{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:33:38Z","timestamp":1790674418216,"version":"4.1.0"},"reference-count":77,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"am","delay-in-days":334,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100007890","name":"University of North Carolina at Chapel Hill","doi-asserted-by":"publisher","award":["5U19AI109784-03"],"award-info":[{"award-number":["5U19AI109784-03"]}],"id":[{"id":"10.13039\/100007890","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["UC6-AI058607"],"award-info":[{"award-number":["UC6-AI058607"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["ECCS-1542015"],"award-info":[{"award-number":["ECCS-1542015"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.jconrel.2018.09.020","type":"journal-article","created":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T13:05:48Z","timestamp":1537794348000},"page":"114-124","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":74,"special_numbering":"C","title":["Investigation of tunable acetalated dextran microparticle platform to optimize M2e-based influenza vaccine efficacy"],"prefix":"10.1016","volume":"289","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7145-0776","authenticated-orcid":false,"given":"Naihan","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew D.","family":"Gallovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Tiet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny P.-Y.","family":"Ting","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristy M.","family":"Ainslie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric M.","family":"Bachelder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"27","key":"10.1016\/j.jconrel.2018.09.020_bb0010","doi-asserted-by":"crossref","first-page":"5086","DOI":"10.1016\/j.vaccine.2007.03.046","article-title":"The annual impact of seasonal influenza in the US: measuring disease burden and costs","volume":"25","author":"Molinari","year":"2007","journal-title":"Vaccine"},{"issue":"2","key":"10.1016\/j.jconrel.2018.09.020_bb0015","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1086\/595861","article-title":"Effectiveness of inactivated influenza vaccines varied substantially with antigenic match from the 2004\u20132005 season to the 2006\u20132007 season","volume":"199","author":"Belongia","year":"2009","journal-title":"J. Infect. Dis."},{"issue":"1","key":"10.1016\/j.jconrel.2018.09.020_bb0020","doi-asserted-by":"crossref","first-page":"105","DOI":"10.3390\/vaccines3010105","article-title":"M2e-based universal influenza A vaccines","volume":"3","author":"Deng","year":"2015","journal-title":"Vaccines (Basel)"},{"issue":"10","key":"10.1016\/j.jconrel.2018.09.020_bb0025","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1038\/13484","article-title":"A universal influenza A vaccine based on the extracellular domain of the M2 protein","volume":"5","author":"Neirynck","year":"1999","journal-title":"Nat. Med."},{"issue":"4 Suppl","key":"10.1016\/j.jconrel.2018.09.020_bb0030","doi-asserted-by":"crossref","first-page":"S63","DOI":"10.1038\/nm1210","article-title":"Targeting the innate immune response with improved vaccine adjuvants","volume":"11","author":"Pashine","year":"2005","journal-title":"Nat. Med."},{"issue":"5","key":"10.1016\/j.jconrel.2018.09.020_bb0035","doi-asserted-by":"crossref","first-page":"347","DOI":"10.4161\/hv.4.5.6438","article-title":"Vaccine adjuvants: the dream becomes real","volume":"4","author":"Tagliabue","year":"2008","journal-title":"Hum Vaccin"},{"key":"10.1016\/j.jconrel.2018.09.020_bb0040","first-page":"15","article-title":"Development of the CpG adjuvant 1018: a case study","volume":"2017","author":"Campbell","year":"1494","journal-title":"Methods Mol. Biol."},{"issue":"19","key":"10.1016\/j.jconrel.2018.09.020_bb0045","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1016\/j.vaccine.2008.02.063","article-title":"Alum boosts TH2-type antibody responses to whole-inactivated virus influenza vaccine in mice but does not confer superior protection","volume":"26","author":"Bungener","year":"2008","journal-title":"Vaccine"},{"issue":"4","key":"10.1016\/j.jconrel.2018.09.020_bb0050","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1177\/2051013613501988","article-title":"Rationale, progress and development of vaccines utilizing STING-activating cyclic dinucleotide adjuvants","volume":"1","author":"Dubensky","year":"2013","journal-title":"Ther Adv Vaccines"},{"key":"10.1016\/j.jconrel.2018.09.020_bb0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2017.11.030","article-title":"A robust microparticle platform for a STING-targeted adjuvant that enhances both humoral and cellular immunity during