{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T16:05:58Z","timestamp":1790525158779,"version":"4.1.0"},"reference-count":60,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,3,20]],"date-time":"2013-03-20T00:00:00Z","timestamp":1363737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"funder":[{"name":"National Science Foundation","award":["DGE 0549500"],"award-info":[{"award-number":["DGE 0549500"]}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"crossref","award":["2RO1 0181549500"],"award-info":[{"award-number":["2RO1 0181549500"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NCI Cancer Nanotechnology Platform Partnership","award":["1U01CA151792-01"],"award-info":[{"award-number":["1U01CA151792-01"]}]},{"name":"U.S. Department of Energy, Office of Basic Energy Sciences, Division of Materials Sciences and Engineering"},{"name":"Sandia National Laboratories' Laboratory Directed Research and Development (LDRD)"},{"name":"US Department of Energy's National Nuclear Security Administration","award":["DE-AC04-94AL85000"],"award-info":[{"award-number":["DE-AC04-94AL85000"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1016\/j.jconrel.2013.03.009","type":"journal-article","created":{"date-parts":[[2013,3,18]],"date-time":"2013-03-18T14:49:56Z","timestamp":1363618196000},"page":"209-224","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":88,"title":["Mesoporous silica-supported lipid bilayers (protocells) for DNA cargo delivery to the spinal cord"],"prefix":"10.1016","volume":"168","author":[{"given":"Ellen C.","family":"Dengler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juewen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audra","family":"Kerwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara M.","family":"Olcott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandi N.","family":"Bowman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leisha","family":"Armijo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Gentry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Wilkerson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Wallace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingmao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric C.","family":"Carnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Jeffrey","family":"Brinker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin D.","family":"Milligan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.jconrel.2013.03.009_bb0005","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1002\/jgm.1100","article-title":"Gene therapy clinical trials worldwide to 2007\u2013an update","volume":"9","author":"Edelstein","year":"2007","journal-title":"J Gene Med"},{"key":"10.1016\/j.jconrel.2013.03.009_bb0010","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1126\/science.334.6052.29","article-title":"Gene therapists celebrate a decade of progress","volume":"334","author":"Kaiser","year":"2011","journal-title":"Science"},{"issue":"8","key":"10.1016\/j.jconrel.2013.03.009_bb0015","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1007\/s11095-010-0364-7","article-title":"Barriers to non-viral vector-mediated gene delivery in the nervous system","volume":"28","author":"Perez-Martinez","year":"2011","journal-title":"Pharm. Res."},{"issue":"24\u201325","key":"10.1016\/j.jconrel.2013.03.009_bb0020","doi-asserted-by":"crossref","first-page":"3477","DOI":"10.1016\/j.biomaterials.2008.04.036","article-title":"Progress in developing cationic vectors for non-viral systemic gene therapy against cancer","volume":"29","author":"Morille","year":"2008","journal-title":"Biomaterials"},{"issue":"31","key":"10.1016\/j.jconrel.2013.03.009_bb0025","doi-asserted-by":"crossref","first-page":"3236","DOI":"10.1039\/b701744h","article-title":"Mesoporous silica nanoparticle based controlled release, drug delivery, and biosensor systems","author":"Trewyn","year":"2007","journal-title":"Chem. Commun. (Camb.)"},{"issue":"2","key":"10.1016\/j.jconrel.2013.03.009_bb0030","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jconrel.2011.08.026","article-title":"Non-viral gene therapy for neurological diseases, with an emphasis on targeted gene delivery","volume":"157","author":"Rogers","year":"2012","journal-title":"J. Control. Release"},{"issue":"1","key":"10.1016\/j.jconrel.2013.03.009_bb0035","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.toxlet.2008.10.012","article-title":"Oxidative stress and pro-inflammatory responses induced by silica nanoparticles in vivo and in vitro","volume":"184","author":"Park","year":"2009","journal-title":"Toxicol. Lett."