{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T11:19:25Z","timestamp":1775215165027,"version":"3.50.1"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","award":["GR 1517"],"award-info":[{"award-number":["GR 1517"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1016\/j.jconrel.2015.08.019","type":"journal-article","created":{"date-parts":[[2015,8,12]],"date-time":"2015-08-12T01:19:10Z","timestamp":1439342350000},"page":"121-131","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Cytotoxic T cell vaccination with PLGA microspheres interferes with influenza A virus replication in the lung and suppresses the infectious disease"],"prefix":"10.1016","volume":"216","author":[{"given":"Valerie L.","family":"Herrmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Hartmayer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Planz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus","family":"Groettrup","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2015.08.019_bb0005","author":"WHO"},{"key":"10.1016\/j.jconrel.2015.08.019_bb0010","first-page":"63","article-title":"Haemagglutination-inhibiting antibody to influenza virus","volume":"115","author":"de Jong","year":"2003","journal-title":"Dev. Biol."},{"key":"10.1016\/j.jconrel.2015.08.019_bb0015","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1126\/science.1122438","article-title":"Global patterns of influenza a virus in wild birds","volume":"312","author":"Olsen","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.jconrel.2015.08.019_bb0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/cid\/ciq015","article-title":"Potent CD8+ T-cell immunogenicity in humans of a novel heterosubtypic influenza A vaccine, MVA-NP+M1","volume":"52","author":"Berthoud","year":"2011","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.jconrel.2015.08.019_bb0025","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/j.micinf.2008.07.002","article-title":"Heterosubtypic immunity to influenza A virus: where do we stand?","volume":"10","author":"Grebe","year":"2008","journal-title":"Microbes Infect."},{"key":"10.1016\/j.jconrel.2015.08.019_bb0030","doi-asserted-by":"crossref","first-page":"3173","DOI":"10.1073\/pnas.1113342109","article-title":"Impact of cross-protective vaccines on epidemiological and evolutionary dynamics of influenza","volume":"109","author":"Arinaminpathy","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jconrel.2015.08.019_bb0035","doi-asserted-by":"crossref","first-page":"3212","DOI":"10.1016\/S0264-410X(03)00234-2","article-title":"Intranasal immunization with formalin-inactivated virus vaccine induces a broad spectrum of heterosubtypic immunity against influenza A virus infection in mice","volume":"21","author":"Takada","year":"2003","journal-title":"Vaccine"},{"key":"10.1016\/j.jconrel.2015.08.019_bb0040","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1056\/NEJM198307073090103","article-title":"Cytotoxic T-cell immunity to influenza","volume":"309","author":"McMichael","year":"1983","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jconrel.2015.08.019_bb0045","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1084\/jem.165.2.408","article-title":"Identification of viral molecules recognized by influenza-specific human cytotoxic T lymphocytes","volume":"165","author":"Gotch","year":"1987","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jconrel.2015.08.019_bb0050","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/267354a0","article-title":"Cytotoxic T cells kill influenza virus infected cells but do not distinguish between serologically distinct type A viruses","volume":"267","author":"Zweerink","year":"1977","journal-title":"Nature"},{"key":"10.1016\/j.jconrel.2015.08.019_bb0055","doi-asserted-by":"crossref","first-page":"e24626","DOI":"10.1371\/journal.pone.0024626","article-title":"Cross-protective peptide vaccine against influenza A viruses developed in HLA-A*2402 human immunity model","volume":"6","author":"Ichihashi","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jconrel.2015.08.019_bb0060","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0378-1135(96)00004-1","article-title":"Protective immune response of chickens against Newcastle disease, induced by the intranasal vaccination with inactivated virus","volume":"50","author":"Takada","year":"1996","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.jconrel.2015.08.019_bb0065","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1006\/viro.1998.9521","article-title":"Heterosubtypic immunity to lethal influenza A virus infection is associated with virus-specific CD8(+) cytotoxic T lymphocyte responses induced in mucosa-associated tissues","volume":"254","author":"Nguyen","year":"1999","journal-title":"Virology"},{"key":"10.1016\/j.jconrel.2015.08.019_bb0070","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1177\/2051013614525375","article-title":"MHC class I antigen presentation and implications for developing a new generation of therapeutic vaccines","volume":"2","author":"Comber","year":"2014","journal-title":"Ther. Adv. Vaccines"},{"key":"10.1016\/j.jconrel.2015.08.019_bb0075","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/nrd2224","article-title":"More