vaccination","volume":"270","author":"Junkins","year":"2018","journal-title":"J. Control. Release"},{"issue":"11","key":"10.1016\/j.jconrel.2018.09.020_bb0060","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1016\/j.jid.2016.05.105","article-title":"Natural STING agonist as an \"ideal\" adjuvant for cutaneous vaccination","volume":"136","author":"Wang","year":"2016","journal-title":"J Invest Dermatol"},{"issue":"8","key":"10.1016\/j.jconrel.2018.09.020_bb0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0104824","article-title":"Intranasal delivery of influenza rNP adjuvanted with c-di-AMP induces strong humoral and cellular immune responses and provides protection against virus challenge","volume":"9","author":"Sanchez","year":"2014","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.jconrel.2018.09.020_bb0070","first-page":"1235","article-title":"Intranasal vaccination with a plant-derived H5 HA vaccine protects mice and ferrets against highly pathogenic avian influenza virus challenge","volume":"11","author":"Major","year":"2015","journal-title":"Hum Vaccin Immunother"},{"issue":"31","key":"10.1016\/j.jconrel.2018.09.020_bb0075","doi-asserted-by":"crossref","first-page":"4973","DOI":"10.1016\/j.vaccine.2011.04.094","article-title":"Intranasal c-di-GMP-adjuvanted plant-derived H5 influenza vaccine induces multifunctional Th1 CD4+ cells and strong mucosal and systemic antibody responses in mice","volume":"29","author":"Madhun","year":"2011","journal-title":"Vaccine"},{"issue":"11","key":"10.1016\/j.jconrel.2018.09.020_bb0080","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0026973","article-title":"Evaluation of the sublingual route for administration of influenza H5N1 virosomes in combination with the bacterial second messenger c-di-GMP","volume":"6","author":"Pedersen","year":"2011","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.jconrel.2018.09.020_bb0085","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1111\/irv.12056","article-title":"A study of Chitosan and c-di-GMP as mucosal adjuvants for intranasal influenza H5N1 vaccine","volume":"7","author":"Svindland","year":"2013","journal-title":"Influenza Other Respir. Viruses"},{"issue":"26","key":"10.1016\/j.jconrel.2018.09.020_bb0090","doi-asserted-by":"crossref","first-page":"3216","DOI":"10.1016\/j.vaccine.2014.04.011","article-title":"A new adjuvanted nanoparticle-based H1N1 influenza vaccine induced antigen-specific local mucosal and systemic immune responses after administration into the lung","volume":"32","author":"Neuhaus","year":"2014","journal-title":"Vaccine"},{"issue":"11","key":"10.1016\/j.jconrel.2018.09.020_bb0095","doi-asserted-by":"crossref","first-page":"3840","DOI":"10.4049\/jimmunol.1700972","article-title":"Innate immune activation by cGMP-AMP nanoparticles leads to potent and long-acting antiretroviral response against HIV-1","volume":"199","author":"Aroh","year":"2017","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.jconrel.2018.09.020_bb0100","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.nano.2017.10.013","article-title":"Biodegradable STING agonist nanoparticles for enhanced cancer immunotherapy","volume":"14","author":"Wilson","year":"2017","journal-title":"Nanomedicine"},{"key":"10.1016\/j.jconrel.2018.09.020_bb0105","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.actbio.2015.10.025","article-title":"Submicron-sized hydrogels incorporating cyclic dinucleotides for selective delivery and elevated cytokine release in macrophages","volume":"29","author":"Lee","year":"2016","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jconrel.2018.09.020_bb0110","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jconrel.2014.04.004","article-title":"A new adjuvant delivery system 'cyclic di-GMP\/YSK05 liposome' for cancer immunotherapy","volume":"184","author":"Miyabe","year":"2014","journal-title":"J. Control. Release"},{"issue":"6","key":"10.1016\/j.jconrel.2018.09.020_bb0115","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.1172\/JCI79915","article-title":"Nanoparticulate STING agonists are potent lymph node-targeted vaccine adjuvants","volume":"125","author":"Hanson","year":"2015","journal-title":"J. Clin. Invest."},{"issue":"19","key":"10.1016\/j.jconrel.2018.09.020_bb0120","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.1016\/j.vaccine.2017.03.067","article-title":"Investigation of phosphorylated adjuvants co-encapsulated with a model cancer peptide antigen for the treatment of colorectal cancer and liver metastasis","volume":"35","author":"Goodwin","year":"2017","journal-title":"Vaccine"},{"issue":"1\u20132","key":"10.1016\/j.jconrel.2018.09.020_bb0125","article-title":"Liposomal Delivery Enhances Immune Activation by STING Agonists for Cancer Immunotherapy","volume":"1","author":"Koshy","year":"2017","journal-title":"Advanced Biosystems"},{"issue":"32","key":"10.1016\/j.jconrel.2018.09.020_bb0130","doi-asserted-by":"crossref","first-page":"10494","DOI":"10.1021\/ja803947s","article-title":"Acetal-derivatized dextran: an acid-responsive biodegradable material for therapeutic applications","volume":"130","author":"Bachelder","year":"2008","journal-title":"J. Am. Chem. Soc."