},{"issue":"30","key":"10.1016\/j.jconrel.2013.03.009_bb0040","doi-asserted-by":"crossref","first-page":"4045","DOI":"10.1016\/j.biomaterials.2008.07.007","article-title":"The biocompatibility of mesoporous silicates","volume":"29","author":"Hudson","year":"2008","journal-title":"Biomaterials"},{"issue":"5","key":"10.1016\/j.jconrel.2013.03.009_bb0045","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nmat2992","article-title":"The targeted delivery of multicomponent cargos to cancer cells by nanoporous particle-supported lipid bilayers","volume":"10","author":"Ashley","year":"2011","journal-title":"Nat. Mater."},{"key":"10.1016\/j.jconrel.2013.03.009_bb0050","doi-asserted-by":"crossref","DOI":"10.1021\/ar3000986","article-title":"Mesoporous Silica Nanoparticle Nanocarriers: Biofunctionality and Biocompatibility","author":"Tarn","year":"2013","journal-title":"Acc. Chem. Res."},{"issue":"11","key":"10.1016\/j.jconrel.2013.03.009_bb0055","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1016\/j.addr.2008.03.012","article-title":"Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers","volume":"60","author":"Slowing","year":"2008","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2013.03.009_bb0060","first-page":"1","article-title":"Immunological priming potentiates non-viral anti-inflammatory gene therapy treatment of neuropathic pain","volume":"1","author":"Sloane","year":"2009","journal-title":"Gene Ther."},{"issue":"5","key":"10.1016\/j.jconrel.2013.03.009_bb0065","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1007\/s11095-010-0077-y","article-title":"Release of plasmid DNA-encoding IL-10 from PLGA microparticles facilitates long-term reversal of neuropathic pain following a single intrathecal administration","volume":"27","author":"Soderquist","year":"2010","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2013.03.009_bb0070","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1111\/j.1460-9568.2005.04057.x","article-title":"Controlling pathological pain by adenovirally driven spinal production of the anti-inflammatory cytokine, Interleukin-10","volume":"21","author":"Milligan","year":"2005","journal-title":"Eur. J. Neurosci."},{"issue":"5","key":"10.1016\/j.jconrel.2013.03.009_bb0075","first-page":"431","article-title":"Intrathecal gene transger by adeno-associated virus for pain","volume":"7","author":"Beutler","year":"2005","journal-title":"Curr. Opin. Mol. Ther."},{"key":"10.1016\/j.jconrel.2013.03.009_bb0080","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1017\/S1740925X07000488","article-title":"Intrathecal polymer-based interleukin-10* gene delivery for neuropathic pain","volume":"2","author":"Milligan","year":"2006","journal-title":"Neuron Glia Biol."},{"issue":"22","key":"10.1016\/j.jconrel.2013.03.009_bb0085","doi-asserted-by":"crossref","first-page":"7567","DOI":"10.1021\/ja902039y","article-title":"Electrostatically mediated liposome fusion and lipid exchange with a nanoparticle-supported bilayer for control of surface charge, drug containment, and delivery","volume":"131","author":"Liu","year":"2009","journal-title":"J. Am. Chem. Soc."},{"issue":"4","key":"10.1016\/j.jconrel.2013.03.009_bb0090","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1021\/ja808018y","article-title":"Porous nanoparticle supported lipid bilayers (protocells) as delivery vehicles","volume":"131","author":"Liu","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jconrel.2013.03.009_bb0095","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","article-title":"Quantitative assessment of tactile allodynia in the rat paw","volume":"53","author":"Chaplan","year":"1994","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.jconrel.2013.03.009_bb0100","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0006-8993(00)02050-3","article-title":"Thermal hyperalgesia and mechanical allodynia produced by intrathecal administration of the Human Immunodeficiency Virus-1 (HIV-1) envelope glycoprotein, gp120","volume":"861","author":"Milligan","year":"2000","journal-title":"Brain Res."