{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:12:46Z","timestamp":1791925966814,"version":"4.3.4"},"reference-count":323,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.jconrel.2015.09.055","type":"journal-article","created":{"date-parts":[[2015,10,8]],"date-time":"2015-10-08T06:02:02Z","timestamp":1444284122000},"page":"576-595","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"special_numbering":"C","title":["Targeted endothelial nanomedicine for common acute pathological conditions"],"prefix":"10.1016","volume":"219","author":[{"given":"Vladimir V.","family":"Shuvaev","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob S.","family":"Brenner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir R.","family":"Muzykantov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jconrel.2015.09.055_bb0005","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1146\/annurev.bb.07.060178.002251","article-title":"Interactions of liposomes with mammalian cells","volume":"7","author":"Pagano","year":"1978","journal-title":"Annu. Rev. Biophys. Bioeng."},{"issue":"1","key":"10.1016\/j.jconrel.2015.09.055_bb0010","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/j.1749-6632.1978.tb22034.x","article-title":"Liposomes in therapeutic and preventive medicine: the development of the drug-carrier concept","volume":"308","author":"Gregoriadis","year":"1978","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.jconrel.2015.09.055_bb0015","first-page":"549","article-title":"Liposomes \u2014 methodology and applications","volume":"48","author":"Ryman","year":"1979","journal-title":"Front. Biol."},{"issue":"5","key":"10.1016\/j.jconrel.2015.09.055_bb0020","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1139\/y78-112","article-title":"Drug delivery systems: a brief review","volume":"56","author":"Juliano","year":"1978","journal-title":"Can. J. Physiol. Pharmacol."},{"issue":"4","key":"10.1016\/j.jconrel.2015.09.055_bb0025","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0142-9612(81)90059-4","article-title":"Present and future applications of biomaterials in controlled drug delivery systems","volume":"2","author":"Langer","year":"1981","journal-title":"Biomaterials"},{"issue":"7","key":"10.1016\/j.jconrel.2015.09.055_bb0030","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1039\/c2cs15327k","article-title":"Design of polymeric nanoparticles for biomedical delivery applications","volume":"41","author":"Elsabahy","year":"2012","journal-title":"Chem. Soc. Rev."},{"issue":"10","key":"10.1016\/j.jconrel.2015.09.055_bb0035","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1021\/ar2000315","article-title":"PRINT: a novel platform toward shape and size specific nanoparticle theranostics","volume":"44","author":"Perry","year":"2011","journal-title":"Acc. Chem. Res."},{"issue":"7","key":"10.1016\/j.jconrel.2015.09.055_bb0040","doi-asserted-by":"crossref","first-page":"232","DOI":"10.3109\/09687688.2010.516276","article-title":"Multifunctionality of lipid-core micelles for drug delivery and tumour targeting","volume":"27","author":"Sawant","year":"2010","journal-title":"Mol. Membr. Biol."},{"issue":"14\u201315","key":"10.1016\/j.jconrel.2015.09.055_bb0045","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1016\/j.addr.2011.06.016","article-title":"The effects of polymeric nanostructure shape on drug delivery","volume":"63","author":"Venkataraman","year":"2011","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"4","key":"10.1016\/j.jconrel.2015.09.055_bb0050","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1021\/bc900553n","article-title":"Design, synthesis, and biological evaluation of a robust, biodegradable dendrimer","volume":"21","author":"van der Poll","year":"2010","journal-title":"Bioconjug. Chem."},{"issue":"1","key":"10.1016\/j.jconrel.2015.09.055_bb0055","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1146\/annurev.bb.09.060180.002343","article-title":"Comparative properties and methods of preparation of lipid vesicles (liposomes)","volume":"9","author":"Szoka","year":"1980","journal-title":"Annu. Rev. Biophys. Bioeng."},{"issue":"5981","key":"10.1016\/j.jconrel.2015.09.055_bb0060","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1126\/science.1185547","article-title":"Self-assembly of Janus dendrimers into uniform dendrimersomes and other complex architectures","volume":"328","author":"Percec","year":"2010","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.jconrel.2015.09.055_bb0065","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.biomaterials.2004.03.003","article-title":"Characterization of biodegradable drug delivery vehicles with the adhesive properties of leukocytes II: effect of degradation on targeting activity","volume":"26","author":"Eniola","year":"2005","journal-title":"Biomaterials"},{"issue":"5417","key":"10.1016\/j.jconrel.2015.09.055_bb0070","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1126\/science.284.5417.1143","article-title":"Polymersomes: tough vesicles made from diblock copolymers","volume":"284","author":"Discher","year":"1999","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.jconrel.2015.09.055_bb0075","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1021\/nn900002m","article-title":"Impact of nanotechnology on drug delivery","volume":"3","author":"Farokhzad","year":"2009","journal-title":"ACS Nano"},{"issue":"5","key":"10.1016\/j.jconrel.2015.09.055_bb0080","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1021\/nn800072t","article-title":"Multifunctional inorganic nanoparticles for imaging, targeting, and drug delivery","volume":"2","author":"Liong","year":"2008","journal-title":"ACS Nano"},{"issue":"5","key":"10.1016\/j.jconrel.2015.09.055_bb0085","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1021\/nn900448g","article-title":"Nanofabrication beyond electronics","volume":"3","author":"Wang","year":"2009","journal-title":"ACS Nano"},{"issue":"3","key":"10.1016\/j.jconrel.2015.09.055_bb0090","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.jconrel.2008.06.021","article-title":"Advances in recognitive, conductive and responsive delivery systems","volume":"132","author":"Bayer","year":"2008","journal-title":"J. Control. Release"},{"issue":"2","key":"10.1016\/j.jconrel.2015.09.055_bb0095","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1002\/wnan.1209","article-title":"Clinical developments of chemotherapeutic nanomedicines: polymers and liposomes for delivery of camptothecins and platinum (II) drugs","volume":"5","author":"Kieler-Ferguson","year":"2013","journal-title":"Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol."},{"issue":"2","key":"10.1016\/j.jconrel.2015.09.055_bb0100","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jconrel.2008.04.013","article-title":"Pluronic block copolymers: evolution of drug delivery concept from inert nanocarriers to biological response modifiers","volume":"130","author":"Batrakova","year":"2008","journal-title":"J. Control. Release"},{"issue":"4","key":"10.1016\/j.jconrel.2015.09.055_bb0105","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1002\/jmri.20866","article-title":"Molecular imaging and therapy of atherosclerosis with targeted nanoparticles","volume":"25","author":"Wickline","year":"2007","journal-title":"J. Magn. Reson. Imaging"},{"issue":"3","key":"10.1016\/j.jconrel.2015.09.055_bb0110","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.jacc.2003.07.048","article-title":"Intravascular ultrasound molecular imaging of atheroma components in vivo","volume":"43","author":"Hamilton","year":"2004","journal-title":"J. Am. Coll. Cardiol."},{"issue":"4","key":"10.1016\/j.jconrel.2015.09.055_bb0115","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1073\/pnas.251662398","article-title":"Targeting endothelium and its dynamic caveolae for tissue-specific transcytosis in vivo: a pathway to overcome cell barriers to drug and gene delivery","volume":"99","author":"McIntosh","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jconrel.2015.09.055_bb0120","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0928-4680(98)00006-6","article-title":"Immunotargeting of drugs to the pulmonary vascular endothelium as a therapeutic strategy","volume":"5","author":"Muzykantov","year":"1998","journal-title":"Pathophysiology"},{"issue":"5","key":"10.1016\/j.jconrel.2015.09.055_bb0125","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S1535-6108(03)00276-9","article-title":"Advancing the field of drug delivery: taking aim at cancer","volume":"4","author":"Moses","year":"2003","journal-title":"Cancer Cell"},{"issue":"11","key":"10.1016\/j.jconrel.2015.09.055_bb0130","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/nbt1184-979","article-title":"Dehydration\u2013rehydration vesicles: a simple method for high yield drug entrapment in liposomes","volume":"2","author":"Kirby","year":"1984","journal-title":"Nat. Biotechnol."},{"issue":"4","key":"10.1016\/j.jconrel.2015.09.055_bb0135","first-page":"1172","article-title":"Anti-HER2 immunoliposomes: enhanced efficacy attributable to targeted delivery","volume":"8","author":"Park","year":"2002","journal-title":"Clin. Cancer Res."},{"issue":"5","key":"10.1016\/j.jconrel.2015.09.055_bb0140","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1517\/17425247.2.5.909","article-title":"Biomedical aspects of targeted delivery of drugs to pulmonary endothelium","volume":"2","author":"Muzykantov","year":"2005","journal-title":"Expert Opin. Drug Deliv."},{"issue":"6","key":"10.1016\/j.jconrel.2015.09.055_bb0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/ars.2008.2378","article-title":"Redox signaling across cell membranes","volume":"11","author":"Fisher","year":"2009","journal-title":"Antioxid. Redox Signal."},{"issue":"3","key":"10.1016\/j.jconrel.2015.09.055_bb0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0009631","article-title":"NADPH oxidase limits innate immune responses in the lungs in mice","volume":"5","author":"Segal","year":"2010","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.jconrel.2015.09.055_bb0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2008.03.011","article-title":"Redox-based regulation of signal transduction: principles, pitfalls, and promises","volume":"45","author":"Janssen-Heininger","year":"2008","journal-title":"Free Radic. Biol. Med."},{"issue":"6","key":"10.1016\/j.jconrel.2015.09.055_bb0160","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/j.freeradbiomed.2007.11.016","article-title":"NADPH oxidases in lung biology and pathology: host defense enzymes, and more","volume":"44","author":"van der Vliet","year":"2008","journal-title":"Free Radic. Biol. Med."},{"issue":"5782","key":"10.1016\/j.jconrel.2015.09.055_bb0165","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1126\/science.1130481","article-title":"Cell signaling. H2O2, a necessary evil for cell signaling","volume":"312","author":"Rhee","year":"2006","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.jconrel.2015.09.055_bb0170","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1021\/bi9020378","article-title":"Signaling functions of reactive oxygen species","volume":"49","author":"Forman","year":"2010","journal-title":"Biochemistry"},{"issue":"4995","key":"10.1016\/j.jconrel.2015.09.055_bb0175","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1126\/science.1990440","article-title":"Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis","volume":"251","author":"Cybulsky","year":"1991","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.jconrel.2015.09.055_bb0180","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1161\/01.RES.85.2.199","article-title":"Patterns of vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 expression in rabbit and mouse atherosclerotic lesions and at sites predisposed to lesion formation","volume":"85","author":"Iiyama","year":"1999","journal-title":"Circ. Res."},{"issue":"18","key":"10.1016\/j.jconrel.2015.09.055_bb0185","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.2174\/1381612054367274","article-title":"Targeting of antioxidant and anti-thrombotic drugs to endothelial cell adhesion molecules","volume":"11","author":"Muro","year":"2005","journal-title":"Curr. Pharm. Des."},{"issue":"1","key":"10.1016\/j.jconrel.2015.09.055_bb0190","doi-asserted-by":"crossref","first-page":"11","DOI":"10.5482\/HAMO-14-11-0075","article-title":"Endothelium and haemostasis","volume":"35","author":"Aird","year":"2015","journal-title":"Hamostaseologie"},{"issue":"2","key":"10.1016\/j.jconrel.2015.09.055_bb0195","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.semnephrol.2012.02.001","article-title":"Vascular heterogeneity in the kidney","volume":"32","author":"Molema","year":"2012","journal-title":"Semin. Nephrol."},{"issue":"1","key":"10.1016\/j.jconrel.2015.09.055_bb0200","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1476-5926-1-1","article-title":"Structural and functional aspects of liver sinusoidal endothelial cell fenestrae: a review","volume":"1","author":"Braet","year":"2002","journal-title":"Comp. Hepatol."},{"key":"10.1016\/j.jconrel.2015.09.055_bb0205","first-page":"117","article-title":"The role of the sinusoidal endothelium in liver function","volume":"14","author":"Reichen","year":"1999","journal-title":"News Physiol. Sci."