{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:55:38Z","timestamp":1789570538947,"version":"build-2803163510"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Development Agency of Hungary","award":["TECH-08-D1-2008-0030"],"award-info":[{"award-number":["TECH-08-D1-2008-0030"]}]},{"DOI":"10.13039\/100000065","name":"Miskolc University, T\u00c1MOP-4.2.1.B to \u201cApplied Materials and Nanotechnology Center of Excelence\u201d; EU","doi-asserted-by":"publisher","award":["FP7-NMP-2012-LARGE-6-309820"],"award-info":[{"award-number":["FP7-NMP-2012-LARGE-6-309820"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Phospholipid Research Center, Heidelberg, Germany"},{"name":"Gedeon Richter NyRT"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1016\/j.jconrel.2014.08.009","type":"journal-article","created":{"date-parts":[[2014,8,19]],"date-time":"2014-08-19T08:45:28Z","timestamp":1408437928000},"page":"2-10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":91,"special_numbering":"C","title":["Features of complement activation-related pseudoallergy to liposomes with different surface charge and PEGylation: Comparison of the porcine and rat responses"],"prefix":"10.1016","volume":"195","author":[{"given":"L\u00e1szl\u00f3","family":"D\u00e9zsi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam\u00e1s","family":"F\u00fcl\u00f6p","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam\u00e1s","family":"M\u00e9sz\u00e1ros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e1bor","family":"Sz\u00e9n\u00e1si","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf","family":"Urbanics","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Csenge","family":"V\u00e1zsonyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"\u0150rfi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"Rosivall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9ka","family":"Nemes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robbert Jan","family":"Kok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josbert M.","family":"Metselaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gert","family":"Storm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e1nos","family":"Szebeni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2014.08.009_bb0005","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1161\/01.CIR.99.17.2302","article-title":"Hemodynamic changes induced by liposomes and liposome-encapsulated hemoglobin in pigs: a model for pseudo-allergic cardiopulmonary reactions to liposomes. Role of complement and inhibition by soluble CR1 and anti-C5a antibody","volume":"99","author":"Szebeni","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.jconrel.2014.08.009_bb0010","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.tox.2005.07.023","article-title":"Complement activation-related pseudoallergy: a new class of drug-induced immune toxicity","volume":"216","author":"Szebeni","year":"2005","journal-title":"Toxicology"},{"key":"10.1016\/j.jconrel.2014.08.009_bb0015","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0163-7827(03)00033-X","article-title":"Stealth liposomes and long circulating nanoparticles: critical issues in pharmacokinetics, opsonization and protein-binding properties","volume":"42","author":"Moghimi","year":"2003","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.jconrel.2014.08.009_bb0020","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1166\/jbn.2009.1045","article-title":"Complement: alive and kicking nanomedicines","volume":"5","author":"Andersen","year":"2009","journal-title":"J. Biomed. Nanotechnol."},{"key":"10.1016\/j.jconrel.2014.08.009_bb0025","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1096\/fj.06-6186fje","article-title":"Methylation of the phosphate oxygen moiety of phospholipid-methoxy(polyethylene glycol) conjugate prevents PEGylated liposome-mediated complement activation and anaphylatoxin production","volume":"20","author":"Moghimi","year":"2006","journal-title":"FASEB J."},{"key":"10.1016\/j.jconrel.2014.08.009_bb0030","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/j.addr.2011.06.017","article-title":"Activation of complement by therapeutic liposomes and other lipid excipient-based therapeutic products: Prediction and prevention","volume":"63","author":"Szebeni","year":"2011","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2014.08.009_bb0035","first-page":"33","article-title":"Hemocompatibility testing for nanomedicines and biologicals: predictive assays for complement mediated infusion reactions","volume":"5","author":"Szebeni","year":"2012","journal-title":"Eur. J. Nanomed."