{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T23:59:18Z","timestamp":1774483158868,"version":"3.50.1"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"ISCIII-RETIC","award":["RD12\/0019\/0031"],"award-info":[{"award-number":["RD12\/0019\/0031"]}]},{"DOI":"10.13039\/501100003329","name":"MINECO","doi-asserted-by":"publisher","award":["PLE2009-0116"],"award-info":[{"award-number":["PLE2009-0116"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CARDIOBIO","award":["SAF2013-42528-R"],"award-info":[{"award-number":["SAF2013-42528-R"]}]},{"name":"INELPY","award":["Health-2007-2.4.2.-5"],"award-info":[{"award-number":["Health-2007-2.4.2.-5"]}]},{"name":"FUN"},{"name":"Caja de Ahorros de Navarra"},{"name":"Spanish Ministerio de Educaci\u00f3n"},{"name":"FPI","award":["BES-2014-067838"],"award-info":[{"award-number":["BES-2014-067838"]}]},{"name":"FPU","award":["AP2009-4556"],"award-info":[{"award-number":["AP2009-4556"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.jconrel.2015.10.058","type":"journal-article","created":{"date-parts":[[2015,11,9]],"date-time":"2015-11-09T21:13:36Z","timestamp":1447103616000},"page":"388-396","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"PA","title":["Tracking the in vivo release of bioactive NRG from PLGA and PEG\u2013PLGA microparticles in infarcted hearts"],"prefix":"10.1016","volume":"220","author":[{"given":"S.","family":"Pascual-Gil","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Sim\u00f3n-Yarza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Garbayo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Prosper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.J.","family":"Blanco-Prieto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2015.10.058_bb0005","series-title":"Global Atlas on Cardiovascular Disease Prevention and Control","year":"2011"},{"key":"10.1016\/j.jconrel.2015.10.058_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2015.02.009","article-title":"Heart regeneration after miocardial infarction using synthetic biomaterials","author":"Pascual-Gil","year":"2015","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2015.10.058_bb0015","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/pr.2011.61","article-title":"Stem cell therapy for cardiac disease","volume":"71","author":"Bernstein","year":"2012","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.jconrel.2015.10.058_bb0020","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s12265-010-9207-5","article-title":"Protein therapeutics for cardiac regeneration after myocardial infarction","volume":"3","author":"Segers","year":"2010","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"10.1016\/j.jconrel.2015.10.058_bb0025","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1161\/CIRCRESAHA.108.176826","article-title":"Paracrine mechanisms in adult stem cell signaling and therapy","volume":"103","author":"Gnecchi","year":"2008","journal-title":"Circ. Res."},{"key":"10.1016\/j.jconrel.2015.10.058_bb0030","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1161\/CIRCRESAHA.113.301202","article-title":"Bone-derived stem cells repair the heart after myocardial infarction through transdifferentiation and paracrine signaling mechanisms","volume":"113","author":"Duran","year":"2013","journal-title":"Circ. Res."},{"key":"10.1016\/j.jconrel.2015.10.058_bb0035","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1172\/JCI63068","article-title":"Regenerating new heart with stem cells","volume":"123","author":"Anversa","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jconrel.2015.10.058_bb0040","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.jacc.2010.05.039","article-title":"Rebuilding the damaged heart: the potential of cytokines and growth factors in the treatment of ischemic heart disease","volume":"56","author":"Beohar","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.jconrel.2015.10.058_bb0045","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s10741-011-9285-8","article-title":"Angiogenic therapy for cardiac repair based on protein delivery systems","volume":"17","author":"Formiga","year":"2012","journal-title":"Heart Fail. Rev."},{"key":"10.1016\/j.jconrel.2015.10.058_bb0050","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.cell.2009.04.060","article-title":"Neuregulin1\/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury","volume":"138","author":"Bersell","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.jconrel.2015.10.058_bb0055","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1161\/CIRCRESAHA.112.267286","article-title":"Neuregulin in cardiovascular development and disease","volume":"111","author":"Odiete","year":"2012","journal-title":"Circ. Res."