{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:22:49Z","timestamp":1790778169365,"version":"4.1.0"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["P01CA174645"],"award-info":[{"award-number":["P01CA174645"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"ERC","doi-asserted-by":"publisher","award":["PIOF-GA-2012-331813"],"award-info":[{"award-number":["PIOF-GA-2012-331813"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004622","name":"Dutch Cancer Society","doi-asserted-by":"publisher","award":["2013-5861"],"award-info":[{"award-number":["2013-5861"]}],"id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.jconrel.2016.08.001","type":"journal-article","created":{"date-parts":[[2016,8,4]],"date-time":"2016-08-04T01:50:43Z","timestamp":1470275443000},"page":"281-288","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":94,"special_numbering":"C","title":["Growth inhibition in a brain metastasis model by antibody delivery using focused ultrasound-mediated blood-brain barrier disruption"],"prefix":"10.1016","volume":"238","author":[{"given":"Thiele","family":"Kobus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis K.","family":"Zervantonakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongzhi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan J.","family":"McDannold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2016.08.001_bb0005","doi-asserted-by":"crossref","DOI":"10.1093\/neuonc\/nov318","article-title":"Early treatment of HER2-amplified brain tumors with targeted NK-92 cells and focused ultrasound improves survival","author":"Alkins","year":"2016","journal-title":"Neuro-Oncology"},{"issue":"1\u20132","key":"10.1016\/j.jconrel.2016.08.001_bb0010","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jconrel.2013.04.007","article-title":"Multiple treatments with liposomal doxorubicin and ultrasound-induced disruption of blood\u2013tumor and blood\u2013brain barriers improve outcomes in a rat glioma model","volume":"169","author":"Aryal","year":"2013","journal-title":"J. Control. Release"},{"issue":"2","key":"10.1016\/j.jconrel.2016.08.001_bb0015","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1056\/NEJMoa1113216","article-title":"Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer","volume":"366","author":"Baselga","year":"2012","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.jconrel.2016.08.001_bb0020","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/BF01053937","article-title":"Brain metastases in breast cancer; natural history, prognostic factors and outcome","volume":"15","author":"Boogerd","year":"1993","journal-title":"J. Neuro-Oncol."},{"issue":"10","key":"10.1016\/j.jconrel.2016.08.001_bb0025","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1093\/neuonc\/noq054","article-title":"Novel magnetic\/ultrasound focusing system enhances nanoparticle drug delivery for glioma treatment","volume":"12","author":"Chen","year":"2010","journal-title":"Neuro-Oncology"},{"issue":"9","key":"10.1016\/j.jconrel.2016.08.001_bb0030","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/j.mri.2012.05.001","article-title":"3D slicer as an image computing platform for the quantitative imaging network","volume":"30","author":"Fedorov","year":"2012","journal-title":"Magn. Reson. Imaging"},{"issue":"2","key":"10.1016\/j.jconrel.2016.08.001_bb0035","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s00280-009-1160-0","article-title":"Preclinical study of prolonged administration of trastuzumab as combination therapy after disease progression during trastuzumab monotherapy","volume":"66","author":"Fujimoto-Ouchi","year":"2010","journal-title":"Cancer Chemother. Pharmacol."},{"issue":"5","key":"10.1016\/j.jconrel.2016.08.001_bb0040","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0027-9684(15)31298-0","article-title":"Characteristics of breast cancer patients with central nervous system metastases: a single-center experience","volume":"100","author":"Harputluoglu","year":"2008","journal-title":"J. Natl. Med. Assoc."},{"issue":"3","key":"10.1016\/j.jconrel.2016.08.001_bb0045","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1148\/radiol.2202001804","article-title":"Noninvasive MR imaging\u2013guided focal opening of the blood-brain barrier in rabbits","volume":"220","author":"Hynynen","year":"2001","journal-title":"Radiology"},{"issue":"31","key":"10.1016\/j.jconrel.2016.08.001_bb0050","doi-asserted-by":"crossref","first-page":"11719","DOI":"10.1073\/pnas.0604318103","article-title":"Noninvasive localized delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced blood-brain barrier disruption","volume":"103","author":"Kinoshita","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"31","key":"10.1016\/j.jconrel.2016.08.001_bb0055","doi-asserted-by":"crossref","first-page":"5278","DOI":"10.1200\/JCO.2008.19.8481","article-title":"Human epidermal growth factor receptor 2-positive breast cancer and central nervous system metastases","volume":"27","author":"Leyland-Jones","year":"2009","journal-title":"J. Clin. Oncol."