{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:30:12Z","timestamp":1792510212666,"version":"4.5.0"},"reference-count":129,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51673190"],"award-info":[{"award-number":["51673190"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51303174"],"award-info":[{"award-number":["51303174"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51473165"],"award-info":[{"award-number":["51473165"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51390484"],"award-info":[{"award-number":["51390484"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.jconrel.2017.02.032","type":"journal-article","created":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T03:39:12Z","timestamp":1488339552000},"page":"108-124","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":202,"special_numbering":"C","title":["Nanotherapeutics relieve rheumatoid arthritis"],"prefix":"10.1016","volume":"252","author":[{"given":"Modi","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangru","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5232-8863","authenticated-orcid":false,"given":"Jianxun","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3542-9256","authenticated-orcid":false,"given":"Xuesi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2017.02.032_bb0005","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/nature01661","article-title":"Evolving concepts of rheumatoid arthritis","volume":"423","author":"Firestein","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.jconrel.2017.02.032_bb0010","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/S0140-6736(10)60826-4","article-title":"Rheumatoid arthritis","volume":"376","author":"Scott","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.jconrel.2017.02.032_bb0015","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1136\/ard.2010.134684","article-title":"State-of-the-art: Rheumatoid arthritis","volume":"69","author":"McInnes","year":"2010","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0020","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/nrd1109","article-title":"Therapeutic strategies for rheumatoid arthritis","volume":"2","author":"Smolen","year":"2003","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0025","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1002\/wnan.157","article-title":"Nanotherapeutic approaches for the treatment of rheumatoid arthritis","volume":"3","author":"Pham","year":"2011","journal-title":"Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0030","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.addr.2012.03.006","article-title":"Development of macromolecular prodrug for rheumatoid arthritis","volume":"64","author":"Yuan","year":"2012","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0035","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1136\/ard.60.8.729","article-title":"Anti-inflammatory mechanisms of methotrexate in rheumatoid arthritis","volume":"60","author":"Cutolo","year":"2001","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0040","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1517\/17425247.2012.642362","article-title":"Methotrexate: A detailed review on drug delivery and clinical aspects","volume":"9","author":"Khan","year":"2012","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0045","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/nrrheum.2010.179","article-title":"Current view of glucocorticoid co-therapy with DMARDs in rheumatoid arthritis","volume":"6","author":"Hoes","year":"2010","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0050","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1136\/annrheumdis-2013-204573","article-title":"EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update","volume":"73","author":"Smolen","year":"2014","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0055","first-page":"CD008794","article-title":"Adverse effects of biologics: A network meta-analysis and Cochrane overview","volume":"16","author":"Singh","year":"2011","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0060","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1136\/ard.2010.132134","article-title":"Indirect comparisons of the efficacy of biological antirheumatic agents in rheumatoid arthritis in patients with an inadequate response to conventional disease-modifying antirheumatic drugs or to an anti-tumour necrosis factor agent: A meta-analysis","volume":"70","author":"Salliot","year":"2011","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0065","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1136\/ard.2009.118935","article-title":"Drug-specific risk of tuberculosis in patients with rheumatoid arthritis treated with anti-TNF therapy: Results from the British Society for Rheumatology Biologics Register (BSRBR)","volume":"69","author":"Dixon","year":"2010","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0070","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/S0140-6736(14)61704-9","article-title":"Risk of serious infection in biological treatment of patients with rheumatoid arthritis: A systematic review and