{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:27:08Z","timestamp":1790720828537,"version":"4.1.0"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.jconrel.2016.10.019","type":"journal-article","created":{"date-parts":[[2016,10,25]],"date-time":"2016-10-25T06:45:45Z","timestamp":1477377945000},"page":"291-302","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"special_numbering":"C","title":["Transcutaneous immunization via rapidly dissolvable microneedles protects against hand-foot-and-mouth disease caused by enterovirus 71"],"prefix":"10.1016","volume":"243","author":[{"given":"Zhuangzhi","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohua","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Ku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingwei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoyun","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huafei","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hansen","family":"Luan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenghao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoqiong","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CheeYen","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2016.10.019_bb0005","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1017\/S0950268809991555","article-title":"Human enterovirus 71 and hand, foot and mouth disease","volume":"138","author":"Wong","year":"2010","journal-title":"Epidemiol. Infect."},{"key":"10.1016\/j.jconrel.2016.10.019_bb0010","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/S1473-3099(10)70194-8","article-title":"Virology, epidemiology, pathogenesis, and control of enterovirus 71","volume":"10","author":"Solomon","year":"2010","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.jconrel.2016.10.019_bb0015","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.3201\/eid1311.070632","article-title":"Epidemiologic and virologic investigation of hand, foot, and mouth disease, southern Vietnam, 2005","volume":"13","author":"Tu","year":"2007","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.jconrel.2016.10.019_bb0020","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/S1473-3099(13)70342-6","article-title":"Hand, foot, and mouth disease in China, 2008\u201312: an epidemiological study","volume":"14","author":"Xing","year":"2014","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.jconrel.2016.10.019_bb0025","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1574-6976.2002.tb00601.x","article-title":"An overview of the evolution of enterovirus 71 and its clinical and public health significance","volume":"26","author":"McMinn","year":"2002","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.jconrel.2016.10.019_bb0030","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1586\/erv.09.152","article-title":"Development of enterovirus 71 vaccines","volume":"9","author":"Lee","year":"2010","journal-title":"Expert Rev. Vaccines"},{"key":"10.1016\/j.jconrel.2016.10.019_bb0035","doi-asserted-by":"crossref","first-page":"e739","DOI":"10.1016\/j.ijid.2009.12.002","article-title":"Enterovirus 71 vaccine: close but still far","volume":"14","author":"Zhang","year":"2010","journal-title":"Int. J. Infect. Dis."},{"key":"10.1016\/j.jconrel.2016.10.019_bb0040","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1586\/14760584.2016.1138862","article-title":"EV71 vaccine, a new tool to control outbreaks of hand, foot and mouth disease (HFMD)","volume":"15","author":"Mao","year":"2016","journal-title":"Expert Rev. Vaccines"},{"key":"10.1016\/j.jconrel.2016.10.019_bb0045","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1016\/S0140-6736(13)61049-1","article-title":"Efficacy, safety, and immunology of an inactivated alum-adjuvant enterovirus 71 vaccine in children in China: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial","volume":"381","author":"Zhu","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.jconrel.2016.10.019_bb0050","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1586\/erv.10.115","article-title":"Virus-like particles in vaccine development","volume":"9","author":"Rold\u00e3o","year":"2010","journal-title":"Expert Rev. Vaccines"},{"key":"10.1016\/j.jconrel.2016.10.019_bb0055","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0057601","article-title":"Neutralizing antibodies induced by recombinant virus-like particles of enterovirus 71 genotype C4 inhibit infection at pre- and post-attachment steps","volume":"8","author":"Ku","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jconrel.2016.10.019_bb0060","doi-asserted-by":"crossref","first-page":"137","DOI":"10.2174\/156720106776359249","article-title":"Vaccine delivery-current trends and future","volume":"3","author":"Azad","year":"2006","journal-title":"Curr. Drug Deliv."