than one reason to rethink the use of peptides in vaccine design","volume":"6","author":"Purcell","year":"2007","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jconrel.2015.08.019_bb0080","doi-asserted-by":"crossref","first-page":"3123","DOI":"10.1016\/S0264-410X(02)00261-X","article-title":"Intranasal administration of a synthetic peptide vaccine encapsulated in liposome together with an anti-CD40 antibody induces protective immunity against influenza A virus in mice","volume":"20","author":"Ninomiya","year":"2002","journal-title":"Vaccine"},{"key":"10.1016\/j.jconrel.2015.08.019_bb0085","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0939-6411(00)00079-5","article-title":"Revisiting PLA\/PLGA microspheres: an analysis of their potential in parenteral vaccination","volume":"50","author":"Johansen","year":"2000","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.jconrel.2015.08.019_bb0090","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/pros.20231","article-title":"Dendritic cells generated from androgen-independent prostate carcinoma patients are not impaired in migration and T cell stimulation","volume":"64","author":"Waeckerle-Men","year":"2005","journal-title":"Prostate"},{"key":"10.1016\/j.jconrel.2015.08.019_bb0095","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/S0264-410X(02)00521-2","article-title":"Encapsulation of peptides prolongs their presentation to cytotoxic T cells by antigen presenting cells in vitro","volume":"21","author":"Audran","year":"2003","journal-title":"Vaccine"},{"key":"10.1016\/j.jconrel.2015.08.019_bb0100","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1002\/jbm.10019","article-title":"Uptake of poly(d,l-lactic-co-glycolic acid) microspheres by antigen-presenting cells in vivo","volume":"60","author":"Newman","year":"2002","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.jconrel.2015.08.019_bb0105","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1007\/s00262-006-0157-3","article-title":"Dendritic cell-based multi-epitope immunotherapy of hormone-refractory prostate carcinoma","volume":"55","author":"Waeckerle-Men","year":"2006","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.jconrel.2015.08.019_bb0110","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1016\/j.vaccine.2008.01.030","article-title":"TLR ligands and antigen need to be coencapsulated into the same biodegradable microsphere for the generation of potent cytotoxic T lymphocyte responses","volume":"26","author":"Schlosser","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.jconrel.2015.08.019_bb0115","first-page":"35","article-title":"Delivery of tumor antigens to dendritic cells using biodegradable microspheres","volume":"109","author":"Waeckerle-Men","year":"2005","journal-title":"Methods Mol. Med."},{"key":"10.1016\/j.jconrel.2015.08.019_bb0120","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3389\/fmicb.2014.00171","article-title":"Antiviral activity of Ladania067, an extract from wild black currant leaves against influenza A virus in vitro and in vivo","volume":"5","author":"Haasbach","year":"2014","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.jconrel.2015.08.019_bb0125","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/S0198-8859(00)00105-1","article-title":"Human memory CTL response specific for influenza A virus is broad and multispecific","volume":"61","author":"Gianfrani","year":"2000","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.jconrel.2015.08.019_bb0130","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.coi.2013.07.005","article-title":"Correlates of protection against influenza infection in humans\u2014on the path to a universal vaccine?","volume":"25","author":"Li","year":"2013","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.jconrel.2015.08.019_bb0135","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/326881a0","article-title":"Cytotoxic T lymphocytes recognize a fragment of influenza virus matrix protein in association with HLA-A2","volume":"326","author":"Gotch","year":"1987","journal-title":"Nature"},{"key":"10.1016\/j.jconrel.2015.08.019_bb0140","doi-asserted-by":"crossref","first-page":"3681","DOI":"10.1016\/S0264-410X(01)00078-0","article-title":"Protective immunity against influenza A virus induced by immunization with DNA plasmid containing influenza M gene","volume":"19","author":"Okuda","year":"2001","journal-title":"Vaccine"},{"key":"10.1016\/j.jconrel.2015.08.019_bb0145","doi-asserted-by":"crossref","first-page":"6845","DOI":"10.1016\/j.vaccine.2007.07.035","article-title":"Partial protection against H5N1 influenza in mice with a single dose of a chimpanzee adenovirus vector expressing nucleoprotein","volume":"25","author":"Roy","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.jconrel.2015.08.019_bb0150","doi-asserted-by":"crossref","first-page":"5404","DOI":"10.1016\/j.vaccine.2005.04.047","article-title":"Protection against multiple influenza A subtypes by vaccination with highly conserved