{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:51:03Z","timestamp":1787169063347,"version":"build-2736575974"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100006965","name":"Telemedicine and Advanced Technology Research Center","doi-asserted-by":"publisher","award":["W81XWH-09-1-0711"],"award-info":[{"award-number":["W81XWH-09-1-0711"]}],"id":[{"id":"10.13039\/100006965","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007710","name":"University of Connecticut","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000182","name":"Medical Research and Materiel Command","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000182","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.jconrel.2016.05.065","type":"journal-article","created":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T02:38:11Z","timestamp":1464748691000},"page":"176-181","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["l-DOPA as a small molecule surrogate to promote angiogenesis and prevent dexamethasone-induced ischemia"],"prefix":"10.1016","volume":"235","author":[{"given":"Claire F.","family":"Price","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane J.","family":"Burgess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michail","family":"Kastellorizios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2016.05.065_bb0005","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1177\/193229681100500504","article-title":"Design and fabrication of a high-performance electrochemical glucose sensor","volume":"5","author":"Vaddiraju","year":"2011","journal-title":"J. Diabetes Sci. Technol."},{"key":"10.1016\/j.jconrel.2016.05.065_bb0010","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.jconrel.2012.12.028","article-title":"Polymeric \u201csmart\u201d coatings to prevent foreign body response to implantable biosensors","volume":"169","author":"Wang","year":"2013","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2016.05.065_bb0015","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1039\/C5LC00842E","article-title":"Soft implantable microelectrodes for future medicine: prosthetics, neural signal recording and neuromodulation","volume":"16","author":"Lee","year":"2016","journal-title":"Lab Chip"},{"key":"10.1016\/j.jconrel.2016.05.065_bb0020","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1089\/dia.2005.7.968","article-title":"The bioartificial pancreas: progress and challenges","volume":"7","author":"Kizilel","year":"2005","journal-title":"Diabetes Technol. Ther."},{"key":"10.1016\/j.jconrel.2016.05.065_bb0025","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.urology.2007.08.017","article-title":"Long-term follow-up of single versus double cuff artificial urinary sphincter insertion for the treatment of severe postprostatectomy stress urinary incontinence","volume":"71","author":"O'Connor","year":"2008","journal-title":"Urology"},{"key":"10.1016\/j.jconrel.2016.05.065_bb0030","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1002\/mabi.200400026","article-title":"Bone tissue engineering: state of the art and future trends","volume":"4","author":"Salgado","year":"2004","journal-title":"Macromol. Biosci."},{"key":"10.1016\/j.jconrel.2016.05.065_bb0035","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1016\/j.bios.2004.12.003","article-title":"Biosensors for real-time in vivo measurements","volume":"20","author":"Wilson","year":"2004","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.jconrel.2016.05.065_bb0040","doi-asserted-by":"crossref","first-page":"6423","DOI":"10.3390\/s130506423","article-title":"Biosensors in clinical practice: focus on oncohematology","volume":"13","author":"Fracchiolla","year":"2013","journal-title":"Sensors (Basel)"},{"key":"10.1016\/j.jconrel.2016.05.065_bb0045","first-page":"1","article-title":"Biosensors: the new wave in cancer diagnosis","volume":"4","author":"Bohunicky","year":"2010","journal-title":"Nanotechnol. Sci. Appl."},{"key":"10.1016\/j.jconrel.2016.05.065_bb0050","doi-asserted-by":"crossref","first-page":"213ra165","DOI":"10.1126\/scitranslmed.3007095","article-title":"Real-time, aptamer-based tracking of circulating therapeutic agents in living animals","volume":"5","author":"Ferguson","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jconrel.2016.05.065_bb0055","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1177\/193229681000400632","article-title":"Technologies for continuous glucose monitoring: current problems and future promises","volume":"4","author":"Vaddiraju","year":"2010","journal-title":"J. Diabetes Sci. Technol."