},{"key":"10.1016\/j.jconrel.2015.10.058_bb0060","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1016\/j.jacc.2009.12.044","article-title":"A Phase II, randomized, double-blind, multicenter, based on standard therapy, placebo-controlled study of the efficacy and safety of recombinant human neuregulin-1 in patients with chronic heart failure","volume":"55","author":"Gao","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.jconrel.2015.10.058_bb0065","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1093\/eurjhf\/hfq152","article-title":"Parenteral administration of recombinant human neuregulin-1 to patients with stable chronic heart failure produces favourable acute and chronic haemodynamic responses","volume":"13","author":"Jabbour","year":"2011","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.jconrel.2015.10.058_bb0070","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1161\/hc0802.104407","article-title":"Pharmacological treatment of coronary artery disease with recombinant fibroblast growth factor-2: double-blind, randomized, controlled clinical trial","volume":"105","author":"Simons","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.jconrel.2015.10.058_bb0075","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1161\/01.CIR.0000061911.47710.8A","article-title":"The VIVA trial: vascular endothelial growth factor in Ischemia for vascular angiogenesis","volume":"107","author":"Henry","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.jconrel.2015.10.058_bb0080","article-title":"Drug and cell delivery for cardiac regeneration","author":"Hastings","year":"2014","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2015.10.058_bb0085","unstructured":"M.N. Ravi Kumar, Nano and microparticles as controlled drug delivery devices., J. Pharm. Pharm. Sci. 3 (n.d.) 234\u201358. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10994037 (accessed June 17, 2014)."},{"key":"10.1016\/j.jconrel.2015.10.058_bb0090","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1615\/CritRevTherDrugCarrierSyst.2013006955","article-title":"Peptide and protein delivery using new drug delivery systems","volume":"30","author":"Jain","year":"2013","journal-title":"Crit. Rev. Ther. Drug Carrier Syst."},{"key":"10.1016\/j.jconrel.2015.10.058_bb0095","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1177\/0885328211408946","article-title":"Review paper: critical issues in tissue engineering: biomaterials, cell sources, angiogenesis, and drug delivery systems","volume":"26","author":"Naderi","year":"2011","journal-title":"J. Biomater. Appl."},{"key":"10.1016\/j.jconrel.2015.10.058_bb0100","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ijpharm.2012.07.006","article-title":"PEGylated-PLGA microparticles containing VEGF for long term drug delivery","volume":"440","author":"Sim\u00f3n-Yarza","year":"2013","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2015.10.058_bb0105","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jconrel.2013.10.034","article-title":"Controlled delivery of fibroblast growth factor-1 and neuregulin-1 from biodegradable microparticles promotes cardiac repair in a rat myocardial infarction model through activation of endogenous regeneration","volume":"173","author":"Formiga","year":"2014","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2015.10.058_bb0110","first-page":"3071","article-title":"Critical evaluation of biodegradable polymers used in nanodrugs","volume":"8","author":"Marin","year":"2013","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.jconrel.2015.10.058_bb0115","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.ejpb.2013.02.017","article-title":"Biodegradation and heart retention of polymeric microparticles in a rat model of myocardial ischemia","volume":"85","author":"Formiga","year":"2013","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.jconrel.2015.10.058_bb0120","series-title":"Controlled Intramyocardial Delivery of NRG-1 and FGF-1 from Biodegradable Microparticles in a Large Preclinical Myocardial Infarction Model, submitted in","author":"Garbayo","year":"2015"},{"key":"10.1016\/j.jconrel.2015.10.058_bb0125","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0927-7765(99)00156-3","article-title":"\u201cStealth\u201d corona-core nanoparticles surface modified by polyethylene glycol (PEG): influences of the corona (PEG chain length and surface density) and of the core composition on phagocytic uptake and plasma protein adsorption","volume":"18","author":"Gref","year":"2000","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.jconrel.2015.10.058_bb0130","doi-asserted-by":"crossref","first-page":"4655","DOI":"10.1002\/jps.21350","article-title":"PEGylation as a tool for the biomedical engineering of surface modified microparticles","volume":"97","author":"Wattendorf","year":"2008","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2015.10.058_bb0135","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.ejpb.2013.03.022","article-title":"Adipose-derived stem cells combined with neuregulin-1 delivery systems for heart tissue engineering","volume":"85","author":"D\u00edaz-Herr\u00e1ez","year":"2013","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.jconrel.2015.10.058_bb0140","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.jconrel.2010.07.097","article-title":"Sustained release of VEGF through PLGA microparticles improves vasculogenesis and tissue remodeling in an acute myocardial ischemia-reperfusion model","volume":"147","author":"Formiga","year":"2010","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2015.10.058_bb0145","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.ijpharm.2013.04.015","article-title":"Functional benefits of PLGA particulates carrying VEGF and CoQ10 in an animal of myocardial ischemia","volume":"454","author":"Sim\u00f3n-Yarza","year":"2013","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2015.10.058_bb0150","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/520445a","article-title":"Regenerative biology: Neuregulin 1 makes heart muscle","volume":"520","author":"Yutzey","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.jconrel.2015.10.058_bb0155","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1161\/CIRCRESAHA.113.300215","article-title":"Protein engineering for cardiovascular therapeutics: untapped potential for cardiac repair","volume":"113","author":"Jay","year":"2013","journal-title":"Circ. Res."