{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T07:33:56Z","timestamp":1778052836661,"version":"3.51.4"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T00:00:00Z","timestamp":1531267200000},"content-version":"am","delay-in-days":313,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"name":"Serbian Ministry of Education and Science","award":["OI 174028"],"award-info":[{"award-number":["OI 174028"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U54CA143837"],"award-info":[{"award-number":["U54CA143837"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U54CA151668"],"award-info":[{"award-number":["U54CA151668"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"US Department of Defense","doi-asserted-by":"crossref","award":["W81XWH-09-1-0212"],"award-info":[{"award-number":["W81XWH-09-1-0212"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Marie Curie Individual Fellowship","award":["705791"],"award-info":[{"award-number":["705791"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.jconrel.2017.05.031","type":"journal-article","created":{"date-parts":[[2017,5,31]],"date-time":"2017-05-31T18:04:38Z","timestamp":1496253878000},"page":"216-222","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Tumor progression effects on drug vector access to tumor-associated capillary bed"],"prefix":"10.1016","volume":"261","author":[{"given":"Vaidotas","family":"Kiseliovas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miljan","family":"Milosevic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milos","family":"Kojic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linas","family":"Mazutis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megumi","family":"Kai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan Ting","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Yokoi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Ferrari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arturas","family":"Ziemys","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.jconrel.2017.05.031_bb0005","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.jconrel.2017.05.031_bb0010","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.tibtech.2009.12.007","article-title":"Frontiers in cancer nanomedicine: directing mass transport through biological barriers","volume":"28","author":"Ferrari","year":"2010","journal-title":"Trends Biotechnol."},{"issue":"8","key":"10.1016\/j.jconrel.2017.05.031_bb0015","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1063\/PT.3.1678","article-title":"Nanotechnology in cancer medicine","volume":"65","author":"Grossman","year":"2012","journal-title":"Phys. Today"},{"issue":"1","key":"10.1016\/j.jconrel.2017.05.031_bb0020","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0168-3659(99)00248-5","article-title":"Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review","volume":"65","author":"Maeda","year":"2000","journal-title":"J. Control. Release"},{"issue":"12 Part 1","key":"10.1016\/j.jconrel.2017.05.031_bb0025","first-page":"6387","article-title":"A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs","volume":"46","author":"Matsumura","year":"1986","journal-title":"Cancer Res."},{"key":"10.1016\/j.jconrel.2017.05.031_bb0030","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.jconrel.2015.09.044","article-title":"Liposomal doxorubicin extravasation controlled by phenotype-specific transport properties of tumor microenvironment and vascular barrier","volume":"217","author":"Yokoi","year":"2015","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2017.05.031_bb0035","article-title":"Computational analysis of drug transport in tumor microenvironment as a critical compartment for nanotherapeutic pharmacokinetics","author":"Ziemys","year":"2015","journal-title":"Drug Deliv."},{"issue":"8907","key":"10.1016\/j.jconrel.2017.05.031_bb0040","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1016\/S0140-6736(94)92399-X","article-title":"Association of intratumoral pharmacokinetics of fluorouracil with clinical response","volume":"343","author":"Presant","year":"1994","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.jconrel.2017.05.031_bb0045","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.clpt.2004.08.012","article-title":"Tumor-based pharmacokinetics has greater significance for anticancer drugs than does blood-based pharmacokinetics","volume":"76","author":"Wolf","year":"2004","journal-title":"Clin. Pharmacol. Therap."},{"issue":"5","key":"10.1016\/j.jconrel.2017.05.031_bb0050","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1128\/AAC.48.5.1441-1453.2004","article-title":"Issues in pharmacokinetics and pharmacodynamics of anti-infective agents: distribution in tissue","volume":"48","author":"M\u00fcller","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"issue":"16","key":"10.1016\/j.jconrel.2017.05.031_bb0055","doi-asserted-by":"crossref","first-page":"4239","DOI":"10.1158\/0008-5472.CAN-13-3494","article-title":"Capillary-wall collagen as a biophysical marker of nanotherapeutic permeability into the tumor microenvironment","volume":"74","author":"Yokoi","year":"2014","journal-title":"Cancer Res."