meta-analysis","volume":"386","author":"Singh","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.jconrel.2017.02.032_bb0075","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1001\/jama.295.19.2275","article-title":"Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: Systematic review and meta-analysis of rare harmful effects in randomized controlled trials","volume":"295","author":"Bongartz","year":"2006","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0080","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.2217\/nnm.15.45","article-title":"Nanomedicine delivers promising treatments for rheumatoid arthritis","volume":"10","author":"Prasad","year":"2015","journal-title":"Nanomedicine"},{"key":"10.1016\/j.jconrel.2017.02.032_bb0085","first-page":"1015","article-title":"Polymer Nanotherapeutics for Rheumatoid Arthritis Therapy","volume":"2","author":"Feng","year":"2017","journal-title":"Austin Arthritis"},{"key":"10.1016\/j.jconrel.2017.02.032_bb0090","doi-asserted-by":"crossref","first-page":"S55","DOI":"10.1098\/rsif.2009.0285.focus","article-title":"Targeted drug-delivery approaches by nanoparticulate carriers in the therapy of inflammatory diseases","volume":"7","author":"Ulbrich","year":"2010","journal-title":"J. R. Soc. Interface"},{"key":"10.1016\/j.jconrel.2017.02.032_bb0095","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1007\/s12272-011-1109-9","article-title":"Designing micro- and nano-particles for treating rheumatoid arthritis","volume":"34","author":"Mitragotri","year":"2011","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0100","first-page":"6387","article-title":"A new concept for macromolecular therapeutics in cancer chemotherapy: Mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs","volume":"46","author":"Matsumura","year":"1986","journal-title":"Cancer Res."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0105","doi-asserted-by":"crossref","first-page":"888","DOI":"10.3109\/1061186X.2013.832769","article-title":"Multifunctional nanoparticles for targeting cancer and inflammatory diseases","volume":"21","author":"Jain","year":"2013","journal-title":"J. Drug Target."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0110","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0031-6997(24)01494-7","article-title":"Long-circulating and target-specific nanoparticles: Theory to practice","volume":"53","author":"Moghimi","year":"2001","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0115","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ejps.2005.08.002","article-title":"In vivo tumor targeting of tumor necrosis factor-\u03b1-loaded stealth nanoparticles: Effect of MePEG molecular weight and particle size","volume":"27","author":"Fang","year":"2006","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0120","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1124\/jpet.108.150276","article-title":"Treatment of experimental arthritis with stealth-type polymeric nanoparticles encapsulating betamethasone phosphate","volume":"329","author":"Ishihara","year":"2009","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0125","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s000110050575","article-title":"The suppression of rat collagen-induced arthritis and inhibition of macrophage derived mediator release by liposomal methotrexate formulations","volume":"49","author":"Williams","year":"2000","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0130","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1093\/rheumatology\/40.4.375","article-title":"Amelioration of rat antigen-induced arthritis by liposomally conjugated methotrexate is accompanied by down-regulation of cytokine mRNA expression","volume":"40","author":"Williams","year":"2001","journal-title":"Rheumatology"},{"key":"10.1016\/j.jconrel.2017.02.032_bb0135","doi-asserted-by":"crossref","first-page":"177","DOI":"10.2147\/IJN.S25310","article-title":"Investigation of nano lipid vesicles of methotrexate for anti-rheumatoid activity","volume":"7","author":"Prabhu","year":"2012","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.jconrel.2017.02.032_bb0140","first-page":"6603","article-title":"Methotrexate-loaded lipid-core nanocapsules are highly effective in the control of inflammation in synovial cells and a chronic arthritis model","volume":"10","author":"Boechat","year":"2015","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.jconrel.2017.02.032_bb0145","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.colsurfb.2016.07.046","article-title":"Effective transdermal delivery of methotrexate through nanostructured lipid carriers in an experimentally induced arthritis model","volume":"147","author":"Garg","year":"2016","journal-title":"Colloid Surf. B"},{"key":"10.1016\/j.jconrel.2017.02.032_bb0150","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.colsurfb.2015.04.048","article-title":"Temperature-responsive polymeric nanospheres containing methotrexate and gold nanoparticles: A multi-drug system for theranostic in rheumatoid arthritis","volume":"133","author":"Lima","year":"2015","journal-title":"Colloid Surf. B"},{"key":"10.1016\/j.jconrel.2017.02.032_bb0155","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1002\/art.11140","article-title":"Complete remission of experimental arthritis by joint targeting of glucocorticoids with long-circulating