{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T14:45:52Z","timestamp":1771512352250,"version":"3.50.1"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["REMEDIS 53902532"],"award-info":[{"award-number":["REMEDIS 53902532"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.jconrel.2016.02.029","type":"journal-article","created":{"date-parts":[[2016,2,17]],"date-time":"2016-02-17T18:48:09Z","timestamp":1455734889000},"page":"1-12","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Simultaneous magnetic resonance imaging and pharmacokinetic analysis of intramuscular depots"],"prefix":"10.1016","volume":"227","author":[{"given":"Mareike","family":"Probst","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens-Peter","family":"K\u00fchn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eberhard","family":"Scheuch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Seidlitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Hadlich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katja","family":"Evert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Oswald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Werner","family":"Siegmund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3492-7747","authenticated-orcid":false,"given":"Werner","family":"Weitschies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2016.02.029_bb0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0378-5173(88)90209-8","article-title":"Release and absorption rate aspects of intramuscularly injected pharmaceuticals","volume":"47","author":"Zuidema","year":"1988","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2016.02.029_bb0010","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0378-5173(94)90103-1","article-title":"Release and absorption rates of intramuscularly and subcutaneously injected pharmaceuticals (II)","volume":"105","author":"Zuidema","year":"1994","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2016.02.029_bb0015","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1248\/cpb.20.443","article-title":"Absorption of drugs from the skeletal muscle of the rats. (3). Effect of watersoluble adjuvants and vehicles on the intramuscular absorption","volume":"20","author":"Kakemi","year":"1972","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.jconrel.2016.02.029_bb0020","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1002\/jps.2600710434","article-title":"Effect of propylene glycol on subcutaneous absorption of a benzimidazole hydrochloride","volume":"71","author":"Yu","year":"1982","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2016.02.029_bb0025","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1002\/cpt1975184449","article-title":"Bioavailability and single-dose pharmacokinetics of intramuscular phenytoin","volume":"18","author":"Kostenbauder","year":"1975","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.jconrel.2016.02.029_bb0030","first-page":"359","article-title":"Sex differences in the absorption of dapsone after intramuscular injection","volume":"51","author":"Modderman","year":"1983","journal-title":"Int. J. Lepr."},{"key":"10.1016\/j.jconrel.2016.02.029_bb0035","doi-asserted-by":"crossref","first-page":"289","DOI":"10.3109\/07853899109148062","article-title":"Effect of exercise on pharmacokinetics","volume":"23","author":"Ylitalo","year":"1991","journal-title":"Ann. Med."},{"key":"10.1016\/j.jconrel.2016.02.029_bb0040","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1192\/bjp.153.3.382","article-title":"Plasma levels of fluphenazine decanoate. Effects of site of injection, massage and muscle activity","volume":"153","author":"Soni","year":"1988","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.jconrel.2016.02.029_bb0045","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1093\/rheumatology\/35.suppl_1.44","article-title":"Local tissue tolerability of meloxicam, a new NSAID: indications for parenteral, dermal and mucosal administration","volume":"35","author":"Stei","year":"1996","journal-title":"Rheumatology"},{"key":"10.1016\/j.jconrel.2016.02.029_bb0050","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/j.1600-0773.1978.tb02217.x","article-title":"A comparative study of serum creatine phosphokinase (CPK) activity in rabbits, pigs and humans after intramuscular injection of local damaging drugs*","volume":"42","author":"Steiness","year":"1978","journal-title":"Acta Pharmacol. Toxicol."},{"key":"10.1016\/j.jconrel.2016.02.029_bb0055","series-title":"Disease, Metabolism and Reproduction in the Toxic Response to Drugs and Other Chemicals","first-page":"472","article-title":"Intramuscular injections and muscle damage: effects of concentration, volume, injection speed and vehicle","author":"Svendsen","year":"1984"},{"key":"10.1016\/j.jconrel.2016.02.029_bb0060","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1002\/jps.24014","article-title":"Intramuscular administration of paliperidone palmitate extended-release injectable microsuspension induces a subclinical inflammatory reaction modulating the pharmacokinetics in rats","volume":"103","author":"Darville","year":"2014","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2016.02.029_bb0065","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1111\/j.2042-7158.1993.tb05695.x","article-title":"Pharmacokinetic