{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:48:11Z","timestamp":1792813691072,"version":"4.5.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,7,17]],"date-time":"2016-07-17T00:00:00Z","timestamp":1468713600000},"content-version":"am","delay-in-days":320,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000005","name":"Department of Defense","doi-asserted-by":"publisher","award":["1W81XWH-13-1-0146"],"award-info":[{"award-number":["1W81XWH-13-1-0146"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research to Prevent Blindness (New York, NY)"},{"name":"Oshman Foundation (Houston, TX)"},{"name":"William Stamps Farish Fund (Houston, TX)"},{"name":"Hamill Foundation (Houston, TX)"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.jconrel.2015.07.007","type":"journal-article","created":{"date-parts":[[2015,7,13]],"date-time":"2015-07-13T15:44:00Z","timestamp":1436802240000},"page":"168-174","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":90,"special_numbering":"C","title":["Dexamethasone nanowafer as an effective therapy for dry eye disease"],"prefix":"10.1016","volume":"213","author":[{"given":"Terry G.","family":"Coursey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna Tukler","family":"Henriksson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela C.","family":"Marcano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crystal S.","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas C.","family":"Isenhart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faheem","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cintia S.","family":"De Paiva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen C.","family":"Pflugfelder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghanashyam","family":"Acharya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2015.07.007_bb0005","doi-asserted-by":"crossref","first-page":"157","DOI":"10.17925\/EOR.2012.06.03.157","article-title":"Biomarkers in dry eye disease","volume":"6","author":"Lemp","year":"2012","journal-title":"Eur. Ophthalmic Rev."},{"key":"10.1016\/j.jconrel.2015.07.007_bb0010","series-title":"Dry Eye Disease: The Clinician's Guide to Diagnosis and Treatment","first-page":"1","article-title":"Epidemiology of dry eye disease","author":"Tomlinson","year":"2006"},{"key":"10.1016\/j.jconrel.2015.07.007_bb0015","doi-asserted-by":"crossref","first-page":"405","DOI":"10.2147\/OPTH.S5555","article-title":"Etiology, prevalence, and treatment of dry eye disease","volume":"3","author":"Gayton","year":"2009","journal-title":"Clin. Ophthalmol."},{"key":"10.1016\/j.jconrel.2015.07.007_bb0020","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1097\/ICU.0b013e3283023d4c","article-title":"Dry eyes: etiology and management","volume":"19","author":"Latkany","year":"2008","journal-title":"Curr. Opin. Ophthalmol."},{"key":"10.1016\/j.jconrel.2015.07.007_bb0025","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1007\/s11882-004-0077-2","article-title":"Dry eye: diagnosis and current treatment strategies","volume":"4","author":"O'Brien","year":"2004","journal-title":"Curr. Allergy Asthma Rep."},{"key":"10.1016\/j.jconrel.2015.07.007_bb0030","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S0002-9394(03)00218-6","article-title":"Prevalence of dry eye syndrome among US women","volume":"136","author":"Schaumberg","year":"2003","journal-title":"Am J. Ophthalmol."},{"key":"10.1016\/j.jconrel.2015.07.007_bb0035","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.ajo.2008.05.016","article-title":"Advances in understanding and managing dry eye disease","volume":"146","author":"Lemp","year":"2008","journal-title":"Am J. Ophthalmol."},{"key":"10.1016\/j.jconrel.2015.07.007_bb0040","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S1542-0124(12)70082-4","article-title":"The epidemiology of dry eye disease. Report of the epidemiology subcommittee of the international dry eye work shop","volume":"5","year":"2007","journal-title":"Ocul. Surf."},{"issue":"Suppl. 2","key":"10.1016\/j.jconrel.2015.07.007_bb0045","doi-asserted-by":"crossref","first-page":"S221","DOI":"10.1016\/S0039-6257(00)00201-0","article-title":"Diagnosis of dry eye","volume":"45","author":"Bron","year":"2001","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.jconrel.2015.07.007_bb0050","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.ajo.2013.10.014","article-title":"Dry eye disease and work productivity loss in visual display users: the Osaka study","volume":"157","author":"Uchino","year":"2014","journal-title":"Am J. Ophthalmol."},{"key":"10.1016\/j.jconrel.2015.07.007_bb0055","series-title":"Dry Eye and the Ocular Surface","first-page":"1","article-title":"The problem","author":"Pflugfelder","year":"2004"},{"key":"10.1016\/j.jconrel.2015.07.007_bb0060","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S1542-0124(12)70081-2","article-title":"The definition and classification of dry eye disease: report of the definition and classification subcommittee of the international dry eye work shop","volume":"5","year":"2007","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.jconrel.2015.07.007_bb0065","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1097\/ICO.0b013e31802e1e04","article-title":"Clinical performance of a mid-viscosity artificial tear for dry eye treatment","volume":"26","author":"Simmons","year":"2007","journal-title":"Cornea"},{"key":"10.1016\/j.jconrel.2015.07.007_bb0070","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1097\/ICO.0000000000000358","article-title":"Tear film thickness after treatment with artificial tears in patients with moderate dry eye disease","volume":"34","author":"Schmidl","year":"2015","journal-title":"Cornea"},{"key":"10.1016\/j.jconrel.2015.07.007_bb0075","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.ajo.2003.10.036","article-title":"Anti-inflammatory therapy of dry eye","volume":"137","author":"Pflugfelder","year":"2004","journal-title":"Am J. Ophthalmol."