liposomes","volume":"48","author":"Metselaar","year":"2003","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0160","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1136\/ard.2003.009944","article-title":"Liposomal targeting of glucocorticoids to synovial lining cells strongly increases therapeutic benefit in collagen type II arthritis","volume":"63","author":"Metselaar","year":"2004","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0165","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.ijpharm.2011.02.060","article-title":"Liposomal targeting of glucocorticoids to the inflamed synovium inhibits cartilage matrix destruction during murine antigen-induced arthritis","volume":"416","author":"Hofkens","year":"2011","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0170","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.jconrel.2011.12.024","article-title":"Glucocorticoids in nano-liposomes administered intravenously and subcutaneously to adjuvant arthritis rats are superior to the free drugs in suppressing arthritis and inflammatory cytokines","volume":"160","author":"Ulmansky","year":"2012","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2017.02.032_bb0175","doi-asserted-by":"crossref","first-page":"e54016","DOI":"10.1371\/journal.pone.0054016","article-title":"Liposomal targeting of prednisolone phosphate to synovial lining macrophages during experimental arthritis inhibits M1 activation but does not favor M2 differentiation","volume":"8","author":"Hofkens","year":"2013","journal-title":"PloS ONE"},{"key":"10.1016\/j.jconrel.2017.02.032_bb0180","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/j.nano.2014.02.011","article-title":"Liposomal encapsulation of dexamethasone modulates cytotoxicity, inflammatory cytokine response, and migratory properties of primary human macrophages","volume":"10","author":"Bartneck","year":"2014","journal-title":"Nanomedicine"},{"key":"10.1016\/j.jconrel.2017.02.032_bb0185","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jconrel.2016.03.035","article-title":"Targeted delivery of low-dose dexamethasone using PCL\u2013PEG micelles for effective treatment of rheumatoid arthritis","volume":"230","author":"Wang","year":"2016","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2017.02.032_bb0190","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1136\/ard.2004.030759","article-title":"Treatment of experimental arthritis with poly(d,l-lactic\/glycolic acid) nanoparticles encapsulating betamethasone sodium phosphate","volume":"64","author":"Higaki","year":"2005","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0195","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/art.23230","article-title":"Amphipathic weak acid glucocorticoid prodrugs remote-loaded into sterically stabilized nanoliposomes evaluated in arthritic rats and in a Beagle dog: A novel approach to treating autoimmune arthritis","volume":"58","author":"Avnir","year":"2008","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0200","first-page":"359","article-title":"Alpha-methylprednisolone conjugated cyclodextrin polymer-based nanoparticles for rheumatoid arthritis therapy","volume":"3","author":"Hwang","year":"2008","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.jconrel.2017.02.032_bb0205","doi-asserted-by":"crossref","first-page":"7254","DOI":"10.1002\/anie.201202713","article-title":"Glucocorticoid-loaded core-cross-linked polymeric micelles with tailorable release kinetics for targeted therapy of rheumatoid arthritis","volume":"51","author":"Crielaard","year":"2012","journal-title":"Angew. Chem., Int. Ed."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0210","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1021\/nn4048205","article-title":"Nanomedicines for inflammatory arthritis: Head-to-head comparison of glucocorticoid-containing polymers, micelles, and liposomes","volume":"8","author":"Quan","year":"2014","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2017.02.032_bb0215","doi-asserted-by":"crossref","first-page":"R147","DOI":"10.1186\/ar3089","article-title":"Liposomal encapsulation enhances and prolongs the anti-inflammatory effects of water-soluble dexamethasone phosphate in experimental adjuvant arthritis","volume":"12","author":"Anderson","year":"2010","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0220","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.ijpharm.2011.02.062","article-title":"Safety of glucocorticoids can be improved by lower yet still effective dosages of liposomal steroid formulations in murine antigen-induced arthritis: Comparison of prednisolone with budesonide","volume":"416","author":"Hofkens","year":"2011","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0225","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.ijpharm.2011.03.025","article-title":"Optimizing the therapeutic index of liposomal glucocorticoids in experimental arthritis","volume":"416","author":"van den Hoven","year":"2011","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0230","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1007\/s11095-007-9322-4","article-title":"Local delivery of indomethacin to arthritis-bearing rats through polymeric micelles based on amphiphilic