nucleoprotein","volume":"23","author":"Epstein","year":"2005","journal-title":"Vaccine"},{"key":"10.1016\/j.jconrel.2015.08.019_bb0155","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1016\/j.bbrc.2009.12.100","article-title":"A CTL-based liposomal vaccine capable of inducing protection against heterosubtypic influenza viruses in HLA-A*0201 transgenic mice","volume":"391","author":"Matsui","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jconrel.2015.08.019_bb0160","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3201\/eid1201.051237","article-title":"Cell-mediated protection in influenza infection","volume":"12","author":"Thomas","year":"2006","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.jconrel.2015.08.019_bb0165","doi-asserted-by":"crossref","first-page":"4047","DOI":"10.4049\/jimmunol.147.12.4047","article-title":"The minimum peptide epitope from the influenza virus matrix protein","volume":"147","author":"Bednarek","year":"1991","journal-title":"J. Immunol."},{"key":"10.1016\/j.jconrel.2015.08.019_bb0170","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1002\/eji.1830220404","article-title":"Identification of the nonamer peptide from influenza A matrix protein and the role of pockets of HLA-A2 in its recognition by cytotoxic T lymphocytes","volume":"22","author":"Morrison","year":"1992","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jconrel.2015.08.019_bb0175","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1016\/j.vaccine.2005.10.032","article-title":"Encapsulation of proteins and peptides into biodegradable poly(d,l-lactide-co-glycolide) microspheres prolongs and enhances antigen presentation by human dendritic cells","volume":"24","author":"WaeckerleMen","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.jconrel.2015.08.019_bb0180","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.4049\/jimmunol.126.3.1042","article-title":"Recovery from a viral respiratory infection. II. Passive transfer of immune spleen cells to mice with influenza pneumonia","volume":"126","author":"Wells","year":"1981","journal-title":"J. Immunol."},{"key":"10.1016\/j.jconrel.2015.08.019_bb0185","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/273238a0","article-title":"Transfer of specific cytotoxic T lymphocytes protects mice inoculated with influenza virus","volume":"273","author":"Yap","year":"1978","journal-title":"Nature"},{"key":"10.1016\/j.jconrel.2015.08.019_bb0190","doi-asserted-by":"crossref","first-page":"696","DOI":"10.4049\/jimmunol.174.2.696","article-title":"Vaccination with an acidic polymerase epitope of influenza virus elicits a potent antiviral T cell response but delayed clearance of an influenza virus challenge","volume":"174","author":"Crowe","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.jconrel.2015.08.019_bb0195","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0169-409X(01)00167-3","article-title":"Microparticles for intranasal immunization","volume":"51","author":"Vajdy","year":"2001","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2015.08.019_bb0200","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1126\/science.8493576","article-title":"Protection against vaginal SIV transmission with microencapsulated vaccine","volume":"260","author":"Marx","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.jconrel.2015.08.019_bb0205","doi-asserted-by":"crossref","first-page":"537","DOI":"10.4049\/jimmunol.176.1.537","article-title":"Memory T cell populations in the lung airways are maintained by continual recruitment","volume":"176","author":"Ely","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.jconrel.2015.08.019_bb0210","doi-asserted-by":"crossref","first-page":"8270","DOI":"10.1016\/j.vaccine.2007.09.051","article-title":"Influenza hemagglutinin vaccine with poly(gamma-glutamic acid) nanoparticles enhances the protection against influenza virus infection through both humoral and cell-mediated immunity","volume":"25","author":"Okamoto","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.jconrel.2015.08.019_bb0215","doi-asserted-by":"crossref","first-page":"e1003875","DOI":"10.1371\/journal.ppat.1003875","article-title":"Intranasal vaccination promotes detrimental Th17-mediated immunity against influenza infection","volume":"10","author":"Maroof","year":"2014","journal-title":"PLoS Pathog."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365915300651?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365915300651?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,12]],"date-time":"2023-08-12T22:55:47Z","timestamp":1691880947000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365915300651"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":43,"alternative-id":["S0168365915300651"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2015.08.019","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cytotoxic T cell vaccination with PLGA microspheres interferes with influenza A virus replication in the lung and suppresses the infectious disease","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2015.08.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}