},{"key":"10.1016\/j.jconrel.2015.10.058_bb0160","doi-asserted-by":"crossref","first-page":"6340","DOI":"10.2174\/1381612811319350010","article-title":"Microspheres and microcapsules for protein delivery: strategies of drug activity retention","volume":"19","author":"Wang","year":"2013","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.jconrel.2015.10.058_bb0165","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1111\/j.1582-4934.2008.00532.x","article-title":"Drug releasing systems in cardiovascular tissue engineering","volume":"13","author":"Spadaccio","year":"2009","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.jconrel.2015.10.058_bb0170","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/978-1-59745-196-3_13","article-title":"High-throughput biotinylation of proteins","volume":"498","author":"Kay","year":"2009","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jconrel.2015.10.058_bb0175","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1073\/pnas.040575997","article-title":"Isotope-labeled immunoassays without radiation waste","volume":"97","author":"Shan","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jconrel.2015.10.058_bb0180","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.jconrel.2013.04.022","article-title":"Functionalized nanoparticles provide early cardioprotection after acute myocardial infarction","volume":"170","author":"Chang","year":"2013","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2015.10.058_bb0185","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/2008-2231-21-57","article-title":"In-vitro\/in-vivo comparison of leuprolide acetate release from an in-situ forming PLGA system","volume":"21","author":"Mashayekhi","year":"2013","journal-title":"Daru"},{"key":"10.1016\/j.jconrel.2015.10.058_bb0190","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1211\/002235702760089009","article-title":"Pharmacokinetic characterization of 14C-vascular endothelial growth factor controlled release microspheres using a rat model","volume":"54","author":"Kim","year":"2002","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.jconrel.2015.10.058_bb0195","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.2174\/0929866521666140807114240","article-title":"Recent advances in protein and peptide drug delivery: a special emphasis on polymeric nanoparticles","volume":"21","author":"Patel","year":"2014","journal-title":"Protein Pept. Lett."},{"key":"10.1016\/j.jconrel.2015.10.058_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2014.09.003","article-title":"Microencapsulation of protein drugs for drug delivery: strategy, preparation, and applications","author":"Ma","year":"2014","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2015.10.058_bb0205","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1023\/A:1026498209874","article-title":"Protein instability in poly(lactic-co-glycolic acid) microparticles","volume":"17","author":"van de Weert","year":"2000","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2015.10.058_bb0210","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.jconrel.2010.05.011","article-title":"Issues in long-term protein delivery using biodegradable microparticles","volume":"146","author":"Ye","year":"2010","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2015.10.058_bb0215","doi-asserted-by":"crossref","first-page":"206039","DOI":"10.1155\/2013\/206039","article-title":"Danger signals in the initiation of the inflammatory response after myocardial infarction","volume":"2013","author":"de Haan","year":"2013","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.jconrel.2015.10.058_bb0220","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ijpharm.2005.10.010","article-title":"Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles","volume":"307","author":"Owens","year":"2006","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2015.10.058_bb0225","doi-asserted-by":"crossref","first-page":"6288","DOI":"10.1002\/anie.200902672","article-title":"Poly(ethylene glycol) in drug delivery: pros and cons as well as potential alternatives","volume":"49","author":"Knop","year":"2010","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.jconrel.2015.10.058_bb0230","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.ijpharm.2014.02.037","article-title":"Influence of particle geometry and PEGylation on phagocytosis of particulate carriers","volume":"465","author":"Mathaes","year":"2014","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2015.10.058_bb0235","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1073\/pnas.1015623108","article-title":"Modulation of cardiac macrophages by phosphatidylserine-presenting liposomes improves infarct repair","volume":"108","author":"Harel-Adar","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365915302236?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365915302236?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T15:05:20Z","timestamp":1572534320000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365915302236"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":47,"alternative-id":["S0168365915302236"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2015.10.058","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tracking the in vivo release of bioactive NRG from PLGA and PEG\u2013PLGA microparticles in infarcted hearts","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2015.10.058","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}