{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:27:32Z","timestamp":1790684852535,"version":"4.1.0"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81173010"],"award-info":[{"award-number":["81173010"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.jconrel.2015.12.008","type":"journal-article","created":{"date-parts":[[2015,12,16]],"date-time":"2015-12-16T18:22:39Z","timestamp":1450290159000},"page":"67-77","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":250,"special_numbering":"C","title":["Efficient mucus permeation and tight junction opening by dissociable \u201cmucus-inert\u201d agent coated trimethyl chitosan nanoparticles for oral insulin delivery"],"prefix":"10.1016","volume":"222","author":[{"given":"Min","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaju","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhirong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2015.12.008_bb0005","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1038\/nbt1204-1513","article-title":"Recombinant protein therapeutics\u2014success rates, market trends and values to 2010","volume":"22","author":"Pavlou","year":"2004","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jconrel.2015.12.008_bb0010","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1021\/ar200234q","article-title":"pH-responsive nanoparticles shelled with chitosan for oral delivery of insulin: from mechanism to therapeutic applications","volume":"45","author":"Sung","year":"2012","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.jconrel.2015.12.008_bb0015","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.jconrel.2013.05.006","article-title":"Noninvasive imaging oral absorption of insulin delivered by nanoparticles and its stimulated glucose utilization in controlling postprandial hyperglycemia during OGTT in diabetic rats","volume":"172","author":"Chuang","year":"2013","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2015.12.008_bb0020","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nrd1695","article-title":"Protein drug stability: a formulation challenge","volume":"4","author":"Frokjaer","year":"2005","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jconrel.2015.12.008_bb0025","doi-asserted-by":"crossref","first-page":"237","DOI":"10.3109\/10717544.2013.819611","article-title":"Oral delivery of therapeutic proteins and peptides: a review on recent developments","volume":"20","author":"Gupta","year":"2013","journal-title":"Drug deliv."},{"key":"10.1016\/j.jconrel.2015.12.008_bb0030","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.jconrel.2012.11.011","article-title":"Calcium depletion-mediated protease inhibition and apical\u2013junctional-complex disassembly via an EGTA-conjugated carrier for oral insulin delivery","volume":"169","author":"Chuang","year":"2013","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2015.12.008_bb0035","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1016\/j.biomaterials.2011.10.075","article-title":"Goblet cell-targeting nanoparticles for oral insulin delivery and the influence of mucus on insulin transport","volume":"33","author":"Jin","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2015.12.008_bb0040","doi-asserted-by":"crossref","first-page":"3887","DOI":"10.1002\/adma.201201800","article-title":"Mucus penetrating nanoparticles: biophysical tool and method of drug and gene delivery","volume":"24","author":"Ensign","year":"2012","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2015.12.008_bb0045","doi-asserted-by":"crossref","first-page":"387","DOI":"10.2217\/nnm.13.26","article-title":"Development and in vitro evaluation of slippery nanoparticles for enhanced diffusion through native mucus","volume":"9","author":"Laffleur","year":"2014","journal-title":"Nanomedicine"},{"key":"10.1016\/j.jconrel.2015.12.008_bb0050","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.addr.2011.12.009","article-title":"Oral drug delivery with polymeric nanoparticles: the gastrointestinal mucus barriers","volume":"64","author":"Ensign","year":"2012","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2015.12.008_bb0055","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1021\/mp400493b","article-title":"Penetratin derivative-based nanocomplexes for enhanced intestinal insulin delivery","volume":"11","author":"Zhu","year":"2014","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jconrel.2015.12.008_bb0060","doi-asserted-by":"crossref","first-page":"9726","DOI":"10.1002\/anie.200803526","article-title":"Addressing the PEG mucoadhesivity paradox to engineer nanoparticles that \"slip\" through the human mucus barrier","volume":"47","author":"Wang","year":"2008","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.jconrel.2015.12.008_bb0065","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jconrel.2014.01.007","article-title":"Lung gene therapy with highly compacted DNA nanoparticles that overcome the mucus barrier","volume":"178","author":"Suk","year":"2014","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2015.12.008_bb0070","doi-asserted-by":"crossref","first-page":"19268","DOI":"10.1073\/pnas.0905998106","article-title":"Biodegradable polymer nanoparticles that rapidly penetrate the human mucus barrier","volume":"106","author":"Tang","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jconrel.2015.12.008_bb0075","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1021\/nn204240b","article-title":"Sheddable ternary nanoparticles for tumor acidity-targeted siRNA delivery","volume":"6","author":"Yang","year":"2012","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2015.12.008_bb0080","doi-asserted-by":"crossref","first-page":"6434","DOI":"10.1021\/nn201624c","article-title":"Cellular uptake and fate of PEGylated gold nanoparticles is dependent on both cell-penetration peptides and particle size","volume":"5","author":"Oh","year":"2011","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2015.12.008_bb0085","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0169-409X(01)00231-9","article-title":"Oral drug absorption enhancement by chitosan and its derivatives","volume":"52","author":"Thanou","year":"2001","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2015.12.008_bb0090","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.progpolymsci.2006.06.001","article-title":"Chitin and chitosan: properties and applications","volume":"31","author":"Rinaudo","year":"2006","journal-title":"Prog. Polym. Sci."