polyphosphazenes","volume":"24","author":"Zhang","year":"2007","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0235","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1002\/jbm.a.31560","article-title":"Physicochemical characterization, in vitro, and in vivo evaluation of indomethacin-loaded nanocarriers self-assembled by amphiphilic polyphosphazene","volume":"86A","author":"Zhang","year":"2008","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.jconrel.2017.02.032_bb0240","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.jconrel.2006.09.013","article-title":"Indomethacin-loaded polymeric nanocarriers based on amphiphilic polyphosphazenes with poly(N-isopropylacrylamide) and ethyl tryptophan as side groups: Preparation, in vitro and in vivo evaluation","volume":"116","author":"Zhang","year":"2006","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2017.02.032_bb0245","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1111\/j.1476-5381.2009.00244.x","article-title":"Effects of indomethacin-loaded nanocapsules in experimental models of inflammation in rats","volume":"158","author":"Bernardi","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0250","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.jconrel.2011.03.013","article-title":"Highly efficient nanomedicines assembled via polymer\u2013drug multiple interactions: Tissue-selective delivery carriers","volume":"152","author":"Zhu","year":"2011","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2017.02.032_bb0255","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.ijpharm.2012.09.017","article-title":"Assembled nanomedicines as efficient and safe therapeutics for articular inflammation","volume":"439","author":"Che","year":"2012","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0260","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1248\/bpb.b13-00917","article-title":"Effect of solid nanoparticle of indomethacin on therapy for rheumatoid arthritis in adjuvant-induced arthritis rat","volume":"37","author":"Nagai","year":"2014","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0265","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1080\/10611860701725191","article-title":"Enhanced efficacy of diclofenac sodium-loaded lipogelosome formulation in intra-articular treatment of rheumatoid arthritis","volume":"16","author":"Turker","year":"2008","journal-title":"J. Drug Target."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0270","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jconrel.2013.07.012","article-title":"Temperature-modulated noncovalent interaction controllable complex for the long-term delivery of etanercept to treat rheumatoid arthritis","volume":"171","author":"Jung","year":"2013","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2017.02.032_bb0275","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.nano.2014.12.003","article-title":"Therapeutic applications of nanomedicine in autoimmune diseases: From immunosuppression to tolerance induction","volume":"11","author":"Gharagozloo","year":"2015","journal-title":"Nanomedicine"},{"key":"10.1016\/j.jconrel.2017.02.032_bb0280","doi-asserted-by":"crossref","first-page":"4790","DOI":"10.1021\/nn500685h","article-title":"Hyaluronate-gold nanoparticle\/tocilizumab complex for the treatment of rheumatoid arthritis","volume":"8","author":"Lee","year":"2014","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2017.02.032_bb0285","doi-asserted-by":"crossref","first-page":"170","DOI":"10.22203\/eCM.v023a13","article-title":"Multivalent structure of galectin-1-nanogold complex serves as potential therapeutics for rheumatoid arthritis by enhancing receptor clustering","volume":"23","author":"Huang","year":"2012","journal-title":"Eur. Cell Mater."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0290","doi-asserted-by":"crossref","first-page":"137r","DOI":"10.1093\/glycob\/cwl025","article-title":"Galectin-1: a small protein with major functions","volume":"16","author":"Camby","year":"2006","journal-title":"Glycobiology"},{"key":"10.1016\/j.jconrel.2017.02.032_bb0295","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0076-6879(05)91022-7","article-title":"Liposomal superoxide dismutases and their use in the treatment of experimental arthritis","volume":"391","author":"Cruz","year":"2005","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0300","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.jconrel.2004.12.008","article-title":"Developments in the rat adjuvant arthritis model and its use in therapeutic evaluation of novel non-invasive treatment by SOD in Transfersomes","volume":"103","author":"Simoes","year":"2005","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2017.02.032_bb0305","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0005-2736(02)00457-1","article-title":"Superoxide dismutase entrapped in long-circulating liposomes: Formulation design and therapeutic activity in rat adjuvant arthritis","volume":"1564","author":"Luisa Corvo","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jconrel.2017.02.032_bb0310","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.jconrel.2006.10.018","article-title":"Enzymosomes with surface-exposed superoxide dismutase: In vivo behaviour and therapeutic activity in a model of adjuvant