI)1097-0029(20000515)49:4<346::AID-JEMT3>3.0.CO;2-B","article-title":"Intestinal absorption of peptides through the enterocytes","volume":"49","author":"Ziv","year":"2000","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0125","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jconrel.2007.05.019","article-title":"Effective oral delivery of insulin in animal models using vitamin B12-coated dextran nanoparticles","volume":"122","author":"Chalasani","year":"2007","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2012.11.005_bb0130","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.jconrel.2004.08.010","article-title":"Recent advances on chitosan-based micro- and nanoparticles in drug delivery","volume":"100","author":"Agnihotri","year":"2004","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2012.11.005_bb0135","doi-asserted-by":"crossref","first-page":"11797","DOI":"10.1021\/ie201623d","article-title":"Colon targeting of 5-fluorouracil using polyethylene glycol cross-linked chitosan microspheres enteric coated with cellulose acetate phthalate","volume":"50","author":"Ganguly","year":"2011","journal-title":"Ind. Eng. Chem. Res."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0140","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1016\/j.biomaterials.2007.01.005","article-title":"Mucoadhesion mechanism of chitosan and thiolated chitosan-poly(isobutyl cyanoacrylate) core-shell nanoparticles","volume":"28","author":"Bravo-Osuna","year":"2007","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2012.11.005_bb0145","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1023\/A:1018967116988","article-title":"Effect of chitosan on the permeability of monolayers of intestinal epithelial cells (Caco-2)","volume":"11","author":"Artursson","year":"1994","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0150","doi-asserted-by":"crossref","first-page":"6164","DOI":"10.1016\/j.biomaterials.2011.03.056","article-title":"Mechanism and consequence of chitosan-mediated reversible epithelial tight junction opening","volume":"32","author":"Yeh","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2012.11.005_bb0155","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1023\/B:PHAM.0000003379.76417.3e","article-title":"Uptake of chitosan and associated insulin in Caco-2 cell monolayers: a comparison between chitosan molecules and chitosan nanoparticles","volume":"20","author":"Ma","year":"2003","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1517\/14712598.4.6.881","article-title":"Hydrogels for oral delivery of therapeutic proteins","volume":"4","author":"Peppas","year":"2004","journal-title":"Expert. Opin. Biol. Ther."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0165","article-title":"Oral insulin delivery by self-assembled chitosan nanoparticles: in vitro and in vivo studies in diabetic animal model","author":"Mukhopadhyay","year":"2012","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.jconrel.2012.11.005_bb0170","doi-asserted-by":"crossref","first-page":"6849","DOI":"10.1016\/j.biomaterials.2010.05.042","article-title":"Biodistribution, pharmacodynamics and pharmacokinetics of insulin analogues in a rat model: oral delivery using pH-responsive nanoparticles vs. subcutaneous injection","volume":"31","author":"Sonaje","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2012.11.005_bb0175","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1021\/ar200234q","article-title":"pH-responsive nanoparticles shelled with chitosan for oral delivery of insulin: from mechanism to therapeutic applications","volume":"45","author":"Sung","year":"2012","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0180","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1208\/s12249-011-9647-5","article-title":"Chitosan\u2013sodium lauryl sulfate nanoparticles as a carrier system for the in vivo delivery of oral insulin","volume":"12","author":"Elsayed","year":"2011","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.jconrel.2012.11.005_bb0185","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1177\/0885328208091562","article-title":"Review paper: chitosan derivatives as promising materials for controlled drug delivery","volume":"23","author":"Prabaharan","year":"2008","journal-title":"J. Biomater. Appl."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0190","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1002\/jps.21550","article-title":"Modified chitosans for oral drug delivery","volume":"98","author":"Werle","year":"2009","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0195","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1021\/bc800076n","article-title":"Oral delivery of peptide drugs using nanoparticles self-assembled by poly(g-glutamic acid) and a chitosan derivative functionalized by trimethylation","volume":"19","author":"Mi","year":"2008","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0200","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1016\/j.biomaterials.2011.10.075","article-title":"Goblet cell-targeting nanoparticles for oral insulin delivery and the influence of mucus on insulin transport","volume":"33","author":"Jin","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2012.11.005_bb0205","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.ejps.2006.06.008","article-title":"Insulin encapsulation in reinforced alginate microspheres prepared by internal gelation","volume":"29","author":"Catarina","year":"2006","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0210","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1002\/app.30775","article-title":"A novel insulin oral delivery system assisted by cationic \u03b2-cyclodextrin polymers","volume":"115","author":"Huang","year":"2010","journal-title":"J. Appl. Polym. Sci."