and pharmacodynamic aspects of artelinic acid in rodents","volume":"45","author":"Titulaer","year":"1993","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.jconrel.2016.02.029_bb0070","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S1056-8719(00)00049-6","article-title":"Bioavailability of diclofenac after intramuscular administration to rats with experimental spinal cord injury","volume":"42","author":"Garc\u0131\u0301a-L\u00f3pez","year":"1999","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"10.1016\/j.jconrel.2016.02.029_bb0075","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.mri.2008.01.004","article-title":"In vivo determination of the time and location of mucoadhesive drug delivery systems disintegration in the gastrointestinal tract","volume":"26","author":"Kremser","year":"2008","journal-title":"Magn. Reson. Imaging"},{"key":"10.1016\/j.jconrel.2016.02.029_bb0080","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jconrel.2006.06.023","article-title":"Comparative in vivo mucoadhesion studies of thiomer formulations using magnetic resonance imaging and fluorescence detection","volume":"115","author":"Albrecht","year":"2006","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2016.02.029_bb0085","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.ejpb.2009.06.008","article-title":"Non-invasive in vivo evaluation of in situ forming PLGA implants by benchtop magnetic resonance imaging (BT-MRI) and EPR spectroscopy","volume":"74","author":"Kempe","year":"2010","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.jconrel.2016.02.029_bb0090","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.envint.2006.11.017","article-title":"Aquatic toxicity of acetaminophen, carbamazepine, cimetidine, diltiazem and six major sulfonamides, and their potential ecological risks in Korea","volume":"33","author":"Kim","year":"2007","journal-title":"Environ. Int."},{"key":"10.1016\/j.jconrel.2016.02.029_bb0095","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.chroma.2003.10.036","article-title":"Simultaneous solid-phase extraction of acidic, neutral and basic pharmaceuticals from aqueous samples at ambient (neutral) pH and their determination by gas chromatography\u2013mass spectrometry","volume":"1023","author":"Weigel","year":"2004","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jconrel.2016.02.029_bb0100","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0378-5173(01)00688-3","article-title":"Solubility of drugs in the presence of gelatin: effect of drug lipophilicity and degree of ionization","volume":"221","author":"Kallinteri","year":"2001","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2016.02.029_bb0105","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1021\/ac048767n","article-title":"Chasing equilibrium: measuring the intrinsic solubility of weak acids and bases","volume":"77","author":"Stuart","year":"2005","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jconrel.2016.02.029_bb0110","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1023\/A:1007526826979","article-title":"pH-metric solubility. 2: Correlation between the acid\u2013base titration and the saturation shake-flask solubility-pH methods","volume":"17","author":"Avdeef","year":"2000","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2016.02.029_bb0115","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/j.addr.2004.02.005","article-title":"Sustained release veterinary parenteral products","volume":"56","author":"Medlicott","year":"2004","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2016.02.029_bb0120","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0378-5173(00)00656-6","article-title":"Parenteral water\/oil emulsions containing hydrophilic compounds with enhanced in vivo retention: formulation, rheological characterisation and study of in vivo fate using whole body gamma-scintigraphy","volume":"215","author":"Bjerregaard","year":"2001","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2016.02.029_bb0125","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1111\/j.1365-2044.1991.tb09946.x","article-title":"Continued problems with diclofenac injections","volume":"46","author":"Ali","year":"1991","journal-title":"Anaesthesia"},{"key":"10.1016\/j.jconrel.2016.02.029_bb0130","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1081\/DDC-120003858","article-title":"Tissue tolerance of diclofenac sodium encapsulated in liposomes after intramuscular administration","volume":"28","author":"Lima","year":"2002","journal-title":"Drug Dev. Ind. Pharm."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016836591630092X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016836591630092X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,26]],"date-time":"2022-06-26T11:38:29Z","timestamp":1656243509000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016836591630092X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":26,"alternative-id":["S016836591630092X"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2016.02.029","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Simultaneous magnetic resonance imaging and pharmacokinetic analysis of intramuscular depots","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2016.02.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}