{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T22:14:28Z","timestamp":1787696068149,"version":"build-2784847793"},"reference-count":38,"publisher":"Elsevier BV","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1016\/j.jconrel.2013.12.012","type":"journal-article","created":{"date-parts":[[2013,12,24]],"date-time":"2013-12-24T18:45:14Z","timestamp":1387910714000},"page":"35-43","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Polymer-enhanced delivery increases adenoviral gene expression in an orthotopic model of bladder cancer"],"prefix":"10.1016","volume":"176","author":[{"given":"Helen","family":"Gosnell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura M.","family":"Kasman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thrimoorthy","family":"Potta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Vu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Garrett-Mayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaushal","family":"Rege","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Voelkel-Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2013.12.012_bb0005","doi-asserted-by":"crossref","first-page":"220","DOI":"10.3322\/caac.21149","article-title":"Cancer treatment and survivorship statistics, 2012","volume":"62","author":"Siegel","year":"2012","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.jconrel.2013.12.012_bb0010","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.urology.2006.03.062","article-title":"Clinical model of lifetime cost of treating bladder cancer and associated complications","volume":"68","author":"Avritscher","year":"2006","journal-title":"Urology"},{"key":"10.1016\/j.jconrel.2013.12.012_bb0015","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.cytogfr.2010.02.003","article-title":"Virus therapy for bladder cancer","volume":"21","author":"Burke","year":"2010","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.jconrel.2013.12.012_bb0020","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1159\/000098076","article-title":"Adenoviral receptor expression of normal bladder and transitional cell carcinoma of the bladder","volume":"78","author":"Buscarini","year":"2007","journal-title":"Urol. Int."},{"key":"10.1016\/j.jconrel.2013.12.012_bb0025","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.urology.2005.02.033","article-title":"Loss of coxsackie and adenovirus receptor expression is associated with features of aggressive bladder cancer","volume":"66","author":"Matsumoto","year":"2005","journal-title":"Urology"},{"key":"10.1016\/j.jconrel.2013.12.012_bb0030","doi-asserted-by":"crossref","first-page":"908","DOI":"10.2174\/138620711797537076","article-title":"Discovery of cationic polymers for non-viral gene delivery using combinatorial approaches","volume":"14","author":"Barua","year":"2011","journal-title":"Comb. Chem. High Throughput Screen."},{"key":"10.1016\/j.jconrel.2013.12.012_bb0035","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1021\/mp9000958","article-title":"Polymer-enhanced adenoviral transduction of CAR-negative bladder cancer cells","volume":"6","author":"Kasman","year":"2009","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jconrel.2013.12.012_bb0040","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1021\/bp060336y","article-title":"Retrovirus-polymer complexes: study of the factors affecting the dose response of transduction","volume":"23","author":"Landazuri","year":"2007","journal-title":"Biotechnol. Prog."},{"key":"10.1016\/j.jconrel.2013.12.012_bb0045","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.bbrc.2005.03.035","article-title":"Highly efficient transduction of repopulating bone marrow cells using rapidly concentrated polymer-complexed retrovirus","volume":"330","author":"McMillin","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jconrel.2013.12.012_bb0050","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1002\/jgm.618","article-title":"Complexation of retroviruses with charged polymers enhances gene transfer by increasing the rate that viruses are delivered to cells","volume":"6","author":"Landazuri","year":"2004","journal-title":"J. Gene Med."},{"key":"10.1016\/j.jconrel.2013.12.012_bb0055","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/S0006-3495(04)74197-1","article-title":"Charged polymers modulate retrovirus transduction via membrane charge neutralization and virus aggregation","volume":"86","author":"Davis","year":"2004","journal-title":"Biophys. J."},{"key":"10.1016\/j.jconrel.2013.12.012_bb0060","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1021\/bp990049c","article-title":"Differential inhibition of retrovirus transduction by proteoglycans and free glycosaminoglycans","volume":"15","author":"Le Doux","year":"1999","journal-title":"Biotechnol. Prog."},{"key":"10.1016\/j.jconrel.2013.12.012_bb0065","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1016\/j.biomaterials.2009.11.043","article-title":"The effect of surface modification of adenovirus with an arginine-grafted bioreducible polymer on transduction efficiency and immunogenicity in cancer gene therapy","volume":"31","author":"Kim","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2013.12.012_bb0070","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1038\/mt.2011.111","article-title":"Engineering biomaterial systems to enhance viral vector gene delivery","volume":"19","author":"Jang","year":"2011","journal-title":"Mol. Ther."},{"key":"10.1016\/j.jconrel.2013.12.012_bb0075","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1021\/mp300366f","article-title":"Adenoviral vectors coated with PAMAM dendrimer conjugates allow CAR independent virus uptake and targeting to the EGF receptor","volume":"10","author":"Vetter","year":"2013","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jconrel.2013.12.012_bb0080","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1023\/A:1007548826495","article-title":"Cationic polymer based gene delivery systems","volume":"17","author":"De Smedt","year":"2000","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2013.12.012_bb0085","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.addr.2006.03.007","article-title":"Current status of polymeric gene delivery systems","volume":"58","author":"Park","year":"2006","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2013.12.012_bb0090","doi-asserted-by":"crossref","first-page":"3477","DOI":"10.1016\/j.biomaterials.2008.04.036","article-title":"Progress in developing cationic vectors for non-viral systemic gene therapy against cancer","volume":"29","author":"Morille","year":"2008","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2013.12.012_bb0095","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1021\/ar200151m","article-title":"Recent