},{"key":"10.1016\/j.jconrel.2016.10.019_bb0065","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1517\/17425247.4.5.459","article-title":"Needle-free vaccine delivery","volume":"4","author":"Kersten","year":"2007","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.jconrel.2016.10.019_bb0070","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/nri1310","article-title":"Immune surveillance in the skin: mechanisms and clinical consequences","volume":"4","author":"Kupper","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jconrel.2016.10.019_bb0075","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.vaccine.2011.11.020","article-title":"Devices for intradermal vaccination","volume":"30","author":"Kis","year":"2012","journal-title":"Vaccine"},{"key":"10.1016\/j.jconrel.2016.10.019_bb0080","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/ni0504-460","article-title":"Vaccine development strategies for improving immunization the role of modern immunology","volume":"5","author":"Levine","year":"2004","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jconrel.2016.10.019_bb0085","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/nri2622","article-title":"Skin immune sentinels in health and disease","volume":"9","author":"Nestle","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jconrel.2016.10.019_bb0090","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.jconrel.2010.09.018","article-title":"Advances in transcutaneous vaccine delivery: do all ways lead to Rome?","volume":"148","author":"Bal","year":"2010","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2016.10.019_bb0095","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1517\/17425247.2013.760542","article-title":"Transcutaneous vaccines \u2013 current and emerging strategies","volume":"10","author":"Hirobe","year":"2013","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.jconrel.2016.10.019_bb0100","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1038\/nbt.1504","article-title":"Transdermal drug delivery","volume":"26","author":"Prausnitz","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jconrel.2016.10.019_bb0105","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1016\/j.vaccine.2013.03.022","article-title":"Frontiers of transcutaneous vaccination systems: novel technologies and devices for vaccine delivery","volume":"31","author":"Matsuo","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.jconrel.2016.10.019_bb0110","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1016\/j.addr.2012.04.005","article-title":"Microneedles for drug and vaccine delivery","volume":"64","author":"Kim","year":"2012","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2016.10.019_bb0115","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1517\/17425247.2012.676038","article-title":"Microneedle-mediated vaccine delivery: harnessing cutaneous immunobiology to improve efficacy","volume":"9","author":"Al-Zahrani","year":"2012","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.jconrel.2016.10.019_bb0120","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jconrel.2015.11.019","article-title":"Microneedle patches for vaccination in developing countries","volume":"240","author":"Arya","year":"2016","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2016.10.019_bb0125","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0013460","article-title":"Skin vaccination against cervical cancer associated human papillomavirus with a novel micro-projection array in a mouse model","volume":"5","author":"Corbett","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.jconrel.2016.10.019_bb0130","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.jconrel.2010.07.125","article-title":"Dose sparing enabled by skin immunization with influenza virus-like particle vaccine using microneedles","volume":"147","author":"Quan","year":"2010","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2016.10.019_bb0135","doi-asserted-by":"crossref","first-page":"3396","DOI":"10.1016\/j.vaccine.2012.11.027","article-title":"Dose sparing and enhanced immunogenicity of inactivated rotavirus vaccine administered by skin vaccination using a microneedle patch","volume":"31","author":"Moon","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.jconrel.2016.10.019_bb0140","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1016\/j.biomaterials.2007.12.048","article-title":"Dissolving microneedles for transdermal drug delivery","volume":"29","author":"Lee","year":"2008","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2016.10.019_bb0145","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.jconrel.2012.04.001","article-title":"Transcutaneous immunization using a dissolving microneedle array protects against tetanus, diphtheria, malaria, and influenza","volume":"160","author":"Matsuo","year":"2012","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2016.10.019_bb0150","doi-asserted-by":"crossref","first-page":"3348","DOI":"10.1007\/s11095-014-1424-1","article-title":"Rapidly dissolvable microneedle patches for transdermal delivery of exenatide","volume":"31","author":"Zhu","year":"2014","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2016.10.019_bb0155","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.jbiosc.2013.08.015","article-title":"Evaluation of the stability of enterovirus 71 virus-like particle","volume":"117","author":"Lin","year":"2014","journal-title":"J. Biosci. Bioeng."