},{"key":"10.1016\/j.jconrel.2015.12.008_bb0095","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/j.progpolymsci.2012.04.004","article-title":"Strategies for effective oral insulin delivery with modified chitosan nanoparticles: a review","volume":"37","author":"Mukhopadhyay","year":"2012","journal-title":"Prog. Polym. Sci."},{"key":"10.1016\/j.jconrel.2015.12.008_bb0100","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.peptides.2012.07.019","article-title":"Protein transduction in human cells is enhanced by cell-penetrating peptides fused with an endosomolytic HA2 sequence","volume":"37","author":"Liou","year":"2012","journal-title":"Peptides"},{"key":"10.1016\/j.jconrel.2015.12.008_bb0105","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1023\/A:1019854327540","article-title":"Comparative uptake studies of bioadhesive and non-bioadhesive nanoparticles in human intestinal cell lines and rats: the effect of mucus on particle adsorption and transport","volume":"19","author":"Behrens","year":"2002","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2015.12.008_bb0110","doi-asserted-by":"crossref","first-page":"9678","DOI":"10.1016\/j.biomaterials.2013.08.048","article-title":"Intestinal mucosa permeability following oral insulin delivery using core shell corona nanolipoparticles","volume":"34","author":"Li","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2015.12.008_bb0115","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.addr.2008.11.002","article-title":"Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues","volume":"61","author":"Lai","year":"2009","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2015.12.008_bb0120","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.3892\/ijo_00000293","article-title":"Phase II studies of polymer-doxorubicin (PK1, FCE28068) in the treatment of breast, lung and colorectal cancer","volume":"34","author":"Seymour","year":"2009","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.jconrel.2015.12.008_bb0125","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/sj.bjc.6601922","article-title":"Phase I and pharmacokinetic (PK) study of MAG-CPT (PNU 166148): a polymeric derivative of camptothecin (CPT)","volume":"91","author":"Bissett","year":"2004","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.jconrel.2015.12.008_bb0130","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0168-3659(97)00235-6","article-title":"Targetable HPMA copolymer\u2013adriamycin conjugates. Recognition, internalization, and subcellular fate","volume":"53","author":"Omelyanenko","year":"1998","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2015.12.008_bb0135","doi-asserted-by":"crossref","first-page":"5171","DOI":"10.1016\/j.biomaterials.2014.03.027","article-title":"Doxorubicin-loaded, charge reversible, folate modified HPMA copolymer conjugates for active cancer cell targeting","volume":"35","author":"Li","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2015.12.008_bb0140","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.ijpharm.2007.11.052","article-title":"Preparation, characterization and antibacterial activities of chitosan, N-trimethyl chitosan (TMC) and N-diethylmethyl chitosan (DEMC) nanoparticles loaded with insulin using both the ionotropic gelation and polyelectrolyte complexation methods","volume":"355","author":"Sadeghi","year":"2008","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2015.12.008_bb0145","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.jconrel.2013.06.010","article-title":"On employing a translationally controlled tumor protein-derived protein transduction domain analog for transmucosal delivery of drugs","volume":"170","author":"Bae","year":"2013","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2015.12.008_bb0150","first-page":"3151","article-title":"Novel mucus-penetrating liposomes as a potential oral drug delivery system: preparation, in vitro characterization, and enhanced cellular uptake","volume":"6","author":"Li","year":"2011","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.jconrel.2015.12.008_bb0155","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.ejpb.2014.06.011","article-title":"Design and evaluation of solid lipid nanoparticles modified with peptide ligand for oral delivery of protein drugs","volume":"88","author":"Fan","year":"2014","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.jconrel.2015.12.008_bb0160","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jconrel.2013.01.018","article-title":"Nanoparticle diffusion in, and microrheology of, the bovine vitreous ex vivo","volume":"167","author":"Xu","year":"2013","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2015.12.008_bb0165","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1021\/acsnano.5b00028","article-title":"Overcoming the diffusion barrier of mucus and absorption barrier of epithelium by self-assembled nanoparticles for oral delivery of insulin","volume":"9","author":"Shan","year":"2015","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2015.12.008_bb0170","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1023\/A:1010974909998","article-title":"Transport of lipophilic drug molecules in a new mucus-secreting cell culture model based on HT29-MTX cells","volume":"18","author":"Behrens","year":"2001","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2015.12.008_bb0175","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/s11095-004-9007-1","article-title":"In vitro and ex vivo intestinal tissue models to measure mucoadhesion of poly (methacrylate) and N-trimethylated chitosan polymers","volume":"22","author":"Keely","year":"2005","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2015.12.008_bb0180","doi-asserted-by":"crossref","first-page":"6164","DOI":"10.1016\/j.biomaterials.2011.03.056","article-title":"Mechanism and consequence of chitosan-mediated reversible epithelial tight junction opening","volume":"32","author":"Yeh","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2015.12.008_bb0185","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1021\/mp400685v","article-title":"Mechanism study of cellular uptake and tight junction opening mediated by goblet cell-specific trimethyl chitosan nanoparticles","volume":"11","author":"Zhang","year":"2014","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jconrel.2015.12.008_bb0190","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1002\/ptr.3045","article-title":"Mangiferin prevents diabetic nephropathy progression in streptozotocin-induced diabetic rats","volume":"24","author":"Li","year":"2010","journal-title":"Phytother. Res."