},{"key":"10.1016\/j.jconrel.2013.03.009_bb0105","doi-asserted-by":"crossref","first-page":"2808","DOI":"10.1523\/JNEUROSCI.21-08-02808.2001","article-title":"Intrathecal HIV-1 envelope glycoprotein gp120 enhanced pain states mediated by spinal cord proinflammatory cytokines","volume":"21","author":"Milligan","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jconrel.2013.03.009_bb0110","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0304-3959(88)90209-6","article-title":"A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man","volume":"33","author":"Bennett","year":"1988","journal-title":"Pain"},{"key":"10.1016\/j.jconrel.2013.03.009_bb0115","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.pain.2006.07.009","article-title":"Repeated intrathecal injections of plasmid DNA encoding interleukin-10 produce prolonged reversal of neuropathic pain","volume":"126","author":"Milligan","year":"2006","journal-title":"Pain"},{"issue":"6679 Suppl.","key":"10.1016\/j.jconrel.2013.03.009_bb0120","first-page":"5","article-title":"Drug delivery and targeting","volume":"392","author":"Langer","year":"1998","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.jconrel.2013.03.009_bb0125","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/sj.gt.3300554","article-title":"Inclusion of cholesterol in DOTAP transfection complexes increases the delivery of DNA to cells in vitro in the presence of serum","volume":"5","author":"Crook","year":"1998","journal-title":"Gene Ther."},{"issue":"1","key":"10.1016\/j.jconrel.2013.03.009_bb0130","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1021\/ja01145a126","article-title":"The Determination of Pore volume and Area distributions in Porous Substances. I. Computations from Nitrogen isotherms","volume":"73","author":"Barrett","year":"1951","journal-title":"J. Am. Chem. Soc."},{"issue":"14","key":"10.1016\/j.jconrel.2013.03.009_bb0135","doi-asserted-by":"crossref","first-page":"4512","DOI":"10.1021\/ja058260+","article-title":"Aerosol-assisted self-assembly of single-crystal core\/nanoporous shell particles as model controlled release capsules","volume":"128","author":"Jiang","year":"2006","journal-title":"J. Am. Chem. Soc."},{"issue":"2","key":"10.1016\/j.jconrel.2013.03.009_bb0140","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1021\/ja01269a023","article-title":"Adsorption of Gases in Multimolecular Layers","volume":"60","author":"Brunauer","year":"1938","journal-title":"J. Am. Chem. Soc."},{"issue":"2","key":"10.1016\/j.jconrel.2013.03.009_bb0145","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/brb3.44","article-title":"Immunofluorescent spectral analysis reveals the intrathecal cannabinoid agonist, AM1241, produces spinal anti-inflammatory cytokine responses in neuropathic rats exhibiting relief from allodynia","volume":"2","author":"Wilkerson","year":"2012","journal-title":"Brain Behav."},{"key":"10.1016\/j.jconrel.2013.03.009_bb0150","doi-asserted-by":"crossref","first-page":"623","DOI":"10.3758\/BF03201438","article-title":"Efficient estimation of sensory thresholds","volume":"18","author":"Harvey","year":"1986","journal-title":"Behav. Res. Methods Instrum. Comput."},{"issue":"6","key":"10.1016\/j.jconrel.2013.03.009_bb0155","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1080\/10611860400003858","article-title":"Sustained polymeric delivery of gene silencing antisense ODNs, siRNA, DNAzymes and ribozymes: in vitro and in vivo studies","volume":"12","author":"Khan","year":"2004","journal-title":"J. Drug Target."},{"issue":"4","key":"10.1016\/j.jconrel.2013.03.009_bb0160","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1007\/s12272-011-0418-3","article-title":"Anti-inflammatory effects of eriodictyol in lipopolysaccharide-stimulated raw 264.7 murine macrophages","volume":"34","author":"Lee","year":"2011","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.jconrel.2013.03.009_bb0165","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1186\/1476-511X-10-177","article-title":"Suppression of nitric oxide induction and pro-inflammatory cytokines by novel proteasome inhibitors in various experimental models","volume":"10","author":"Qureshi","year":"2011","journal-title":"Lipids Health Dis."