},{"issue":"4","key":"10.1016\/j.jconrel.2015.09.055_bb0210","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1111\/j.1582-4934.2007.00075.x","article-title":"Endothelial stomatal and fenestral diaphragms in normal vessels and angiogenesis","volume":"11","author":"Stan","year":"2007","journal-title":"J. Cell. Mol. Med."},{"issue":"6","key":"10.1016\/j.jconrel.2015.09.055_bb0215","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1172\/JCI119266","article-title":"Vascular endothelium: in defense of blood fluidity","volume":"99","author":"Schafer","year":"1997","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.jconrel.2015.09.055_bb0220","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s00281-011-0285-5","article-title":"Endothelium\u2014role in regulation of coagulation and inflammation","volume":"34","author":"van Hinsbergh","year":"2012","journal-title":"Semin. Immunopathol."},{"issue":"2","key":"10.1016\/j.jconrel.2015.09.055_bb0225","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1002\/cphy.c140024","article-title":"Endothelial cell regulation of pulmonary vascular tone, inflammation, and coagulation","volume":"5","author":"Goldenberg","year":"2015","journal-title":"Comp. Physiol."},{"key":"10.1016\/j.jconrel.2015.09.055_bb0230","unstructured":"P.M. Vanhoutte, Endothelium-derived free radicals: for worse and for better. J. Clin. Invest. 107(1) (2001) 23\u201325."},{"issue":"5","key":"10.1016\/j.jconrel.2015.09.055_bb0235","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/jemt.10086","article-title":"Transcytosis of plasma macromolecules in endothelial cells: a cell biological survey","volume":"57","author":"Simionescu","year":"2002","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.jconrel.2015.09.055_bb0240","doi-asserted-by":"crossref","unstructured":"M.A. Gimbrone, Jr., Vascular endothelium, hemodynamic forces, and atherogenesis. Am. J. Pathol. 155(1) (1999) 1\u20135.","DOI":"10.1016\/S0002-9440(10)65090-0"},{"issue":"7","key":"10.1016\/j.jconrel.2015.09.055_bb0245","doi-asserted-by":"crossref","first-page":"694","DOI":"10.3109\/07853890.2011.585658","article-title":"Nitric oxide: orchestrator of endothelium-dependent responses","volume":"44","author":"Feletou","year":"2012","journal-title":"Ann. Med."},{"issue":"2","key":"10.1016\/j.jconrel.2015.09.055_bb0250","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s00281-013-0412-6","article-title":"Neutrophil and monocyte recruitment by PECAM, CD99, and other molecules via the LBRC","volume":"36","author":"Sullivan","year":"2014","journal-title":"Semin. Immunopathol."},{"issue":"11","key":"10.1016\/j.jconrel.2015.09.055_bb0255","doi-asserted-by":"crossref","first-page":"3955","DOI":"10.1073\/pnas.1322937111","article-title":"Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates","volume":"111","author":"Dong","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"12","key":"10.1016\/j.jconrel.2015.09.055_bb0260","doi-asserted-by":"crossref","first-page":"11129","DOI":"10.1021\/nn404853z","article-title":"Delivering nanoparticles to lungs while avoiding liver and spleen through adsorption on red blood cells","volume":"7","author":"Anselmo","year":"2013","journal-title":"ACS Nano"},{"issue":"2","key":"10.1016\/j.jconrel.2015.09.055_bb0265","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jconrel.2010.08.027","article-title":"To exploit the tumor microenvironment: passive and active tumor targeting of nanocarriers for anti-cancer drug delivery","volume":"148","author":"Danhier","year":"2010","journal-title":"J. Control. Release"},{"issue":"6992","key":"10.1016\/j.jconrel.2015.09.055_bb0270","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/nature02580","article-title":"Subtractive proteomic mapping of the endothelial surface in lung and solid tumours for tissue-specific therapy","volume":"429","author":"Oh","year":"2004","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.jconrel.2015.09.055_bb0275","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1056\/NEJM199808133390711","article-title":"Vascular targeting as a strategy for cancer therapy","volume":"339","author":"Schnitzer","year":"1998","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.jconrel.2015.09.055_bb0280","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0883-2897(90)90147-S","article-title":"Rat monoclonal antibody distribution in mice: an epitope inside the lung vascular space mediates very efficient localization","volume":"17","author":"Kennel","year":"1990","journal-title":"Int. J. Rad. Appl. Instrum. B"},{"issue":"16","key":"10.1016\/j.jconrel.2015.09.055_bb0285","doi-asserted-by":"crossref","first-page":"8795","DOI":"10.1073\/pnas.94.16.8795","article-title":"Immunotargeting of liposomes to activated vascular endothelial cells: a strategy for site-selective delivery in the cardiovascular system","volume":"94","author":"Spragg","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7","key":"10.1016\/j.jconrel.2015.09.055_bb0290","doi-asserted-by":"crossref","first-page":"312","DOI":"10.3109\/09687688.2010.522117","article-title":"Dynamic and cellular interactions of nanoparticles in vascular-targeted drug delivery","volume":"27","author":"Huang","year":"2010","journal-title":"Mol. Membr. Biol."},{"issue":"5","key":"10.1016\/j.jconrel.2015.09.055_bb0295","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1002\/med.20238","article-title":"Targeted drug delivery and penetration into solid tumors","volume":"32","author":"Corti","year":"2012","journal-title":"Med. Res. Rev."},{"issue":"4","key":"10.1016\/j.jconrel.2015.09.055_bb0300","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1517\/14728222.8.4.335","article-title":"Development of ligand-targeted liposomes for cancer therapy","volume":"8","author":"Noble","year":"2004","journal-title":"Expert Opin. Ther. Targets"},{"issue":"19","key":"10.1016\/j.jconrel.2015.09.055_bb0305","doi-asserted-by":"crossref","first-page":"6811","DOI":"10.1021\/jm100509v","article-title":"Folate-targeted therapies for cancer","volume":"53","author":"Xia","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jconrel.2015.09.055_bb0310","series-title":"Targeted Delivery of Imaging Agents","first-page":"465","author":"Muzykantov","year":"1995"},{"issue":"2","key":"10.1016\/j.jconrel.2015.09.055_bb0315","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1002\/(SICI)1097-0215(19960117)65:2<192::AID-IJC11>3.0.CO;2-G","article-title":"Lu-ECAM-1-mediated adhesion of melanoma cells to endothelium under conditions of flow","volume":"65","author":"Goetz","year":"1996","journal-title":"Int. J. Cancer"},{"issue":"5299","key":"10.1016\/j.jconrel.2015.09.055_bb0320","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1126\/science.275.5299.547","article-title":"Tumor infarction in mice by antibody-directed targeting of tissue factor to tumor vasculature","volume":"275","author":"Huang","year":"1997","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.jconrel.2015.09.055_bb0325","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1083\/jcb.145.6.1189","article-title":"Isolation, cloning, and localization of rat PV-1, a novel endothelial caveolar protein","volume":"145","author":"Stan","year":"1999","journal-title":"J. Cell Biol."},{"issue":"2","key":"10.1016\/j.jconrel.2015.09.055_bb0330","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1172\/JCI3008","article-title":"Molecular heterogeneity of the vascular endothelium revealed by in vivo phage display","volume":"102","author":"Rajotte","year":"1998","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.jconrel.2015.09.055_bb0335","first-page":"118","article-title":"Lung is the target organ for a monoclonal antibody to angiotensin-converting enzyme","volume":"64","author":"Danilov","year":"1991","journal-title":"Lab. Investig."},{"issue":"7","key":"10.1016\/j.jconrel.2015.09.055_bb0340","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/89704","article-title":"Vascular targeting and antigen presentation","volume":"2","author":"Pasqualini","year":"2001","journal-title":"Nat. Immunol."},{"issue":"11","key":"10.1016\/j.jconrel.2015.09.055_bb0345","doi-asserted-by":"crossref","first-page":"5213","DOI":"10.1073\/pnas.93.11.5213","article-title":"Immunotargeting of antioxidant enzyme to the pulmonary endothelium","volume":"93","author":"Muzykantov","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"9","key":"10.1016\/j.jconrel.2015.09.055_bb0350","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1038\/nbt0901-838","article-title":"Combined transductional and transcriptional targeting improves the specificity of transgene expression in vivo","volume":"19","author":"Reynolds","year":"2001","journal-title":"Nat. Biotechnol."},{"issue":"6679 Suppl.","key":"10.1016\/j.jconrel.2015.09.055_bb0355","first-page":"5","article-title":"Drug delivery and targeting","volume":"392","author":"Langer","year":"1998","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.jconrel.2015.09.055_bb0360","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0167-4781(92)90030-4","article-title":"Cationic liposomes enhance targeted delivery and expression of exogenous DNA mediated by N-terminal modified poly(l-lysine)-antibody conjugate in mouse lung endothelial cells","volume":"1131","author":"Trubetskoy","year":"1992","journal-title":"Biochim. Biophys. Acta"},{"issue":"10","key":"10.1016\/j.jconrel.2015.09.055_bb0365","first-page":"1686","article-title":"Radioimmunoimaging of lung vessels: an approach using indium-111-labeled monoclonal antibody to angiotensin-converting enzyme","volume":"30","author":"Danilov","year":"1989","journal-title":"J. Nucl. Med."},{"issue":"1","key":"10.1016\/j.jconrel.2015.09.055_bb0370","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/0005-2736(94)00263-O","article-title":"Targetability of novel immunoliposomes modified with amphipathic poly(ethylene glycol)s conjugated at their distal terminals to monoclonal antibodies","volume":"1234","author":"Maruyama","year":"1995","journal-title":"Biochim. Biophys. Acta"},{"issue":"3","key":"10.1016\/j.jconrel.2015.09.055_bb0375","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1124\/jpet.300.3.777","article-title":"Platelet-endothelial cell adhesion molecule-1-directed immunotargeting to cardiopulmonary vasculature","volume":"300","author":"Scherpereel","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"3","key":"10.1016\/j.jconrel.2015.09.055_bb0380","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1124\/jpet.107.120535","article-title":"Delivery of anti-platelet-endothelial cell adhesion molecule single-chain variable fragment-urokinase fusion protein to the cerebral vasculature lyses arterial clots and attenuates postischemic brain edema","volume":"321","author":"Danielyan","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"8","key":"10.1016\/j.jconrel.2015.09.055_bb0385","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1038\/nbt993","article-title":"Direct proteomic mapping of the lung microvascular endothelial cell surface in vivo and in cell culture","volume":"22","author":"Durr","year":"2004","journal-title":"Nat. Biotechnol."},{"issue":"6","key":"10.1016\/j.jconrel.2015.09.055_bb0390","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1309\/AJCPF3QWIG8FWXIH","article-title":"A search for reliable molecular markers of prognosis in prostate cancer: a study of 240 cases","volume":"137","author":"Tradonsky","year":"2012","journal-title":"Am. J. Clin. Pathol."},{"issue":"2","key":"10.1016\/j.jconrel.2015.09.055_bb0395","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1021\/bc700408r","article-title":"Tumor-targeted gene delivery using molecularly engineered hybrid polymers functionalized with a tumor-homing peptide","volume":"19","author":"Wood","year":"2008","journal-title":"Bioconjug. Chem."},{"issue":"2","key":"10.1016\/j.jconrel.2015.09.055_bb0400","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1073\/pnas.0506938103","article-title":"Screening phage display libraries for organ-specific vascular immunotargeting in vivo","volume":"103","author":"Valadon","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"10.1016\/j.jconrel.2015.09.055_bb0405","doi-asserted-by":"crossref","first-page":"4100","DOI":"10.1021\/nn500136z","article-title":"Vascular targeting of nanocarriers: perplexing aspects of the seemingly straightforward paradigm","volume":"8","author":"Howard","year":"2014","journal-title":"ACS Nano"},{"issue":"3","key":"10.1016\/j.jconrel.2015.09.055_bb0410","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.jconrel.2008.06.007","article-title":"Differential intra-endothelial delivery of polymer nanocarriers targeted to distinct PECAM-1 epitopes","volume":"130","author":"Garnacho","year":"2008","journal-title":"J. Control. Release"},{"issue":"4","key":"10.1016\/j.jconrel.2015.09.055_bb0415","doi-asserted-by":"crossref","first-page":"H1282","DOI":"10.1152\/ajpheart.00117.2002","article-title":"Role of glycocalyx in leukocyte-endothelial cell adhesion","volume":"283","author":"Mulivor","year":"2002","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"3","key":"10.1016\/j.jconrel.2015.09.055_bb0420","first-page":"453","article-title":"Endotoxin reduces specific pulmonary uptake of radiolabeled monoclonal antibody to angiotensin-converting enzyme","volume":"32","author":"Muzykantov","year":"1991","journal-title":"J. Nucl. Med."},{"issue":"Suppl. 