{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T22:08:50Z","timestamp":1793311730169,"version":"4.5.0"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F30 HL134255"],"award-info":[{"award-number":["F30 HL134255"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL137365"],"award-info":[{"award-number":["R01HL137365"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL063954"],"award-info":[{"award-number":["R01HL063954"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.jconrel.2018.07.004","type":"journal-article","created":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T13:40:20Z","timestamp":1530711620000},"page":"152-161","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":124,"special_numbering":"C","title":["Injectable and protease-degradable hydrogel for siRNA sequestration and triggered delivery to the heart"],"prefix":"10.1016","volume":"285","author":[{"given":"Leo L.","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer J.","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth C.","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selen","family":"Uman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavan","family":"Atluri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2006-332X","authenticated-orcid":false,"given":"Jason A.","family":"Burdick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2018.07.004_bb0005","doi-asserted-by":"crossref","first-page":"e146","DOI":"10.1161\/CIR.0000000000000485","article-title":"Heart disease and stroke statistics\u20142017 update: a report from the American Heart Association","volume":"135","author":"Benjamin","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.jconrel.2018.07.004_bb0010","first-page":"e28","article-title":"Heart disease and stroke statistics--2014 update: a report from the American Heart Association","volume":"129","author":"Go","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.jconrel.2018.07.004_bb0015","first-page":"e29","article-title":"Heart disease and stroke Statistics-2015 update: a report from the American Heart Association","volume":"131","author":"Mozaffarian","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.jconrel.2018.07.004_bb0020","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1161\/01.CIR.99.1.135","article-title":"Restraining infarct expansion preserves left ventricular geometry and function after acute anteroapical infarction","volume":"99","author":"Kelley","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.jconrel.2018.07.004_bb0025","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1016\/j.athoracsur.2005.05.089","article-title":"Early Postinfarction ventricular restraint improves Borderzone Wall thickening dynamics during remodeling","volume":"80","author":"Pilla","year":"2005","journal-title":"Ann. Thorac. Surg."},{"key":"10.1016\/j.jconrel.2018.07.004_bb0030","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/S0003-4975(02)03747-5","article-title":"Infarct restraint attenuates remodeling and reduces chronic ischemic mitral regurgitation after postero-lateral infarction","volume":"74","author":"Moainie","year":"2002","journal-title":"Ann. Thorac. Surg."},{"key":"10.1016\/j.jconrel.2018.07.004_bb0035","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1007\/s12265-011-9291-1","article-title":"Injectable acellular hydrogels for cardiac repair","volume":"4","author":"Tous","year":"2011","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"10.1016\/j.jconrel.2018.07.004_bb0040","doi-asserted-by":"crossref","first-page":"173ra25","DOI":"10.1126\/scitranslmed.3005503","article-title":"Safety and efficacy of an injectable extracellular matrix hydrogel for treating myocardial infarction","volume":"5","author":"Seif-Naraghi","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jconrel.2018.07.004_bb0045","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.116.004058","article-title":"Injectable shear-thinning hydrogels for minimally invasive delivery to infarcted myocardium to limit left ventricular remodeling","volume":"9","author":"Rodell","year":"2016","journal-title":"Circ. Cardiovasc. Interv."},{"key":"10.1016\/j.jconrel.2018.07.004_bb0050","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.1002\/adma.201205234","article-title":"Oxime cross-linked injectable hydrogels for catheter delivery","volume":"25","author":"Grover","year":"2013","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2018.07.004_bb0055","doi-asserted-by":"crossref","first-page":"3146","DOI":"10.1021\/acsbiomaterials.7b00734","article-title":"Methods to assess shear-thinning hydrogels for application as injectable biomaterials","volume":"3","author":"Chen","year":"2017","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.jconrel.2018.07.004_bb0060","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.jbiomech.2017.08.024","article-title":"Computational sensitivity investigation of hydrogel injection characteristics for myocardial support","volume":"64","author":"Wang","year":"2017","journal-title":"J. Biomech."