},{"issue":"8","key":"10.1016\/j.jconrel.2013.03.009_bb0170","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1016\/j.bmcl.2011.02.071","article-title":"Anti-inflammatory effect of soyasaponins through suppressing nitric oxide production in LPS-stimulated RAW 264.7 cells by attenuation of NF-kappaB-mediated nitric oxide synthase expression","volume":"21","author":"Zha","year":"2011","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"20","key":"10.1016\/j.jconrel.2013.03.009_bb0175","doi-asserted-by":"crossref","first-page":"5189","DOI":"10.1523\/JNEUROSCI.3338-07.2008","article-title":"Cytokine mechanisms of central sensitization: Distinct and overlapping role of interleukin-1b, interleukin-6, and tumor necrosis factor-a in regulating syntapic and neuronal activity in the superficial spinal cord","volume":"28","author":"Kawasaki","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jconrel.2013.03.009_bb0180","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/35068566","article-title":"Interleukin-1b-mediated induction of COX-2 in the CNS contributes to inflammatory pain hypersensitivity","volume":"410","author":"Samad","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.jconrel.2013.03.009_bb0185","series-title":"Proc Soc Neurosci","article-title":"Central neuroimmune interactions after peripheral inflammation: interleukin-1\u03b2 potentiates synaptic transmission in the spinal cord","author":"Samad","year":"2004"},{"issue":"1","key":"10.1016\/j.jconrel.2013.03.009_bb0190","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1002\/(SICI)1097-4547(19981001)54:1<68::AID-JNR8>3.0.CO;2-F","article-title":"Macrophage and microglial responses to cytokines in vitro: phagocytic activity, proteolytic enzyme release, and free radical production","volume":"54","author":"Smith","year":"1998","journal-title":"J. Neurosci. Res."},{"issue":"4","key":"10.1016\/j.jconrel.2013.03.009_bb0195","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1152\/physrev.00011.2002","article-title":"Beyond neurons: evidence that immune and glial cells contribute to pathological pain states","volume":"82","author":"Watkins","year":"2002","journal-title":"Physiol. Rev."},{"issue":"6","key":"10.1016\/j.jconrel.2013.03.009_bb0200","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1021\/jp807956r","article-title":"Monodispersed mesoporous silica nanoparticles with very large pores for enhanced adsorption and release of DNA","volume":"113","author":"Gao","year":"2009","journal-title":"J. Phys. Chem. B"},{"issue":"5","key":"10.1016\/j.jconrel.2013.03.009_bb0205","doi-asserted-by":"crossref","first-page":"3568","DOI":"10.1021\/nn103130q","article-title":"Facile synthesis of monodispersed mesoporous silica nanoparticles with ultralarge pores and their application in gene delivery","volume":"5","author":"Kim","year":"2011","journal-title":"ACS Nano"},{"issue":"8","key":"10.1016\/j.jconrel.2013.03.009_bb0210","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.2174\/138920012802850047","article-title":"Toxicological profile of therapeutic nanodelivery systems","volume":"13","author":"Bimbo","year":"2012","journal-title":"Curr. Drug Metab."},{"issue":"7","key":"10.1016\/j.jconrel.2013.03.009_bb0215","doi-asserted-by":"crossref","first-page":"3864","DOI":"10.1021\/la062576t","article-title":"Nanoporous microbead supported bilayers: stability, physical characterization, and incorporation of functional transmembrane proteins","volume":"23","author":"Davis","year":"2007","journal-title":"Langmuir"},{"issue":"5245","key":"10.1016\/j.jconrel.2013.03.009_bb0220","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1126\/science.271.5245.43","article-title":"Supported membranes: scientific and practical applications","volume":"271","author":"Sackmann","year":"1996","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.jconrel.2013.03.009_bb0225","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1166\/jbn.2011.1201","article-title":"Liposome-mesoporous silica nanoparticles fused cores: a safer mode of drug carrier","volume":"7","author":"Singh","year":"2011","journal-title":"J. Biomed. Nanotechnol."},{"issue":"1","key":"10.1016\/j.jconrel.2013.03.009_bb0230","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cis.2007.02.003","article-title":"An overview of lipid membrane supported by colloidal particles","volume":"133","author":"Troutier","year":"2007","journal-title":"Adv. Colloid Interf. Sci."},{"issue":"8","key":"10.1016\/j.jconrel.2013.03.009_bb0235","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1021\/nl071184j","article-title":"Optical detection of ion-channel-induced proton transport in supported phospholipid bilayers","volume":"7","author":"Yang","year":"2007","journal-title":"Nano Lett."},{"key":"10.1016\/j.jconrel.2013.03.009_bb0240","doi-asserted-by":"crossref","first-page":"792639","DOI":"10.1155\/2011\/792639","article-title":"Mitogen-Activated Protein Kinases and Reactive Oxygen Species: How Can ROS Activate MAPK Pathways?","volume":"2011","author":"Son","year":"2011","journal-title":"J. Signal Transduct."