arthritis","volume":"117","author":"Gaspar","year":"2007","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2017.02.032_bb0315","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/S0952-7915(02)00407-7","article-title":"TNF ligands and receptors in autoimmunity: An update","volume":"14","author":"Mackay","year":"2002","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0320","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1172\/JCI200320297","article-title":"The TRAIL to arthritis","volume":"112","author":"Tsokos","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0325","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.4049\/jimmunol.171.2.1061","article-title":"TRAIL-R2 (DR5) mediates apoptosis of synovial fibroblasts in rheumatoid arthritis","volume":"171","author":"Ichikawa","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0330","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.ijpharm.2008.07.013","article-title":"Stability and bioactivity of nanocomplex of TNF-related apoptosis-inducing ligand","volume":"363","author":"Na","year":"2008","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0335","doi-asserted-by":"crossref","first-page":"9057","DOI":"10.1016\/j.biomaterials.2010.08.015","article-title":"Ionic complex systems based on hyaluronic acid and PEGylated TNF-related apoptosis-inducing ligand for treatment of rheumatoid arthritis","volume":"31","author":"Kim","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2017.02.032_bb0340","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jconrel.2013.01.027","article-title":"An intra-articular salmon calcitonin-based nanocomplex reduces experimental inflammatory arthritis","volume":"167","author":"Ryan","year":"2013","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2017.02.032_bb0345","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.addr.2004.01.012","article-title":"Folate receptor-mediated targeting of therapeutic and imaging agents to activated macrophages in rheumatoid arthritis","volume":"56","author":"Paulos","year":"2004","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0350","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1021\/ar7000815","article-title":"Discovery and development of folic-acid-based receptor targeting for imaging and therapy of cancer and inflammatory diseases","volume":"41","author":"Low","year":"2008","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0355","doi-asserted-by":"crossref","first-page":"10349","DOI":"10.1039\/c3cc44260h","article-title":"Self-assembled dextran sulphate nanoparticles for targeting rheumatoid arthritis","volume":"49","author":"Kim","year":"2013","journal-title":"Chem. Commun."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0360","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1146\/annurev.nu.16.070196.002441","article-title":"Folate receptors","volume":"16","author":"Antony","year":"1996","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0365","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1002\/1529-0131(199908)42:8<1609::AID-ANR7>3.0.CO;2-L","article-title":"Selective expression of folate receptor beta and its possible role in methotrexate transport in synovial macrophages from patients with rheumatoid arthritis","volume":"42","author":"Nakashima-Matsushita","year":"1999","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0370","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1002\/art.10405","article-title":"Folate-targeted imaging of activated macrophages in rats with adjuvant-induced arthritis","volume":"46","author":"Turk","year":"2002","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0375","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1002\/art.21228","article-title":"Effectiveness of anti-folate receptor beta antibody conjugated with truncated Pseudomonas exotoxin in the targeting of rheumatoid arthritis synovial macrophages","volume":"52","author":"Nagayoshi","year":"2005","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0380","doi-asserted-by":"crossref","first-page":"R77","DOI":"10.1186\/ar1944","article-title":"Folate-targeted immunotherapy effectively treats established adjuvant and collagen-induced arthritis","volume":"8","author":"Paulos","year":"2006","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0385","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/art.24219","article-title":"Folate receptor beta as a potential delivery route for novel folate antagonists to macrophages in the synovial tissue of rheumatoid arthritis patients","volume":"60","author":"van der Heijden","year":"2009","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0390","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1039\/C5TB02479J","article-title":"Activated macrophage-targeted dextran-methotrexate\/folate conjugate prevents deterioration of collagen-induced arthritis in mice","volume":"4","author":"Yang","year":"2016","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.jconrel.2017.02.032_bb0395","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/jbm.a.31122","article-title":"Folate coupled poly(ethyleneglycol) conjugates of anionic poly(amidoamine) dendrimer for inflammatory tissue specific drug