},{"key":"10.1016\/j.jconrel.2017.05.031_bb0060","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.jconrel.2014.03.057","article-title":"EPR: evidence and fallacy","volume":"190","author":"Nichols","year":"2014","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2017.05.031_bb0065","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jconrel.2016.11.015","article-title":"To exploit the tumor microenvironment: since the EPR effect fails in the clinic, what is the future of nanomedicine?","volume":"244","author":"Danhier","year":"2016","journal-title":"J. Control. Release"},{"issue":"3","key":"10.1016\/j.jconrel.2017.05.031_bb0070","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/micc.12228","article-title":"A retrospective 30 years after discovery of the enhanced permeability and retention effect of solid tumors: next-generation chemotherapeutics and photodynamic therapy\u2014problems, solutions, and prospects","volume":"23","author":"Maeda","year":"2016","journal-title":"Microcirculation"},{"key":"10.1016\/j.jconrel.2017.05.031_bb0075","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.addr.2015.01.002","article-title":"Toward a full understanding of the EPR effect in primary and metastatic tumors as well as issues related to its heterogeneity","volume":"91","author":"Maeda","year":"2015","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"3","key":"10.1016\/j.jconrel.2017.05.031_bb0080","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.jconrel.2013.09.026","article-title":"Mind the gap: a survey of how cancer drug carriers are susceptible to the gap between research and practice","volume":"172","author":"Stirland","year":"2013","journal-title":"J. Control. Release"},{"issue":"8","key":"10.1016\/j.jconrel.2017.05.031_bb0085","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.addr.2011.04.002","article-title":"Role of tumor vascular architecture in drug delivery","volume":"63","author":"Narang","year":"2011","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"18","key":"10.1016\/j.jconrel.2017.05.031_bb0090","first-page":"5110","article-title":"Microvascular pressure is the principal driving force for interstitial hypertension in solid tumors: implications for vascular collapse","volume":"52","author":"Boucher","year":"1992","journal-title":"Cancer Res."},{"issue":"3","key":"10.1016\/j.jconrel.2017.05.031_bb0095","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/sj.neo.7900037","article-title":"Causes and effects of heterogeneous perfusion in tumors","volume":"1","author":"Gillies","year":"1999","journal-title":"Neoplasia"},{"issue":"2","key":"10.1016\/j.jconrel.2017.05.031_bb0100","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s10456-010-9176-y","article-title":"Intravital microscopy in window chambers: a unique tool to study tumor angiogenesis and delivery of nanoparticles","volume":"13","author":"Hak","year":"2010","journal-title":"Angiogenesis"},{"issue":"6","key":"10.1016\/j.jconrel.2017.05.031_bb0105","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/nm0603-713","article-title":"Imaging of angiogenesis: from microscope to clinic","volume":"9","author":"McDonald","year":"2003","journal-title":"Nat. Med."},{"issue":"4","key":"10.1016\/j.jconrel.2017.05.031_bb0110","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/nrc778","article-title":"Dissecting tumour pathophysiology using intravital microscopy","volume":"2","author":"Jain","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jconrel.2017.05.031_bb0115","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.jconrel.2015.08.010","article-title":"Multistage vector (MSV) therapeutics","volume":"219","author":"Wolfram","year":"2015","journal-title":"J. Control. Release"},{"issue":"7","key":"10.1016\/j.jconrel.2017.05.031_bb0120","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"issue":"5","key":"10.1016\/j.jconrel.2017.05.031_bb0125","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/nprot.2013.046","article-title":"Single-cell analysis and sorting using droplet-based microfluidics","volume":"8","author":"Mazutis","year":"2013","journal-title":"Nat. Protoc."},{"issue":"11","key":"10.1016\/j.jconrel.2017.05.031_bb0130","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1002\/jemt.20829","article-title":"3D reconstruction of histological sections: application to mammary gland tissue","volume":"73","author":"Arganda-Carreras","year":"2010","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.jconrel.2017.05.031_bb0135","series-title":"Computer Modeling in Bioengineering: Theoretical Background, Examples and Software","first-page":"121","volume":"vol. 195","author":"Kojic","year":"2008"},{"issue":"2","key":"10.1016\/j.jconrel.2017.05.031_bb0140","doi-asserted-by":"crossref","first-page":"14","DOI":"10.5937\/jsscm1402014I","article-title":"A computational study of trajectories of micro-and nano-particles with different shapes in flow through small channels","volume":"8","author":"Isailovic","year":"2014","journal-title":"J. Serbian Soc. Comput. Mech."},{"key":"10.1016\/j.jconrel.2017.05.031_bb0145","series-title":"PAK-S \u2013 Finite Element Package for Linear and Nonlinear Analysis of Solids","author":"Kojic","year":"1998"},{"issue":"2","key":"10.1016\/j.jconrel.2017.05.031_bb0150","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1158\/0008-5472.CAN-15-1576","article-title":"Redirecting transport of nanoparticle albumin-bound paclitaxel to macrophages enhances therapeutic efficacy against liver metastases","volume":"76","author":"Tanei","year":"2016","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.jconrel.2017.05.031_bb0155","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.canlet.2013.11.015","article-title":"Serum biomarkers for personalization of nanotherapeutics-based therapy in different tumor and organ microenvironments","volume":"345","author":"Yokoi","year":"2014","journal-title":"Cancer Lett."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365917306260?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365917306260?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T15:32:29Z","timestamp":1759159949000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365917306260"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":31,"alternative-id":["S0168365917306260"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2017.05.031","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tumor progression effects on drug vector access to tumor-associated capillary bed","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2017.05.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}