},{"key":"10.1016\/j.jconrel.2018.07.004_bb0065","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1093\/cvr\/cvn154","article-title":"Post-infarct treatment with an erythropoietin-gelatin hydrogel drug delivery system for cardiac repair","volume":"79","author":"Kobayashi","year":"2008","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.jconrel.2018.07.004_bb0070","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/nmat3922","article-title":"Injectable and bioresponsive hydrogels for on-demand matrix metalloproteinase inhibition","volume":"13","author":"Purcell","year":"2014","journal-title":"Nat. Mater."},{"key":"10.1016\/j.jconrel.2018.07.004_bb0075","doi-asserted-by":"crossref","DOI":"10.3791\/52450","article-title":"An injectable and drug-loaded supramolecular hydrogel for local catheter injection into the pig heart","author":"Pape","year":"2015","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.jconrel.2018.07.004_bb0080","doi-asserted-by":"crossref","first-page":"8050","DOI":"10.1021\/nn5020787","article-title":"Injectable graphene oxide\/hydrogel-based angiogenic gene delivery system for Vasculogenesis and cardiac repair","volume":"8","author":"Paul","year":"2014","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2018.07.004_bb0085","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201601041","article-title":"Engineered hydrogels for local and sustained delivery of RNA-interference therapies","volume":"6","author":"Wang","year":"2017","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.jconrel.2018.07.004_bb0090","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1038\/s41551-017-0157-y","article-title":"Sustained miRNA delivery from an injectable hydrogel promotes cardiomyocyte proliferation and functional regeneration after ischaemic injury","volume":"1","author":"Wang","year":"2017","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.jconrel.2018.07.004_bb0095","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1081\/DDC-120006428","article-title":"Stimulus-responsive \u201csmart\u201d hydrogels as novel drug delivery systems","volume":"28","author":"Soppimath","year":"2002","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.jconrel.2018.07.004_bb0100","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1161\/CIRCULATIONAHA.108.786640","article-title":"Dynamic changes in matrix metalloprotienase activity within the human myocardial interstitium during myocardial arrest and reperfusion","volume":"118","author":"Spinale","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.jconrel.2018.07.004_bb0105","first-page":"727","article-title":"Matrix metalloproteinases and myocardial infarction","volume":"23","author":"Phatharajaree","year":"2007","journal-title":"Can. J. Cardiol."},{"key":"10.1016\/j.jconrel.2018.07.004_bb0110","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.3390\/cancers6031298","article-title":"Roles of matrix metalloproteinases and their natural inhibitors in prostate cancer progression","volume":"6","author":"Gong","year":"2014","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jconrel.2018.07.004_bb0115","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.cardiores.2005.10.002","article-title":"Relevance of matrix metalloproteinases and their inhibitors after myocardial infarction: a temporal and spatial window","volume":"69","author":"Vanhoutte","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.jconrel.2018.07.004_bb0120","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.1161\/01.CIR.0000068375.40887.FA","article-title":"Region- and type-specific induction of matrix metalloproteinases in post-myocardial infarction remodeling","volume":"107","author":"Wilson","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.jconrel.2018.07.004_bb0125","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.cardfail.2003.11.003","article-title":"Plasma MMP-9 and MMP-2 following acute myocardial infarction in man: correlation with echocardiographic and neurohumoral parameters of left ventricular dysfunction","volume":"10","author":"Squire","year":"2004","journal-title":"J. Card. Fail."},{"key":"10.1016\/j.jconrel.2018.07.004_bb0130","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1161\/01.CIR.99.23.3063","article-title":"Matrix metalloproteinase inhibition attenuates early left ventricular enlargement after experimental myocardial infarction in mice","volume":"99","author":"Rohde","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.jconrel.2018.07.004_bb0135","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1161\/01.CIR.0000046449.36178.00","article-title":"Myocardial infarct expansion and matrix metalloproteinase inhibition","volume":"107","author":"Mukherjee","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.jconrel.2018.07.004_bb0140","doi-asserted-by":"crossref","first-page":"H1229","DOI":"10.1152\/ajpheart.00207.2003","article-title":"Targeted deletion of MMP-2 attenuates early LV rupture and late remodeling after experimental myocardial infarction","volume":"285","author":"Hayashidani","year":"2003","journal-title":"Am. J. Physiol. Circ. Physiol."