delivery","volume":"82","author":"Chandrasekar","year":"2007","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.jconrel.2017.02.032_bb0400","doi-asserted-by":"crossref","first-page":"2671","DOI":"10.1002\/art.30459","article-title":"Folate-targeted nanoparticles show efficacy in the treatment of inflammatory arthritis","volume":"63","author":"Thomas","year":"2011","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0405","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/j.nano.2015.12.365","article-title":"Folate-targeted nanoparticles for rheumatoid arthritis therapy","volume":"12","author":"Nogueira","year":"2016","journal-title":"Nanomedicine"},{"key":"10.1016\/j.jconrel.2017.02.032_bb0410","doi-asserted-by":"crossref","first-page":"2904","DOI":"10.1021\/acs.biomac.5b00823","article-title":"Peptide anchor for folate-targeted liposomal delivery","volume":"16","author":"Nogueira","year":"2015","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.jconrel.2017.02.032_bb0415","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1097\/00041433-199810000-00006","article-title":"Recent progress in defining the role of scavenger receptors in lipid transport, atherosclerosis and host defence","volume":"9","author":"Greaves","year":"1998","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0420","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1161\/01.ATV.20.2.290","article-title":"Macrophage scavenger receptor class A: A multifunctional receptor in atherosclerosis","volume":"20","author":"de Winther","year":"2000","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0425","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/S0022-2275(20)32118-0","article-title":"Cellular cholesterol regulates expression of the macrophage type B scavenger receptor, CD36","volume":"40","author":"Han","year":"1999","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0430","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.cardiores.2007.03.010","article-title":"CD36 and macrophages in atherosclerosis","volume":"75","author":"Collot-Teixeira","year":"2007","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0435","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S1286-4579(00)01362-9","article-title":"The function of scavenger receptors expressed by macrophages and their role in the regulation of inflammation","volume":"3","author":"Peiser","year":"2001","journal-title":"Microbes Infect."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0440","doi-asserted-by":"crossref","first-page":"9238","DOI":"10.1073\/pnas.85.23.9238","article-title":"Purification and characterization of a bovine acetyl low-density lipoprotein receptor","volume":"85","author":"Kodama","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0445","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/343531a0","article-title":"Type-1 macrophage scavenger receptor contains \u03b1-helical and collagen-like coiled coils","volume":"343","author":"Kodama","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.jconrel.2017.02.032_bb0450","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1038\/nm1102-1235","article-title":"The macrophage foam cell as a target for therapeutic intervention","volume":"8","author":"Li","year":"2002","journal-title":"Nat. Med."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0455","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1146\/annurev.bi.63.070194.003125","article-title":"Structures and functions of multiligand lipoprotein receptors-macrophage scavenger receptors and LDL receptor-related protein (LRP)","volume":"63","author":"Krieger","year":"1994","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0460","doi-asserted-by":"crossref","first-page":"97","DOI":"10.7150\/thno.16844","article-title":"Scavenger receptor-mediated targeted treatment of collagen-induced arthritis by dextran sulfate-methotrexate prodrug","volume":"7","author":"Yang","year":"2017","journal-title":"Theranostics"},{"key":"10.1016\/j.jconrel.2017.02.032_bb0465","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1021\/nn301215q","article-title":"Targeted chemo-photothermal treatments of rheumatoid arthritis using gold half-shell multifunctional nanoparticles","volume":"7","author":"Lee","year":"2013","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2017.02.032_bb0470","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S1471-4914(01)01963-3","article-title":"A crucial role for CD44 in inflammation","volume":"7","author":"Pure","year":"2001","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0475","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.bmc.2009.12.053","article-title":"Synthesis and optimization of hyaluronic acid-methotrexate conjugates to maximize benefit in the treatment of osteoarthritis","volume":"18","author":"Homma","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0480","doi-asserted-by":"crossref","first-page":"7632","DOI":"10.1039\/c4cc02595d","article-title":"A hyaluronic acid-methotrexate conjugate for targeted therapy of rheumatoid arthritis","volume":"50","author":"Shin","year":"2014","journal-title":"Chem. Commun."