{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T05:41:00Z","timestamp":1781329260579,"version":"3.54.1"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Dutch Ministry of Economic Affairs"},{"name":"Netherlands CardioVascular Research Initiative (CVON)"},{"name":"The Dutch Heart Foundation"},{"DOI":"10.13039\/501100012524","name":"Dutch Federation of University Medical Centers","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012524","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001826","name":"The Netherlands Organization for Health Research and Development","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001722","name":"Royal Netherlands Academy of Sciences","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001722","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.jconrel.2015.11.020","type":"journal-article","created":{"date-parts":[[2015,11,23]],"date-time":"2015-11-23T22:34:39Z","timestamp":1448318079000},"page":"18-31","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"special_numbering":"C","title":["Increased local delivery of antagomir therapeutics to the rodent myocardium using ultrasound and microbubbles"],"prefix":"10.1016","volume":"222","author":[{"given":"Rick F.J.","family":"Kwekkeboom","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost P.G.","family":"Sluijter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben J.","family":"van Middelaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corina H.","family":"Metz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maike A.","family":"Brans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otto","family":"Kamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter J.","family":"Paulus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9 J.P.","family":"Musters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2015.11.020_bb0005","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/35040556","article-title":"Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA","volume":"408","author":"Pasquinelli","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.jconrel.2015.11.020_bb0010","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1161\/CIRCULATIONAHA.109.889048","article-title":"MicroRNAs add a new dimension to cardiovascular disease","volume":"121","author":"Small","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.jconrel.2015.11.020_bb0015","doi-asserted-by":"crossref","first-page":"441","DOI":"10.2174\/1389557515666150324123913","article-title":"MicroRNA therapeutics for cardiac regeneration","volume":"15","author":"Lei","year":"2015","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.jconrel.2015.11.020_bb0020","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/nature04303","article-title":"Silencing of microRNAs in vivo with \u2018antagomirs\u2019","volume":"438","author":"Krutzfeldt","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.jconrel.2015.11.020_bb0025","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1161\/CIRCULATIONAHA.108.814145","article-title":"MicroRNA-320 is involved in the regulation of cardiac ischemia\/reperfusion injury by targeting heat-shock protein 20","volume":"119","author":"Ren","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.jconrel.2015.11.020_bb0030","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1038\/nature07511","article-title":"MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts","volume":"456","author":"Thum","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.jconrel.2015.11.020_bb0035","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1021\/mp2006483","article-title":"Synthetic microRNA cassette dosing: pharmacokinetics, tissue distribution and bioactivity","volume":"9","author":"Wang","year":"2012","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jconrel.2015.11.020_bb0040","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1161\/01.CIR.101.22.2554","article-title":"Echocardiographic destruction of albumin microbubbles directs gene delivery to the myocardium","volume":"101","author":"Shohet","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.jconrel.2015.11.020_bb0045","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ultrasmedbio.2003.09.004","article-title":"Impact of myocardial contrast echocardiography on vascular permeability: comparison of three different contrast agents","volume":"30","author":"Li","year":"2004","journal-title":"Ultrasound Med. Biol."},{"key":"10.1016\/j.jconrel.2015.11.020_bb0050","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1161\/CIRCRESAHA.108.183806","article-title":"Ultrasound and microbubble-targeted delivery of macromolecules is regulated by induction of endocytosis and pore formation","volume":"104","author":"Meijering","year":"2009","journal-title":"Circ. Res."},{"key":"10.1016\/j.jconrel.2015.11.020_bb0055","article-title":"Myocardial regeneration in adriamycin cardiomyopathy by nuclear expression of GLP1 using ultrasound targeted microbubble destruction","author":"Chen","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jconrel.2015.11.020_bb0060","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.biomaterials.2013.10.043","article-title":"The use of MMP2 antibody-conjugated cationic microbubble to target the ischemic myocardium, enhance Timp3 gene transfection and improve cardiac function","volume":"35","author":"Yan","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2015.11.020_bb0065","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.lfs.2012.03.003","article-title":"A targeted high-efficiency angiogenesis strategy as therapy for myocardial infarction","volume":"90","author":"Yuan","year":"2012","journal-title":"Life Sci."},{"key":"10.1016\/j.jconrel.2015.11.020_bb0070","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.bbrc.2005.08.052","article-title":"Sonoporation using microbubble BR14 promotes pDNA\/siRNA transduction to murine heart","volume":"336","author":"Tsunoda","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jconrel.2015.11.020_bb0075","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.ultrasmedbio.2014.08.012","article-title":"Ultrasound and microbubble-induced local delivery of MicroRNA-based therapeutics","volume":"41","author":"Kwekkeboom","year":"2015","journal-title":"Ultrasound Med. Biol."