9","key":"10.1016\/j.jconrel.2015.09.055_bb0425","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1097\/00005344-199200209-00003","article-title":"Bradykinin-degrading enzymes: structure, function, distribution, and potential roles in cardiovascular pharmacology","volume":"20","author":"Skidgel","year":"1992","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"5","key":"10.1016\/j.jconrel.2015.09.055_bb0430","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1083\/jcb.138.5.1117","article-title":"Vascular bed-specific expression of an endothelial cell gene is programmed by the tissue microenvironment","volume":"138","author":"Aird","year":"1997","journal-title":"J. Cell Biol."},{"issue":"2","key":"10.1016\/j.jconrel.2015.09.055_bb0435","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1161\/01.RES.0000255691.76142.4a","article-title":"Phenotypic heterogeneity of the endothelium: I. Structure, function, and mechanisms","volume":"100","author":"Aird","year":"2007","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.jconrel.2015.09.055_bb0440","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/ncpcardio1397","article-title":"Hemodynamic shear stress and the endothelium in cardiovascular pathophysiology","volume":"6","author":"Davies","year":"2009","journal-title":"Nat. Clin. Pract. Cardiovasc. Med."},{"issue":"5\u20136","key":"10.1016\/j.jconrel.2015.09.055_bb0445","doi-asserted-by":"crossref","first-page":"337","DOI":"10.3109\/10408369109106868","article-title":"Angiotensin-converting enzyme: clinical applications and laboratory investigations on serum and other biological fluids","volume":"28","author":"Beneteau-Burnat","year":"1991","journal-title":"Crit. Rev. Clin. Lab. Sci."},{"issue":"2","key":"10.1016\/j.jconrel.2015.09.055_bb0450","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.jconrel.2006.12.025","article-title":"Factors modulating the delivery and effect of enzymatic cargo conjugated with antibodies targeted to the pulmonary endothelium","volume":"118","author":"Shuvaev","year":"2007","journal-title":"J. Control. Release"},{"issue":"6","key":"10.1016\/j.jconrel.2015.09.055_bb0455","doi-asserted-by":"crossref","first-page":"L1335","DOI":"10.1152\/ajplung.2001.280.6.L1335","article-title":"Lung uptake of antibodies to endothelial antigens: key determinants of vascular immunotargeting","volume":"280","author":"Danilov","year":"2001","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"issue":"2","key":"10.1016\/j.jconrel.2015.09.055_bb0460","first-page":"276","article-title":"Imaging vascular endothelial activation: an approach using radiolabeled monoclonal antibodies against the endothelial cell adhesion molecule E-selectin","volume":"35","author":"Keelan","year":"1994","journal-title":"J. Nucl. Med."},{"issue":"3","key":"10.1016\/j.jconrel.2015.09.055_bb0465","doi-asserted-by":"crossref","first-page":"281","DOI":"10.2174\/1570161043385736","article-title":"Endothelial endocytic pathways: gates for vascular drug delivery","volume":"2","author":"Muro","year":"2004","journal-title":"Curr. Vasc. Pharmacol."},{"issue":"Suppl.","key":"10.1016\/j.jconrel.2015.09.055_bb0470","first-page":"S9","article-title":"Cellular and molecular aspects of PECAM-1","volume":"34","author":"Newman","year":"1992","journal-title":"Nouv. Rev. Fr. Hematol."},{"issue":"5","key":"10.1016\/j.jconrel.2015.09.055_bb0475","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.devcel.2013.08.020","article-title":"VE-cadherin and endothelial adherens junctions: active guardians of vascular integrity","volume":"26","author":"Giannotta","year":"2013","journal-title":"Dev. Cell"},{"issue":"7","key":"10.1016\/j.jconrel.2015.09.055_bb0480","doi-asserted-by":"crossref","first-page":"2852","DOI":"10.1182\/blood-2004-09-3606","article-title":"Endothelial tetraspanin microdomains regulate leukocyte firm adhesion during extravasation","volume":"105","author":"Barreiro","year":"2005","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.jconrel.2015.09.055_bb0485","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1089\/ars.2010.3522","article-title":"Vascular cell adhesion molecule-1 expression and signaling during disease: regulation by reactive oxygen species and antioxidants","volume":"15","author":"Cook-Mills","year":"2011","journal-title":"Antioxid. Redox Signal."},{"issue":"5","key":"10.1016\/j.jconrel.2015.09.055_bb0490","first-page":"1278","article-title":"Apical topography and modulation of ICAM-1 expression on activated endothelium","volume":"147","author":"Almenar-Queralt","year":"1995","journal-title":"Am. J. Pathol."},{"issue":"5","key":"10.1016\/j.jconrel.2015.09.055_bb0495","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/j.1399-0039.2004.00321.x","article-title":"Tetraspanin microdomains in immune cell signalling and malignant disease","volume":"64","author":"Wright","year":"2004","journal-title":"Tissue Antigens"},{"issue":"3","key":"10.1016\/j.jconrel.2015.09.055_bb0500","doi-asserted-by":"crossref","first-page":"241","DOI":"10.3109\/10623329909053414","article-title":"A novel, 85kDa endothelial antigen differentiates plasma membrane macrodomains in lung alveolar capillaries","volume":"6","author":"Ghitescu","year":"1999","journal-title":"Endothelium"},{"issue":"7","key":"10.1016\/j.jconrel.2015.09.055_bb0505","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1164\/ajrccm.164.7.2010076","article-title":"Vascular immunotargeting to endothelial surface in a specific macrodomain in alveolar capillaries","volume":"164","author":"Murciano","year":"2001","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"3","key":"10.1016\/j.jconrel.2015.09.055_bb0510","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nbt1292","article-title":"Live dynamic imaging of caveolae pumping targeted antibody rapidly and specifically across endothelium in the lung","volume":"25","author":"Oh","year":"2007","journal-title":"Nat. Biotechnol."},{"issue":"8","key":"10.1016\/j.jconrel.2015.09.055_bb0515","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1093\/intimm\/6.8.1153","article-title":"Interaction of mAb to angiotensin-converting enzyme (ACE) with antigen in vitro and in vivo: antibody targeting to the lung induces ACE antigenic modulation","volume":"6","author":"Danilov","year":"1994","journal-title":"Int. Immunol."},{"issue":"5","key":"10.1016\/j.jconrel.2015.09.055_bb0520","first-page":"1529","article-title":"Microdistribution of specific rat monoclonal antibodies to mouse tissues and human tumor xenografts","volume":"51","author":"Kennel","year":"1991","journal-title":"Cancer Res."},{"issue":"4","key":"10.1016\/j.jconrel.2015.09.055_bb0525","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1161\/01.HYP.16.4.363","article-title":"Angiotensin I converting enzyme and the changes in our concepts through the years. Lewis K. Dahl memorial lecture","volume":"16","author":"Erdos","year":"1990","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.jconrel.2015.09.055_bb0530","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1161\/01.HYP.37.1.72","article-title":"Angiotensin-(1\u20137)-stimulated nitric oxide and superoxide release from endothelial cells","volume":"37","author":"Heitsch","year":"2001","journal-title":"Hypertension"},{"issue":"Pt 3","key":"10.1016\/j.jconrel.2015.09.055_bb0535","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1042\/bj3620585","article-title":"Epitope-specific antibody-induced cleavage of angiotensin-converting enzyme from the cell surface","volume":"362","author":"Balyasnikova","year":"2002","journal-title":"Biochem. J."},{"key":"10.1016\/j.jconrel.2015.09.055_bb0540","series-title":"Biomedical Aspects of Drug Targeting","first-page":"129","author":"Muzykantov","year":"2002"},{"issue":"1","key":"10.1016\/j.jconrel.2015.09.055_bb0545","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0168-3659(01)00215-2","article-title":"Targeting of superoxide dismutase and catalase to vascular endothelium","volume":"71","author":"Muzykantov","year":"2001","journal-title":"J. Control. Release"},{"issue":"2","key":"10.1016\/j.jconrel.2015.09.055_bb0550","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1002\/jcp.1041500228","article-title":"Lipopolysaccharides decrease angiotensin converting enzyme activity expressed by cultured human endothelial cells","volume":"150","author":"Watanabe","year":"1992","journal-title":"J. Cell. Physiol."},{"issue":"6","key":"10.1016\/j.jconrel.2015.09.055_bb0555","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/BF00177581","article-title":"Systemic administration of platelet-activating factor in rat reduces specific pulmonary uptake of circulating monoclonal antibody to angiotensin-converting enzyme","volume":"170","author":"Atochina","year":"1992","journal-title":"Lung"},{"issue":"1","key":"10.1016\/j.jconrel.2015.09.055_bb0560","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1399-0039.2005.00516.x","article-title":"Monoclonal antibodies to native mouse angiotensin-converting enzyme (CD143): ACE expression quantification, lung endothelial cell targeting and gene delivery","volume":"67","author":"Balyasnikova","year":"2006","journal-title":"Tissue Antigens"},{"issue":"4 Pt 1","key":"10.1016\/j.jconrel.2015.09.055_bb0565","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1164\/ajrccm.156.4.96-12116","article-title":"Normoxic lung ischemia\/reperfusion accelerates shedding of angiotensin converting enzyme from the pulmonary endothelium","volume":"156","author":"Atochina","year":"1997","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"5 Pt 1","key":"10.1016\/j.jconrel.2015.09.055_bb0570","first-page":"L704","article-title":"Endothelial cells internalize monoclonal antibody to angiotensin-converting enzyme","volume":"270","author":"Muzykantov","year":"1996","journal-title":"Am. J. Phys."},{"issue":"4","key":"10.1016\/j.jconrel.2015.09.055_bb0575","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.pupt.2004.12.008","article-title":"Selective rat lung endothelial targeting with a new set of monoclonal antibodies to angiotensin I-converting enzyme","volume":"18","author":"Balyasnikova","year":"2005","journal-title":"Pulm. Pharmacol. Ther."},{"issue":"6","key":"10.1016\/j.jconrel.2015.09.055_bb0580","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1006\/mthe.2000.0205","article-title":"A targetable, injectable adenoviral vector for selective gene delivery to pulmonary endothelium in vivo","volume":"2","author":"Reynolds","year":"2000","journal-title":"Mol. Ther."},{"issue":"2","key":"10.1016\/j.jconrel.2015.09.055_bb0585","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.ymthe.2005.02.025","article-title":"Targeting endothelial cells with adenovirus expressing nitric oxide synthase prevents elevation of blood pressure in stroke-prone spontaneously hypertensive rats","volume":"12","author":"Miller","year":"2005","journal-title":"Mol. Ther."},{"issue":"5","key":"10.1016\/j.jconrel.2015.09.055_bb0590","doi-asserted-by":"crossref","first-page":"L1182","DOI":"10.1152\/ajplung.00020.2006","article-title":"Bone morphogenetic protein type 2 receptor gene therapy attenuates hypoxic pulmonary hypertension","volume":"292","author":"Reynolds","year":"2007","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"issue":"12","key":"10.1016\/j.jconrel.2015.09.055_bb0595","doi-asserted-by":"crossref","first-page":"H1585","DOI":"10.1152\/ajpheart.00096.2013","article-title":"Thrombomodulin and the vascular endothelium: insights into functional, regulatory, and therapeutic aspects","volume":"304","author":"Martin","year":"2013","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"3","key":"10.1016\/j.jconrel.2015.09.055_bb0600","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/S0002-9440(10)64935-8","article-title":"Vascular immunotargeting of glucose oxidase to the endothelial antigens induces distinct forms of oxidant acute lung injury: targeting to thrombomodulin, but not to PECAM-1, causes pulmonary thrombosis and neutrophil transmigration","volume":"160","author":"Christofidou-Solomidou","year":"2002","journal-title":"Am. J. Pathol."},{"issue":"6","key":"10.1016\/j.jconrel.2015.09.055_bb0605","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1165\/rcmb.4692","article-title":"Gene expression profiling of the early pulmonary response to hyperoxia in mice","volume":"28","author":"Perkowski","year":"2003","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"6","key":"10.1016\/j.jconrel.2015.09.055_bb0610","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1055\/s-0038-1646353","article-title":"Antibodies to thrombomodulin induce receptor-mediated endocytosis in human saphenous vein endothelial cells","volume":"68","author":"Brisson","year":"1992","journal-title":"Thromb. Haemost."},{"issue":"7","key":"10.1016\/j.jconrel.2015.09.055_bb0615","first-page":"553","article-title":"Anti-thrombomodulin antibodies and venous thrombosis","volume":"15","author":"Guermazi","year":"2004","journal-title":"Blood Coagul. Fibrinolysis"},{"issue":"3","key":"10.1016\/j.jconrel.2015.09.055_bb0620","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/nrm2122","article-title":"The multiple faces of caveolae","volume":"8","author":"Parton","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"6","key":"10.1016\/j.jconrel.2015.09.055_bb0625","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/S0092-8674(00)80461-4","article-title":"Molecular mechanisms of endocytosis","volume":"91","author":"Riezman","year":"1997","journal-title":"Cell"},{"issue":"2 Pt 2","key":"10.1016\/j.jconrel.2015.09.055_bb0630","first-page":"H725","article-title":"Plasmalemmal vesicles represent the large pore system of continuous microvascular endothelium","volume":"265","author":"Predescu","year":"1993","journal-title":"Am. J. Phys."