{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:11:01Z","timestamp":1790262661340,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"MINECO\/ISCIII","award":["SAF2017-87349-R"],"award-info":[{"award-number":["SAF2017-87349-R"]}]},{"name":"MINECO\/ISCIII","award":["PIE14\/00034"],"award-info":[{"award-number":["PIE14\/00034"]}]},{"name":"the Catalan government","award":["2017 SGR 1604"],"award-info":[{"award-number":["2017 SGR 1604"]}]},{"DOI":"10.13039\/100008666","name":"Fundaci\u00f3 la Marat\u00f3 de TV3","doi-asserted-by":"publisher","award":["20152031"],"award-info":[{"award-number":["20152031"]}],"id":[{"id":"10.13039\/100008666","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"FWO","doi-asserted-by":"publisher","award":["SBO-140028"],"award-info":[{"award-number":["SBO-140028"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIDDK Intramural Research Program","award":["ZIADK031117"],"award-info":[{"award-number":["ZIADK031117"]}]},{"name":"MINECO\/FEDER","award":["CTQ2015-65439-R"],"award-info":[{"award-number":["CTQ2015-65439-R"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.jconrel.2018.05.033","type":"journal-article","created":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T22:31:49Z","timestamp":1527805909000},"page":"135-142","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"special_numbering":"C","title":["Remote control of movement disorders using a photoactive adenosine A2A receptor antagonist"],"prefix":"10.1016","volume":"283","author":[{"given":"Jaume","family":"Taura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernest G.","family":"Nolen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisela","family":"Cabr\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Hernando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Squarcialupi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"L\u00f3pez-Cano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8104-1493","authenticated-orcid":false,"given":"Kenneth A.","family":"Jacobson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00edctor","family":"Fern\u00e1ndez-Due\u00f1as","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0832-3739","authenticated-orcid":false,"given":"Francisco","family":"Ciruela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl. 4","key":"10.1016\/j.jconrel.2018.05.033_bb0005","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.1016\/S1353-8020(09)70831-4","article-title":"The clinical progression of Parkinson's disease","volume":"15","author":"Poewe","year":"2009","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.jconrel.2018.05.033_bb0010","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1146\/annurev.biochem.74.082803.133400","article-title":"The biochemistry of Parkinson's disease","volume":"74","author":"Cookson","year":"2005","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.jconrel.2018.05.033_bb0015","series-title":"Handbook of Chemical Neuroanatomy, Elsevier, Amsterdam","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0924-8196(96)80004-2","article-title":"The basal ganglia","author":"Gerfen","year":"1996"},{"key":"10.1016\/j.jconrel.2018.05.033_bb0020","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1007\/s002130100799","article-title":"Neural circuit regulation of prepulse inhibition of startle in the rat: current knowledge and future challenges","volume":"156","author":"Swerdlow","year":"2001","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.jconrel.2018.05.033_bb0025","doi-asserted-by":"crossref","first-page":"6262","DOI":"10.1523\/JNEUROSCI.0015-10.2010","article-title":"Coding of task reward value in the dorsal raphe nucleus","volume":"30","author":"Bromberg-Martin","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jconrel.2018.05.033_bb0030","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1517\/14656566.4.10.1747","article-title":"Rationale for current therapies in Parkinson's disease","volume":"4","author":"Romrell","year":"2003","journal-title":"Expert. Opin. Pharmacother."},{"key":"10.1016\/j.jconrel.2018.05.033_bb0035","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1124\/pr.111.005678","article-title":"The pharmacology of L-DOPA-induced dyskinesia in Parkinson's disease","volume":"65","author":"Huot","year":"2013","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.jconrel.2018.05.033_bb0040","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/S1474-4422(08)70214-X","article-title":"Non-dopaminergic treatments in development for Parkinson's disease","volume":"7","author":"Fox","year":"2008","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.jconrel.2018.05.033_bb0045","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1212\/WNL.52.8.1673","article-title":"Antiparkinsonian effect of a new selective adenosine A2A receptor antagonist in MPTP-treated monkeys","volume":"52","author":"Grondin","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.jconrel.2018.05.033_bb0050","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1212\/01.WNL.0000073136.00548.D4","article-title":"Adenosine A2A receptor antagonist treatment of Parkinson's disease","volume":"61","author":"Bara-Jimenez","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.jconrel.2018.05.033_bb0055","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1517\/14740338.2015.1014798","article-title":"The safety of istradefylline for the treatment of Parkinson's disease","volume":"14","author":"M\u00fcller","year":"2015","journal-title":"Expert Opin. Drug Saf."