},{"key":"10.1016\/j.jconrel.2015.11.020_bb0080","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1093\/cvr\/cvs003","article-title":"MicroRNA-214 inhibits angiogenesis by targeting quaking and reducing angiogenic growth factor release","volume":"93","author":"van Mil","year":"2012","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.jconrel.2015.11.020_bb0085","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1007\/s00395-012-0270-8","article-title":"Inhibition of RIP1-dependent necrosis prevents adverse cardiac remodeling after myocardial ischemia\u2013reperfusion in vivo","volume":"107","author":"Oerlemans","year":"2012","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.jconrel.2015.11.020_bb0090","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1152\/physiol.00021.2012","article-title":"No rest for the weary: diastolic calcium homeostasis in the normal and failing myocardium","volume":"27","author":"Louch","year":"2012","journal-title":"Physiology"},{"key":"10.1016\/j.jconrel.2015.11.020_bb0095","doi-asserted-by":"crossref","first-page":"221","DOI":"10.33549\/physiolres.932410","article-title":"Systemic administration of an antagomir designed to inhibit miR-92, a regulator of angiogenesis, failed to modulate skeletal anabolic response to mechanical loading","volume":"62","author":"Sengul","year":"2013","journal-title":"Physiol. Res."},{"key":"10.1016\/j.jconrel.2015.11.020_bb0100","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/emmm.201100191","article-title":"MicroRNA therapeutics in cardiovascular medicine","volume":"4","author":"Thum","year":"2011","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.jconrel.2015.11.020_bb0105","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1161\/CIRCULATIONAHA.111.039008","article-title":"MicroRNA-24 regulates vascularity after myocardial infarction","volume":"124","author":"Fiedler","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.jconrel.2015.11.020_bb0110","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1093\/eurheartj\/ehq475","article-title":"Repeated and targeted transfer of angiogenic plasmids into the infarcted rat heart via ultrasound targeted microbubble destruction enhances cardiac repair","volume":"32","author":"Fujii","year":"2011","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.jconrel.2015.11.020_bb0115","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/gt.2012.89","article-title":"Stimulation of adult resident cardiac progenitor cells by durable myocardial expression of thymosin beta 4 with ultrasound-targeted microbubble delivery","volume":"20","author":"Chen","year":"2013","journal-title":"Gene Ther."},{"key":"10.1016\/j.jconrel.2015.11.020_bb0120","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0735-1097(03)00627-2","article-title":"Optimization of ultrasound parameters for cardiac gene delivery of adenoviral or plasmid deoxyribonucleic acid by ultrasound-targeted microbubble destruction","volume":"42","author":"Chen","year":"2003","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.jconrel.2015.11.020_bb0125","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.jconrel.2012.08.014","article-title":"Crucial factors and emerging concepts in ultrasound-triggered drug delivery","volume":"164","author":"Geers","year":"2012","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2015.11.020_bb0130","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1161\/CIRCRESAHA.107.148676","article-title":"Therapeutic arteriogenesis by ultrasound-mediated VEGF165 plasmid gene delivery to chronically ischemic skeletal muscle","volume":"101","author":"Leong-Poi","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.jconrel.2015.11.020_bb0135","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1016\/j.jacc.2005.09.078","article-title":"Microvascular permeabilization and cardiomyocyte injury provoked by myocardial contrast echocardiography in a canine model","volume":"47","author":"Miller","year":"2006","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.jconrel.2015.11.020_bb0140","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1148\/radiol.2371041467","article-title":"Influence of contrast agent dose and ultrasound exposure on cardiomyocyte injury induced by myocardial contrast echocardiography in rats","volume":"237","author":"Miller","year":"2005","journal-title":"Radiology"},{"key":"10.1016\/j.jconrel.2015.11.020_bb0145","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1161\/01.CIR.98.13.1264","article-title":"Delivery of colloidal particles and red blood cells to tissue through microvessel ruptures created by targeted microbubble destruction with ultrasound","volume":"98","author":"Price","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.jconrel.2015.11.020_bb0150","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1161\/01.CIR.98.4.290","article-title":"Direct in vivo visualization of intravascular destruction of microbubbles by ultrasound and its local effects on tissue","volume":"98","author":"Skyba","year":"1998","journal-title":"Circulation"}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365915302431?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365915302431?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,3,13]],"date-time":"2021-03-13T10:34:29Z","timestamp":1615631669000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365915302431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":30,"alternative-id":["S0168365915302431"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2015.11.020","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increased local delivery of antagomir therapeutics to the rodent myocardium using ultrasound and microbubbles","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2015.11.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}