},{"key":"10.1016\/j.jconrel.2015.07.007_bb0080","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S0002-9394(03)00326-X","article-title":"The comparison of efficacies of topical corticosteroids and nonsteroidal anti-inflammatory drops on dry eye patients: a clinical and immunocytochemical study","volume":"136","author":"Avunduk","year":"2003","journal-title":"Am J. Ophthalmol."},{"key":"10.1016\/j.jconrel.2015.07.007_bb0085","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1089\/jop.2012.0096","article-title":"Evaluation of corneal morphologic and functional parameters after use of topical cyclosporine-a 0.05% in dry eye","volume":"28","author":"Kara","year":"2012","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"10.1016\/j.jconrel.2015.07.007_bb0090","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1097\/00055735-199604000-00014","article-title":"Side effects of antiglaucomatous drugs on the ocular surface","volume":"7","author":"Baudouin","year":"1996","journal-title":"Curr. Opin. Ophthalmol."},{"key":"10.1016\/j.jconrel.2015.07.007_bb0095","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1046\/j.1442-9071.2000.00237.x","article-title":"Adverse effects of topical antiglaucoma drugs on the ocular surface","volume":"28","author":"Arici","year":"2000","journal-title":"Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.jconrel.2015.07.007_bb0100","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.jconrel.2014.06.043","article-title":"Ocular delivery of macromolecules","volume":"190","author":"Kim","year":"2014","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2015.07.007_bb0105","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.jconrel.2011.01.010","article-title":"Development and characterization of cyclosporine A loaded nanoparticles for ocular drug delivery: cellular toxicity, uptake, and kinetic studies","volume":"151","author":"Aksungur","year":"2011","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2015.07.007_bb0110","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.jconrel.2013.07.016","article-title":"A rapamycin-binding protein polymer nanoparticle shows potent therapeutic activity in suppressing autoimmune dacryoadenitis in a mouse model of Sjogren's syndrome","volume":"171","author":"Shah","year":"2013","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2015.07.007_bb0115","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.preteyeres.2010.08.002","article-title":"Applications of nanoparticles in ophthalmology","volume":"29","author":"Diebold","year":"2010","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.jconrel.2015.07.007_bb0120","doi-asserted-by":"crossref","first-page":"4808","DOI":"10.1167\/iovs.08-2515","article-title":"Mucoadhesive microdiscs engineered for ophthalmic drug delivery: effect of particle geometry and formulation on preocular residence time","volume":"49","author":"Choy","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jconrel.2015.07.007_bb0125","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jconrel.2015.01.023","article-title":"Sustained drug release by contact lenses for glaucoma treatment \u2014 a review","volume":"202","author":"Carvalho","year":"2015","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2015.07.007_bb0130","first-page":"87","article-title":"Novel approaches in formulation and drug delivery using contact lenses","volume":"2","author":"Singh","year":"2011","journal-title":"J. Basic Clin. Pharm."},{"key":"10.1016\/j.jconrel.2015.07.007_bb0135","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1167\/iovs.11-8215","article-title":"Sustained ocular delivery of ciprofloxacin using nanospheres and conventional contact lens materials","volume":"53","author":"Garhwal","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jconrel.2015.07.007_bb0140","first-page":"1419","article-title":"Artificial tears potpourri: a literature review","volume":"8","author":"Moshirfar","year":"2014","journal-title":"Clin. Ophthalmol."},{"key":"10.1016\/j.jconrel.2015.07.007_bb0145","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1016\/j.addr.2005.07.005","article-title":"Mucoadhesive polymers in ocular drug delivery","volume":"57","author":"Ludwig","year":"2005","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2015.07.007_bb0150","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1167\/iovs.06-0848","article-title":"Carboxy methyl cellulose binds to human corneal epithelial cells and is a modulator of corneal epithelial wound healing","volume":"48","author":"Garrett","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jconrel.2015.07.007_bb0155","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1089\/jop.2005.21.139","article-title":"Preservation of tear film integrity and inhibition of corneal injury by dexamethasone in a rabbit model of lacrimal gland inflammation-induced dry eye","volume":"21","author":"Nagelhout","year":"2005","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"10.1016\/j.jconrel.2015.07.007_bb0160","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1097\/01.ico.0000208815.02120.90","article-title":"Inhibition of inflammatory cytokine production in human corneal cells by dexamethasone, but not cyclosporin","volume":"25","author":"Djalilian","year":"2006","journal-title":"Cornea"},{"key":"10.1016\/j.jconrel.2015.07.007_bb0165","first-page":"633","article-title":"Ocular iontophoresis of EGP-437 (dexamethasone phosphate) in dry eye patients: results of a randomized clinical trial","volume":"5","author":"Patane","year":"2011","journal-title":"Clin. Ophthalmol."