},{"key":"10.1016\/j.jconrel.2016.10.019_bb0160","first-page":"3143","article-title":"Protein encapsulation in polymeric microneedles by photolithography","volume":"7","author":"Kochhar","year":"2012","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.jconrel.2016.10.019_bb0165","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.jconrel.2012.05.030","article-title":"The development and characteristics of novel microneedle arrays fabricated from hyaluronic acid, and their application in the transdermal delivery of insulin","volume":"161","author":"Liu","year":"2012","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2016.10.019_bb0170","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1002\/smll.201000331","article-title":"Nanopatch-targeted skin vaccination against West Nile virus and Chikungunya virus in mice","volume":"6","author":"Prow","year":"2010","journal-title":"Small"},{"key":"10.1016\/j.jconrel.2016.10.019_bb0175","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0010266","article-title":"Potent immunity to low doses of influenza vaccine by probabilistic guided micro-targeted skin delivery in a mouse model","volume":"5","author":"Fernando","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.jconrel.2016.10.019_bb0180","doi-asserted-by":"crossref","first-page":"8952","DOI":"10.1016\/j.actbio.2013.06.029","article-title":"Dissolving polymer microneedle patches for rapid and efficient transdermal delivery of insulin to diabetic rats","volume":"9","author":"Ling","year":"2013","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jconrel.2016.10.019_bb0185","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0022-3565(25)08751-8","article-title":"Methods for the study of irritation and toxicity of substances applied topically to the skin and mucous membranes","volume":"82","author":"Draize","year":"1944","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.jconrel.2016.10.019_bb0190","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jconrel.2012.01.033","article-title":"A low-invasive and effective transcutaneous immunization system using a novel dissolving microneedle array for soluble and particulate antigens","volume":"161","author":"Matsuo","year":"2012","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2016.10.019_bb0195","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1128\/JVI.01848-13","article-title":"Chimeric virus-like particle vaccines displaying conserved enterovirus 71 epitopes elicit protective neutralizing antibodies in mice through divergent mechanisms","volume":"88","author":"Ye","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.jconrel.2016.10.019_bb0200","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1016\/j.vaccine.2013.03.007","article-title":"Active immunization with a coxsackievirus A16 experimental inactivated vaccine induces neutralizing antibodies and protects mice against lethal infection","volume":"31","author":"Cai","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.jconrel.2016.10.019_bb0205","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1002\/adfm.201000966","article-title":"Site-selectively coated, densely-packed microprojection array patches for targeted delivery of vaccines to skin","volume":"21","author":"Chen","year":"2011","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.jconrel.2016.10.019_bb0210","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.pid.2013.09.003","article-title":"Clinical metamorphosis of hand, foot and mouth disease (HFMD)","volume":"5","author":"Kapse","year":"2013","journal-title":"Pediatr. Infect. Dis."},{"key":"10.1016\/j.jconrel.2016.10.019_bb0215","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.micinf.2014.11.004","article-title":"Towards broadly protective polyvalent vaccines against hand, foot and mouth disease","volume":"17","author":"Liu","year":"2015","journal-title":"Microbes Infect."},{"key":"10.1016\/j.jconrel.2016.10.019_bb0220","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.4161\/hv.21739","article-title":"Production of EV71 vaccine candidates","volume":"8","author":"Chong","year":"2012","journal-title":"Hum. Vaccin. Immunother."},{"key":"10.1016\/j.jconrel.2016.10.019_bb0225","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.vaccine.2015.12.002","article-title":"Microneedle technology for immunisation: perception, acceptability and suitability for paediatric use","volume":"34","author":"Marshall","year":"2016","journal-title":"Vaccine"},{"key":"10.1016\/j.jconrel.2016.10.019_bb0230","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1002\/smll.201001091","article-title":"Dissolving microneedle patch for transdermal delivery of human growth hormone","volume":"7","author":"Lee","year":"2011","journal-title":"Small"},{"key":"10.1016\/j.jconrel.2016.10.019_bb0235","doi-asserted-by":"crossref","first-page":"4228","DOI":"10.1002\/jps.22140","article-title":"Fabrication of dissolving polymer microneedles for controlled drug encapsulation and delivery: bubble and pedestal microneedle designs","volume":"99","author":"Chu","year":"2010","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2016.10.019_bb0240","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.ejps.2014.09.011","article-title":"Investigation on fabrication process of dissolving microneedle arrays to improve effective needle drug distribution","volume":"66","author":"Wang","year":"2015","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2016.10.019_bb0245","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.ijpharm.2012.10.042","article-title":"Performance and characteristics evaluation of a sodium hyaluronate-based microneedle patch for a transcutaneous drug delivery