},{"issue":"5","key":"10.1016\/j.jconrel.2015.09.055_bb0635","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1002\/jemt.10089","article-title":"Structure and function of endothelial caveolae","volume":"57","author":"Stan","year":"2002","journal-title":"Microsc. Res. Tech."},{"issue":"2","key":"10.1016\/j.jconrel.2015.09.055_bb0640","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s00418-001-0367-x","article-title":"Vesicle formation and trafficking in endothelial cells and regulation of endothelial barrier function","volume":"117","author":"Minshall","year":"2002","journal-title":"Histochem. Cell Biol."},{"issue":"3","key":"10.1016\/j.jconrel.2015.09.055_bb0645","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0169-409X(01)00141-7","article-title":"Caveolae: from basic trafficking mechanisms to targeting transcytosis for tissue-specific drug and gene delivery in vivo","volume":"49","author":"Schnitzer","year":"2001","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"5229","key":"10.1016\/j.jconrel.2015.09.055_bb0650","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1126\/science.7660128","article-title":"Separation of caveolae from associated microdomains of GPI-anchored proteins","volume":"269","author":"Schnitzer","year":"1995","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.jconrel.2015.09.055_bb0655","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1083\/jcb.150.5.1057","article-title":"Endothelial cell-surface gp60 activates vesicle formation and trafficking via G(i)-coupled Src kinase signaling pathway","volume":"150","author":"Minshall","year":"2000","journal-title":"J. Cell Biol."},{"issue":"1","key":"10.1016\/j.jconrel.2015.09.055_bb0660","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1006\/mvre.2000.2274","article-title":"Evidence of transcellular permeability pathway in microvessels","volume":"61","author":"Vogel","year":"2001","journal-title":"Microvasc. Res."},{"issue":"1","key":"10.1016\/j.jconrel.2015.09.055_bb0665","doi-asserted-by":"crossref","first-page":"L187","DOI":"10.1152\/ajplung.00152.2002","article-title":"Quantitative analysis of albumin uptake and transport in the rat microvessel endothelial monolayer","volume":"284","author":"John","year":"2003","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"issue":"41","key":"10.1016\/j.jconrel.2015.09.055_bb0670","doi-asserted-by":"crossref","first-page":"25968","DOI":"10.1074\/jbc.272.41.25968","article-title":"Gp60 activation mediates albumin transcytosis in endothelial cells by tyrosine kinase-dependent pathway","volume":"272","author":"Tiruppathi","year":"1997","journal-title":"J. Biol. Chem."},{"issue":"21","key":"10.1016\/j.jconrel.2015.09.055_bb0675","doi-asserted-by":"crossref","first-page":"13932","DOI":"10.1073\/pnas.212253499","article-title":"Transport of nitrated albumin across continuous vascular endothelium","volume":"99","author":"Predescu","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"21","key":"10.1016\/j.jconrel.2015.09.055_bb0680","doi-asserted-by":"crossref","first-page":"5406","DOI":"10.1016\/j.biomaterials.2012.04.036","article-title":"Endothelial targeting of polymeric nanoparticles stably labeled with the PET imaging radioisotope iodine-124","volume":"33","author":"Simone","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2015.09.055_bb0685","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1477-3155-10-33","article-title":"Uptake of ricinB-quantum dot nanoparticles by a macropinocytosis-like mechanism","volume":"10","author":"Iversen","year":"2012","journal-title":"J. Nanobiotechnol."},{"issue":"12","key":"10.1016\/j.jconrel.2015.09.055_bb0690","doi-asserted-by":"crossref","first-page":"4110","DOI":"10.1021\/nn9012274","article-title":"Size and dynamics of caveolae studied using nanoparticles in living endothelial cells","volume":"3","author":"Wang","year":"2009","journal-title":"ACS Nano"},{"issue":"6283","key":"10.1016\/j.jconrel.2015.09.055_bb0695","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/346425a0","article-title":"Adhesion receptors of the immune system","volume":"346","author":"Springer","year":"1990","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.jconrel.2015.09.055_bb0700","doi-asserted-by":"crossref","first-page":"4609","DOI":"10.4049\/jimmunol.157.10.4609","article-title":"The role of P-selectin and ICAM-1 in acute lung injury as determined using blocking antibodies and mutant mice","volume":"157","author":"Doerschuk","year":"1996","journal-title":"J. Immunol."},{"key":"10.1016\/j.jconrel.2015.09.055_bb0705","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S1054-3589(08)60431-7","article-title":"Integrins, ICAMs, and selectins: role and regulation of adhesion molecules in neutrophil recruitment to inflammatory sites","volume":"25","author":"Kishimoto","year":"1994","journal-title":"Adv. Pharmacol."},{"issue":"3","key":"10.1016\/j.jconrel.2015.09.055_bb0710","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1165\/ajrcmb\/4.3.195","article-title":"Endothelial and epithelial cell adhesion molecules","volume":"4","author":"Albelda","year":"1991","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.jconrel.2015.09.055_bb0715","series-title":"In Vivo Imaging of Activated Endothelium Using an Anti-VCAM-1 Magneto-Optical Probe","author":"Tsourkas","year":"2005"},{"issue":"8","key":"10.1016\/j.jconrel.2015.09.055_bb0720","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1161\/01.ATV.15.8.1211","article-title":"Immunoselective targeting of an anti-thrombin agent to the surface of cytokine-activated vascular endothelial cells","volume":"15","author":"Kiely","year":"1995","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"10","key":"10.1016\/j.jconrel.2015.09.055_bb0725","doi-asserted-by":"crossref","first-page":"5060","DOI":"10.4049\/jimmunol.152.10.5060","article-title":"Cytokine-activated endothelial cells internalize E-selectin into a lysosomal compartment of vesiculotubular shape. A tubulin-driven process","volume":"152","author":"Kuijpers","year":"1994","journal-title":"J. Immunol."},{"key":"10.1016\/j.jconrel.2015.09.055_bb0730","unstructured":"K.S. Straley, S.A. Green, Rapid transport of internalized P-selectin to late endosomes and the TGN: roles in regulating cell surface expression and recycling to secretory granules. J. Cell Biol. 151(1) (2000) 107\u2013116."},{"issue":"10","key":"10.1016\/j.jconrel.2015.09.055_bb0735","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1002\/eji.1830221009","article-title":"Evidence for endocytosis of E-selectin in human endothelial cells","volume":"22","author":"von Asmuth","year":"1992","journal-title":"Eur. J. Immunol."},{"issue":"2","key":"10.1016\/j.jconrel.2015.09.055_bb0740","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0005-2736(01)00368-6","article-title":"Investigation of the cellular uptake of E-selectin-targeted immunoliposomes by activated human endothelial cells","volume":"1514","author":"Kessner","year":"2001","journal-title":"Biochim. Biophys. Acta"},{"issue":"2","key":"10.1016\/j.jconrel.2015.09.055_bb0745","doi-asserted-by":"crossref","first-page":"883","DOI":"10.4049\/jimmunol.168.2.883","article-title":"Selective intracellular delivery of dexamethasone into activated endothelial cells using an E-selectin-directed immunoconjugate","volume":"168","author":"Everts","year":"2002","journal-title":"J. Immunol."},{"issue":"5","key":"10.1016\/j.jconrel.2015.09.055_bb0750","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/sj.gt.3300898","article-title":"Targeting an adenoviral gene vector to cytokine-activated vascular endothelium via E-selectin","volume":"6","author":"Harari","year":"1999","journal-title":"Gene Ther."},{"issue":"17","key":"10.1016\/j.jconrel.2015.09.055_bb0755","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1161\/hc4201.097061","article-title":"Ultrasound assessment of inflammation and renal tissue injury with microbubbles targeted to P-selectin","volume":"104","author":"Lindner","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.jconrel.2015.09.055_bb0760","series-title":"Biomedical Aspects of Drug Targeting","first-page":"149","author":"Lindner","year":"2003"},{"issue":"3","key":"10.1016\/j.jconrel.2015.09.055_bb0765","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1080\/10623320213631","article-title":"Endothelial cells at inflammatory sites as target for therapeutic intervention","volume":"9","author":"Koning","year":"2002","journal-title":"Endothelium"},{"issue":"2","key":"10.1016\/j.jconrel.2015.09.055_bb0770","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1182\/blood-2004-05-1714","article-title":"ICAM-1 recycling in endothelial cells: a novel pathway for sustained intracellular delivery and prolonged effects of drugs","volume":"105","author":"Muro","year":"2005","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.jconrel.2015.09.055_bb0775","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1124\/mi.6.2.7","article-title":"Advanced drug delivery systems that target the vascular endothelium","volume":"6","author":"Ding","year":"2006","journal-title":"Mol. Interv."},{"issue":"Pt 8","key":"10.1016\/j.jconrel.2015.09.055_bb0780","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1242\/jcs.00367","article-title":"A novel endocytic pathway induced by clustering endothelial ICAM-1 or PECAM-1","volume":"116","author":"Muro","year":"2003","journal-title":"J. Cell Sci."},{"issue":"34","key":"10.1016\/j.jconrel.2015.09.055_bb0785","doi-asserted-by":"crossref","first-page":"7136","DOI":"10.1016\/j.biomaterials.2005.05.005","article-title":"In vitro characterization of leukocyte mimetic for targeting therapeutics to the endothelium using two receptors","volume":"26","author":"Omolola Eniola","year":"2005","journal-title":"Biomaterials"},{"issue":"5","key":"10.1016\/j.jconrel.2015.09.055_bb0790","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.biomaterials.2009.09.107","article-title":"The role of antibody synergy and membrane fluidity in the vascular targeting of immunoliposomes","volume":"31","author":"Gunawan","year":"2010","journal-title":"Biomaterials"},{"issue":"5","key":"10.1016\/j.jconrel.2015.09.055_bb0795","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1096\/fj.09-148981","article-title":"Superior sensitivity of novel molecular imaging probe: simultaneously targeting two types of endothelial injury markers","volume":"24","author":"Sun","year":"2010","journal-title":"FASEB J."},{"issue":"4","key":"10.1016\/j.jconrel.2015.09.055_bb0800","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.1016\/S0006-3495(03)74695-5","article-title":"Interplay between rolling and firm adhesion elucidated with a cell-free system engineered with two distinct receptor-ligand pairs","volume":"85","author":"Eniola","year":"2003","journal-title":"Biophys. J."},{"issue":"5","key":"10.1016\/j.jconrel.2015.09.055_bb0805","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1021\/mp9003095","article-title":"Immunoliposomes that target endothelium in vitro are dependent on lipid raft formation","volume":"7","author":"Gunawan","year":"2010","journal-title":"Mol. Pharm."},{"issue":"36","key":"10.1016\/j.jconrel.2015.09.055_bb0810","doi-asserted-by":"crossref","first-page":"9848","DOI":"10.1016\/j.biomaterials.2011.08.093","article-title":"Complementary targeting of liposomes to IL-1alpha and TNF-alpha activated endothelial cells via the transient expression of VCAM1 and E-selectin","volume":"32","author":"Gunawan","year":"2011","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.jconrel.2015.09.055_bb0815","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1161\/ATVBAHA.107.145466","article-title":"Magnetic resonance imaging of endothelial adhesion molecules in mouse atherosclerosis using dual-targeted microparticles of iron oxide","volume":"28","author":"McAteer","year":"2008","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"6","key":"10.1016\/j.jconrel.2015.09.055_bb0820","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1002\/bit.20625","article-title":"Targeted ultrasound contrast agents: in vitro assessment of endothelial dysfunction and multi-targeting to ICAM-1 and sialyl Lewisx","volume":"92","author":"Weller","year":"2005","journal-title":"Biotechnol. Bioeng."