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0215","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.ijpharm.2010.04.006","article-title":"Effective protection and controlled release of insulin by cationic b-cyclodextrin polymers from alginate\/chitosan nanoparticles","volume":"393","author":"Zhang","year":"2010","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0220","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ejpb.2010.09.016","article-title":"Preparation and evaluation of alginate\u2013chitosan microspheres for oral delivery of insulin","volume":"77","author":"Zhang","year":"2011","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0225","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.ejps.2010.12.007","article-title":"Design and evaluation of novel pH-sensitive chitosan nanoparticles for oral insulin delivery","volume":"42","author":"Makhlof","year":"2011","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0230","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.carbpol.2010.10.070","article-title":"In vitro evaluation of N-(2-hydroxy) propyl-3-trimethyl ammonium chitosan for oral insulin delivery","volume":"84","author":"Sonia","year":"2011","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0235","doi-asserted-by":"crossref","first-page":"2902","DOI":"10.1002\/app.32979","article-title":"Bioadhesive hydrophobic chitosan microparticles for oral delivery of insulin: in vitro characterization and in vivo uptake studies","volume":"119","author":"Sonia","year":"2011","journal-title":"J. Appl. Polym. Sci."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0240","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.jconrel.2009.01.011","article-title":"Synthesis and evaluation of lauryl succinyl chitosan particles towards oral insulin delivery and absorption","volume":"135","author":"Rekha","year":"2009","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2012.11.005_bb0245","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1211\/jpp.59.3.0001","article-title":"Recent developments in superporous hydrogels","volume":"59","author":"Omidian","year":"2007","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0250","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0168-3659(01)00232-2","article-title":"Development and characterization of a novel peroral peptide drug delivery system","volume":"71","author":"Dorkoosh","year":"2001","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2012.11.005_bb0255","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0939-6411(01)00222-3","article-title":"Evaluation of superporous hydrogel (SPH) and SPH composite in porcine intestine ex vivo: assessment of drug transport, morphology effect, and mechanical fixation to intestinal wall","volume":"53","author":"Dorkoosh","year":"2002","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0260","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0928-0987(02)00028-3","article-title":"Peroral delivery systems based on superporous hydrogel polymers: release characteristics for the peptide drugs buserelin, octreotide and insulin","volume":"15","author":"Dorkoosh","year":"2002","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0265","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/j.biomaterials.2006.11.008","article-title":"Superporous hydrogels containing poly(acrylic acid-co-acrylamide)\/O-carboxymethyl chitosan interpenetrating polymer networks","volume":"28","author":"Yin","year":"2007","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2012.11.005_bb0270","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.ijpharm.2007.08.051","article-title":"Beneficial properties for insulin absorption using superporous hydrogel containing interpenetrating polymer network as oral delivery vehicles","volume":"350","author":"Yin","year":"2008","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0275","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0939-6411(03)00061-4","article-title":"Thiolated polymers: evidence for the formation of disulphide bonds with mucus glycoproteins","volume":"56","author":"Leitner","year":"2003","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0280","doi-asserted-by":"crossref","first-page":"5691","DOI":"10.1016\/j.biomaterials.2009.06.055","article-title":"Drug permeability and mucoadhesion properties of thiolated trimethyl chitosan nanoparticles in oral insulin delivery","volume":"30","author":"Yin","year":"2009","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2012.11.005_bb0285","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1002\/app.22311","article-title":"Interpolymer complex microparticles based on polymethacrylic acid\u2013chitosan for oral insulin delivery","volume":"99","author":"Sajeesh","year":"2006","journal-title":"J. Appl. Polym. Sci."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0290","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1002\/jbm.b.30372","article-title":"Novel pH responsive polymethacrylic acid\u2013chitosan\u2013polyethylene glycol nanoparticles for oral peptide delivery","volume":"76B","author":"Sajeesh","year":"2006","journal-title":"J. Biomed. Mater. Res. B"},{"key":"10.1016\/j.jconrel.2012.11.005_bb0295","doi-asserted-by":"crossref","first-page":"3072","DOI":"10.1016\/j.actbio.2010.02.007","article-title":"Thiol functionalized polymethacrylic acid-based hydrogel microparticles for oral insulin delivery","volume":"6","author":"Sajeesh","year":"2010","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0300","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jconrel.2010.08.007","article-title":"Cyclodextrin complexed insulin encapsulated hydrogel microparticles: an oral delivery system for insulin","volume":"147","author":"Sajeesh","year":"2010","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2012.11.005_bb0305","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.nano.2009.04.007","article-title":"Preparation and characterization of insulin nanoparticles using chitosan and Arabic gum with ionic gelation method","volume":"6","author":"Avadi","year":"2010","journal-title":"Nanomedicine: NBM"},{"key":"10.1016\/j.jconrel.2012.11.005_bb0310","first-page":"1","article-title":"Ex vivo evaluation of insulin nanoparticles using chitosan and Arabic gum","author":"Avadi","year":"2011","journal-title":"ISRN Pharm."