},{"key":"10.1016\/j.jconrel.2014.08.009_bb0040","series-title":"Handbook of Harnessing Biomaterials in Nanomedicine: Preparation, Toxicity, and Applications","first-page":"309","article-title":"Complement activation, immunogenicity, and immune suppression as potential side effects of liposomes","author":"Szebeni","year":"2012"},{"key":"10.1016\/j.jconrel.2014.08.009_bb0045","author":"European Medicines Agency"},{"key":"10.1016\/j.jconrel.2014.08.009_bb0050","series-title":"ANSI\/AAMI\/ISO 10993-4:2002\/(R), 10 March 2009","article-title":"Association for the advancement of medical instrumentation and international organization for standardization, biological evaluation of medical devices \u2014 part 4: selection of tests for interaction with blood","author":"American National Standards Institute","year":"2009"},{"key":"10.1016\/j.jconrel.2014.08.009_bb0055","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.4236\/health.2013.56138","article-title":"Cardiopulmonary and hemodynamic changes in complement activation-related pseudoallergy","volume":"6","author":"D\u00e9zsi","year":"2013","journal-title":"Health"},{"key":"10.1016\/j.jconrel.2014.08.009_bb0060","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1080\/08982100701375118","article-title":"Animal models of complement-mediated hypersensitivity reactions to liposomes and other lipid-based nanoparticles","volume":"17","author":"Szebeni","year":"2007","journal-title":"J. Liposome Res."},{"key":"10.1016\/j.jconrel.2014.08.009_bb0065","first-page":"H1319","article-title":"Liposome-induced pulmonary hypertension: properties and mechanism of a complement-mediated pseudoallergic reaction","volume":"279","author":"Szebeni","year":"2000","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.jconrel.2014.08.009_bb0070","first-page":"H1050","article-title":"Complement activation-related cardiac anaphylaxis in pigs: role of C5a anaphylatoxin and adenosine in liposome-induced abnormalities in ECG and heart function","volume":"290","author":"Szebeni","year":"2006","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.jconrel.2014.08.009_bb0075","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1016\/j.addr.2012.07.005","article-title":"A porcine model of complement-mediated infusion reactions to drug carrier nanosystems and other medicines","volume":"64","author":"Szebeni","year":"2012","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2014.08.009_bb0080","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.nano.2011.06.003","article-title":"Liposome-induced complement activation and related cardiopulmonary distress in pigs: factors promoting reactogenicity of Doxil and AmBisome","volume":"8","author":"Szebeni","year":"2012","journal-title":"Nanomedicine: NBM"},{"key":"10.1016\/j.jconrel.2014.08.009_bb0085","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.jconrel.2012.02.029","article-title":"Prevention of infusion reactions to PEGylated liposomal doxorubicin via tachyphylaxis induction by placebo vesicles: a porcine model","volume":"160","author":"Szebeni","year":"2012","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2014.08.009_bb0090","first-page":"263","article-title":"Encapsulation of Hemoglobin in Liposomes, in Red Blood Cell Substitutes: Fundamental Principles and Clinical Applications","author":"Rabinovici","year":"1998"},{"key":"10.1016\/j.jconrel.2014.08.009_bb0095","first-page":"115","article-title":"Characterization of hemodynamic, hematologic and biochemical responses to administration of liposome-encapsulated hemoglobin in the conscious, freely moving rat","volume":"29","author":"Rabinovici","year":"1989","journal-title":"Circ. Shock."},{"key":"10.1016\/j.jconrel.2014.08.009_bb0100","first-page":"124","article-title":"Biological responses to exchange transfusion with liposome-encapsulated hemoglobin","volume":"37","author":"Rabinovici","year":"1992","journal-title":"Circ. Shock."},{"key":"10.1016\/j.jconrel.2014.08.009_bb0105","first-page":"1","article-title":"Liposome-encapsulated hemoglobin: an oxygen-carrying fluid","volume":"32","author":"Rabinovici","year":"1990","journal-title":"Circ. Shock."},{"key":"10.1016\/j.jconrel.2014.08.009_bb0110","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1097\/00005373-199307000-00019","article-title":"A new salutary resuscitative fluid: liposome encapsulated hemoglobin\/hypertonic saline solution","volume":"35","author":"Rabinovici","year":"1993","journal-title":"J. Trauma"},{"key":"10.1016\/j.jconrel.2014.08.009_bb0115","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1097\/00003246-199403000-00019","article-title":"Lyophilized liposome-encapsulated hemoglobin: evaluation of hemodynamic, biochemical, and hematologic responses","volume":"22","author":"Rabinovici","year":"1994","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.jconrel.2014.08.009_bb0120","first-page":"431","article-title":"Biological responses to liposome-encapsulated hemoglobin (LEH) are improved by a PAF antagonist","volume":"31","author":"Rabinovici","year":"1990","journal-title":"Circ. Shock."},{"key":"10.1016\/j.jconrel.2014.08.009_bb0125","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1097\/00003246-199703000-00015","article-title":"Liposome-encapsulated hemoglobin modulates lipopolysaccharide-induced tumor necrosis-alpha production in mice","volume":"25","author":"Rudolph","year":"1997","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.jconrel.2014.08.009_bb0130","first-page":"415","article-title":"Infusion of liposome-encapsulated hemoglobin in normovolemic primates","volume":"24","author":"Rudolph","year":"1996","journal-title":"Artif. Cells Blood Substit. Immobil. Biotechnol."