},{"key":"10.1016\/j.jconrel.2016.05.065_bb0060","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1002\/(SICI)1097-4636(19971205)37:3<401::AID-JBM11>3.0.CO;2-E","article-title":"Engineering the tissue which encapsulates subcutaneous implants. I. Diffusion properties","volume":"37","author":"Sharkawy","year":"1997","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.jconrel.2016.05.065_bb0065","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.ijpharm.2015.10.056","article-title":"In vitro and in vivo performance of dexamethasone loaded PLGA microspheres prepared using polymer blends","volume":"496","author":"Gu","year":"2015","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2016.05.065_bb0070","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jconrel.2015.07.021","article-title":"Multiple tissue response modifiers to promote angiogenesis and prevent the foreign body reaction around subcutaneous implants","volume":"214","author":"Kastellorizios","year":"2015","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2016.05.065_bb0075","doi-asserted-by":"crossref","first-page":"3332","DOI":"10.1021\/acs.molpharmaceut.5b00326","article-title":"Drug distribution in microspheres enhances their anti-inflammatory properties in the Gottingen Minipig","volume":"12","author":"Kastellorizios","year":"2015","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jconrel.2016.05.065_bb0080","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jconrel.2015.01.038","article-title":"Prevention of foreign body reaction in a pre-clinical large animal model","volume":"202","author":"Kastellorizios","year":"2015","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2016.05.065_bb0085","doi-asserted-by":"crossref","first-page":"4206","DOI":"10.1016\/j.actbio.2014.06.038","article-title":"Multifunctional hydrogel-based scaffold for improving the functionality of encapsulated therapeutic cells and reducing inflammatory response","volume":"10","author":"Acarregui","year":"2014","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jconrel.2016.05.065_bb0090","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s11095-013-1166-5","article-title":"Microspheres prepared with PLGA blends for delivery of dexamethasone for implantable medical devices","volume":"31","author":"Wang","year":"2014","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2016.05.065_bb0095","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s10544-012-9708-x","article-title":"A miniaturized transcutaneous system for continuous glucose monitoring","volume":"15","author":"Croce","year":"2013","journal-title":"Biomed. Microdevices"},{"key":"10.1016\/j.jconrel.2016.05.065_bb0100","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/jbm.10016","article-title":"In vivo evaluation of a dexamethasone\/PLGA microsphere system designed to suppress the inflammatory tissue response to implantable medical devices","volume":"61","author":"Hickey","year":"2002","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.jconrel.2016.05.065_bb0105","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1016\/S0142-9612(01)00291-5","article-title":"Dexamethasone\/PLGA microspheres for continuous delivery of an anti-inflammatory drug for implantable medical devices","volume":"23","author":"Hickey","year":"2002","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2016.05.065_bb0110","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jconrel.2006.10.013","article-title":"Concurrent delivery of dexamethasone and VEGF for localized inflammation control and angiogenesis","volume":"117","author":"Patil","year":"2007","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2016.05.065_bb0115","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/978-3-319-18603-0_6","article-title":"Foreign body reaction to subcutaneous implants","volume":"865","author":"Kastellorizios","year":"2015","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.jconrel.2016.05.065_bb0120","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0014-2999(97)01464-7","article-title":"Corticosteroids inhibit the expression of the vascular endothelial growth factor gene in human vascular smooth muscle cells","volume":"341","author":"Nauck","year":"1998","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jconrel.2016.05.065_bb0125","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1165\/ajrcmb.16.4.9115750","article-title":"Induction of vascular endothelial growth factor by platelet-activating factor and platelet-derived growth factor is downregulated by corticosteroids","volume":"16","author":"Nauck","year":"1997","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.jconrel.2016.05.065_bb0130","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1007\/s00216-010-4097-6","article-title":"Modeling the relative impact of capsular tissue effects