},{"issue":"13","key":"10.1016\/j.jconrel.2015.09.055_bb0825","doi-asserted-by":"crossref","first-page":"3459","DOI":"10.1016\/j.biomaterials.2013.01.069","article-title":"In vivo performance of polymer nanocarriers dually-targeted to epitopes of the same or different receptors","volume":"34","author":"Papademetriou","year":"2013","journal-title":"Biomaterials"},{"issue":"43","key":"10.1016\/j.jconrel.2015.09.055_bb0830","doi-asserted-by":"crossref","first-page":"26806","DOI":"10.1016\/S0021-9258(18)47091-3","article-title":"Structure-function analysis of angiotensin I-converting enzyme using monoclonal antibodies. Selective inhibition of the amino-terminal active site","volume":"269","author":"Danilov","year":"1994","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.jconrel.2015.09.055_bb0835","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1399-0039.2009.01416.x","article-title":"Fine epitope mapping of monoclonal antibodies 9B9 and 3G8 to the N domain of angiotensin-converting enzyme (CD143) defines a region involved in regulating angiotensin-converting enzyme dimerization and shedding","volume":"75","author":"Gordon","year":"2010","journal-title":"Tissue Antigens"},{"issue":"4","key":"10.1016\/j.jconrel.2015.09.055_bb0840","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0034958","article-title":"Collaborative enhancement of antibody binding to distinct PECAM-1 epitopes modulates endothelial targeting","volume":"7","author":"Chacko","year":"2012","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.jconrel.2015.09.055_bb0845","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.nano.2012.05.015","article-title":"Effect of ligand density, receptor density, and nanoparticle size on cell targeting","volume":"9","author":"Elias","year":"2013","journal-title":"Nanomedicine"},{"issue":"3","key":"10.1016\/j.jconrel.2015.09.055_bb0850","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1002\/jps.22342","article-title":"Controlling ligand surface density optimizes nanoparticle binding to ICAM-1","volume":"100","author":"Fakhari","year":"2011","journal-title":"J. Pharm. Sci."},{"issue":"7","key":"10.1016\/j.jconrel.2015.09.055_bb0855","doi-asserted-by":"crossref","first-page":"2586","DOI":"10.1073\/pnas.0711714105","article-title":"Precise engineering of targeted nanoparticles by using self-assembled biointegrated block copolymers","volume":"105","author":"Gu","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.jconrel.2015.09.055_bb0860","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1021\/nn305773f","article-title":"Reduction of nanoparticle avidity enhances the selectivity of vascular targeting and PET detection of pulmonary inflammation","volume":"7","author":"Zern","year":"2013","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2015.09.055_bb0865","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/978-3-319-16555-4_12","article-title":"Calibration-quality cancer nanotherapeutics","volume":"166","author":"Perry","year":"2015","journal-title":"Cancer Treat. Res."},{"issue":"8","key":"10.1016\/j.jconrel.2015.09.055_bb0870","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1002\/iub.497","article-title":"Novel platforms for vascular carriers with controlled geometry","volume":"63","author":"Pillai","year":"2011","journal-title":"IUBMB Life"},{"issue":"3","key":"10.1016\/j.jconrel.2015.09.055_bb0875","doi-asserted-by":"crossref","first-page":"3169","DOI":"10.1021\/acsnano.5b00147","article-title":"Elasticity of nanoparticles influences their blood circulation, phagocytosis, endocytosis, and targeting","volume":"9","author":"Anselmo","year":"2015","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2015.09.055_bb0880","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1146\/annurev-chembioeng-060713-040447","article-title":"From stealthy polymersomes and filomicelles to \u201cself\u201d peptide-nanoparticles for cancer therapy","volume":"5","author":"Oltra","year":"2014","journal-title":"Annu. Rev. Chem. Biomol. Eng."},{"issue":"8","key":"10.1016\/j.jconrel.2015.09.055_bb0885","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1002\/iub.481","article-title":"Lung vascular targeting through inhalation delivery: insight from filamentous viruses and other shapes","volume":"63","author":"Mahmud","year":"2011","journal-title":"IUBMB Life"},{"issue":"28","key":"10.1016\/j.jconrel.2015.09.055_bb0890","doi-asserted-by":"crossref","first-page":"3717","DOI":"10.1002\/adma.201202080","article-title":"Materials for drug delivery: innovative solutions to address complex biological hurdles","volume":"24","author":"Mitragotri","year":"2012","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2015.09.055_bb0895","doi-asserted-by":"crossref","DOI":"10.1021\/acs.nanolett.5b01362","article-title":"Targeted PRINT hydrogels: the role of nanoparticle size and ligand density on cell association, biodistribution, and tumor accumulation","author":"Reuter","year":"2015","journal-title":"Nano Lett."},{"key":"10.1016\/j.jconrel.2015.09.055_bb0900","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biomaterials.2015.08.040","article-title":"Towards programming immune tolerance through geometric manipulation of phosphatidylserine","volume":"72","author":"Roberts","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2015.09.055_bb0905","doi-asserted-by":"crossref","DOI":"10.1021\/acs.molpharmaceut.5b00054","article-title":"Reductively responsive hydrogel nanoparticles with uniform size, shape, and tunable composition for systemic siRNA delivery in vivo","author":"Ma","year":"2015","journal-title":"Mol. Pharm."},{"issue":"1","key":"10.1016\/j.jconrel.2015.09.055_bb0910","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s11095-008-9697-x","article-title":"Intravascular delivery of particulate systems: does geometry really matter?","volume":"26","author":"Decuzzi","year":"2009","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2015.09.055_bb0915","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.jconrel.2014.03.050","article-title":"Cell-mediated delivery of nanoparticles: taking advantage of circulatory cells to target nanoparticles","volume":"190","author":"Anselmo","year":"2014","journal-title":"J. Control. Release"},{"issue":"8","key":"10.1016\/j.jconrel.2015.09.055_bb0920","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1038\/mt.2008.127","article-title":"Control of endothelial targeting and intracellular delivery of therapeutic enzymes by modulating the size and shape of ICAM-1-targeted carriers","volume":"16","author":"Muro","year":"2008","journal-title":"Mol. Ther."},{"issue":"3","key":"10.1016\/j.jconrel.2015.09.055_bb0925","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.jconrel.2010.10.026","article-title":"Modulation of endothelial targeting by size of antibody-antioxidant enzyme conjugates","volume":"149","author":"Shuvaev","year":"2011","journal-title":"J. Control. Release"},{"issue":"26","key":"10.1016\/j.jconrel.2015.09.055_bb0930","doi-asserted-by":"crossref","first-page":"10753","DOI":"10.1073\/pnas.1308345110","article-title":"Using shape effects to target antibody-coated nanoparticles to lung and brain endothelium","volume":"110","author":"Kolhar","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"9","key":"10.1016\/j.jconrel.2015.09.055_bb0935","doi-asserted-by":"crossref","first-page":"6991","DOI":"10.1021\/nn2015453","article-title":"Endothelial targeting of antibody-decorated polymeric filomicelles","volume":"5","author":"Shuvaev","year":"2011","journal-title":"ACS Nano"},{"issue":"5","key":"10.1016\/j.jconrel.2015.09.055_bb0940","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1002\/(SICI)1521-4141(199805)28:05<1708::AID-IMMU1708>3.0.CO;2-Y","article-title":"VCAM-1 is internalized by a clathrin-related pathway in human endothelial cells but its alpha 4 beta 1 integrin counter-receptor remains associated with the plasma membrane in human T lymphocytes","volume":"28","author":"Ricard","year":"1998","journal-title":"Eur. J. Immunol."},{"issue":"26","key":"10.1016\/j.jconrel.2015.09.055_bb0945","doi-asserted-by":"crossref","first-page":"15895","DOI":"10.1073\/pnas.2631433100","article-title":"Leukocyte-inspired biodegradable particles that selectively and avidly adhere to inflamed endothelium in vitro and in vivo","volume":"100","author":"Sakhalkar","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.jconrel.2015.09.055_bb0950","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1021\/bc050002e","article-title":"In vivo imaging of activated endothelium using an anti-VCAM-1 magnetooptical probe","volume":"16","author":"Tsourkas","year":"2005","journal-title":"Bioconjug. Chem."},{"issue":"3","key":"10.1016\/j.jconrel.2015.09.055_bb0955","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1161\/01.RES.0000155722.17881.dd","article-title":"Detection of vascular adhesion molecule-1 expression using a novel multimodal nanoparticle","volume":"96","author":"Kelly","year":"2005","journal-title":"Circ. Res."},{"issue":"2","key":"10.1016\/j.jconrel.2015.09.055_bb0960","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1124\/mi.3.2.90","article-title":"Blood\u2013brain barrier drug targeting: the future of brain drug development","volume":"3","author":"Pardridge","year":"2003","journal-title":"Mol. Interv."},{"issue":"1","key":"10.1016\/j.jconrel.2015.09.055_bb0965","doi-asserted-by":"crossref","first-page":"47","DOI":"10.2165\/00151829-200605010-00004","article-title":"Antioxidant strategies in respiratory medicine","volume":"5","author":"Christofidou-Solomidou","year":"2006","journal-title":"Treat. Respir. Med."},{"issue":"12","key":"10.1016\/j.jconrel.2015.09.055_bb0970","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/S1471-4914(02)02429-2","article-title":"Probing the structural and molecular diversity of tumor vasculature","volume":"8","author":"Pasqualini","year":"2002","journal-title":"Trends Mol. Med."},{"issue":"6","key":"10.1016\/j.jconrel.2015.09.055_bb0975","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1002\/ijc.2910470625","article-title":"Selection of monoclonal antibodies which induce internalization and phosphorylation of p185HER2 and growth inhibition of cells with HER2\/NEU gene amplification","volume":"47","author":"Tagliabue","year":"1991","journal-title":"Int. J. Cancer"},{"issue":"7","key":"10.1016\/j.jconrel.2015.09.055_bb0980","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1038\/sj.gt.3300453","article-title":"Selection and use of ligands for receptor-mediated gene delivery to myogenic cells","volume":"4","author":"Feero","year":"1997","journal-title":"Gene Ther."},{"issue":"2","key":"10.1016\/j.jconrel.2015.09.055_bb0985","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.abb.2012.05.007","article-title":"Selection and characterization of cell binding and internalizing phage antibodies","volume":"526","author":"Zhou","year":"2012","journal-title":"Arch. Biochem. Biophys."},{"issue":"1","key":"10.1016\/j.jconrel.2015.09.055_bb0990","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jmb.2010.09.006","article-title":"Internalizing cancer antibodies from phage libraries selected on tumor cells and yeast-displayed tumor antigens","volume":"404","author":"Zhou","year":"2010","journal-title":"J. Mol. Biol."},{"issue":"1\u20132","key":"10.1016\/j.jconrel.2015.09.055_bb0995","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0022-1759(00)00340-9","article-title":"Selection of cell binding and internalizing epidermal growth factor receptor antibodies from a phage display library","volume":"248","author":"Heitner","year":"2001","journal-title":"J. Immunol. Methods"},{"issue":"2","key":"10.1016\/j.jconrel.2015.09.055_bb1000","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jconrel.2012.05.052","article-title":"Challenges in design and characterization of ligand-targeted drug delivery systems","volume":"164","author":"Muro","year":"2012","journal-title":"J. Control. Release"},{"issue":"8","key":"10.1016\/j.jconrel.2015.09.055_bb1005","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/nrc1146","article-title":"Caveolae: mining little caves for new cancer targets","volume":"3","author":"Carver","year":"2003","journal-title":"Nat. Rev. Cancer"},{"issue":"5","key":"10.1016\/j.jconrel.2015.09.055_bb1010","doi-asserted-by":"crossref","first-page":"C1339","DOI":"10.1152\/ajpcell.00099.2003","article-title":"Slow intracellular trafficking of catalase nanoparticles targeted to ICAM-1 protects endothelial cells from oxidative stress","volume":"285","author":"Muro","year":"2003","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"1","key":"10.1016\/j.jconrel.2015.09.055_bb1015","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ymthe.2005.07.687","article-title":"Lysosomal enzyme delivery by ICAM-1-targeted nanocarriers bypassing glycosylation- and clathrin-dependent endocytosis","volume":"13","author":"Muro","year":"2006","journal-title":"Mol. Ther."},{"issue":"3","key":"10.1016\/j.jconrel.2015.09.055_bb1020","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.jconrel.2011.09.067","article-title":"Effect of flow on endothelial endocytosis of nanocarriers targeted to ICAM-1","volume":"157","author":"Bhowmick","year":"2012","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2015.09.055_bb1025","first-page":"2943","article-title":"Multifactorial determinants that govern nanoparticle uptake by human endothelial cells under flow","volume":"7","author":"Samuel","year":"2012","journal-title":"Int. J. Nanomedicine"},{"issue":"12","key":"10.1016\/j.jconrel.2015.09.055_bb1030","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.1111\/j.1538-7836.2010.04088.x","article-title":"Internalization of microparticles by endothelial cells promotes platelet\/endothelial cell interaction under flow","volume":"8","author":"Terrisse","year":"2010","journal-title":"J. Thromb. Haemost."