advances in nonviral vectors for gene delivery","volume":"45","author":"Guo","year":"2012","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.jconrel.2013.12.012_bb0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10565-009-9139-5","article-title":"Using viral vectors as gene transfer tools (cell biology and toxicology special issue: ETCS-UK 1 day meeting on genetic manipulation of cells)","volume":"26","author":"Howarth","year":"2010","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.jconrel.2013.12.012_bb0105","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.7150\/thno.4492","article-title":"Generation of a focused poly(amino ether) library: polymer-mediated transgene delivery and gold-nanorod based theranostic systems","volume":"2","author":"Vu","year":"2012","journal-title":"Theranostics"},{"key":"10.1016\/j.jconrel.2013.12.012_bb0110","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1021\/mp800151j","article-title":"Parallel synthesis and screening of polymers for nonviral gene delivery","volume":"6","author":"Barua","year":"2009","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jconrel.2013.12.012_bb0115","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/S0968-0896(99)00071-1","article-title":"Enhanced RNA binding of dimerized aminoglycosides","volume":"7","author":"Michael","year":"1999","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.jconrel.2013.12.012_bb0120","doi-asserted-by":"crossref","first-page":"520","DOI":"10.4161\/cbt.1.5.169","article-title":"Doxorubicin pretreatment sensitizes prostate cancer cell lines to TRAIL induced apoptosis which correlates with the loss of c-FLIP expression","volume":"1","author":"Kelly","year":"2002","journal-title":"Cancer Biol. Ther."},{"issue":"82","key":"10.1016\/j.jconrel.2013.12.012_bb0125","doi-asserted-by":"crossref","DOI":"10.3791\/50181","article-title":"An orthotopic bladder cancer model for gene delivery studies","author":"Kasman","year":"2013","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.jconrel.2013.12.012_bb0130","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/sj.cgt.7700746","article-title":"In vitro efficacy of Fas ligand gene therapy for the treatment of bladder cancer","volume":"12","author":"Sudarshan","year":"2005","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.jconrel.2013.12.012_bb0135","first-page":"4784","article-title":"Limitations of the reporter green fluorescent protein under simulated tumor conditions","volume":"61","author":"Coralli","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.jconrel.2013.12.012_bb0140","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1097\/00005392-200102000-00091","article-title":"Evaluation of gene transfer efficiency by viral vectors to murine bladder epithelium","volume":"165","author":"Siemens","year":"2001","journal-title":"J. Urol."},{"key":"10.1016\/j.jconrel.2013.12.012_bb0145","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.ymthe.2004.07.002","article-title":"Identification of pretreatment agents to enhance adenovirus infection of bladder epithelium","volume":"10","author":"Ramesh","year":"2004","journal-title":"Mol. Ther."},{"key":"10.1016\/j.jconrel.2013.12.012_bb0150","doi-asserted-by":"crossref","first-page":"10274","DOI":"10.1128\/JVI.74.22.10274-10286.2000","article-title":"Dependence of adenovirus infectivity on length of the fiber shaft domain","volume":"74","author":"Shayakhmetov","year":"2000","journal-title":"J. Virol."},{"key":"10.1016\/j.jconrel.2013.12.012_bb0155","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1038\/mt.2011.111","article-title":"Engineering biomaterial systems to enhance viral vector gene delivery","volume":"19","author":"Jang","year":"2011","journal-title":"Mol. Ther."},{"key":"10.1016\/j.jconrel.2013.12.012_bb0160","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1038\/78523","article-title":"Enhancement of transfection by physical concentration of DNA at the cell surface","volume":"18","author":"Luo","year":"2000","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jconrel.2013.12.012_bb0165","doi-asserted-by":"crossref","first-page":"9396","DOI":"10.1073\/pnas.85.24.9396","article-title":"Charge configurations in viral proteins","volume":"85","author":"Karlin","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jconrel.2013.12.012_bb0170","doi-asserted-by":"crossref","first-page":"7614","DOI":"10.1128\/JVI.70.11.7614-7621.1996","article-title":"Comparative analysis of adenovirus fiber-cell interaction: adenovirus type 2 (Ad2) and Ad9 utilize the same cellular fiber receptor but use different binding strategies for attachment","volume":"70","author":"Roelvink","year":"1996","journal-title":"J. Virol."},{"key":"10.1016\/j.jconrel.2013.12.012_bb0175","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1128\/JVI.74.1.42-48.2000","article-title":"Adenovirus type 37 uses sialic acid as a cellular receptor","volume":"74","author":"Arnberg","year":"2000","journal-title":"J. Virol."},{"key":"10.1016\/j.jconrel.2013.12.012_bb0180","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1097\/CJI.0b013e3181acea69","article-title":"Local AdCD40L gene therapy is effective for disseminated murine experimental cancer by breaking T-cell tolerance and inducing tumor cell growth inhibition","volume":"32","author":"Lindqvist","year":"2009","journal-title":"J. Immunother."},{"key":"10.1016\/j.jconrel.2013.12.012_bb0185","doi-asserted-by":"crossref","first-page":"3279","DOI":"10.1158\/1078-0432.CCR-10-0385","article-title":"AdCD40L immunogene therapy for bladder carcinoma\u2014the first phase I\/IIa trial","volume":"16","author":"Malmstrom","year":"2010","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.jconrel.2013.12.012_bb0190","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/sj.gt.3301851","article-title":"Adenovirus-mediated gene therapy for bladder cancer: efficient gene delivery to normal and malignant human urothelial cells in vitro and ex vivo","volume":"10","author":"Chester","year":"2003","journal-title":"Gene Ther."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365913009541?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365913009541?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T21:22:49Z","timestamp":1597267369000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365913009541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":38,"alternative-id":["S0168365913009541"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2013.12.012","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Polymer-enhanced delivery increases adenoviral gene expression in an orthotopic model of bladder cancer","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2013.12.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}