on implanted glucose sensor time lag and signal attenuation","volume":"398","author":"Novak","year":"2010","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.jconrel.2016.05.065_bb0135","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/jbm.a.31756","article-title":"A novel porous collagen scaffold around an implantable biosensor for improving biocompatibility. I. In vitro\/in vivo stability of the scaffold and in vitro sensitivity of the glucose sensor with scaffold","volume":"87","author":"Ju","year":"2008","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.jconrel.2016.05.065_bb0140","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/(SICI)1097-4652(199711)173:2<206::AID-JCP22>3.0.CO;2-C","article-title":"Molecular mechanisms of vasculogenesis and embryonic angiogenesis","volume":"173","author":"Flamme","year":"1997","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.jconrel.2016.05.065_bb0145","series-title":"Angiogenesis","author":"Adair","year":"2010"},{"key":"10.1016\/j.jconrel.2016.05.065_bb0150","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1098\/rsif.2010.0223","article-title":"Growth factor delivery-based tissue engineering: general approaches and a review of recent developments","volume":"8","author":"Lee","year":"2011","journal-title":"Journal of the Royal Society, Interface\/the Royal Society"},{"key":"10.1016\/j.jconrel.2016.05.065_bb0155","series-title":"Material Biocompatibility and Applications in Metabolic Monitoring, in: School of Pharmacy","author":"Kastelloizios","year":"2015"},{"key":"10.1016\/j.jconrel.2016.05.065_bb0160","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nrd1695","article-title":"Protein drug stability: a formulation challenge","volume":"4","author":"Frokjaer","year":"2005","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jconrel.2016.05.065_bb0165","doi-asserted-by":"crossref","first-page":"2468","DOI":"10.1056\/NEJMct0800326","article-title":"Levodopa for the treatment of Parkinson's disease","volume":"359","author":"Lewitt","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jconrel.2016.05.065_bb0170","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1093\/brain\/awr165","article-title":"Vascular endothelial growth factor is upregulated by l-dopa in the parkinsonian brain: implications for the development of dyskinesia","volume":"134","author":"Ohlin","year":"2011","journal-title":"Brain"},{"key":"10.1016\/j.jconrel.2016.05.065_bb0175","series-title":"Quantification of Angiogenesis in the Chicken Chorioallantoic Membrane (CAM), International Society for Stereology, 24","author":"Blacher","year":"2005"},{"key":"10.1016\/j.jconrel.2016.05.065_bb0180","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0076-6879(08)02802-4","article-title":"Chapter 2. Chick embryo chorioallantoic membrane models to quantify angiogenesis induced by inflammatory and tumor cells or purified effector molecules","volume":"444","author":"Deryugina","year":"2008","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.jconrel.2016.05.065_bb0185","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1067\/mlc.2003.19","article-title":"A novel early chorioallantoic membrane assay demonstrates quantitative and qualitative changes caused by antiangiogenic substances","volume":"141","author":"Hazel","year":"2003","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.jconrel.2016.05.065_bb0190","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S1937-6448(08)01405-6","article-title":"Chick embryo chorioallantoic membrane as a useful tool to study angiogenesis","volume":"270","author":"Ribatti","year":"2008","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"10.1016\/j.jconrel.2016.05.065_bb0195","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.0959-9673.2004.00396.x","article-title":"Current methods for assaying angiogenesis in vitro and in vivo","volume":"85","author":"Staton","year":"2004","journal-title":"Int. J. Exp. Pathol."},{"key":"10.1016\/j.jconrel.2016.05.065_bb0200","first-page":"123","article-title":"Angiogenesis assays in the chick CAM","volume":"294","author":"Storgard","year":"2005","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jconrel.2016.05.065_bb0205","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/j.addr.2007.04.019","article-title":"The chick embryo and its chorioallantoic membrane (CAM) for the in vivo evaluation of drug delivery systems","volume":"59","author":"Vargas","year":"2007","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2016.05.065_bb0210","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1023\/A:1008950713001","article-title":"The chorioallantoic membrane of the chick embryo as a simple model for the study of the angiogenic and inflammatory response to biomaterials","volume":"12","author":"Zwadlo-Klarwasser","year":"2001","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"10.1016\/j.jconrel.2016.05.065_bb0215","first-page":"20","article-title":"Study of insolubility problems of dexamethasone and digoxin: cyclodextrin complexation","volume":"143","author":"Dilova","year":"2004","journal-title":"Boll. Chim. Farm."