},{"key":"10.1016\/j.jconrel.2018.05.033_bb0060","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/S0306-4522(99)00473-X","article-title":"Localization and action of adenosine A2A receptors in regions of the brainstem important in cardiovascular control","volume":"95","author":"Thomas","year":"2000","journal-title":"Neuroscience"},{"key":"10.1016\/j.jconrel.2018.05.033_bb0065","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1161\/01.CIR.102.3.285","article-title":"Dose and time effects of caffeine intake on human platelet adenosine A2A receptors: functional and biochemical aspects","volume":"102","author":"Varani","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.jconrel.2018.05.033_bb0070","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/sj.bjp.0703532","article-title":"Study of A 2A adenosine receptor gene deficient mice reveals that adenosine analogue CGS 21680 possesses no A 2A receptor-unrelated lymphotoxicity","volume":"131","author":"Apasov","year":"2000","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jconrel.2018.05.033_bb0075","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1046\/j.1471-4159.1994.63010207.x","article-title":"Excitatory and inhibitory effects of A1 and A2A adenosine receptor activation on the electrically evoked [3H]acetylcholine release from different areas of the rat hippocampus","volume":"63","author":"Cunha","year":"1994","journal-title":"J. Neurochem."},{"key":"10.1016\/j.jconrel.2018.05.033_bb0080","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1038\/sj.bjp.0703170","article-title":"The stimulant effects of caffeine on locomotor behaviour in mice are mediated through its blockade of adenosine A2A receptors","volume":"129","author":"El Yacoubi","year":"2000","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jconrel.2018.05.033_bb0085","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1038\/nn1491","article-title":"Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine","volume":"8","author":"Huang","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jconrel.2018.05.033_bb0090","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1038\/nn.4094","article-title":"Optogenetics and the future of neuroscience","volume":"18","author":"Boyden","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jconrel.2018.05.033_bb0095","first-page":"97","article-title":"Optogenetics enlightens neuroscience drug discovery","volume":"15","author":"Song","year":"2016","journal-title":"Nat. Rev."},{"key":"10.1016\/j.jconrel.2018.05.033_bb0100","doi-asserted-by":"crossref","first-page":"10978","DOI":"10.1002\/anie.201601931","article-title":"Emerging targets in photopharmacology","volume":"55","author":"Lerch","year":"2016","journal-title":"Angew. Chem."},{"key":"10.1016\/j.jconrel.2018.05.033_bb0105","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1021\/ja413063e","article-title":"Photopharmacology: beyond proof of principle","volume":"136","author":"Velema","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jconrel.2018.05.033_bb0110","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1021\/bc5003373","article-title":"Photomodulation of G protein-coupled adenosine receptors by a novel light-switchable ligand","volume":"25","author":"Bahamonde","year":"2014","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.jconrel.2018.05.033_bb0115","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1039\/C3CC48263D","article-title":"Photoreleasable thiol chemistry for facile and efficient bioconjugation","volume":"50","author":"Liu","year":"2014","journal-title":"Chem. Commun."},{"key":"10.1016\/j.jconrel.2018.05.033_bb0120","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1021\/ac9507653","article-title":"A photochemical procedure for determining reaction quantum efficiencies in systems with multicomponent inner filter absorbances","volume":"68","author":"Lees","year":"1996","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jconrel.2018.05.033_bb0125","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.1021\/cb5005383","article-title":"Uncovering Caffeine's adenosine A2A receptor inverse Agonism in experimental parkinsonism","volume":"9","author":"Fern\u00e1ndez-Due\u00f1as","year":"2014","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.jconrel.2018.05.033_bb0130","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.neuint.2013.04.006","article-title":"Dopamine D2 receptor-mediated modulation of adenosine A2A receptor agonist binding within the A2AR\/D2R oligomer framework","volume":"63","author":"Fern\u00e1ndez-Due\u00f1as","year":"2013","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.jconrel.2018.05.033_bb0135","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/978-1-4939-3064-7_28","article-title":"Determination of GPCR-mediated cAMP accumulation in rat striatal synaptosomes","volume":"110","author":"Taura","year":"2016","journal-title":"NeuroMethods"},{"key":"10.1016\/j.jconrel.2018.05.033_bb0140","series-title":"Special Report: The 1996 Guide for the Care and Use of Laboratory Animals","first-page":"41","volume":"vol. 38","author":"Clark","year":"1997"},{"key":"10.1016\/j.jconrel.2018.05.033_bb0145","series-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Franklin","year":"2008"},{"key":"10.1016\/j.jconrel.2018.05.033_bb0150","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S0301-0082(98)00053-7","article-title":"Tremulous jaw movements in rats: a model of parkinsonian