},{"issue":"23","key":"10.1016\/j.jconrel.2016.08.001_bb0060","doi-asserted-by":"crossref","first-page":"5664","DOI":"10.1158\/1078-0432.CCR-10-1564","article-title":"Heterogeneous blood\u2013tumor barrier permeability determines drug efficacy in experimental brain metastases of breast cancer","volume":"16","author":"Lockman","year":"2010","journal-title":"Clin. Cancer Res."},{"issue":"6","key":"10.1016\/j.jconrel.2016.08.001_bb0065","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1158\/0008-5472.CAN-08-1056","article-title":"Trastuzumab-induced HER reprogramming in \u2018resistant\u2019 breast carcinoma cells","volume":"69","author":"Narayan","year":"2009","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.jconrel.2016.08.001_bb0070","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.jconrel.2013.08.029","article-title":"Drug delivery to the brain by focused ultrasound induced blood\u2013brain barrier disruption: quantitative evaluation of enhanced permeability of cerebral vasculature using two-photon microscopy","volume":"172","author":"Nhan","year":"2013","journal-title":"J. Control. Release"},{"issue":"1\u20132","key":"10.1016\/j.jconrel.2016.08.001_bb0075","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.drudis.2006.10.013","article-title":"Blood-brain barrier delivery","volume":"12","author":"Pardridge","year":"2007","journal-title":"Drug Discov. Today"},{"issue":"3","key":"10.1016\/j.jconrel.2016.08.001_bb0080","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.jconrel.2012.09.007","article-title":"Ultrasound-mediated blood\u2013brain\/blood-tumor barrier disruption improves outcomes with trastuzumab in a breast cancer brain metastasis model","volume":"163","author":"Park","year":"2012","journal-title":"J. Control. Release"},{"issue":"5","key":"10.1016\/j.jconrel.2016.08.001_bb0085","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1093\/annonc\/mdp353","article-title":"Trastuzumab treatment in patients with breast cancer and metastatic CNS disease","volume":"21","author":"Pie\u0144kowski","year":"2009","journal-title":"Ann. Oncol."},{"issue":"2","key":"10.1016\/j.jconrel.2016.08.001_bb0090","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/sj.jcbfm.9600336","article-title":"Multiphoton imaging of ultrasound\/optison mediated cerebrovascular effects in vivo","volume":"27","author":"Raymond","year":"2007","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"3","key":"10.1016\/j.jconrel.2016.08.001_bb0095","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1007\/s12031-010-9451-9","article-title":"Mechanism of low-frequency ultrasound in opening blood\u2013tumor barrier by tight junction","volume":"43","author":"Shang","year":"2011","journal-title":"J. Mol. Neurosci."},{"issue":"9","key":"10.1016\/j.jconrel.2016.08.001_bb0100","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/j.ultrasmedbio.2006.05.015","article-title":"Brain arterioles show more active vesicular transport of blood-borne tracer molecules than capillaries and venules after focused ultrasound-evoked opening of the blood-brain barrier","volume":"32","author":"Sheikov","year":"2006","journal-title":"Ultrasound Med. Biol."},{"issue":"7","key":"10.1016\/j.jconrel.2016.08.001_bb0105","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.ultrasmedbio.2007.12.015","article-title":"Effect of focused ultrasound applied with an ultrasound contrast agent on the tight junctional integrity of the brain microvascular endothelium","volume":"34","author":"Sheikov","year":"2008","journal-title":"Ultrasound Med. Biol."},{"key":"10.1016\/j.jconrel.2016.08.001_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.ultrasmedbio.2012.04.015","article-title":"Improved anti-tumor effect of liposomal doxorubicin after targeted blood-brain barrier disruption by MRI-guided focused ultrasound in rat glioma","author":"Treat","year":"2012","journal-title":"Ultrasound Med. Biol."},{"issue":"2","key":"10.1016\/j.jconrel.2016.08.001_bb0115","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1080\/02841860500486630","article-title":"Incidence, pattern and timing of brain metastases among patients with advanced breast cancer treated with trastuzumab","volume":"45","author":"Yau","year":"2006","journal-title":"Acta Oncol. (Stockh., Sweden)"}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365916305028?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365916305028?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T15:13:50Z","timestamp":1572534830000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365916305028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":23,"alternative-id":["S0168365916305028"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2016.08.001","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Growth inhibition in a brain metastasis model by antibody delivery using focused ultrasound-mediated blood-brain barrier disruption","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2016.08.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}