},{"key":"10.1016\/j.jconrel.2015.12.008_bb0195","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1002\/jps.10573","article-title":"Biodegradable nanoparticles containing protein\u2013fatty acid complexes for oral delivery of salmon calcitonin","volume":"93","author":"Sang Yoo","year":"2004","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2015.12.008_bb0200","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1007\/s11095-014-1513-1","article-title":"The glucose-lowering potential of exenatide delivered orally via goblet cell-targeting nanoparticles","volume":"32","author":"Li","year":"2015","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2015.12.008_bb0205","doi-asserted-by":"crossref","first-page":"6849","DOI":"10.1016\/j.biomaterials.2010.05.042","article-title":"Biodistribution, pharmacodynamics and pharmacokinetics of insulin analogues in a rat model: oral delivery using pH-responsive nanoparticles vs. subcutaneous injection","volume":"31","author":"Sonaje","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2015.12.008_bb0210","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.ijpharm.2009.11.002","article-title":"Preparation and evaluation of anti-neuroexcitation peptide (ANEP) loaded N-trimethyl chitosan chloride nanoparticles for brain-targeting","volume":"386","author":"Wang","year":"2010","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2015.12.008_bb0215","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.addr.2008.09.012","article-title":"Micro-and macrorheology of mucus","volume":"61","author":"Lai","year":"2009","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2015.12.008_bb0220","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1073\/pnas.0608611104","article-title":"Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus","volume":"104","author":"Lai","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jconrel.2015.12.008_bb0225","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1136\/gut.10.11.931","article-title":"Viscosity of gastric mucus in duodenal ulceration","volume":"10","author":"Curt","year":"1969","journal-title":"Gut"},{"key":"10.1016\/j.jconrel.2015.12.008_bb0230","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1016\/j.biomaterials.2008.12.076","article-title":"The penetration of fresh undiluted sputum expectorated by cystic fibrosis patients by non-adhesive polymer nanoparticles","volume":"30","author":"Suk","year":"2009","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2015.12.008_bb0235","doi-asserted-by":"crossref","first-page":"6164","DOI":"10.1016\/j.biomaterials.2011.03.056","article-title":"Mechanism and consequence of chitosan-mediated reversible epithelial tight junction opening","volume":"32","author":"Yeh","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2015.12.008_bb0240","doi-asserted-by":"crossref","first-page":"6254","DOI":"10.1016\/j.biomaterials.2012.05.013","article-title":"Elucidating the signaling mechanism of an epithelial tight-junction opening induced by chitosan","volume":"33","author":"Hsu","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2015.12.008_bb0245","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.jconrel.2012.11.011","article-title":"Calcium depletion-mediated protease inhibition and apical-junctional-complex disassembly via an EGTA-conjugated carrier for oral insulin delivery","volume":"169","author":"Chuang","year":"2013","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2015.12.008_bb0250","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.biotechadv.2014.07.006","article-title":"A review of advanced oral drug delivery technologies facilitating the protection and absorption of protein and peptide molecules","volume":"32","author":"Choonara","year":"2014","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.jconrel.2015.12.008_bb0255","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/nrd4363","article-title":"Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies","volume":"13","author":"Mitragotri","year":"2014","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jconrel.2015.12.008_bb0260","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.addr.2012.10.010","article-title":"Recent advances in chitosan-based nanoparticles for oral delivery of macromolecules","volume":"65","author":"Chen","year":"2013","journal-title":"Adv. Drug Deliv. Dev."},{"key":"10.1016\/j.jconrel.2015.12.008_bb0265","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.ajps.2014.12.007","article-title":"Developments of mucus penetrating nanoparticles","volume":"10","author":"Liu","year":"2015","journal-title":"Asian J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2015.12.008_bb0270","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.jconrel.2010.05.023","article-title":"The characteristics, cellular uptake and intracellular trafficking of nanoparticles made of hydrophobically-modified chitosan","volume":"146","author":"Chiu","year":"2010","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2015.12.008_bb0275","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.addr.2008.09.012","article-title":"Micro- and macrorheology of mucus","volume":"61","author":"Lai","year":"2009","journal-title":"Adv. Drug Deliv. Rev."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365915302601?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365915302601?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,12]],"date-time":"2020-09-12T20:06:53Z","timestamp":1599941213000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365915302601"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":55,"alternative-id":["S0168365915302601"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2015.12.008","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficient mucus permeation and tight junction opening by dissociable \u201cmucus-inert\u201d agent coated trimethyl chitosan nanoparticles for oral insulin delivery","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2015.12.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}