},{"issue":"14","key":"10.1016\/j.jconrel.2018.09.020_bb0135","doi-asserted-by":"crossref","first-page":"5497","DOI":"10.1073\/pnas.0901592106","article-title":"Acetalated dextran is a chemically and biologically tunable material for particulate immunotherapy","volume":"106","author":"Broaders","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"8","key":"10.1016\/j.jconrel.2018.09.020_bb0140","doi-asserted-by":"crossref","first-page":"4149","DOI":"10.1021\/am3008888","article-title":"Synthesis and characterization of acetalated dextran polymer and microparticles with ethanol as a degradation product","volume":"4","author":"Kauffman","year":"2012","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"1\u20132","key":"10.1016\/j.jconrel.2018.09.020_bb0145","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ijpharm.2012.04.043","article-title":"Enhanced stability of horseradish peroxidase encapsulated in acetalated dextran microparticles stored outside cold chain conditions","volume":"431","author":"Kanthamneni","year":"2012","journal-title":"Int. J. Pharm."},{"issue":"2","key":"10.1016\/j.jconrel.2018.09.020_bb0150","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/bit.21301","article-title":"Microparticles and nanoparticles for drug delivery","volume":"96","author":"Kohane","year":"2007","journal-title":"Biotechnol. Bioeng."},{"issue":"3","key":"10.1016\/j.jconrel.2018.09.020_bb0155","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1021\/mp3005098","article-title":"Electrospray encapsulation of toll-like receptor agonist resiquimod in polymer microparticles for the treatment of visceral leishmaniasis","volume":"10","author":"Duong","year":"2013","journal-title":"Mol. Pharm."},{"issue":"3","key":"10.1016\/j.jconrel.2018.09.020_bb0160","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/adbi.201700022","article-title":"Co-delivery of disease associated peptide and rapamycin via acetalated dextran microparticles for treatment of multiple sclerosis","volume":"1","author":"Chen","year":"2017","journal-title":"Advanced Biosystems"},{"issue":"1","key":"10.1016\/j.jconrel.2018.09.020_bb0165","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ijpharm.2016.08.031","article-title":"Degradation of acetalated dextran can be broadly tuned based on cyclic acetal coverage and molecular weight","volume":"512","author":"Chen","year":"2016","journal-title":"Int. J. Pharm."},{"issue":"12","key":"10.1016\/j.jconrel.2018.09.020_bb0170","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1002\/pola.28579","article-title":"Degradation of poly(beta-amino ester) gels in alcohols through transesterification: a method to conjugate drugs to polymer matrices","volume":"55","author":"Gupta","year":"2017","journal-title":"J. Polym. Sci. A Polym. Chem."},{"issue":"1","key":"10.1016\/j.jconrel.2018.09.020_bb0175","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jconrel.2011.02.029","article-title":"Multi-responsive nanogels containing motifs of ortho ester, oligo(ethylene glycol) and disulfide linkage as carriers of hydrophobic anti-cancer drugs","volume":"152","author":"Qiao","year":"2011","journal-title":"J. Control. Release"},{"issue":"6","key":"10.1016\/j.jconrel.2018.09.020_bb0180","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1021\/bc700442g","article-title":"Polyketal copolymers: a new acid-sensitive delivery vehicle for treating acute inflammatory diseases","volume":"19","author":"Yang","year":"2008","journal-title":"Bioconjug. Chem."},{"issue":"12\u221213","key":"10.1016\/j.jconrel.2018.09.020_bb0185","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/j.micinf.2007.07.009","article-title":"Extended immunization intervals enhance the immunogenicity and protective efficacy of plasmid DNA vaccines","volume":"9","author":"Brice","year":"2007","journal-title":"Microbes Infect."},{"issue":"3","key":"10.1016\/j.jconrel.2018.09.020_bb0190","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1093\/infdis\/jit180","article-title":"Prime-boost interval matters: a randomized phase 1 study to identify the minimum interval necessary to observe the H5 DNA influenza vaccine priming effect","volume":"208","author":"Ledgerwood","year":"2013","journal-title":"J. Infect. Dis."