tremor","volume":"56","author":"Salamone","year":"1998","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.jconrel.2018.05.033_bb0155","doi-asserted-by":"crossref","first-page":"4359","DOI":"10.1021\/jm0009843","article-title":"Design, radiosynthesis, and biodistribution of a new potent and selective ligand for in vivo imaging of the adenosine A2A receptor system using positron emission tomography","volume":"43","author":"Todde","year":"2000","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jconrel.2018.05.033_bb0160","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.23545","article-title":"Optical control of pain in vivo with a photoactive mGlu 5 receptor negative allosteric modulator","volume":"6","author":"Font","year":"2017","journal-title":"elife"},{"key":"10.1016\/j.jconrel.2018.05.033_bb0165","doi-asserted-by":"crossref","first-page":"4620","DOI":"10.1021\/ol201842x","article-title":"Coumarin-caged dG for improved wavelength-selective uncaging of DNA","volume":"13","author":"Menge","year":"2011","journal-title":"Org. Lett."},{"key":"10.1016\/j.jconrel.2018.05.033_bb0170","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0968-0896(01)00254-1","article-title":"Rapid photolytic release of cytidine 5\u2032-diphosphate from a coumarin derivative: a new tool for the investigation of ribonucleotide reductases","volume":"10","author":"Sch\u00f6nleber","year":"2002","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.jconrel.2018.05.033_bb0175","doi-asserted-by":"crossref","DOI":"10.1111\/gbb.12432","article-title":"Behavioral control by striatal adenosine A 2A -dopamine D 2 receptor heteromers","volume":"17","author":"Taura","year":"2018","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.jconrel.2018.05.033_bb0180","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.pbb.2009.11.011","article-title":"Oral tremor induced by the muscarinic agonist pilocarpine is suppressed by the adenosine A2A antagonists MSX-3 and SCH58261, but not the adenosine A1 antagonist DPCPX","volume":"94","author":"Collins","year":"2010","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.jconrel.2018.05.033_bb0185","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s40263-014-0161-7","article-title":"Adenosine A2A receptor antagonists in Parkinson's disease: progress in clinical trials from the newly approved istradefylline to drugs in early development and those already discontinued","volume":"28","author":"Pinna","year":"2014","journal-title":"CNS Drugs"},{"key":"10.1016\/j.jconrel.2018.05.033_bb0190","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1212\/WNL.0000000000004003","article-title":"Preladenant early Parkinson disease study group, randomized trial of preladenant, given as monotherapy, in patients with early Parkinson disease","volume":"88","author":"Stocchi","year":"2017","journal-title":"Neurology"},{"key":"10.1016\/j.jconrel.2018.05.033_bb0195","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S1474-4422(11)70012-6","article-title":"Preladenant in patients with Parkinson's disease and motor fluctuations: a phase 2, double-blind, randomised trial","volume":"10","author":"Hauser","year":"2011","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.jconrel.2018.05.033_bb0200","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1007\/s40265-013-0066-7","article-title":"Istradefylline: first global approval","volume":"73","author":"Dungo","year":"2013","journal-title":"Drugs"},{"key":"10.1016\/j.jconrel.2018.05.033_bb0205","doi-asserted-by":"crossref","first-page":"2970","DOI":"10.1523\/JNEUROSCI.5255-07.2008","article-title":"A critical role of the adenosine A2A receptor in extrastriatal neurons in modulating psychomotor activity as revealed by opposite phenotypes of striatum and forebrain A2A receptor knock-outs","volume":"28","author":"Shen","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jconrel.2018.05.033_bb0210","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/nmeth1072","article-title":"Caged compounds: photorelease technology for control of cellular chemistry and physiology","volume":"4","author":"Ellis-Davies","year":"2007","journal-title":"Nat. Methods"},{"key":"10.1016\/j.jconrel.2018.05.033_bb0215","doi-asserted-by":"crossref","first-page":"S143","DOI":"10.1088\/1741-2560\/4\/3\/S02","article-title":"An optical neural interface: in vivo control of rodent motor cortex with integrated fiberoptic and optogenetic technology","volume":"4","author":"Aravanis","year":"2007","journal-title":"J. Neural Eng."},{"key":"10.1016\/j.jconrel.2018.05.033_bb0220","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.neuron.2016.12.031","article-title":"Flexible near-field wireless optoelectronics as subdermal implants for broad applications in Optogenetics","volume":"93","author":"Shin","year":"2017","journal-title":"Neuron"}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365918303171?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365918303171?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T15:35:55Z","timestamp":1759160155000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365918303171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":44,"alternative-id":["S0168365918303171"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2018.05.033","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Remote control of movement disorders using a photoactive adenosine A2A receptor antagonist","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2018.05.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}