{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T21:58:37Z","timestamp":1777240717888,"version":"3.51.4"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.jconrel.2017.07.018","type":"journal-article","created":{"date-parts":[[2017,7,11]],"date-time":"2017-07-11T14:46:20Z","timestamp":1499784380000},"page":"10-17","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"special_numbering":"C","title":["Development of PEGylated carboxylic acid-modified polyamidoamine dendrimers as bone-targeting carriers for the treatment of bone diseases"],"prefix":"10.1016","volume":"262","author":[{"given":"Shugo","family":"Yamashita","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidemasa","family":"Katsumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nozomi","family":"Hibino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yugo","family":"Isobe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumiko","family":"Yagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosuke","family":"Kusamori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiyasu","family":"Sakane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2017.07.018_bb0005","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1002\/aja.1001290408","article-title":"Morphological and physiological consideration in a new concept of calcium transport in bone","volume":"129","author":"Talmage","year":"1970","journal-title":"Am. J. Anat."},{"key":"10.1016\/j.jconrel.2017.07.018_bb0010","first-page":"4","article-title":"The physiology of bone blood flow: a review","volume":"88","author":"McCarthy","year":"2006","journal-title":"J. Bone Joint Surg. Am."},{"key":"10.1016\/j.jconrel.2017.07.018_bb0015","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1002\/jps.24476","article-title":"Actively targeted delivery of doxorubicin to bone metastases by a pH-sensitive conjugation","volume":"104","author":"Ye","year":"2015","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2017.07.018_bb0020","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.addr.2004.12.011","article-title":"Bone-targeting macromolecular therapeutics","volume":"57","author":"Wang","year":"2005","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2017.07.018_bb0025","doi-asserted-by":"crossref","first-page":"e0135966","DOI":"10.1371\/journal.pone.0135966","article-title":"Molecular design of bisphosphonate-modified proteins for efficient bone targeting in vivo","volume":"10","author":"Katsumi","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jconrel.2017.07.018_bb0030","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1038\/nature02079","article-title":"Bone recognition mechanism of porcine osteocalcin from crystal structure","volume":"425","author":"Hoang","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.jconrel.2017.07.018_bb0035","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0167-4838(95)00190-5","article-title":"Acidic amino acid-rich sequences as binding sites of osteonectin to hydroxyapatite crystals","volume":"1292","author":"Fujisawa","year":"1996","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jconrel.2017.07.018_bb0040","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1359\/jbmr.2000.15.5.936","article-title":"Selective drug delivery system to bone: small peptide (Asp)6 conjugation","volume":"15","author":"Kasugai","year":"2000","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.jconrel.2017.07.018_bb0045","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s00223-009-9312-0","article-title":"Specific binding and mineralization of calcified surfaces by small peptides","volume":"86","author":"Yarbrough","year":"2010","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.jconrel.2017.07.018_bb0050","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1021\/acs.molpharmaceut.6b00557","article-title":"Development of PEGylated cysteine-modified lysine dendrimers with multiple reduced thiols to prevent hepatic ischemia\/reperfusion injury","volume":"13","author":"Katsumi","year":"2016","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jconrel.2017.07.018_bb0055","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.1007\/s11095-006-9122-2","article-title":"Transport of poly(amidoamine) dendrimers across Caco-2 cell monolayers: influence of size, charge and fluorescent labeling","volume":"23","author":"Kitchens","year":"2006","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2017.07.018_bb0060","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/0020-708X(82)90144-2","article-title":"The preparation and labeling of DTPA-coupled albumin","volume":"33","author":"Hnatowich","year":"1982","journal-title":"Int. J. Appl. Radiat. Isot."},{"key":"10.1016\/j.jconrel.2017.07.018_bb0065","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1089\/cbr.2004.19.627","article-title":"Preclinical investigations of drug and radionuclide conjugates of bisphosphonates for the treatment of metastatic bone cancer","volume":"19","author":"El-Mabhouh","year":"2004","journal-title":"Cancer Biother. Radiopharm."},{"key":"10.1016\/j.jconrel.2017.07.018_bb0070","first-page":"879","article-title":"A pharmacokinetic analysis program (MULTI) for microcomputer","volume":"4","author":"Yamaoka","year":"1981","journal-title":"Aust. J. Pharm."},{"key":"10.1016\/j.jconrel.2017.07.018_bb0075","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1021\/nn700062z","article-title":"Multimodal nanoprobes for radionuclide and five-color near-infrared optical lymphatic imaging","volume":"1","author":"Kobayashi","year":"2007","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2017.07.018_bb0080","doi-asserted-by":"crossref","first-page":"715","DOI":"10.4028\/www.scientific.net\/KEM.240-242.715","article-title":"Quantitative monitoring of in vitro mineralization process using fluorescent dyes","volume":"240","author":"Hirose","year":"2003","journal-title":"Key Eng. Mater."