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0485","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s13075-016-0971-8","article-title":"Novel hyaluronic acid\u2013methotrexate conjugate suppresses joint inflammation in the rat knee: Efficacy and safety evaluation in two rat arthritis models","volume":"18","author":"Tamura","year":"2016","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0490","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1159\/000328636","article-title":"Neuropeptides as pleiotropic modulators of the immune response","volume":"94","author":"Souza-Moreira","year":"2011","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.jconrel.2017.02.032_bb0495","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.bbi.2008.06.001","article-title":"Anti-inflammatory neuropeptides: A new class of endogenous immunoregulatory agents","volume":"22","author":"Delgado","year":"2008","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0500","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1749-6632.2000.tb06953.x","article-title":"Vasoactive intestinal peptide mediation of development and functions of T lymphocytes","author":"Dorsam","year":"2000","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0505","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/j.1749-6632.2000.tb06954.x","article-title":"Receptors and transcriptional factors involved in the anti-inflammatory activity of VIP and PACAP","author":"Leceta","year":"2000","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0510","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s00109-001-0291-5","article-title":"Vasoactive intestinal peptide in the immune system: Potential therapeutic role in inflammatory and autoimmune diseases","volume":"80","author":"Delgado","year":"2002","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0515","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1124\/pr.56.2.7","article-title":"The significance of vasoactive intestinal peptide in immunomodulation","volume":"56","author":"Delgado","year":"2004","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0520","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1007\/s11095-010-0330-4","article-title":"Actively targeted low-dose camptothecin as a safe, long-acting, disease-modifying nanomedicine for rheumatoid arthritis","volume":"28","author":"Koo","year":"2011","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0525","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.bbi.2007.07.004","article-title":"Vasoactive intestinal peptide inhibits cycloxygenase-2 expression in activated macrophages, microglia, and dendritic cells","volume":"22","author":"Gonzalez-Rey","year":"2008","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0530","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/icb.2011.23","article-title":"Effect of VIP on the balance between cytokines and master regulators of activated helper T cells","volume":"90","author":"Jimeno","year":"2012","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0535","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/87887","article-title":"Vasoactive intestinal peptide prevents experimental arthritis by downregulating both autoimmune and inflammatory components of the disease","volume":"7","author":"Delgado","year":"2001","journal-title":"Nat. Med."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0540","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1021\/mp300539f","article-title":"Novel, biocompatible, and disease modifying VIP nanomedicine for rheumatoid arthritis","volume":"10","author":"Sethi","year":"2013","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0545","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.ijpharm.2015.12.004","article-title":"Pharmaceutical potential of tacrolimus-loaded albumin nanoparticles having targetability to rheumatoid arthritis tissues","volume":"497","author":"Thao","year":"2016","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0550","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1136\/ard.59.suppl_1.i65","article-title":"The role of angiogenesis in rheumatoid arthritis: Recent developments","volume":"59","author":"Koch","year":"2000","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0555","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1136\/ard.62.suppl_2.ii60","article-title":"Angiogenesis as a target in rheumatoid arthritis","volume":"62","author":"Koch","year":"2003","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0560","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1172\/JCI3756","article-title":"Decreased angiogenesis and arthritic disease in rabbits treated with an alpha v beta 3 antagonist","volume":"103","author":"Storgard","year":"1999","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0565","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/art.1780360203","article-title":"Adhesion molecule expression in human synovial tissue","volume":"36","author":"Johnson","year":"1993","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0570","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1126\/science.7512751","article-title":"Requirement of vascular integrin \u03b1v\u03b23 for angiogenesis","volume":"264","author":"Brooks","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.jconrel.2017.02.032_bb0575","doi-asserted-by":"crossref","first-page":"2978","DOI":"10.1096\/fj.09-129874","article-title":"\u03b1v\u03b23-Targeted nanotherapy suppresses inflammatory arthritis in mice","volume":"23","author":"Zhou","year":"2009","journal-title":"FASEB J."