},{"issue":"1","key":"10.1016\/j.jconrel.2018.09.020_bb0195","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S1074-7613(00)80461-6","article-title":"The duration of antigenic stimulation determines the fate of naive and effector T cells","volume":"8","author":"Iezzi","year":"1998","journal-title":"Immunity"},{"key":"10.1016\/j.jconrel.2018.09.020_bb0200","doi-asserted-by":"crossref","first-page":"563","DOI":"10.3389\/fimmu.2015.00563","article-title":"The timing of t cell priming and cycling","volume":"6","author":"Obst","year":"2015","journal-title":"Front Immunol"},{"issue":"29","key":"10.1016\/j.jconrel.2018.09.020_bb0205","doi-asserted-by":"crossref","first-page":"8385","DOI":"10.1016\/j.biomaterials.2014.05.067","article-title":"Time course study of the antigen-specific immune response to a PLGA microparticle vaccine formulation","volume":"35","author":"Wang","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2018.09.020_bb0210","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1600-065X.1997.tb00969.x","article-title":"Antigen localisation regulates immune responses in a dose- and time-dependent fashion: a geographical view of immune reactivity","volume":"156","author":"Zinkernagel","year":"1997","journal-title":"Immunol. Rev."},{"issue":"3","key":"10.1016\/j.jconrel.2018.09.020_bb0215","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1006\/smim.2000.0253","article-title":"Localization dose and time of antigens determine immune reactivity","volume":"12","author":"Zinkernagel","year":"2000","journal-title":"Semin. Immunol."},{"issue":"8","key":"10.1016\/j.jconrel.2018.09.020_bb0220","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.1021\/mp300643d","article-title":"Efficient delivery of the toll-like receptor agonists polyinosinic:polycytidylic acid and CpG to macrophages by acetalated dextran microparticles","volume":"10","author":"Peine","year":"2013","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jconrel.2018.09.020_bb0225","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jconrel.2018.01.027","article-title":"Tunable degradation of acetalated dextran microparticles enables controlled vaccine adjuvant and antigen delivery to modulate adaptive immune responses","volume":"273","author":"Chen","year":"2018","journal-title":"J. Control. Release"},{"issue":"23\u201324","key":"10.1016\/j.jconrel.2018.09.020_bb0230","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1016\/j.vaccine.2004.02.021","article-title":"Preclinical study of influenza virus A M2 peptide conjugate vaccines in mice, ferrets, and rhesus monkeys","volume":"22","author":"Fan","year":"2004","journal-title":"Vaccine"},{"key":"10.1016\/j.jconrel.2018.09.020_bb0235","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.antiviral.2017.01.021","article-title":"Consensus M2e peptide conjugated to gold nanoparticles confers protection against H1N1, H3N2 and H5N1 influenza A viruses","volume":"141","author":"Tao","year":"2017","journal-title":"Antivir. Res."},{"issue":"3","key":"10.1016\/j.jconrel.2018.09.020_bb0240","doi-asserted-by":"crossref","first-page":"426","DOI":"10.3201\/eid1303.061125","article-title":"Matrix protein 2 vaccination and protection against influenza viruses, including subtype H5N1","volume":"13","author":"Tompkins","year":"2007","journal-title":"Emerg. Infect. Dis."},{"issue":"1","key":"10.1016\/j.jconrel.2018.09.020_bb0250","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/jps.22267","article-title":"Acceptable levels of endotoxin in vaccine formulations during preclinical research","volume":"100","author":"Brito","year":"2011","journal-title":"J. Pharm. Sci."},{"issue":"4","key":"10.1016\/j.jconrel.2018.09.020_bb0255","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0151922","article-title":"Entrapment of H1N1 influenza virus derived conserved peptides in PLGA nanoparticles enhances T cell response and vaccine efficacy in pigs","volume":"11","author":"Hiremath","year":"2016","journal-title":"PLoS One"},{"issue":"40","key":"10.1016\/j.jconrel.2018.09.020_bb0260","doi-asserted-by":"crossref","first-page":"5373","DOI":"10.1016\/j.vaccine.2017.08.013","article-title":"A single dose and long lasting vaccine against pandemic influenza through the controlled release of a heterospecies tandem M2 sequence embedded within detoxified bacterial outer membrane vesicles","volume":"35","author":"Watkins","year":"2017","journal-title":"Vaccine"},{"key":"10.1016\/j.jconrel.2018.09.020_bb0265","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jconrel.2015.08.026","article-title":"Liposomes loaded with a STING pathway ligand, cyclic di-GMP, enhance cancer immunotherapy against metastatic melanoma","volume":"216","author":"Nakamura","year":"2015","journal-title":"J. Control. Release"},{"issue":"5","key":"10.1016\/j.jconrel.2018.09.020_bb0270","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1002\/eji.200737984","article-title":"Nanoparticles target distinct dendritic cell populations according to their size","volume":"38","author":"Manolova","year":"2008","journal-title":"Eur. J. Immunol."