},{"key":"10.1016\/j.jconrel.2016.05.065_bb0220","unstructured":"The Merck Index, 13th ed., Entry #5485 ed."},{"key":"10.1016\/j.jconrel.2016.05.065_bb0225","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.canlet.2010.12.004","article-title":"Endostar, a modified recombinant human endostatin, exhibits synergistic effects with dexamethasone on angiogenesis and hepatoma growth","volume":"301","author":"Li","year":"2010","journal-title":"Cancer Lett."},{"key":"10.1016\/j.jconrel.2016.05.065_bb0230","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1111\/j.1476-5381.1996.tb15578.x","article-title":"Differential effects of angiostatic steroids and dexamethasone on angiogenesis and cytokine levels in rat sponge implants","volume":"118","author":"Hori","year":"1996","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jconrel.2016.05.065_bb0235","doi-asserted-by":"crossref","first-page":"7432","DOI":"10.1016\/j.biomaterials.2011.06.027","article-title":"The effect of vascular endothelial growth factor (VEGF) presentation within fibrin matrices on endothelial cell branching","volume":"32","author":"Anderson","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2016.05.065_bb0240","doi-asserted-by":"crossref","first-page":"14389","DOI":"10.1073\/pnas.95.24.14389","article-title":"Vascular endothelial growth factor C induces angiogenesis in vivo","volume":"95","author":"Cao","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jconrel.2016.05.065_bb0245","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1161\/01.RES.59.2.163","article-title":"Stimulation of angiogenesis by adenosine on the chick chorioallantoic membrane","volume":"59","author":"Dusseau","year":"1986","journal-title":"Circ. Res."},{"key":"10.1016\/j.jconrel.2016.05.065_bb0250","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1479-5876-2-4","article-title":"A novel technique for quantifying changes in vascular density, endothelial cell proliferation and protein expression in response to modulators of angiogenesis using the chick chorioallantoic membrane (CAM) assay","volume":"2","author":"Miller","year":"2004","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.jconrel.2016.05.065_bb0255","series-title":"Quantitative Analysis of Cancer Metastasis Using an Avian Embryo Model","author":"Palmer","year":"2011"},{"key":"10.1016\/j.jconrel.2016.05.065_bb0260","doi-asserted-by":"crossref","first-page":"3420","DOI":"10.2174\/1381612811319190008","article-title":"Osteoinductive small molecules: growth factor alternatives for bone tissue engineering","volume":"19","author":"Aravamudhan","year":"2013","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.jconrel.2016.05.065_bb0265","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/cr.2015.142","article-title":"Pluripotent stem cells induced from mouse neural stem cells and small intestinal epithelial cells by small molecule compounds","volume":"26","author":"Ye","year":"2016","journal-title":"Cell Res."},{"key":"10.1016\/j.jconrel.2016.05.065_bb0270","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.yexcr.2015.11.021","article-title":"Engineering macrophages to control the inflammatory response and angiogenesis","volume":"339","author":"Eaton","year":"2015","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.jconrel.2016.05.065_bb0275","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/sj.cr.7290178","article-title":"Tissue engineering of blood vessels with endothelial cells differentiated from mouse embryonic stem cells","volume":"13","author":"Shen","year":"2003","journal-title":"Cell Res."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365916303558?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365916303558?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:34:46Z","timestamp":1785774886000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365916303558"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":55,"alternative-id":["S0168365916303558"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2016.05.065","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"l-DOPA as a small molecule surrogate to promote angiogenesis and prevent dexamethasone-induced ischemia","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2016.05.065","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}