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0580","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.2217\/nnm.10.78","article-title":"Synergistic effect of antiangiogenic nanotherapy combined with methotrexate in the treatment of experimental inflammatory arthritis","volume":"5","author":"Zhou","year":"2010","journal-title":"Nanomedicine"},{"key":"10.1016\/j.jconrel.2017.02.032_bb0585","doi-asserted-by":"crossref","first-page":"8632","DOI":"10.1016\/j.biomaterials.2012.08.005","article-title":"Suppression of inflammation in a mouse model of rheumatoid arthritis using targeted lipase-labile fumagillin prodrug nanoparticles","volume":"33","author":"Zhou","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2017.02.032_bb0590","doi-asserted-by":"crossref","first-page":"7305","DOI":"10.1021\/nn502372n","article-title":"Fumagillin prodrug nanotherapy suppresses macrophage inflammatory response via endothelial nitric oxide","volume":"8","author":"Zhou","year":"2014","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2017.02.032_bb0595","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1161\/01.CIR.0000093185.16083.95","article-title":"Molecular imaging of angiogenesis in early-stage atherosclerosis with \u03b1v\u03b23-Integrin-targeted nanoparticles","volume":"108","author":"Winter","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.jconrel.2017.02.032_bb0600","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.biomaterials.2015.05.018","article-title":"Drug-loaded gold\/iron\/gold plasmonic nanoparticles for magnetic targeted chemo-photothermal treatment of rheumatoid arthritis","volume":"61","author":"Kim","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2017.02.032_bb0605","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1517\/14728222.11.11.1473","article-title":"Targeting selectins and selectin ligands in inflammation and cancer","volume":"11","author":"Barthel","year":"2007","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.jconrel.2017.02.032_bb0610","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1549-8719.2000.tb00125.x","article-title":"Expression of endothelial cell adhesion molecules in neovascularized tissue","volume":"7","author":"Vallien","year":"2000","journal-title":"Microcirculation"},{"key":"10.1016\/j.jconrel.2017.02.032_bb0615","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s00011-013-0682-4","article-title":"Light and electron microscopic detection of inflammation-targeting liposomes encapsulating high-density colloidal gold in arthritic mice","volume":"63","author":"Maehara","year":"2014","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0620","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.bbrc.2006.12.060","article-title":"Accumulation of liposome with Sialyl Lewis X to inflammation and tumor region: Application to in vivo bio-imaging","volume":"353","author":"Hirai","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0625","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1021\/bc800257m","article-title":"Selectins ligand decorated drug carriers for activated endothelial cell targeting","volume":"19","author":"Banquy","year":"2008","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0630","doi-asserted-by":"crossref","first-page":"e13050","DOI":"10.1371\/journal.pone.0013050","article-title":"Identification of thioaptamer ligand against E-selectin: Potential application for inflamed vasculature targeting","volume":"5","author":"Mann","year":"2010","journal-title":"PloS ONE"},{"key":"10.1016\/j.jconrel.2017.02.032_bb0635","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1021\/bc700227z","article-title":"PLGA nanoparticle-peptide conjugate effectively targets intercellular cell-adhesion molecule-1","volume":"19","author":"Zhang","year":"2008","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0640","doi-asserted-by":"crossref","first-page":"4647","DOI":"10.1016\/j.bmc.2009.04.063","article-title":"Novel hyaluronic acid-methotrexate conjugates for osteoarthritis treatment","volume":"17","author":"Homma","year":"2009","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.jconrel.2017.02.032_bb0645","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jconrel.2010.02.008","article-title":"Chitosan-based nanogels for selective delivery of photosensitizers to macrophages and improved retention in and therapy of articular joints","volume":"144","author":"Schmitt","year":"2010","journal-title":"J. Control. Release"}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365917300901?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365917300901?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,15]],"date-time":"2025-06-15T21:54:34Z","timestamp":1750024474000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365917300901"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":129,"alternative-id":["S0168365917300901"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2017.02.032","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nanotherapeutics relieve rheumatoid arthritis","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2017.02.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}