},{"issue":"8","key":"10.1016\/j.jconrel.2018.09.020_bb0275","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1007\/s11095-008-9562-y","article-title":"Role of particle size in phagocytosis of polymeric microspheres","volume":"25","author":"Champion","year":"2008","journal-title":"Pharm. Res."},{"issue":"5","key":"10.1016\/j.jconrel.2018.09.020_bb0280","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1111\/j.0818-9641.2004.01271.x","article-title":"Vaccines that facilitate antigen entry into dendritic cells","volume":"82","author":"Gamvrellis","year":"2004","journal-title":"Immunol. Cell Biol."},{"issue":"24","key":"10.1016\/j.jconrel.2018.09.020_bb0285","doi-asserted-by":"crossref","first-page":"5158","DOI":"10.1016\/j.vaccine.2006.04.008","article-title":"Protection against H1, H5, H6 and H9 influenza A infection with liposomal matrix 2 epitope vaccines","volume":"24","author":"Ernst","year":"2006","journal-title":"Vaccine"},{"issue":"2","key":"10.1016\/j.jconrel.2018.09.020_bb0290","doi-asserted-by":"crossref","first-page":"237","DOI":"10.2217\/nnm.13.58","article-title":"Gold nanoparticle-M2e conjugate coformulated with CpG induces protective immunity against influenza A virus","volume":"9","author":"Tao","year":"2014","journal-title":"Nanomedicine (Lond)"},{"issue":"20","key":"10.1016\/j.jconrel.2018.09.020_bb0295","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1002\/adhm.201600642","article-title":"Acetalated dextran microparticulate vaccine formulated via coaxial electrospray preserves toxin neutralization and enhances murine survival following inhalational bacillus anthracis exposure","volume":"5","author":"Gallovic","year":"2016","journal-title":"Adv Healthc Mater"},{"issue":"7","key":"10.1016\/j.jconrel.2018.09.020_bb0300","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0101474","article-title":"Alum and squalene-oil-in-water emulsion enhance the titer and avidity of anti-Abeta antibodies induced by multimeric protein antigen (1\u221211)E2, preserving the Igg1-skewed isotype distribution","volume":"9","author":"Mantile","year":"2014","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.jconrel.2018.09.020_bb0305","doi-asserted-by":"crossref","first-page":"5549","DOI":"10.4049\/jimmunol.153.12.5549","article-title":"One gene encodes the heavy chains for three different forms of IgY in the duck","volume":"153","author":"Magor","year":"1994","journal-title":"J. Immunol."},{"key":"10.1016\/j.jconrel.2018.09.020_bb0310","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.antiviral.2014.08.016","article-title":"Evaluation of a fully human monoclonal antibody against multiple influenza A viral strains in mice and a pandemic H1N1 strain in nonhuman primates","volume":"111","author":"Song","year":"2014","journal-title":"Antivir. Res."},{"issue":"2","key":"10.1016\/j.jconrel.2018.09.020_bb0315","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/nri3582","article-title":"The function of Fcgamma receptors in dendritic cells and macrophages","volume":"14","author":"Guilliams","year":"2014","journal-title":"Nat Rev Immunol"},{"issue":"19","key":"10.1016\/j.jconrel.2018.09.020_bb0320","doi-asserted-by":"crossref","first-page":"4957","DOI":"10.1016\/j.biomaterials.2012.03.041","article-title":"Role of sustained antigen release from nanoparticle vaccines in shaping the T cell memory phenotype","volume":"33","author":"Demento","year":"2012","journal-title":"Biomaterials"},{"issue":"4","key":"10.1016\/j.jconrel.2018.09.020_bb0325","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1021\/mp2004059","article-title":"Amphiphilic polyanhydride nanoparticles stabilize Bacillus anthracis protective antigen","volume":"9","author":"Petersen","year":"2012","journal-title":"Mol. Pharm."},{"issue":"1","key":"10.1016\/j.jconrel.2018.09.020_bb0330","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jconrel.2006.01.012","article-title":"Pharmaceutical and immunological evaluation of a single-dose hepatitis B vaccine using PLGA microspheres","volume":"112","author":"Feng","year":"2006","journal-title":"J. Control. Release"},{"issue":"3","key":"10.1016\/j.jconrel.2018.09.020_bb0335","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/nmat1075","article-title":"Molecularly engineered poly(ortho ester) microspheres for enhanced delivery of DNA vaccines","volume":"3","author":"Wang","year":"2004","journal-title":"Nat. Mater."