},{"key":"10.1016\/j.jconrel.2018.07.004_bb0145","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1172\/JCI22304","article-title":"Targeted deletion or pharmacological inhibition of MMP-2 prevents cardiac rupture after myocardial infarction in mice","volume":"115","author":"Matsumura","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jconrel.2018.07.004_bb0150","doi-asserted-by":"crossref","first-page":"C168","DOI":"10.1152\/ajpcell.00606.2004","article-title":"Matrix metalloproteinases mediate \u03b2-adrenergic receptor-stimulated apoptosis in adult rat ventricular myocytes","volume":"289","author":"Menon","year":"2005","journal-title":"Am. J. Physiol. Physiol."},{"key":"10.1016\/j.jconrel.2018.07.004_bb0155","doi-asserted-by":"crossref","first-page":"C254","DOI":"10.1152\/ajpcell.00235.2005","article-title":"\u03b2-Adrenergic receptor-stimulated apoptosis in adult cardiac myocytes involves MMP-2-mediated disruption of \u03b2 1 integrin signaling and mitochondrial pathway","volume":"290","author":"Menon","year":"2006","journal-title":"Am. J. Physiol. Physiol."},{"key":"10.1016\/j.jconrel.2018.07.004_bb0160","first-page":"1","article-title":"Inhibition of MMP-2 expression with siRNA increases baseline cardiomyocyte contractility and protects against simulated ischemic reperfusion injury","volume":"2014","author":"Lin","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.jconrel.2018.07.004_bb0165","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1002\/sctm.16-0329","article-title":"MMP-2 and MMP-14 silencing inhibits VEGFR2 cleavage and induces the differentiation of porcine adipose-derived mesenchymal stem cells to endothelial cells","volume":"6","author":"Almalki","year":"2017","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.jconrel.2018.07.004_bb0170","series-title":"Specificity of Binding with Matrix Metalloproteinases","first-page":"35","author":"Gupta","year":"2012"},{"key":"10.1016\/j.jconrel.2018.07.004_bb0175","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.bbamcr.2010.01.003","article-title":"The tissue inhibitors of metalloproteinases (TIMPs): an ancient family with structural and functional diversity","volume":"1803","author":"Brew","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jconrel.2018.07.004_bb0180","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.cardiores.2005.12.002","article-title":"Structure and function of matrix metalloproteinases and TIMPs","volume":"69","author":"Nagase","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.jconrel.2018.07.004_bb0185","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1038\/nmat3765","article-title":"Delivery materials for siRNA therapeutics","volume":"12","author":"Kanasty","year":"2013","journal-title":"Nat. Mater."},{"key":"10.1016\/j.jconrel.2018.07.004_bb0190","doi-asserted-by":"crossref","first-page":"C199","DOI":"10.1152\/ajpcell.00329.2015","article-title":"Canstatin stimulates migration of rat cardiac fibroblasts via secretion of matrix metalloproteinase-2","volume":"312","author":"Okada","year":"2017","journal-title":"Am. J. Physiol. Physiol."},{"key":"10.1016\/j.jconrel.2018.07.004_bb0195","doi-asserted-by":"crossref","first-page":"4125","DOI":"10.1021\/bm401280z","article-title":"Rational design of network properties in guest\u2013host assembled and shear-thinning hyaluronic acid hydrogels","volume":"14","author":"Rodell","year":"2013","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.jconrel.2018.07.004_bb0200","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms7639","article-title":"Protease-degradable electrospun fibrous hydrogels","volume":"6","author":"Wade","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2018.07.004_bb0205","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.jconrel.2009.10.030","article-title":"Hydrogel-based drug delivery systems: comparison of drug diffusivity and release kinetics","volume":"142","author":"Brandl","year":"2010","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2018.07.004_bb0210","doi-asserted-by":"crossref","first-page":"8010","DOI":"10.1039\/C5TB00981B","article-title":"Sustained small molecule delivery from injectable hyaluronic acid hydrogels through host\u2013guest mediated retention","volume":"3","author":"Mealy","year":"2015","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.jconrel.2018.07.004_bb0215","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1021\/bm049508a","article-title":"Controlled degradation and mechanical behavior of photopolymerized hyaluronic acid networks","volume":"6","author":"Burdick","year":"2005","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.jconrel.2018.07.004_bb0220","first-page":"1","article-title":"Establishing primary adult fibroblast cultures from