},{"issue":"10","key":"10.1016\/j.jconrel.2015.09.055_bb1035","doi-asserted-by":"crossref","first-page":"8824","DOI":"10.1021\/nn302687n","article-title":"Acute and chronic shear stress differently regulate endothelial internalization of nanocarriers targeted to platelet-endothelial cell adhesion molecule-1","volume":"6","author":"Han","year":"2012","journal-title":"ACS Nano"},{"issue":"5","key":"10.1016\/j.jconrel.2015.09.055_bb1040","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1161\/ATVBAHA.111.244186","article-title":"Intercellular adhesion molecule 1 engagement modulates sphingomyelinase and ceramide, supporting uptake of drug carriers by the vascular endothelium","volume":"32","author":"Serrano","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"2","key":"10.1016\/j.jconrel.2015.09.055_bb1045","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1124\/jpet.107.133298","article-title":"Delivery of acid sphingomyelinase in normal and Niemann\u2013Pick disease mice using intercellular adhesion molecule-1-targeted polymer nanocarriers","volume":"325","author":"Garnacho","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"12","key":"10.1016\/j.jconrel.2015.09.055_bb1050","doi-asserted-by":"crossref","first-page":"10597","DOI":"10.1021\/nn404719c","article-title":"Biological functionalization of drug delivery carriers to bypass size restrictions of receptor-mediated endocytosis independently from receptor targeting","volume":"7","author":"Ansar","year":"2013","journal-title":"ACS Nano"},{"issue":"1","key":"10.1016\/j.jconrel.2015.09.055_bb1055","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S1525-0016(02)00018-7","article-title":"Global non-viral gene transfer to the primate brain following intravenous administration","volume":"7","author":"Zhang","year":"2003","journal-title":"Mol. Ther."},{"issue":"5285","key":"10.1016\/j.jconrel.2015.09.055_bb1060","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1126\/science.274.5285.239","article-title":"Role of GTP hydrolysis in fission of caveolae directly from plasma membranes","volume":"274","author":"Schnitzer","year":"1996","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.jconrel.2015.09.055_bb1065","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1177\/002215540104900401","article-title":"The vesiculo-vacuolar organelle (VVO). A new endothelial cell permeability organelle","volume":"49","author":"Dvorak","year":"2001","journal-title":"J. Histochem. Cytochem."},{"issue":"24","key":"10.1016\/j.jconrel.2015.09.055_bb1070","doi-asserted-by":"crossref","first-page":"14399","DOI":"10.1074\/jbc.270.24.14399","article-title":"Endothelial caveolae have the molecular transport machinery for vesicle budding, docking, and fusion including VAMP, NSF, SNAP, annexins, and GTPases","volume":"270","author":"Schnitzer","year":"1995","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.jconrel.2015.09.055_bb1075","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1172\/JCI118997","article-title":"Endothelial adherens junctions: implications in the control of vascular permeability and angiogenesis","volume":"98","author":"Dejana","year":"1996","journal-title":"J. Clin. Invest."},{"issue":"6","key":"10.1016\/j.jconrel.2015.09.055_bb1080","doi-asserted-by":"crossref","first-page":"L1081","DOI":"10.1152\/ajplung.00268.2004","article-title":"Integrated control of lung fluid balance","volume":"287","author":"Mehta","year":"2004","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"issue":"1","key":"10.1016\/j.jconrel.2015.09.055_bb1085","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/S0022-3565(24)37616-5","article-title":"Enhanced endocytosis in cultured human breast carcinoma cells and in vivo biodistribution in rats of a humanized monoclonal antibody after cationization of the protein","volume":"286","author":"Pardridge","year":"1998","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"5","key":"10.1016\/j.jconrel.2015.09.055_bb1090","doi-asserted-by":"crossref","first-page":"L895","DOI":"10.1152\/ajplung.00075.2004","article-title":"Functional and morphological studies of protein transcytosis in continuous endothelia","volume":"287","author":"Predescu","year":"2004","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"issue":"1","key":"10.1016\/j.jconrel.2015.09.055_bb1095","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jconrel.2012.06.007","article-title":"Transport of nanocarriers across gastrointestinal epithelial cells by a new transcellular route induced by targeting ICAM-1","volume":"163","author":"Ghaffarian","year":"2012","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2015.09.055_bb1100","first-page":"4223","article-title":"Biodistribution and endocytosis of ICAM-1-targeting antibodies versus nanocarriers in the gastrointestinal tract in mice","volume":"7","author":"Mane","year":"2012","journal-title":"Int. J. Nanomedicine"},{"issue":"1","key":"10.1016\/j.jconrel.2015.09.055_bb1105","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.jash.2006.11.006","article-title":"Oxidative stress and hypertension","volume":"1","author":"Harrison","year":"2007","journal-title":"J. Am. Soc. Hypertens."},{"issue":"6","key":"10.1016\/j.jconrel.2015.09.055_bb1110","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/hr.2011.39","article-title":"Oxidative stress and endothelial dysfunction in hypertension","volume":"34","author":"Schulz","year":"2011","journal-title":"Hypertens. Res."},{"issue":"6","key":"10.1016\/j.jconrel.2015.09.055_bb1115","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1089\/ars.2008.2407","article-title":"Endosomal Nox2 facilitates redox-dependent induction of NF-kappaB by TNF-alpha","volume":"11","author":"Li","year":"2009","journal-title":"Antioxid. Redox Signal."},{"issue":"3","key":"10.1016\/j.jconrel.2015.09.055_bb1120","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1083\/jcb.200811059","article-title":"Lattices, rafts, and scaffolds: domain regulation of receptor signaling at the plasma membrane","volume":"185","author":"Lajoie","year":"2009","journal-title":"J. Cell Biol."},{"issue":"6","key":"10.1016\/j.jconrel.2015.09.055_bb1125","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1089\/ars.2008.2333","article-title":"Compartmentalization of redox signaling through NADPH oxidase-derived ROS","volume":"11","author":"Ushio-Fukai","year":"2009","journal-title":"Antioxid. Redox Signal."},{"issue":"6","key":"10.1016\/j.jconrel.2015.09.055_bb1130","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1089\/ars.2008.2363","article-title":"Signaling components of redox active endosomes: the redoxosomes","volume":"11","author":"Oakley","year":"2009","journal-title":"Antioxid. Redox Signal."},{"issue":"1","key":"10.1016\/j.jconrel.2015.09.055_bb1135","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1096\/fj.10-169789","article-title":"PECAM-targeted delivery of SOD inhibits endothelial inflammatory response","volume":"25","author":"Shuvaev","year":"2011","journal-title":"FASEB J."},{"issue":"1","key":"10.1016\/j.jconrel.2015.09.055_bb1140","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1089\/152308601750100489","article-title":"Delivery of antioxidant enzyme proteins to the lung","volume":"3","author":"Muzykantov","year":"2001","journal-title":"Antioxid. Redox Signal."},{"issue":"2","key":"10.1016\/j.jconrel.2015.09.055_bb1145","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.radonc.2006.09.013","article-title":"Systemic polyethylene glycol-modified (PEGylated) superoxide dismutase and catalase mixture attenuates radiation pulmonary fibrosis in the C57\/bl6 mouse","volume":"81","author":"Machtay","year":"2006","journal-title":"Radiother. Oncol."},{"issue":"4","key":"10.1016\/j.jconrel.2015.09.055_bb1150","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.freeradbiomed.2010.04.039","article-title":"Pluronic-modified superoxide dismutase 1 attenuates angiotensin II-induced increase in intracellular superoxide in neurons","volume":"49","author":"Yi","year":"2010","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.jconrel.2015.09.055_bb1155","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1021\/bc060259s","article-title":"Polyketal microparticles: a new delivery vehicle for superoxide dismutase","volume":"18","author":"Lee","year":"2007","journal-title":"Bioconjug. Chem."},{"issue":"5","key":"10.1016\/j.jconrel.2015.09.055_bb1160","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1096\/fj.08-116947","article-title":"Nanoparticle-mediated delivery of superoxide dismutase to the brain: an effective strategy to reduce ischemia\u2013reperfusion injury","volume":"23","author":"Reddy","year":"2009","journal-title":"FASEB J."},{"issue":"19","key":"10.1016\/j.jconrel.2015.09.055_bb1165","doi-asserted-by":"crossref","first-page":"5218","DOI":"10.1016\/j.biomaterials.2010.03.026","article-title":"The attenuation of central angiotensin II-dependent pressor response and intra-neuronal signaling by intracarotid injection of nanoformulated copper\/zinc superoxide dismutase","volume":"31","author":"Rosenbaugh","year":"2010","journal-title":"Biomaterials"},{"issue":"9","key":"10.1016\/j.jconrel.2015.09.055_bb1170","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.1111\/j.1743-6109.2009.01552.x","article-title":"Adenosine deaminase enzyme therapy prevents and reverses the heightened cavernosal relaxation in priapism","volume":"7","author":"Wen","year":"2009","journal-title":"J. Sex Med."},{"issue":"2","key":"10.1016\/j.jconrel.2015.09.055_bb1175","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/sj.gt.3301852","article-title":"Cell phenotype specific kinetics of expression of intratracheally injected manganese superoxide dismutase-plasmid\/liposomes (MnSOD-PL) during lung radioprotective gene therapy","volume":"10","author":"Epperly","year":"2003","journal-title":"Gene Ther."},{"issue":"6","key":"10.1016\/j.jconrel.2015.09.055_bb1180","doi-asserted-by":"crossref","first-page":"L917","DOI":"10.1152\/ajplung.00374.2002","article-title":"Synthesis and anti-inflammatory activity of a chimeric recombinant superoxide dismutase: SOD2\/3","volume":"284","author":"Gao","year":"2003","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"issue":"6","key":"10.1016\/j.jconrel.2015.09.055_bb1185","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1177\/147323000703500617","volume":"35","author":"Matsui","year":"2007","journal-title":"J. Int. Med. Res."},{"issue":"3","key":"10.1016\/j.jconrel.2015.09.055_bb1190","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1016\/S0022-3565(25)24056-3","article-title":"Lecithinized superoxide dismutase enhances its pharmacologic potency by increasing its cell membrane affinity","volume":"271","author":"Igarashi","year":"1994","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"2","key":"10.1016\/j.jconrel.2015.09.055_bb1195","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1046\/j.1523-1755.2001.060002786.x","article-title":"Endothelial cell protection against ischemia\/reperfusion injury by lecithinized superoxide dismutase","volume":"60","author":"Koo","year":"2001","journal-title":"Kidney Int."},{"issue":"1","key":"10.1016\/j.jconrel.2015.09.055_bb1200","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1124\/jpet.108.144451","article-title":"Therapeutic effect of lecithinized superoxide dismutase against colitis","volume":"328","author":"Ishihara","year":"2009","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"14","key":"10.1016\/j.jconrel.2015.09.055_bb1205","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/j.addr.2009.06.008","article-title":"Mitochondrial targeting of electron scavenging antioxidants: regulation of selective oxidation vs random chain reactions","volume":"61","author":"Kagan","year":"2009","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"4","key":"10.1016\/j.jconrel.2015.09.055_bb1210","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1053\/bbmt.2002.v8.pm12014807","article-title":"Pulmonary irradiation-induced expression of VCAM-I and ICAM-I is decreased by manganese superoxide dismutase-plasmid\/liposome (MnSOD-PL) gene therapy","volume":"8","author":"Epperly","year":"2002","journal-title":"Biol. Blood Marrow Transplant."},{"issue":"11","key":"10.1016\/j.jconrel.2015.09.055_bb1215","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1164\/rccm.200410-1346OC","article-title":"Polyethylene glycol-superoxide dismutase prevents endotoxin-induced cardiac dysfunction","volume":"173","author":"Supinski","year":"2006","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"4","key":"10.1016\/j.jconrel.2015.09.055_bb1220","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.biopha.2005.03.001","article-title":"Anti-inflammatory properties of a chimeric recombinant superoxide dismutase: SOD2\/3","volume":"59","author":"Hernandez-Saavedra","year":"2005","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.jconrel.2015.09.055_bb1225","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1164\/rccm.200203-232OC","article-title":"A catalytic antioxidant attenuates alveolar structural remodeling in bronchopulmonary dysplasia","volume":"167","author":"Chang","year":"2003","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"6","key":"10.1016\/j.jconrel.2015.09.055_bb1230","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S0891-5849(02)00980-2","article-title":"A small molecular weight catalytic metalloporphyrin antioxidant with superoxide dismutase (SOD) mimetic properties protects lungs from radiation-induced injury","volume":"33","author":"Vujaskovic","year":"2002","journal-title":"Free Radic. Biol. Med."