},{"key":"10.1016\/j.jconrel.2014.08.009_bb0135","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1006\/bbrc.1994.2658","article-title":"Complement activation in rats by liposomes and liposome-encapsulated hemoglobin: evidence for anti-lipid antibodies and alternative pathway activation","volume":"205","author":"Szebeni","year":"1994","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jconrel.2014.08.009_bb0140","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.ejps.2013.03.007","article-title":"Complement activation by PEGylated liposomes containing prednisolone","volume":"49","author":"van den Hoven","year":"2013","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2014.08.009_bb0145","doi-asserted-by":"crossref","first-page":"379","DOI":"10.3109\/10731199709118925","article-title":"Complement activation and thromboxane A2 secretion in rats following administration of liposome-encapsulated hemoglobin: inhibition by soluble complement receptor type 1","volume":"25","author":"Szebeni","year":"1997","journal-title":"Artif. Cells Blood Substit. Immobil. Biotechnol."},{"key":"10.1016\/j.jconrel.2014.08.009_bb0150","author":"Ambisome"},{"key":"10.1016\/j.jconrel.2014.08.009_bb0155","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1128\/AAC.41.6.1275","article-title":"Pharmacokinetics of liposomal amphotericin B (Ambisome) in critically ill patients","volume":"41","author":"Heinemann","year":"1997","journal-title":"Antimicrob. Agents Chemother."},{"issue":"Suppl. B","key":"10.1016\/j.jconrel.2014.08.009_bb0160","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1093\/jac\/28.suppl_B.83","article-title":"Liposomal amphotericin B (AmBisome): safety data from a phase II\/III clinical trial","volume":"28","author":"Meunier","year":"1991","journal-title":"J. Antimicrob. Chemother."},{"issue":"Suppl. B","key":"10.1016\/j.jconrel.2014.08.009_bb0165","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1093\/jac\/28.suppl_B.93","article-title":"Liposomal amphotericin B (AmBisome) in the treatment of fungal infections in neutropenic patients","volume":"28","author":"Chopra","year":"1991","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.jconrel.2014.08.009_bb0170","first-page":"75","article-title":"Liposomal amphotericin B (AmBisome) in Mediterranean visceral leishmaniasis: a multi-centre trial","volume":"87","author":"Davidson","year":"1994","journal-title":"Q. J. Med."},{"key":"10.1016\/j.jconrel.2014.08.009_bb0175","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1093\/clinids\/21.1.188","article-title":"Liposomal amphotericin B (AmBisome) in the treatment of complicated kala-azar under field conditions","volume":"21","author":"Seaman","year":"1995","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.jconrel.2014.08.009_bb0180","first-page":"1195","article-title":"Prophylaxis with liposomal amphotericin B (AmBisome) prevents fungal infections in liver transplant recipients: long-term results of a randomized, placebo-controlled trial","volume":"27","author":"Tollemar","year":"1995","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.jconrel.2014.08.009_bb0185","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1046\/j.1365-2141.1998.0952a.x","article-title":"Anaphylactic reaction to liposomal amphotericin (AmBisome)","volume":"102","author":"Schneider","year":"1998","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.jconrel.2014.08.009_bb0190","doi-asserted-by":"crossref","first-page":"L498","DOI":"10.1152\/ajplung.00322.2011","article-title":"Pulmonary intravascular macrophages and lung health: what are we missing?","volume":"302","author":"Schneberger","year":"2012","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.jconrel.2014.08.009_bb0195","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0022-4804(03)00142-2","article-title":"Prevention of acute lung injury in swine: depletion of pulmonary intravascular macrophages using liposomal clodronate","volume":"112","author":"Gaca","year":"2003","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.jconrel.2014.08.009_bb0200","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0021-9975(08)80021-7","article-title":"Pulmonary intravascular macrophages in lungs of pigs inoculated with African swine fever virus of differing virulence","volume":"102","author":"Sierra","year":"1990","journal-title":"J. Comp. Pathol."},{"key":"10.1016\/j.jconrel.2014.08.009_bb0205","doi-asserted-by":"crossref","first-page":"H1050","DOI":"10.1152\/ajpheart.00622.2005","article-title":"Complement activation-related cardiac anaphylaxis in pigs: role of C5a anaphylatoxin and adenosine in liposome-induced abnormalities in ECG and heart function","volume":"290","author":"Szebeni","year":"2006","journal-title":"Am. J. Physiol. Heart Circ. Physiol."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365914005914?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365914005914?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T03:29:47Z","timestamp":1565753387000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365914005914"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":41,"alternative-id":["S0168365914005914"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2014.08.009","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Features of complement activation-related pseudoallergy to liposomes with different surface charge and PEGylation: Comparison of the porcine and rat responses","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2014.08.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}