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A."},{"key":"10.1016\/j.jconrel.2015.12.012_bb0545","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1021\/nl052396o","article-title":"Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells","volume":"6","author":"Chithrani","year":"2006","journal-title":"Nano Lett."},{"key":"10.1016\/j.jconrel.2015.12.012_bb0550","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1021\/ar2000315","article-title":"PRINT: a novel platform toward shape and size specific nanoparticle theranostics","volume":"44","author":"Perry","year":"2011","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.jconrel.2015.12.012_bb0555","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/978-1-59745-551-0_15","article-title":"Micromolding for the fabrication of biological microarrays","volume":"671","author":"Galloway","year":"2011","journal-title":"Methods Mol. 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