},{"issue":"3","key":"10.1016\/j.jconrel.2015.09.055_bb1235","doi-asserted-by":"crossref","first-page":"G676","DOI":"10.1152\/ajpgi.00049.2004","article-title":"Chimeric SOD2\/3 inhibits at the endothelial-neutrophil interface to limit vascular dysfunction in ischemia\u2013reperfusion","volume":"287","author":"Bonder","year":"2004","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"10","key":"10.1016\/j.jconrel.2015.09.055_bb1240","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1089\/hum.1998.9.10-1487","article-title":"Gene therapy for oxidant injury-related diseases: adenovirus-mediated transfer of superoxide dismutase and catalase cDNAs protects against hyperoxia but not against ischemia\u2013reperfusion lung injury","volume":"9","author":"Danel","year":"1998","journal-title":"Hum. Gene Ther."},{"issue":"7","key":"10.1016\/j.jconrel.2015.09.055_bb1245","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1172\/JCI3816","article-title":"Extracellular superoxide dismutase in the airways of transgenic mice reduces inflammation and attenuates lung toxicity following hyperoxia","volume":"103","author":"Folz","year":"1999","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.jconrel.2015.09.055_bb1250","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1124\/jpet.106.114769","article-title":"Structural requirements for optimized delivery, inhibition of oxidative stress, and antiapoptotic activity of targeted nitroxides","volume":"320","author":"Jiang","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"5","key":"10.1016\/j.jconrel.2015.09.055_bb1255","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1073\/pnas.96.5.2379","article-title":"Streptavidin facilitates internalization and pulmonary targeting of an anti-endothelial cell antibody (platelet-endothelial cell adhesion molecule 1): a strategy for vascular immunotargeting of drugs","volume":"96","author":"Muzykantov","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.jconrel.2015.09.055_bb1260","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1124\/jpet.107.127126","article-title":"Platelet-endothelial cell adhesion molecule-1-directed endothelial targeting of superoxide dismutase alleviates oxidative stress caused by either extracellular or intracellular superoxide","volume":"323","author":"Shuvaev","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"2","key":"10.1016\/j.jconrel.2015.09.055_bb1265","first-page":"276","article-title":"Directed targeting of immunoerythrocytes provides local protection of endothelial cells from damage by hydrogen peroxide","volume":"128","author":"Muzykantov","year":"1987","journal-title":"Am. J. Pathol."},{"issue":"2","key":"10.1016\/j.jconrel.2015.09.055_bb1270","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/0167-4889(87)90025-5","article-title":"Protection of cultured endothelial cells from hydrogen peroxide-induced injury by antibody-conjugated catalase","volume":"930","author":"Sakharov","year":"1987","journal-title":"Biochim. Biophys. Acta"},{"issue":"8","key":"10.1016\/j.jconrel.2015.09.055_bb1275","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/S0891-5849(03)00029-7","article-title":"PECAM-directed immunotargeting of catalase: specific, rapid and transient protection against hydrogen peroxide","volume":"34","author":"Sweitzer","year":"2003","journal-title":"Free Radic. Biol. Med."},{"issue":"4 Pt 1","key":"10.1016\/j.jconrel.2015.09.055_bb1280","first-page":"L806","article-title":"Immunotargeting of catalase to ACE or ICAM-1 protects perfused rat lungs against oxidative stress","volume":"275","author":"Atochina","year":"1998","journal-title":"Am. J. Phys."},{"issue":"2","key":"10.1016\/j.jconrel.2015.09.055_bb1285","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1096\/fj.00-0022com","article-title":"Cell-selective intracellular delivery of a foreign enzyme to endothelium in vivo using vascular immunotargeting","volume":"15","author":"Scherpereel","year":"2001","journal-title":"FASEB J."},{"issue":"4","key":"10.1016\/j.jconrel.2015.09.055_bb1290","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/nbt806","article-title":"Immunotargeting of catalase to the pulmonary endothelium alleviates oxidative stress and reduces acute lung transplantation injury","volume":"21","author":"Kozower","year":"2003","journal-title":"Nat. Biotechnol."},{"issue":"2","key":"10.1016\/j.jconrel.2015.09.055_bb1295","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1124\/jpet.109.156877","article-title":"Targeted detoxification of selected reactive oxygen species in the vascular endothelium","volume":"331","author":"Shuvaev","year":"2009","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.jconrel.2015.09.055_bb1300","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/978-94-007-4549-0_26","article-title":"Immunotargeting of the pulmonary endothelium via angiotensin-converting-enzyme in isolated ventilated and perfused human lung","volume":"756","author":"Nowak","year":"2013","journal-title":"Adv. Exp. Med. Biol."},{"issue":"8","key":"10.1016\/j.jconrel.2015.09.055_bb1305","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1038\/mt.2012.70","article-title":"Gene therapy by targeted adenovirus-mediated knockdown of pulmonary endothelial Tph1 attenuates hypoxia-induced pulmonary hypertension","volume":"20","author":"Morecroft","year":"2012","journal-title":"Mol. Ther."},{"issue":"4","key":"10.1016\/j.jconrel.2015.09.055_bb1310","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.ejcts.2009.10.029","article-title":"Pre-ischaemic conditioning of the pulmonary endothelium by immunotargeting of catalase via angiotensin-converting-enzyme antibodies","volume":"37","author":"Nowak","year":"2010","journal-title":"Eur. J. Cardiothorac. Surg."},{"issue":"1","key":"10.1016\/j.jconrel.2015.09.055_bb1315","doi-asserted-by":"crossref","first-page":"L162","DOI":"10.1152\/ajplung.00001.2007","article-title":"Immunotargeting of catalase to lung endothelium via anti-angiotensin-converting enzyme antibodies attenuates ischemia\u2013reperfusion injury of the lung in vivo","volume":"293","author":"Nowak","year":"2007","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"issue":"1","key":"10.1016\/j.jconrel.2015.09.055_bb1320","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jconrel.2011.03.022","article-title":"Targeted modulation of reactive oxygen species in the vascular endothelium","volume":"153","author":"Shuvaev","year":"2011","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2015.09.055_bb1325","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jconrel.2013.12.035","article-title":"Endothelial targeting of liposomes encapsulating SOD\/catalase mimetic EUK-134 alleviates acute pulmonary inflammation","volume":"177C","author":"Howard","year":"2014","journal-title":"J. Control. Release"},{"issue":"1","key":"10.1016\/j.jconrel.2015.09.055_bb1330","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1124\/jpet.111.180620","article-title":"Catalase and superoxide dismutase conjugated with platelet-endothelial cell adhesion molecule antibody distinctly alleviate abnormal endothelial permeability caused by exogenous reactive oxygen species and vascular endothelial growth factor","volume":"338","author":"Han","year":"2011","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"10","key":"10.1016\/j.jconrel.2015.09.055_bb1335","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0077002","article-title":"Anti-inflammatory effect of targeted delivery of SOD to endothelium: mechanism, synergism with NO donors and protective effects in vitro and in vivo","volume":"8","author":"Shuvaev","year":"2013","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.jconrel.2015.09.055_bb1340","doi-asserted-by":"crossref","first-page":"L283","DOI":"10.1152\/ajplung.00021.2003","article-title":"PECAM-directed delivery of catalase to endothelium protects against pulmonary vascular oxidative stress","volume":"285","author":"Christofidou-Solomidou","year":"2003","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"issue":"2","key":"10.1016\/j.jconrel.2015.09.055_bb1345","doi-asserted-by":"crossref","first-page":"263","DOI":"10.4155\/tde.11.151","article-title":"Targeted interception of signaling reactive oxygen species in the vascular endothelium","volume":"3","author":"Han","year":"2012","journal-title":"Ther. Deliv."},{"issue":"5","key":"10.1016\/j.jconrel.2015.09.055_bb1350","doi-asserted-by":"crossref","first-page":"L809","DOI":"10.1152\/ajplung.00311.2005","article-title":"Control of intracellular trafficking of ICAM-1-targeted nanocarriers by endothelial Na+\/H+ exchanger proteins","volume":"290","author":"Muro","year":"2006","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"issue":"2","key":"10.1016\/j.jconrel.2015.09.055_bb1355","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.jconrel.2004.10.017","article-title":"Polymer nanocarriers protecting active enzyme cargo against proteolysis","volume":"102","author":"Dziubla","year":"2005","journal-title":"J. Control. Release"},{"issue":"1","key":"10.1016\/j.jconrel.2015.09.055_bb1360","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1007\/s11095-008-9744-7","article-title":"Loading PEG-catalase into filamentous and spherical polymer nanocarriers","volume":"26","author":"Simone","year":"2009","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2015.09.055_bb1365","doi-asserted-by":"crossref","DOI":"10.1021\/bm900189x","article-title":"Filamentous polymer nanocarriers of tunable stiffness that encapsulate the therapeutic enzyme catalase","author":"Simone","year":"2009","journal-title":"Biomacromolecules"},{"issue":"2","key":"10.1016\/j.jconrel.2015.09.055_bb1370","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.biomaterials.2007.09.023","article-title":"Endothelial targeting of semi-permeable polymer nanocarriers for enzyme therapies","volume":"29","author":"Dziubla","year":"2008","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2015.09.055_bb1375","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2012.08.031","article-title":"Antioxidant protection by PECAM-targeted delivery of a novel NADPH-oxidase inhibitor to the endothelium in vitro and in vivo","author":"Hood","year":"2012","journal-title":"J. Control. Release"},{"issue":"4","key":"10.1016\/j.jconrel.2015.09.055_bb1380","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1182\/blood-2007-07-103002","article-title":"Prophylactic thrombolysis by thrombin-activated latent prourokinase targeted to PECAM-1 in the pulmonary vasculature","volume":"111","author":"Ding","year":"2008","journal-title":"Blood"},{"issue":"11","key":"10.1016\/j.jconrel.2015.09.055_bb1385","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0080110","article-title":"Vascular immunotargeting to endothelial determinant ICAM-1 enables optimal partnering of recombinant scFv-thrombomodulin fusion with endogenous cofactor","volume":"8","author":"Greineder","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jconrel.2015.09.055_bb1390","doi-asserted-by":"crossref","DOI":"10.1096\/fj.15-271213","article-title":"Dual targeting of therapeutics to endothelial cells: collaborative enhancement of delivery and effect","author":"Greineder","year":"2015","journal-title":"FASEB J."},{"issue":"7","key":"10.1016\/j.jconrel.2015.09.055_bb1395","article-title":"Icam-1 targeted nanogels loaded with dexamethasone alleviate pulmonary inflammation","volume":"9","author":"Ferrer","year":"2014","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.jconrel.2015.09.055_bb1400","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1111\/j.1476-5381.2011.01314.x","article-title":"Liposome-encapsulated dexamethasone attenuates ventilator-induced lung inflammation","volume":"163","author":"Hegeman","year":"2011","journal-title":"Br. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.jconrel.2015.09.055_bb1405","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.atherosclerosis.2006.08.049","article-title":"LipoCardium: endothelium-directed cyclopentenone prostaglandin-based liposome formulation that completely reverses atherosclerotic lesions","volume":"193","author":"Homem de Bittencourt","year":"2007","journal-title":"Atherosclerosis"},{"issue":"3","key":"10.1016\/j.jconrel.2015.09.055_bb1410","doi-asserted-by":"crossref","first-page":"F554","DOI":"10.1152\/ajprenal.00391.2007","article-title":"Inhibition of proinflammatory genes in anti-GBM glomerulonephritis by targeted dexamethasone-loaded AbEsel liposomes","volume":"294","author":"Asgeirsdottir","year":"2008","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"1","key":"10.1016\/j.jconrel.2015.09.055_bb1415","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.exer.2007.10.004","article-title":"High-efficacy site-directed drug delivery system using sialyl-lewis X conjugated liposome","volume":"86","author":"Hashida","year":"2008","journal-title":"Exp. Eye Res."},{"issue":"1","key":"10.1016\/j.jconrel.2015.09.055_bb1420","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1023\/A:1022298725165","article-title":"In vitro cellular handling and in vivo targeting of E-selectin-directed immunoconjugates and immunoliposomes used for drug delivery to inflamed endothelium","volume":"20","author":"Everts","year":"2003","journal-title":"Pharm. Res."