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0315","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.ejps.2010.08.009","article-title":"Pharmacological effect of orally delivered insulin facilitated by multilayered stable nanoparticles","volume":"41","author":"Woitiski","year":"2010","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0320","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1016\/j.actbio.2009.03.007","article-title":"Colloidal carrier integrating biomaterials for oral insulin delivery: influence of component formulation on physicochemical and biological parameters","volume":"5","author":"Woitiski","year":"2009","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0325","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.ijpharm.2011.04.003","article-title":"Facilitated nanoscale delivery of insulin across intestinal membrane models","volume":"412","author":"Woitiski","year":"2011","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0330","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.colsurfb.2011.08.007","article-title":"Submicroparticles composed of amphiphilic chitosan derivative for oral insulin and curcumin release applications","volume":"88","author":"Shelma","year":"2011","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.jconrel.2012.11.005_bb0335","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.carbpol.2007.02.012","article-title":"Insulin-loaded alginate microspheres for oral delivery \u2014 effect of polysaccharide reinforcement on physicochemical properties and release profile","volume":"69","author":"Martins","year":"2007","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0340","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1007\/s11095-007-9367-4","article-title":"Alginate\/chitosan nanoparticles are effective for oral insulin delivery","volume":"24","author":"Sarmento","year":"2007","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0345","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0168-3659(02)00027-5","article-title":"Physicochemical behavior and cytotoxic effects of p(methacrylic acid-g-ethylene glycol) nanoparticles for oral delivery of proteins","volume":"80","author":"Torres-Lugo","year":"2002","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2012.11.005_bb0350","first-page":"75","volume":"vol. 29","author":"Lowman","year":"2004"},{"key":"10.1016\/j.jconrel.2012.11.005_bb0355","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0939-6411(00)00090-4","article-title":"Hydrogels in pharmaceutical formulation","volume":"50","author":"Peppas","year":"2000","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0360","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0378-5173(03)00378-8","article-title":"In vitro release behavior and stability of insulin in complexation hydrogels as oral drug delivery carriers","volume":"266","author":"Kim","year":"2003","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0365","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.jconrel.2003.12.022","article-title":"Oral insulin delivery using P(MAA-g-EG) hydrogels: effects of network morphology on insulin delivery characteristics","volume":"95","author":"Nakamura","year":"2004","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2012.11.005_bb0370","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.jconrel.2006.03.005","article-title":"Characterization of insulin protection properties of complexation hydrogels in gastric and intestinal enzyme fluids","volume":"112","author":"Yamagata","year":"2006","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2012.11.005_bb0375","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.jconrel.2005.10.029","article-title":"Novel oral insulin delivery systems based on complexation polymer hydrogels: single and multiple administration studies in type 1 and 2 diabetic rats","volume":"110","author":"Morishita","year":"2006","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2012.11.005_bb0380","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1002\/macp.201100604","article-title":"Biodegradable pH-dependent thermo-sensitive hydrogels for oral insulin delivery","volume":"213","author":"Zhang","year":"2012","journal-title":"Macromol. Chem. Phys."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0385","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.ijpharm.2012.06.054","article-title":"Thiolated Eudragit nanoparticles for oral insulin delivery: preparation, characterization and in vivo evaluation","volume":"436","author":"Zhang","year":"2012","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0390","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1021\/bm701274p","article-title":"Wheat germ agglutinin functionalized complexation hydrogels for oral insulin delivery","volume":"9","author":"Wood","year":"2008","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.jconrel.2012.11.005_bb0395","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1023\/A:1023406224028","article-title":"Wheat germ agglutinin binds to the epidermal growth factor receptor of artificial Caco-2 membranes as detected by silver nanoparticle enhanced fluorescence","volume":"20","author":"Lochner","year":"2003","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0400","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1021\/bc050344k","article-title":"Synthesis and characterization of insulin-transferrin conjugates","volume":"17","author":"Kavimandan","year":"2006","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0405","doi-asserted-by":"crossref","first-page":"3846","DOI":"10.1016\/j.biomaterials.2006.02.026","article-title":"Novel delivery system based on complexation hydrogels as delivery vehicles for insulin\u2013transferrin conjugates","volume":"27","author":"Kavimandan","year":"2006","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2012.11.005_bb0410","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/mabi.200900223","article-title":"Cellular evaluation of synthesized insulin\/transferrin bioconjugates for oral insulin delivery using intelligent complexation hydrogels","volume":"10","author":"Shofner","year":"2010","journal-title":"Macromol. Biosci."