},{"issue":"24","key":"10.1016\/j.jconrel.2018.09.020_bb0340","doi-asserted-by":"crossref","first-page":"2882","DOI":"10.1016\/j.vaccine.2014.02.027","article-title":"Adjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release","volume":"32","author":"Ilyinskii","year":"2014","journal-title":"Vaccine"},{"issue":"7335","key":"10.1016\/j.jconrel.2018.09.020_bb0345","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/nature09737","article-title":"Programming the magnitude and persistence of antibody responses with innate immunity","volume":"470","author":"Kasturi","year":"2011","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.jconrel.2018.09.020_bb0350","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.jconrel.2005.10.010","article-title":"Encapsulation of the immune potentiators MPL and RC529 in PLG microparticles enhances their potency","volume":"110","author":"Kazzaz","year":"2006","journal-title":"J. Control. Release"},{"issue":"1","key":"10.1016\/j.jconrel.2018.09.020_bb0355","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3201\/eid1201.051237","article-title":"Cell-mediated protection in influenza infection","volume":"12","author":"Thomas","year":"2006","journal-title":"Emerg. Infect. Dis."},{"issue":"27","key":"10.1016\/j.jconrel.2018.09.020_bb0360","doi-asserted-by":"crossref","first-page":"4460","DOI":"10.1016\/j.vaccine.2011.04.040","article-title":"Characterization of the murine Th2 response to immunization with liposomal M2e influenza vaccine","volume":"29","author":"Adler-Moore","year":"2011","journal-title":"Vaccine"},{"issue":"1","key":"10.1016\/j.jconrel.2018.09.020_bb0365","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/s41467-017-02725-4","article-title":"Double-layered protein nanoparticles induce broad protection against divergent influenza A viruses","volume":"9","author":"Deng","year":"2018","journal-title":"Nat. Commun."},{"issue":"13","key":"10.1016\/j.jconrel.2018.09.020_bb0370","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1016\/j.vaccine.2008.01.030","article-title":"TLR ligands and antigen need to be coencapsulated into the same biodegradable microsphere for the generation of potent cytotoxic T lymphocyte responses","volume":"26","author":"Schlosser","year":"2008","journal-title":"Vaccine"},{"issue":"7085","key":"10.1016\/j.jconrel.2018.09.020_bb0375","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1038\/nature04596","article-title":"Toll-dependent selection of microbial antigens for presentation by dendritic cells","volume":"440","author":"Blander","year":"2006","journal-title":"Nature"},{"issue":"20","key":"10.1016\/j.jconrel.2018.09.020_bb0380","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1016\/j.vaccine.2015.03.063","article-title":"M2e-immobilized gold nanoparticles as influenza A vaccine: Role of soluble M2e and longevity of protection","volume":"33","author":"Tao","year":"2015","journal-title":"Vaccine"},{"issue":"5","key":"10.1016\/j.jconrel.2018.09.020_bb0385","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0126650","article-title":"Protection against influenza A virus challenge with M2e-displaying filamentous Escherichia coli phages","volume":"10","author":"Deng","year":"2015","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.jconrel.2018.09.020_bb0390","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1093\/ilar.37.3.141","article-title":"Institutional policies and guidelines on adjuvants and antibody production","volume":"37","author":"Jackson","year":"1995","journal-title":"ILAR J."},{"issue":"2","key":"10.1016\/j.jconrel.2018.09.020_bb0395","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/mt.2012.246","article-title":"Virus-like particles containing multiple M2 extracellular domains confer improved cross-protection against various subtypes of influenza virus","volume":"21","author":"Kim","year":"2013","journal-title":"Mol. Ther."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365918305509?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365918305509?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T15:35:55Z","timestamp":1759160155000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365918305509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":77,"alternative-id":["S0168365918305509"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2018.09.020","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Investigation of tunable acetalated dextran microparticle platform to optimize M2e-based influenza vaccine efficacy","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2018.09.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}