rodents","author":"Seluanov","year":"2010","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.jconrel.2018.07.004_bb0225","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1002\/jbm.a.36323","article-title":"Three-dimensional extrusion bioprinting of single- and double-network hydrogels containing dynamic covalent crosslinks","volume":"106A","author":"Wang","year":"2018","journal-title":"J. Biomed. Mater. Res. Part A"},{"key":"10.1016\/j.jconrel.2018.07.004_bb0230","article-title":"Covalently adaptable elastin-like protein-hyaluronic acid (ELP-HA) hybrid hydrogels with secondary thermoresponsive crosslinking for injectable stem cell delivery","volume":"27","author":"Wang","year":"2017","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.jconrel.2018.07.004_bb0235","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1021\/acs.bioconjchem.5b00483","article-title":"Supramolecular guest\u2013host interactions for the preparation of biomedical materials","volume":"26","author":"Rodell","year":"2015","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.jconrel.2018.07.004_bb0240","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1021\/ma702607r","article-title":"Self-Assembling Hydrogels Based on \u03b2-cyclodextrin\/Cholesterol Inclusion Complexes","volume":"41","author":"van de Manakker","year":"2008","journal-title":"Macromolecules"},{"key":"10.1016\/j.jconrel.2018.07.004_bb0245","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.1002\/adfm.200900603","article-title":"Protein-release behavior of self-assembled PEG- \u03b2 -cyclodextrin\/PEG-cholesterol hydrogels","volume":"19","author":"van de Manakker","year":"2009","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.jconrel.2018.07.004_bb0250","doi-asserted-by":"crossref","first-page":"415","DOI":"10.2174\/1567201812666150326113331","article-title":"Physically cross-linked hydrogels of \u03b2 -cyclodextrin polymer and poly(ethylene glycol)-cholesterol as delivery systems for macromolecules and small drug molecules","volume":"12","author":"Osman","year":"2015","journal-title":"Curr. Drug Deliv."},{"key":"10.1016\/j.jconrel.2018.07.004_bb0255","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.pharmthera.2009.05.002","article-title":"Cardiac fibroblasts: at the heart of myocardial remodeling","volume":"123","author":"Porter","year":"2009","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.jconrel.2018.07.004_bb0260","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/iub.594","article-title":"Regulation of myocardial matrix metalloproteinase expression and activity by cardiac fibroblasts","volume":"64","author":"Turner","year":"2012","journal-title":"IUBMB Life"},{"key":"10.1016\/j.jconrel.2018.07.004_bb0265","doi-asserted-by":"crossref","first-page":"H2216","DOI":"10.1152\/ajpheart.01343.2005","article-title":"Selective spatiotemporal induction of matrix metalloproteinase-2 and matrix metalloproteinase-9 transcription after myocardial infarction","volume":"291","author":"Mukherjee","year":"2006","journal-title":"Am. J. Physiol. Circ. Physiol."},{"key":"10.1016\/j.jconrel.2018.07.004_bb0270","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/90273","article-title":"Determination of protease cleavage site motifs using mixture-based oriented peptide libraries","volume":"19","author":"Turk","year":"2001","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jconrel.2018.07.004_bb0275","doi-asserted-by":"crossref","first-page":"7836","DOI":"10.1016\/j.biomaterials.2010.06.061","article-title":"Enhanced proteolytic degradation of molecularly engineered PEG hydrogels in response to MMP-1 and MMP-2","volume":"31","author":"Patterson","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2018.07.004_bb0280","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1006\/excr.2000.5118","article-title":"MT1-MMP initiates activation of pro-MMP-2 and integrin \u03b1v\u03b23 promotes maturation of MMP-2 in breast carcinoma cells","volume":"263","author":"Deryugina","year":"2001","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.jconrel.2018.07.004_bb0285","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/S0006-291X(03)01405-0","article-title":"Pro-MMP-9 activation by the MT1-MMP\/MMP-2 axis and MMP-3: role of TIMP-2 and plasma membranes","volume":"308","author":"Toth","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365918303985?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365918303985?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T15:36:48Z","timestamp":1759160208000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365918303985"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":57,"alternative-id":["S0168365918303985"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2018.07.004","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Injectable and protease-degradable hydrogel for siRNA sequestration and triggered delivery to the heart","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2018.07.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}