},{"key":"10.1016\/j.jconrel.2015.07.007_bb0170","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1021\/nn506599f","article-title":"Ocular drug delivery nanowafer with enhanced therapeutic efficacy","volume":"9","author":"Yuan","year":"2015","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2015.07.007_bb0175","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.jconrel.2010.03.024","article-title":"A study of drug release from homogeneous PLGA microstructures","volume":"146","author":"Acharya","year":"2010","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2015.07.007_bb0180","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.jconrel.2009.09.032","article-title":"The hydrogel template method for fabrication of homogeneous nano\/microparticles","volume":"141","author":"Acharya","year":"2010","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2015.07.007_bb0185","first-page":"632","article-title":"A mouse model of keratoconjunctivitis sicca","volume":"43","author":"Dursun","year":"2002","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jconrel.2015.07.007_bb0190","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1167\/iovs.05-1281","article-title":"Apical corneal barrier disruption in experimental murine dry eye is abrogated by methylprednisolone and doxycycline","volume":"47","author":"De Paiva","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jconrel.2015.07.007_bb0195","doi-asserted-by":"crossref","first-page":"3293","DOI":"10.1167\/iovs.05-1382","article-title":"Dessicating stress stimulates expression of matrix metalloproteinase by the corneal epithelium","volume":"47","author":"Corrales","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jconrel.2015.07.007_bb0200","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1001\/archophthalmol.2009.316","article-title":"Essential role for c-Jun N-terminal kinase 2 in corneal epithelial response to desiccating stress","volume":"127","author":"De Paiva","year":"2009","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.jconrel.2015.07.007_bb0205","doi-asserted-by":"crossref","first-page":"3293","DOI":"10.1167\/iovs.05-1382","article-title":"Desiccating stress stimulates expression of matrix metalloproteinases by the corneal epithelium","volume":"47","author":"Corrales","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jconrel.2015.07.007_bb0210","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1167\/iovs.09-3425","article-title":"Expression of CXCL9, -10, -11, and CXCR3 in the tear film and ocular surface of patients with dry eye syndrome","volume":"51","author":"Yoon","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jconrel.2015.07.007_bb0215","first-page":"3493","article-title":"Sjogren's syndrome: cytokine and Epstein-Barr viral gene expression within the conjunctival epithelium","volume":"35","author":"Jones","year":"1994","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jconrel.2015.07.007_bb0220","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1076\/ceyr.19.3.201.5309","article-title":"Altered cytokine balance in the tear fluid and conjunctiva of patients with Sjogren's syndrome keratoconjunctivitis sicca","volume":"19","author":"Pflugfelder","year":"1999","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.jconrel.2015.07.007_bb0225","doi-asserted-by":"crossref","first-page":"6279","DOI":"10.1167\/iovs.10-7081","article-title":"Interferon-\u03b3 exacerbates dry eye induced apoptosis in conjunctiva via dual apoptotic pathways","volume":"52","author":"Zhang","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jconrel.2015.07.007_bb0230","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.exer.2013.11.011","article-title":"Topical interferon-\u03b3 neutralization prevents conjunctival goblet cell loss in experimental murine dry eye","volume":"118","author":"Zhang","year":"2014","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.jconrel.2015.07.007_bb0235","article-title":"IFN-\u03b3 promotes goblet cell loss in response to desiccating ocular stress","volume":"47","author":"de Paiva","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jconrel.2015.07.007_bb0240","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1167\/iovs.07-0069","article-title":"Dry eye-induced conjunctival epithelial squamous metaplasia is modulated by interferon-\u03b3","volume":"48","author":"de Paiva","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jconrel.2015.07.007_bb0245","first-page":"1703","article-title":"Regulation of MMP-9 activity in human tear fluid and corneal epithelial culture supernatant","volume":"41","author":"Sobrin","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jconrel.2015.07.007_bb0250","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0002-9440(10)62232-8","article-title":"Matrix metalloproteinase-9 knockout confers resistance to corneal epithelial barrier disruption in experimental dry eye","volume":"166","author":"Pflugfelder","year":"2005","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jconrel.2015.07.007_bb0255","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.exer.2006.02.004","article-title":"Corticosteroid and doxycycline suppress MMP-9 and inflammatory cytokine expression, MAPK activation in the corneal epithelium in experimental dry eye","volume":"83","author":"de Paiva","year":"2006","journal-title":"Exp. Eye Res."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365915300225?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365915300225?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,10]],"date-time":"2019-08-10T06:37:38Z","timestamp":1565419058000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365915300225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":51,"alternative-id":["S0168365915300225"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2015.07.007","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dexamethasone nanowafer as an effective therapy for dry eye disease","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2015.07.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}