system","volume":"441","author":"Hiraishi","year":"2013","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2016.10.019_bb0250","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.ejps.2013.05.005","article-title":"Microneedles for intradermal and transdermal drug delivery","volume":"50","author":"Tuan-Mahmood","year":"2013","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2016.10.019_bb0255","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.jconrel.2010.09.001","article-title":"Improved DNA vaccination by skin-targeted delivery using dry-coated densely-packed microprojection arrays","volume":"148","author":"Chen","year":"2010","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2016.10.019_bb0260","doi-asserted-by":"crossref","first-page":"4296","DOI":"10.1016\/j.vaccine.2014.06.025","article-title":"A virus-like particle based bivalent vaccine confers dual protection against enterovirus 71 and coxsackievirus A16 infections in mice","volume":"32","author":"Ku","year":"2014","journal-title":"Vaccine"},{"key":"10.1016\/j.jconrel.2016.10.019_bb0265","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1016\/j.vaccine.2015.03.034","article-title":"High-yield production of recombinant virus-like particles of enterovirus 71 in Pichia pastoris and their protective efficacy against oral viral challenge in mice","volume":"33","author":"Zhang","year":"2015","journal-title":"Vaccine"},{"key":"10.1016\/j.jconrel.2016.10.019_bb0270","doi-asserted-by":"crossref","first-page":"7916","DOI":"10.1128\/JVI.78.15.7916-7924.2004","article-title":"A mouse-adapted enterovirus 71 strain causes neurological disease in mice after oral infection","volume":"78","author":"Wang","year":"2004","journal-title":"J. Virol."},{"key":"10.1016\/j.jconrel.2016.10.019_bb0275","doi-asserted-by":"crossref","first-page":"3281","DOI":"10.1016\/j.vaccine.2013.05.019","article-title":"Virus-like particles for enterovirus 71 produced from Saccharomyces cerevisiae potently elicits protective immune responses in mice","volume":"31","author":"Li","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.jconrel.2016.10.019_bb0280","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.micinf.2007.06.002","article-title":"Passive protection against lethal enterovirus 71 infection in newborn mice by neutralizing antibodies elicited by a synthetic peptide","volume":"9","author":"Foo","year":"2007","journal-title":"Microbes Infect."},{"key":"10.1016\/j.jconrel.2016.10.019_bb0285","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1016\/j.vaccine.2008.01.058","article-title":"Immunization with virus-like particles of enterovirus 71 elicits potent immune responses and protects mice against lethal challenge","volume":"26","author":"Chung","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.jconrel.2016.10.019_bb0290","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0046043","article-title":"Comparative analysis of the immunogenicity and protective effects of inactivated EV71 vaccines in mice","volume":"7","author":"Mao","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jconrel.2016.10.019_bb0295","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1056\/NEJMoa1304923","article-title":"Efficacy, safety, and immunogenicity of an enterovirus 71 vaccine in China","volume":"370","author":"Zhu","year":"2014","journal-title":"New Engl. J. Med."},{"key":"10.1016\/j.jconrel.2016.10.019_bb0300","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1002\/smll.201000326","article-title":"Targeted, needle-free vaccinations in skin using multilayered, densely-packed dissolving microprojection arrays","volume":"6","author":"Raphael","year":"2010","journal-title":"Small"},{"key":"10.1016\/j.jconrel.2016.10.019_bb0305","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jconrel.2016.01.027","article-title":"Formulations for microprojection\/microneedle vaccine delivery: structure, strength and release profiles","volume":"225","author":"Raphael","year":"2016","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2016.10.019_bb0310","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1208\/s12249-010-9471-3","article-title":"Formulation of microneedles coated with influenza virus-like particle vaccine","volume":"11","author":"Kim","year":"2010","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.jconrel.2016.10.019_bb0315","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mser.2016.03.001","article-title":"Microneedle arrays as transdermal and intradermal drug delivery systems: materials science, manufacture and commercial development","volume":"R104","author":"Larra\u00f1eta","year":"2016","journal-title":"Mater. Sci. Eng."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365916310392?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365916310392?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T20:47:32Z","timestamp":1749674852000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365916310392"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":63,"alternative-id":["S0168365916310392"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2016.10.019","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transcutaneous immunization via rapidly dissolvable microneedles protects against hand-foot-and-mouth disease caused by enterovirus 71","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2016.10.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}