},{"key":"10.1016\/j.jconrel.2017.07.018_bb0085","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nm.2617","article-title":"A delivery system targeting bone formation surfaces to facilitate RNAi-based anabolic therapy","volume":"18","author":"Zhang","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.jconrel.2017.07.018_bb0090","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1679\/aohc.66.123","article-title":"Use of a new adhesive film for the preparation of multi-purpose fresh-frozen sections from hard tissues, whole-animals, insects, and plants","volume":"66","author":"Kawamoto","year":"2003","journal-title":"Arch. Histol. Cytol."},{"key":"10.1016\/j.jconrel.2017.07.018_bb0095","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.jconrel.2006.09.012","article-title":"PEGylated lysine dendrimers for tumor-selective targeting after intravenous injection in tumor-bearing mice","volume":"116","author":"Okuda","year":"2006","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2017.07.018_bb0100","doi-asserted-by":"crossref","first-page":"4428","DOI":"10.1016\/j.biomaterials.2006.04.019","article-title":"Nanocomposites of hydroxyapatite with aspartic acid and glutamic acid and their interaction with osteoblast-like cells","volume":"27","author":"Boanini","year":"2006","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2017.07.018_bb0105","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jconrel.2007.06.003","article-title":"Design of surface-modified poly(d,l-lactide-co-glycolide) nanoparticles for targeted drug delivery to bone","volume":"122","author":"Choi","year":"2007","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2017.07.018_bb0110","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1002\/jps.22773","article-title":"Development of bone-targeted catalase derivatives for inhibition of bone metastasis of tumor cells in mice","volume":"101","author":"Zheng","year":"2012","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2017.07.018_bb0115","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/0003-2697(84)90241-0","article-title":"The interaction of proteins with hydroxyapatite: III. Mechanism","volume":"136","author":"Gorbunoff","year":"1984","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.jconrel.2017.07.018_bb0120","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nbt798","article-title":"Synthesis of a poly(vinylpyrrolidone-co-dimethyl maleic anhydride) co-polymer and its application for renal drug targeting","volume":"21","author":"Kamada","year":"2003","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jconrel.2017.07.018_bb0125","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jconrel.2003.11.017","article-title":"Poly(vinylpyrrolidone-co-dimethyl maleic acid) as a novel renal targeting carrier","volume":"95","author":"Yamamoto","year":"2004","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2017.07.018_bb0130","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1124\/jpet.301.2.467","article-title":"Pharmacokinetic analysis of in vivo disposition of succinylated proteins targeted to liver nonparenchymal cells via scavenger receptors: importance of molecular size and negative charge density for in vivo recognition by receptors","volume":"301","author":"Yamasaki","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.jconrel.2017.07.018_bb0135","first-page":"377","article-title":"The fine structure of the proximal growth plate of the avian tibia","volume":"128","author":"Howlett","year":"1979","journal-title":"J. Anat."},{"key":"10.1016\/j.jconrel.2017.07.018_bb0140","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0034-5288(18)30518-6","article-title":"Vascular pattern of the developing proximal femur in the domestic fowl","volume":"40","author":"Thorp","year":"1986","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.jconrel.2017.07.018_bb0145","doi-asserted-by":"crossref","first-page":"14170","DOI":"10.1073\/pnas.1208916109","article-title":"The role of intracellular calcium phosphate in osteoblast-mediated bone apatite formation","volume":"109","author":"Boonrungsiman","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jconrel.2017.07.018_bb0150","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.bone.2003.12.012","article-title":"The degree of mineralization is a determinant of bone strength: a study on human calcanei","volume":"34","author":"Follet","year":"2004","journal-title":"Bone"},{"key":"10.1016\/j.jconrel.2017.07.018_bb0155","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1056\/NEJM200103223441207","article-title":"Cytokine pathways and joint inflammation in rheumatoid arthritis","volume":"344","author":"Choy","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jconrel.2017.07.018_bb0160","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s00418-001-0376-9","article-title":"RANK ligand, RANK, and OPG expression in type II collagen-induced arthritis mouse","volume":"117","author":"Mori","year":"2002","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.jconrel.2017.07.018_bb0165","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1101\/gad.12.9.1260","article-title":"Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification","volume":"12","author":"Bucay","year":"1998","journal-title":"Genes Dev."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365917307277?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365917307277?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,29]],"date-time":"2019-09-29T11:06:37Z","timestamp":1569755197000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365917307277"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":33,"alternative-id":["S0168365917307277"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2017.07.018","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of PEGylated carboxylic acid-modified polyamidoamine dendrimers as bone-targeting carriers for the treatment of bone diseases","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2017.07.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}