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0415","doi-asserted-by":"crossref","first-page":"384","DOI":"10.3109\/02652048.2011.576782","article-title":"Poly(N-vinylcaprolactam-co-methacrylic acid) hydrogel microparticles for oral insulin delivery","volume":"28","author":"Mundargi","year":"2011","journal-title":"J. Microencapsul."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0420","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.ijpharm.2006.05.050","article-title":"Development of PEGDMA: MAA based hydrogel microparticles for oral insulin delivery","volume":"323","author":"Kumar","year":"2006","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0425","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1002\/app.13211","article-title":"Preparation of pH-sensitive poly(vinyl alcohol-g-methacrylic acid) and poly(vinyl alcohol-g-acrylic acid) hydrogels by gamma ray irradiation and their insulin release behavior","volume":"91","author":"Park","year":"2004","journal-title":"J. Appl. Polym. Sci."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0430","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1016\/j.polymer.2010.02.013","article-title":"Synthesis and characterization of novel pH-, ionic strength and temperature-sensitive hydrogel for insulin delivery","volume":"51","author":"Rasool","year":"2010","journal-title":"Polymer"},{"key":"10.1016\/j.jconrel.2012.11.005_bb0435","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.addr.2003.10.015","article-title":"The lectin\u2013cell interaction and its implications to intestinal lectin-mediated drug delivery","volume":"56","author":"Gabor","year":"2004","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0440","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.carbpol.2011.04.070","article-title":"Lectin-functionalized carboxymethylated kappa-carrageenan microparticles for oral insulin delivery","volume":"86","author":"Leong","year":"2011","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0445","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1002\/pi.4193","article-title":"Thermo- and pH-responsive microgels for controlled release of insulin","volume":"61","author":"Bai","year":"2012","journal-title":"Polym. Int."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0450","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/j.carbpol.2012.03.095","article-title":"Novel thermo- and pH-responsive hydroxypropyl cellulose- and poly (l-glutamic acid)-based microgels for oral insulin controlled release","volume":"89","author":"Bai","year":"2012","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0455","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1002\/jbm.a.32490","article-title":"Starch-based polymeric carriers for oral-insulin delivery","volume":"92","author":"Mahkam","year":"2010","journal-title":"J. Biomed. Mater. Res. Part A"},{"key":"10.1016\/j.jconrel.2012.11.005_bb0460","doi-asserted-by":"crossref","first-page":"9040","DOI":"10.1016\/j.biomaterials.2010.07.111","article-title":"Tuneable semi-synthetic network alginate for absorptive encapsulation and controlled release of protein therapeutics","volume":"31","author":"Chan","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2012.11.005_bb0465","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jconrel.2008.08.001","article-title":"Usefulness of cell-penetrating peptides to improve intestinal insulin absorption","volume":"132","author":"Kamei","year":"2008","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2012.11.005_bb0470","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1016\/j.carbpol.2011.10.002","article-title":"Improving intestinal insulin absorption efficiency through coadministration of cell-penetrating peptide and hydroxypropyl-\u03b2-cyclodextrin","volume":"87","author":"Zhang","year":"2012","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0475","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ijdm.2009.12.014","article-title":"Dietary fiber psyllium based hydrogels for use in insulin delivery","volume":"2","author":"Singh","year":"2010","journal-title":"Int. J. Diabetes Mellitus"},{"key":"10.1016\/j.jconrel.2012.11.005_bb0480","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0168-3659(01)00447-3","article-title":"Modulated insulin delivery from glucose-sensitive hydrogel dosage forms","volume":"77","author":"Kim","year":"2001","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2012.11.005_bb0485","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.ijbiomac.2011.09.014","article-title":"Glucose and pH dual-responsive concanavalin A based microhydrogels for insulin delivery","volume":"49","author":"Yin","year":"2011","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jconrel.2012.11.005_bb0490","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.jconrel.2004.10.032","article-title":"Bioadhesive interaction and hypoglycemic effect of insulin-loaded lectin\u2013microparticle conjugates in oral insulin delivery system","volume":"102","author":"Kim","year":"2005","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2012.11.005_bb0495","article-title":"Efficacy of mucoadhesive hydrogel microparticles of whey protein and alginate for oral insulin delivery","author":"Deat-Laine","year":"2012","journal-title":"Pharm. Res."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365912007596?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365912007596?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T10:32:16Z","timestamp":1714559536000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365912007596"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":99,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["S0168365912007596"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2012.11.005","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]}}}