},{"issue":"2","key":"10.1016\/j.jconrel.2013.03.009_bb0245","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1177\/107385849600200210","article-title":"Glial NO: Normal and pathological roles","volume":"2","author":"Murphy","year":"1996","journal-title":"Neuroscientist"},{"issue":"2","key":"10.1016\/j.jconrel.2013.03.009_bb0250","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.ymthe.2005.03.032","article-title":"Gene transfer to dorsal root ganglia by intrathecal injection: effects on regeneration of peripheral nerves","volume":"12","author":"Wang","year":"2005","journal-title":"Mol. Ther."},{"issue":"2","key":"10.1016\/j.jconrel.2013.03.009_bb0255","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/jgm.2698","article-title":"Gene therapy clinical trials worldwide to 2012 - an update","volume":"15","author":"Ginn","year":"2013","journal-title":"J. Gene Med."},{"issue":"5","key":"10.1016\/j.jconrel.2013.03.009_bb0260","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1586\/14737175.7.5.487","article-title":"Gene therapy applications for the treatment of neuropathic pain","volume":"7","author":"Goss","year":"2007","journal-title":"Expert Rev. Neurother."},{"key":"10.1016\/j.jconrel.2013.03.009_bb0265","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.neuron.2006.09.021","article-title":"Mechanism of neuropathic pain","volume":"52","author":"Campbell","year":"2006","journal-title":"Neuron"},{"issue":"6","key":"10.1016\/j.jconrel.2013.03.009_bb0270","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1111\/j.1525-1403.2012.00462.x","article-title":"Spinal interleukin-10 therapy to treat peripheral neuropathic pain","volume":"15","author":"Milligan","year":"2012","journal-title":"Neuromodulation"},{"issue":"11","key":"10.1016\/j.jconrel.2013.03.009_bb0275","doi-asserted-by":"crossref","first-page":"e1116","DOI":"10.1371\/journal.pone.0001116","article-title":"Glycine inhibitory dysfunction turns touch into pain through PKCgamma interneurons","volume":"2","author":"Miraucourt","year":"2007","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.jconrel.2013.03.009_bb0280","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/gt.2009.21","article-title":"Long-term control of neuropathic pain in a non-viral gene therapy paradigm","volume":"16","author":"Sloane","year":"2009","journal-title":"Gene Ther."},{"issue":"32","key":"10.1016\/j.jconrel.2013.03.009_bb0285","doi-asserted-by":"crossref","first-page":"11539","DOI":"10.1073\/pnas.0504926102","article-title":"Organically modified silica nanoparticles: a nonviral vector for in vivo gene delivery and expression in the brain","volume":"102","author":"Bharali","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.jconrel.2013.03.009_bb0290","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1073\/pnas.0408039101","article-title":"Optical tracking of organically modified silica nanoparticles as DNA carriers: a nonviral, nanomedicine approach for gene delivery","volume":"102","author":"Roy","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jconrel.2013.03.009_bb0295","series-title":"Proceedings of the 11th World Congress on Pain","article-title":"Paclitaxel-induced mechanical allodynia in rats is inhibited by spinal delivery of plasmid DNA encoding interleukin-10","author":"Ledeboer","year":"2006"},{"key":"10.1016\/j.jconrel.2013.03.009_bb0300","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1744-8069-1-9","article-title":"Controlling neuropathic pain by adeno-associated virus driven production of the anti-inflammatory cytokine, interleukin-10","volume":"1","author":"Milligan","year":"2005","journal-title":"Mol. Pain"}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365913001521?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365913001521?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T08:46:25Z","timestamp":1588841185000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365913001521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":60,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["S0168365913001521"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2013.03.009","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2013,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mesoporous silica-supported lipid bilayers (protocells) for DNA cargo delivery to the spinal cord","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2013.03.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V.","name":"copyright","label":"Copyright"}]}}