},{"issue":"1","key":"10.1016\/j.jconrel.2015.09.055_bb1425","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1124\/mol.107.034140","article-title":"Site-specific inhibition of glomerulonephritis progression by targeted delivery of dexamethasone to glomerular endothelium","volume":"72","author":"Asgeirsdottir","year":"2007","journal-title":"Mol. Pharmacol."},{"issue":"1","key":"10.1016\/j.jconrel.2015.09.055_bb1430","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jconrel.2012.12.016","article-title":"Targeted adenovirus mediated inhibition of NF-kappaB-dependent inflammatory gene expression in endothelial cells in vitro and in vivo","volume":"166","author":"Kuldo","year":"2013","journal-title":"J. Control. Release"},{"issue":"2","key":"10.1016\/j.jconrel.2015.09.055_bb1435","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.jconrel.2009.09.008","article-title":"Targeted transfection increases siRNA uptake and gene silencing of primary endothelial cells in vitro\u2014a quantitative study","volume":"141","author":"Asgeirsdottir","year":"2010","journal-title":"J. Control. Release"},{"issue":"8","key":"10.1016\/j.jconrel.2015.09.055_bb1440","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.1073\/pnas.1200718109","article-title":"Polycation-siRNA nanoparticles can disassemble at the kidney glomerular basement membrane","volume":"109","author":"Zuckerman","year":"2012","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"5","key":"10.1016\/j.jconrel.2015.09.055_bb1445","doi-asserted-by":"crossref","first-page":"E781","DOI":"10.1002\/ijc.27361","article-title":"Lipid nanoparticle siRNA systems for silencing the androgen receptor in human prostate cancer in vivo","volume":"131","author":"Lee","year":"2012","journal-title":"Int. J. Cancer"},{"issue":"4","key":"10.1016\/j.jconrel.2015.09.055_bb1450","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1002\/art.21719","article-title":"Targeting of angiogenic endothelial cells at sites of inflammation by dexamethasone phosphate\u2013containing RGD peptide liposomes inhibits experimental arthritis","volume":"54","author":"Koning","year":"2006","journal-title":"Arthritis Rheum."},{"issue":"2","key":"10.1016\/j.jconrel.2015.09.055_bb1455","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.jconrel.2011.09.080","article-title":"Targeted delivery of small interfering RNA to angiogenic endothelial cells with liposome-polycation-DNA particles","volume":"160","author":"Vader","year":"2012","journal-title":"J. Control. Release"},{"issue":"2","key":"10.1016\/j.jconrel.2015.09.055_bb1460","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/wnan.73","article-title":"New biotechnological and nanomedicine strategies for treatment of lysosomal storage disorders","volume":"2","author":"Muro","year":"2010","journal-title":"Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol."},{"issue":"3","key":"10.1016\/j.jconrel.2015.09.055_bb1465","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.ymgme.2006.01.010","article-title":"Lysosomal storage diseases: natural history and ethical and economic aspects","volume":"88","author":"Beutler","year":"2006","journal-title":"Mol. Genet. Metab."},{"issue":"7","key":"10.1016\/j.jconrel.2015.09.055_bb1470","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/nrm1423","article-title":"The cell biology of lysosomal storage disorders","volume":"5","author":"Futerman","year":"2004","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"3","key":"10.1016\/j.jconrel.2015.09.055_bb1475","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1001\/jama.281.3.249","article-title":"Prevalence of lysosomal storage disorders","volume":"281","author":"Meikle","year":"1999","journal-title":"JAMA"},{"issue":"6","key":"10.1016\/j.jconrel.2015.09.055_bb1480","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1517\/17425247.3.6.771","article-title":"Delivery of lysosomal enzymes for therapeutic use: glucocerebrosidase as an example","volume":"3","author":"Grabowski","year":"2006","journal-title":"Expert Opin. Drug Deliv."},{"issue":"12","key":"10.1016\/j.jconrel.2015.09.055_bb1485","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/S1474-4422(04)00938-X","article-title":"Enzyme-replacement therapy for metabolic storage disorders","volume":"3","author":"Brady","year":"2004","journal-title":"Lancet Neurol."},{"issue":"12","key":"10.1016\/j.jconrel.2015.09.055_bb1490","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1038\/nrg963","article-title":"Enzyme replacement and enhancement therapies: lessons from lysosomal disorders","volume":"3","author":"Desnick","year":"2002","journal-title":"Nat. Rev. Genet."},{"issue":"1","key":"10.1016\/j.jconrel.2015.09.055_bb1495","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1083\/jcb.93.1.135","article-title":"Biosynthesis of lysosomal hydrolases: their synthesis in bound polysomes and the role of co- and post-translational processing in determining their subcellular distribution","volume":"93","author":"Rosenfeld","year":"1982","journal-title":"J. Cell Biol."},{"issue":"6","key":"10.1016\/j.jconrel.2015.09.055_bb1500","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1086\/498652","article-title":"The role of mannosylated enzyme and the mannose receptor in enzyme replacement therapy","volume":"77","author":"Du","year":"2005","journal-title":"Am. J. Hum. Genet."},{"issue":"1","key":"10.1016\/j.jconrel.2015.09.055_bb1505","first-page":"77","article-title":"The uptake of enzymes into lysosomes: an overview","volume":"16","author":"Neufeld","year":"1980","journal-title":"Birth Defects Orig. Artic. Ser."},{"issue":"13","key":"10.1016\/j.jconrel.2015.09.055_bb1510","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1096\/fj.00-0014com","article-title":"Infusion of recombinant human acid sphingomyelinase into Niemann\u2013Pick disease mice leads to visceral, but not neurological, correction of the pathophysiology","volume":"14","author":"Miranda","year":"2000","journal-title":"FASEB J."},{"key":"10.1016\/j.jconrel.2015.09.055_bb1515","series-title":"Lysosomal Disorders. The Metabolic and Molecular Bases of Inherited Disease","author":"Schuchman","year":"2000"},{"issue":"5","key":"10.1016\/j.jconrel.2015.09.055_bb1520","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1538\/expanim.53.417","article-title":"Comparative effects of recombinant acid sphingomyelinase administration by different routes in Niemann\u2013Pick disease mice","volume":"53","author":"Bae","year":"2004","journal-title":"Exp. Anim."},{"issue":"5","key":"10.1016\/j.jconrel.2015.09.055_bb1525","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/0092-8674(87)90104-8","article-title":"Purified intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen 1 (LFA-1)","volume":"51","author":"Marlin","year":"1987","journal-title":"Cell"},{"key":"10.1016\/j.jconrel.2015.09.055_bb1530","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1146\/annurev.iy.11.040193.004003","article-title":"Endothelial-leukocyte adhesion molecules","volume":"11","author":"Bevilacqua","year":"1993","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.jconrel.2015.09.055_bb1535","series-title":"Endothelial Biomedicine","first-page":"1058","author":"Muro","year":"2007"},{"issue":"2","key":"10.1016\/j.jconrel.2015.09.055_bb1540","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/1531-8249(200002)47:2<229::AID-ANA13>3.0.CO;2-T","article-title":"Profile of endothelial and leukocyte activation in Fabry patients","volume":"47","author":"DeGraba","year":"2000","journal-title":"Ann. Neurol."},{"issue":"3","key":"10.1016\/j.jconrel.2015.09.055_bb1545","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.jconrel.2010.10.031","article-title":"Enhanced endothelial delivery and biochemical effects of \u03b1-galactosidase by ICAM-1-targeted nanocarriers for Fabry disease","volume":"149","author":"Hsu","year":"2011","journal-title":"J. Control. Release"},{"issue":"5","key":"10.1016\/j.jconrel.2015.09.055_bb1550","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.nano.2011.08.014","article-title":"Enhanced delivery of \u03b1-glucosidase for Pompe disease by ICAM-1-targeted nanocarriers: comparative performance of a strategy for three distinct lysosomal storage disorders","volume":"8","author":"Hsu","year":"2012","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"10.1016\/j.jconrel.2015.09.055_bb1555","article-title":"Comparative binding, endocytosis, and biodistribution of antibodies and antibody-coated carriers for targeted delivery of lysosomal enzymes to ICAM-1 versus transferrin receptor","author":"Papademetriou","year":"2012","journal-title":"J. Inherit. Metab. Dis."},{"issue":"7","key":"10.1016\/j.jconrel.2015.09.055_bb1560","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1046\/j.1538-7836.2003.00261.x","article-title":"Inflammation and thrombosis","volume":"1","author":"Esmon","year":"2003","journal-title":"J. Thromb. Haemost."},{"issue":"2","key":"10.1016\/j.jconrel.2015.09.055_bb1565","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1161\/01.CIR.93.2.301","article-title":"Enhanced in vivo antithrombotic effects of endothelial cells expressing recombinant plasminogen activators transduced with retroviral vectors","volume":"93","author":"Dichek","year":"1996","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.jconrel.2015.09.055_bb1570","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/S0022-3565(25)21218-6","article-title":"Targeting of antibody-conjugated plasminogen activators to the pulmonary vasculature","volume":"279","author":"Muzykantov","year":"1996","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"10","key":"10.1016\/j.jconrel.2015.09.055_bb1575","doi-asserted-by":"crossref","first-page":"3977","DOI":"10.1182\/blood-2002-09-2853","article-title":"ICAM-directed vascular immunotargeting of antithrombotic agents to the endothelial luminal surface","volume":"101","author":"Murciano","year":"2003","journal-title":"Blood"},{"issue":"13","key":"10.1016\/j.jconrel.2015.09.055_bb1580","doi-asserted-by":"crossref","first-page":"4191","DOI":"10.1182\/blood-2005-05-2002","article-title":"Endothelial targeting of a recombinant construct fusing a PECAM-1 single-chain variable antibody fragment (scFv) with prourokinase facilitates prophylactic thrombolysis in the pulmonary vasculature","volume":"106","author":"Ding","year":"2005","journal-title":"Blood"},{"issue":"23","key":"10.1016\/j.jconrel.2015.09.055_bb1585","doi-asserted-by":"crossref","first-page":"5797","DOI":"10.1021\/bi00237a024","article-title":"Single-chain urokinase-type plasminogen activator does not possess measurable intrinsic amidolytic or plasminogen activator activities","volume":"30","author":"Husain","year":"1991","journal-title":"Biochemistry"},{"issue":"8","key":"10.1016\/j.jconrel.2015.09.055_bb1590","doi-asserted-by":"crossref","first-page":"3486","DOI":"10.1016\/S0021-9258(17)35674-0","article-title":"The activation of pro-urokinase by plasma kallikrein and its inactivation by thrombin","volume":"261","author":"Ichinose","year":"1986","journal-title":"J. Biol. Chem."},{"issue":"8","key":"10.1016\/j.jconrel.2015.09.055_bb1595","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1021\/bi00174a043","article-title":"Design and evaluation of a thrombin-activable plasminogen activator","volume":"33","author":"Yang","year":"1994","journal-title":"Biochemistry"},{"issue":"Suppl 1","key":"10.1016\/j.jconrel.2015.09.055_bb1600","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1055\/s-2006-939554","article-title":"Inflammation and the activated protein C anticoagulant pathway","volume":"32","author":"Esmon","year":"2006","journal-title":"Semin. Thromb. Hemost."},{"issue":"3","key":"10.1016\/j.jconrel.2015.09.055_bb1605","first-page":"317","article-title":"Amplified anticoagulant activity of tissue factor-targeted thrombomodulin: in-vivo validation of a tissue factor-neutralizing antibody fused to soluble thrombomodulin","volume":"96","author":"Wang","year":"2006","journal-title":"Thromb. Haemost."},{"issue":"3","key":"10.1016\/j.jconrel.2015.09.055_bb1610","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1164\/rccm.200809-1433OC","article-title":"Anchoring fusion thrombomodulin to the endothelial lumen protects against injury-induced lung thrombosis and inflammation","volume":"180","author":"Ding","year":"2009","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.jconrel.2015.09.055_bb1615","doi-asserted-by":"crossref","DOI":"10.1016\/j.nano.2014.05.001","article-title":"MR cholangiography demonstrates unsuspected rapid biliary clearance of nanoparticles in rodents: implications for clinical translation","author":"Bulte","year":"2014","journal-title":"Nanomedicine"}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365915301553?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365915301553?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T23:22:04Z","timestamp":1748647324000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365915301553"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":323,"alternative-id":["S0168365915301553"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2015.09.055","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeted endothelial nanomedicine for common acute pathological conditions","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2015.09.055","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}